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Browsing by Author "Tural, B."

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    Article
    Citation - WoS: 6
    Citation - Scopus: 14
    Adsorptive Performance of Magnetic Nano-Biosorbent for Binary Dyes and Investigation of Comparative Biosorption
    (Springer Nature, 2019) Tarhan, T.; Tarhan, Tuba; Tural, B.; Boga, K.; Tural, S.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
    The individual and competitive biosorption capacities of Metanil Yellow (MY) and Reactive Black 5 (RB5) by glutaraldehyde cross-linked magnetic chitosan nanoparticles (GMCNs) were studied. Competitive biosorption of the MY and RB5 dyes by the GMCNs has never been reported previously. Fourier transform infrared technique has been used to show the biosorbed MY and RB5 dyes onto GMCNs. During the studies, various essential factors influencing the biosorption, like adsorbate concentration, pH of the solution and contact time have been monitored. The equilibrium was achieved within 17 h for single dyes and 3 h for binary mixture at pH 3. The biosorption capacities were 620 mg/g for dye MY and 2549 mg/g for dye RB5 at pH 3, 30 °C. The second-order kinetic model has good compatibility with the dynamical biosorption behavior of a single dye and binary mixture. In order to study the competition biosorption of the RB5 and MY dyes in mixture solutions, the intraparticle diffusion model was used. Competition biosorption through analysis of the intraparticle diffusion model apparently favored the RB5 dye more than the MY dye on the GMCNs in mixture solutions. The biosorbent was regenerated efficiently through the alkaline solution and was then reused ten times for biosorption–desorption cycles. © 2018, Springer Nature Switzerland AG.
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    Conference Object
    Citation - WoS: 0
    Covalent immobilization of benzoylformate decarboxylase on magnetic solid support and its carboligation reactivity
    (WILEY-BLACKWELL, 2014) Tarhan, T.; Tural, B.; Tural, S.
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    Citation - WoS: 0
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    Article
    Citation - WoS: 11
    Citation - Scopus: 13
    Synthesis and Characterization of New Branched Magnetic Nanocomposite for Loading and Release of Topotecan Anti-Cancer Drug
    (Springer, 2019) Tarhan, T.; Tarhan, Tuba; Tural, B.; Tural, S.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
    The purpose of this study is to synthesize the new branched magnetic nanocomposite to carry the therapeutic agents and bio-macromolecules. Although topotecan (TPT) has significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers, lactone ring opening causes a reduction in cytotoxic activity and severe side effects in physiological conditions. In order to contribute to the removal of the handicap (lactone ring opening), magnetic dextran branched with NαNα-Bis (carboxymethyl)-l-lysine hydrate (NTA) nanoparticles (MD3) were prepared. The characterization of the resulting MD3 material was done by using multi-pronged analyses. The stability and release of TPT with synthesized and characterized new material of the MD3 was studied using various essential factors like concentration, dosage, pH, and time. The entrapment efficiency and loading capacity of TPT onto MD3 was calculated as 32.2% and 1.44 mg/g, respectively, at pH 5. Release studies were performed with drug-loaded MD3 at different pH values. It was seen that the best release was obtained at the cancerous site pH. Initial drug concentration was measured as 0.118 mM. The loaded drug concentration was calculated as 0.0380 mM at pH 5 and 0.00092 mM of drug was released after 90 min at pH 5.8. Percentage released of drug was found as 2.42% during 90 min. [Figure not available: see fulltext.]. © 2019, The Author(s).
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    Citation - WoS: 0
    Synthesis and Characterization of the Branched Magnetic Polymer for Drug Delivery Systems
    (Wiley-Blackwell, 2016) Tarhan, Tuba; Tarhan, T.; Tural, B.; Tural, S.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü