Browsing by Author "Oglak, Suleyman Cemil"

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Placental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus
(2024) Asır, Fırat; Oglak, Suleyman Cemil; Korak, Tugcan; Tas, Fatih; Yılmaz, Mehmet; Erdemcı, Fikri; Bolluk, Gokhan; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
OBJECTIVE: This study investigated vimentin expression in placentas of patients with preeclampsia and gestational diabetes mellitus (GDM). STUDY DESIGN: Placentas of preeclamptic women (n=25), women with GDM (n=25), and control cases (n=25) were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recorded. Vimentin immune activity was analyzed in the placental sections with immunohistochemistry. Sections were imaged and analyzed under a light microscope. A semiquantitative measurement was done be- tween groups by comparing the Vimentin signal and significance was calculated. Network construction and pathway enrichment analysis were conducted using Cytoscape (v3.10.1) and ShinyGO, respectively. RESULTS: Vimentin expression was high in the placental sections of the control group. The preeclamp- sia group showed positive Vimentin expression in cytotrophoblast and syncytiotrophoblast cells and con- nective tissue of placental villi in the preeclampsia group. Vimentin expression was generally recorded as negative in placental villi, fibrinoid substances, and connective tissue cells in the GDM group. Bioinformatic analysis showed that the AGE-RAGE signaling pathway and cancer-related pathways were mainly observed in Vimentin-associated pathways, which finally activate inflammatory pathways in both preeclampsia and GDM. CONCLUSION: Vimentin expression patterns in placental tissue sections reveal nuanced regulatory mechanisms, emphasizing the need for further exploration into the functional roles of vimentin in pla- cental physiology and pathology.
Retrospective Evaluation of Patients Admitted to the Intensive Care Unit Due to Obstetric Reasons in Terms of Maternal Near-Miss, a Five-Year Case-Control Study
(BMC, 2025) Erdem, Ozgur; Oglak, Suleyman Cemil; Toktas, Izzettin; Baydemir, Seher; Yosunkaya, Ahmet; Erdem, Ali
Background Maternal Near-Miss (MNM) has become globally recognized as an indicator of pregnancy, birth and the first 42 days of postpartum care services. The World Health Organization has taken a new approach to detail and better analyze maternal deaths. The clinic-based criteria to evaluate maternal care and the quality of related care services have been developed. Methods This is a retrospective case-control study that was conducted in a tertiary hospital. In the study, the medical files of all patients admitted to the intensive care unit during the five-year period between 2018 and 2022 were examined. All patients who met the MNM criteria of WHO during pregnancy, birth and puerperium were included in the case group of the study. Meanwhile, the participants in the control group were selected from mothers who gave birth in the same hospital between August 15 and October 31, 2023 and did not develop any complications during puerperium, using the systematic sampling method. Data collection was performed using an interviewer-administered structured questionnaire and data abstraction. Results In this five-year period, 198 mothers were diagnosed with MNM. In our study, the prevalence of MNM was found as 218/100.000. The most common laboratory changes that met the MNM criteria were elevated lactate levels (38.89%), acidosis (24.24%) and acute thrombocytopenia. Patients were most frequently admitted to the intensive care unit due to hemorrhage (23.74%), placental abruption (18.18%), pre-eclampsia (15.66%) and cesarean Sect. (10.10%), respectively. The frequency of co-morbidities (Diabetes mellitus, Hypertension, Asthma, Hypothyroidism, etc.) in patients diagnosed with MNM (n = 48; 26.67%) was found to be 5.5 times that of the control group (n = 25; 6.20%) (p < 0.001). Conclusions It can be said that co-morbidities directly affect the course of motherhood. the education level and family income were found higher in the MNM group compared to the control group. In this regard, the results of our study differ from the studies in the literature in terms of the effects of the education level of mothers and the economic status of families. The effects of socioeconomic and cultural factors on MNM may vary.