Browsing by Author "Orhan, Ozhan"

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Acute Cyanide Intoxication Due To Apricot Seed Ingestion
(Soc Argentina Pediatria, 2024) Talay, Mehmet N.; Gungor, Emre; Orhan, Ozhan
Introduction : Cyanide poisoning, whether it be accidental or intentional, remains a significant danger to adults and children, especially in societies where agriculture is a primary source of income. We examined the clinical follow-up, complications, and results of cyanide poisoning cases that occurred after eating the pits and seeds of plants containing cyanide glycosides, such as apricot kernels and almonds. Methods : Between 01/01/2017 and 01/08/2022, 14 children aged 1-18 years who were followed up with a prediagnosis of cyanide poisoning in our Paediatric Intensive Care Unit (PICU) were retrospectively analysed. Results : Eight of the patients followed with a preliminary diagnosis of cyanide poisoning were female and six were male. The most common admission month was July (42.8%) coinciding with the agricultural season. The most common symptoms at presentation were weakness and fatigue (n = 7). In the PICU, 4 patients presented lip cyanosis; 3, altered level of consciousness. Vomiting, seizure, headache, dizziness and palpitatons were less frequent. Four patients were treated with hydroxocobalamin (Cyanokit (R) ) as an antidote due to acidosis in their blood gases. All patients treated for cyanide poisoning were discharged. Conclusions : Cyanide poisoning should be considered in paediatric patients with suspicious findings, sudden loss of consciousness, increased anion gap acidosis and lactic acidosis. The history of eating the seeds of plants such as apricot and almonds should be investigated .
Acute Cyanide Poisoning Due To Ingestion of Apricot Seeds
(Soc Argentina Pediatria, 2024) Talay, Mehmet N.; Gungor, Emre; Orhan, Ozhan
[No Abstract Available]
Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy
(Mdpi, 2025) Orhan, Ozhan; Gokdemir, Gul Sahika
Background/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.
Epidemiology, Clinical and Laboratory Findings of Pediatric Leptospirosis in Southeastern Turkey
(Briefland, 2024) Orhan, Ozhan; Elci, Huseyin
Background: Leptospirosis is a significant zoonotic infection caused by Leptospira spirochetes, which are distributed globally. Infection typically occurs through exposure to water or soil contaminated by the urine of mammals, including dogs, cattle, pigs, or rodents. Objectives: The objective of this study was to elucidate the epidemiological, clinical, and laboratory characteristics of leptospirosis cases in Turkey. Methods: In a retrospective review, we analyzed the clinical and laboratory data of all individuals under 18 years diagnosed with leptospirosis at a secondary care center in Southeast Turkey from the beginning of 2020 to the end of 2O22. Results: Over the two-year period, 36 confirmed cases of leptospirosis in individuals under 18 were identified. All patients had been engaged in activities at wells in cornfields, assisting their families with irrigation or related to well operations. Of these patients, 3 (8%) resided in urban areas, while 33 (92%) lived in rural settings. None required intensive care, and there were no fatalities reported. The most common symptoms at presentation were fatigue (83%), fever (75%), and nausea/vomiting (75%). Laboratory tests revealed that all patients had positive C-reactive protein (CRP) levels, with a significant portion (61%) showing Conclusions: In conclusion, leptospirosis should be considered by clinicians when evaluating patients, especially those with risk factors like occupational exposure. Prompt testing for the disease is advisable under these circumstances.
Evaluation of Children and Adolescents With Thalassemia Major in Terms of Osteoporosis: a Single-Centre Experience
(Mdpi, 2025) Demir, Hasan; Talay, Mehmet Nur; Talay, Mehmet Nur; Ozgun, Nezir; Ozbek, Mehmet Nuri
Background/Objectives: This study aimed to determine the frequency of osteoporosis in children and adolescents with thalassemia major (TM) and to identify risk factors for the early development of osteoporosis. Methods: This retrospective study included 27 patients under 18 years of age receiving regular blood transfusions and chelation therapy for TM at our hospital. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry, and a lumbar spine Z-score <-2 was considered osteoporotic. Patients with osteoporosis were classified as Group 1 and those without osteoporosis as Group 2. Results: Osteoporosis was detected in 22.2% of the study population. The mean age was 13.83 +/- 2.85 years in Group 1 and 7.95 +/- 5.05 years in Group 2 (p = 0.012). Body weight and height were significantly lower in Group 1 (p = 0.012 and p = 0.004). Ferritin levels were 5306 +/- 1506 ng/mL in Group 1 and 2020 +/- 1205 ng/mL in Group 2, and the difference was significant (p = 0.001). Group 1 had significantly lower Ca and P levels (p < 0.001, p = 0.038). BMD was negatively correlated with ferritin (r = -0.791, p < 0.001) and positively correlated with calcium (r = 0.499, p = 0.008). Conclusions: Osteoporosis is a common condition in TM patients. Patients with risk factors should be followed more closely. These patients should be identified before BMD decreases. To prevent osteoporosis, regular BMD scans should be performed, calcium and vitamin D supplementation should be provided, and physical activity should be encouraged.
Evaluation of Measles Cases in a Province in South-Eastern Turkey Receiving Migration From Syria
(Wiley, 2025) Talay, Mehmet Nur; Solmaz, Murat; Talay, Mehmet Nur
Aim: The study aimed to compare the demographic, clinical and vaccination status of measles cases in 2023 in our region receiving migration from Syria and to evaluate the effect of migration on disease dynamics. Methods: This retrospective study analysed the demographic profiles, clinical features and vaccination status of a total of 98 (67 children born and raised in Turkey [group 1] and 31 children of Syrian origin [group 2]) clinically compatible measles patients presenting to all healthcare institutions in Batman, Turkey, in 2023. Results: Significant differences were observed between groups in vaccination coverage (90.3% unvaccinated amongst Group 2 vs. 55.2% amongst Group 1, p < 0.001), IgM positivity (87.1% vs. 26.9%, p < 0.001) and hospitalisation rates (38.7% vs.16.4%, p = 0.015). Group 2 exhibited higher prevalence of fever (93.5% vs. 70.1%, p = 0.010) and cough (58.1% vs. 26.9%, p = 0.003) than Group 1. Conclusion: The study highlights the impact of migration and socio-economic factors on measles dynamics. Lower vaccination rates amongst Syrian migrants contribute to increased measles incidence and severity. Strengthening vaccination programmes and public health initiatives are crucial for controlling measles outbreaks and improving health outcomes, particularly in vulnerable populations.
Evaluation of the Results of the Patients Who Underwent Plasmapheresis in the Pediatric Intensive Care Unit
(Tubitak Scientific & Technological Research Council Turkey, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Kangin, Murat; Turanli, Ese Eda; Ozbek, Mehmet Nuri
Background/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Ya & scedil;argil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients' diagnosis, weight, type of procedure and type of device, where the procedure was performed, duration of the procedure, amount of blood and plasma processed, complications, number of procedures, and death during the procedure or independent of the procedure were evaluated. Results: The median age was 93.0 (14.0-167.0) months. Hemolytic uremic syndrome (HUS) was the most common TPE indication with nine patients. The most common complication related to TPE was fever (11 patients), while no complication was observed in 18 patients. When laboratory results were evaluated according to American Society for Apheresis (ASFA) categories, a significant improvement was observed in the values of platelet, AST, ALT, LDH, urea, and creatinine in ASFA1 after TPE. No significant improvement was observed in ASFA2 (p > 0.05). In ASFA3, a significant improvement was observed in INR, AST, ALT, LDH, total bilirubin, creatinine, pH, and lactate values after TPE (p < 0.05). Five patients died from ASFA1, one from ASFA2, and three patients from ASFA3. Conclusion: Since significant adjustments are observed in clinical and laboratory values in sepsis-MOF, which is in the ASFA3 category, we believe that it should be evaluated in the ASFA2 or ASFA1 category in the early treatment of these diseases. In addition, we think that MIS -C cases, which have not been in any category according to ASFA, should be included in the ASFA2 or ASFA3 category, considering our TPE results.
Hyperinsulinemic Hypoglycemia in Childhood
(Pera Yayincilik Hizmetleri, 2023) Özbek, Mehmet Nuri; Ozbek, Mehmet Nuri; Orhan, Ozhan; Orhan, Özhan
Hyperinsulinemic Hypoglycemia (HH) is the most common cause of permanent hypoglycemia, especially in the neonatal period. Childhood HH is mostly related to genes encoding proteins in the insulin secretion pathways, and may also be seen in syndromes such as Beckwidth Wiedemann, Kabuki, and Turner. The majority of congenital HH cases are the result of KATP channel gene defect. Most of these cases are unresponsive to diazoxide treatment. In this review, recent genetic studies and recent updates in treatment options in childhood HH are reviewed.
Investigation of Vitamin D, Vitamin B12 and Ferritin Levels in Children Receiving Home Health Care Services in Southeastern Türkiye
(2023) Orhan, Ozhan; Solmaz, Murat
Aim: For proper nutrition of children followed by the Home Health Care (HHC) unit, a close follow-up is extremely important. Vitamin deficiencies are common in children in this group who need parental or caregiver-dependent nutrition. The purpose of this study conducted in Batman Province, was to investigate vitamin D, vitamin B12 and ferritin levels of individuals under 18 years of age who are followed by the HHC unit and continue their lives and treatments at home, except for emergencies. Materials and Methods: This study was derived from the files of 416 pediatric patients who were followed up in Batman Province HHC unit between January 1, 2022, and December 31, 2022. It was designed as a retrospective, single-center study evaluating 25-hydroxyvitamin D (OH) levels, vitamin B12 levels, ferritin levels, and demographic variables from individuals followed by HHC unit. The data were collected from the HHC unit’s files. IBM-SPSS version 24 was used for analysis. Results: The mean age of the 416 children receiving home health care services included in the study was 10.38±4.37 years. 234 (56.2%) of the participants were male and 182 (43.8%) were female. The 25(OH)D level was 18.47±5.41 ng/mL for all ages, and the ferritin level was 34.90 (33.08) ng/mL. The vitamin B12 level was 480.31±190.38 ng/L. The 25-OH-D vitamin levels of the children in the study were significantly low. Conclusion: Patients followed within the scope of home health care services are at risk for malnutrition and vitamin deficiencies, and annual follow-up of the patients in this regard and personalized diet programs should be created. Vitamin D insufficiency and deficiency are common in children in this group, who cannot leave the house except for compulsory situations and cannot benefit from sunlight sufficiently. We think that these children with chronic diseases should take vitamin D prophylaxis.
Metahemoglobinemia y hemolisis intravascular aguda despues de una intoxicacion por naftaleno en un paciente pediatrico
(Soc Argentina Pediatria, 2023) Orhan, Ozhan; Talay, Mehmet N.
[No Abstract Available]
Our Treatment Experience in Poisoning With Calcium Channel Blockers: a Series of Twelve Cases
(Briefland, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Ozbek, Mehmet Nuri; Kangin, Murat; Turanli, Ese Eda
Background: Intoxications with cardiovascular system drugs constitute a small percentage of all poisoning cases. Calcium Channel Blockers (CCBs) are the most common drug poisoning in this group. Objectives: We aimed to evaluate the effectiveness of treatments for CCB poisoning and add to the current body of literature by outlining the clinical treatments we employ for bradyarrhythmia, hypotension, and resistant vasodilation resulting from CCB poisoning, as well as sharing our clinical insights in this field. Methods: Twelve patients, ranging in age from 1 month to 18 years, were admitted to the Tertiary Paediatric Intensive Care Unit (PICU) for treatment of medication poisoning related to the CCB group. Patients who ingested several drugs that caused CCB were not allowed to participate in the trial. Results: Twelve patients were followed up in the PICU due to poisoning with CCB group drugs. Of the patients, 7 were male and 5 were female. Five of the patients had taken CCB medication with the purpose of committing suicide, and 7 of them accidentally. All of the patients who received CCB to commit suicide had taken verapamil. Five patients whose hypotension and bradycardia continued were administered inotropes. In addition to PI, calcium gluconate, intravenous lipid, glucagon, insulin, bicarbonate, and methylene blue were given as therapy to our symptomatic patients. Plasmapheresis was applied to a patient who was hospitalized in the PICU due to a sudden loss of consciousness. Conclusions: In the management of patients with CCB poisoning, the use of hyperinsulinemia euglycemia, intravenous lipid emulsion treatment, glucagon treatments, and treatments including methylene blue and extracorporeal life support should be considered in cases of resistant hypotension, bradycardia, and coma in the early period.
Retrospective Investigation of Children Presented With Febrile Convulsion
(2024) Talay, Mehmet Nur; Talay, Mehmet Nur; Solmaz, Murat
Aim: In this study, we aimed to determine the characteristics of patients admitted with the diagnosis of febrile convulsion (FC) and to evaluate the most common diagnosis and the most frequent months of presentation. Materials and Methods: A total of 172 children who were admitted to the pediatric emergency unit in the last one year due to FC and were admitted for observation were included in the study. The age range of the children included in the study was 5 months - 6 years (72 months). Patients were analyzed in terms of age, gender, diagnosis at presentation, type of FC, month of presentation, whether brain tomography was performed, sodium level, CRP level, white blood cell (WBC) count, and glucose level. SPSS (Statistical Package for Social Sciences) for Windows 22.0 program was used for statistical analysis. Results: The median age of the patients was 20 (11-34) months and 58.7% were male. Upper respiratory tract infections were the most common cause of convulsions with 72.7%. Acute gastroenteritis followed with 20.9%. Simple febrile convulsion was present in 89.5% of cases. Brain tomography was required in 33.1% of the patients admitted due to FC. The most common month of presentation was November with 16.3%. Mean WBC level was 13.4±6.0 (x103 /µL), mean CRP level was 24.2±35.3 (mg/L), mean Glucose level was 117±29.8 (mg/dL), mean Sodium level was 137±13.9 (mmol/L). Conclusion: In the management of this condition, which is uncomplicated and has no long-term effects in most patients, it is important to avoid unnecessary examinations and to provide accurate information to families.