Browsing by Author "Ugras, Seda"

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    Article
    Can Inflammatory Indices Predict Myringosclerosis
    (Saudi Med J, 2025) Sari, Neslihan; Savas, Hasan Basri; Ugras, Seda; Durucu, Cengiz
    Objectives: To examine the relationships between the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) in myringosclerosis after ventilation tube insertion (VTI). Methods: We conducted this descriptive case-control study between March 2022 and September 2024. A total of 75 children aged 6 to 12 years with a history of VTI were enrolled. Myringosclerosis+ (n=43) included children with myringosclerosis, while Myringosclerosis-(n=32) included children without myringosclerosis. Preoperative values for NLR, PLR, and SII were collected by hematological testing and calculations. Demographic factors, prognostic risk factors and discrimination power of parameters were determined by statistical methods. Results: Compared to the myringosclerosis-, the myringosclerosis+ had significantly higher NLR, PLR, and SII values (p=0.00, p=0.04, and p=0.01, respectively). Receiver operating characteristic (ROC) curve area of NLR is 0,76 (95% CI: 0.65-0.87, p=0.00). Area under curve of SII is 0,62 (95%CI: 0.57-0.81, p=0.01). Neutrophil-to-lymphocyte ratio affects myringosclerosis development at 1.34 with sensitivity=0.63, specificity=0.78. Neutrophilto-lymphocyte ratio(NLR) and systemic immune inflammation index(SII) show myringosclerosis development at different powers of predictivity. The ROC area of NLR is highest of all parameters but is moderately predictive (<0.80). It is slight for SII. The NLR may be a marker of prediction of myringosclerosis OR=0.182 (95%CI:0.067-0.496). Conclusion: Neutrophil-to-lymphocyte ratio and SII are systemic inflammatory prognostic markers in myringosclerosis, and elevated NLR values are a predictor of myringosclerosis with modest affect. Other parameters should be sought in myringosclerosis development.
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    Article
    Cardiac Autonomic Control Reflects Sympathovagal Changes Associated With Withholding Urination
    (Wiley, 2025) Alabdo, Ahmad; Oflazoglu, Basak; Kus, Mehmet Mustafa; Cakan, Pinar; Ugras, Seda; Yildiz, Sedat
    IntroductionIncreased volume of the urinary bladder causes urge to urinate and constricts the sphincter by increasing the tonus of the sympathetic nervous system (SNS). Activity of the autonomic nervous system (or sympatho-vagal balance) can be assessed by heart rate variability (HRV). Current study aimed to test in healthy young male participants whether HRV technique reflects increased sympathovagal balance during bladder distention as revealed by strong urge to urinate.Materials and MethodsA total of young and apparently healthy 11 males agreed to participate to the current study. They were asked to provide 5-min continuous electrocardiogram (ECG) recordings in supine position for determination of HRV on two occasions, i.e. before and approximately for 3 1/2 hours after withholding urination. HRV parameters included heart rate (HR, per min), total power (TP, ms2), and standard deviation of RR intervals (SDNN, ms); percentage of successive RR intervals that were different >= 50 ms (pNN50), low frequency (LF) and high frequency (HF) bands and their normalized units (LFnu and HFnu, respectively) and their ratios (LF/HF). Half of the students provided samples on both occasions and those data were compared by paired t-test following log10 transformation.ResultsWithholding urination did not change HR (from 80.0 +/- 4.1 to 84.5 +/- 3.1 per min, p = 0.135) but decreased total power (from 2692 +/- 802 to 1605 +/- 357 ms2, p = 0.008), SDNN (from 50.4 +/- 5.8 to 38.7 +/- 3.8 ms, p = 0.007) and pNN50 (from 15.6 +/- 3.3 to 5.9 +/- 2.6%, p = 0.016) and increased LFnu (from 57.3 +/- 5.3 to 65.1 +/- 4.5, p = 0.029) and LF/HF ratio (from 1.77 +/- 0. 73 to 2.42 +/- 0.47, p = 0.047).ConclusionsIncreased LF/HF together with decreased SDNN and pNN50 suggest that HRV successfully reflects increased sympathetic tonus over the parasympathetic to help accommodate the urine in the bladder. Moreover, it seems that HRV can be used to assess sympathovagal changes non-invasively during voiding. Additionally, it appears that in all HRV measurements, participants should not have postponed their urination during recording.