PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Evaluation of Serum Levels of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) as Potential Biomarkers of Renal Tubular Damage in Brucellosis Patients
(Dove Medical Press Ltd, 2025) Dundar, Ahmet; Irmak, Halit; Ayhanci, Tugba; Yildiz, Songul Cetik
Background: Brucellosis is a zoonotic and multisystemic disease that is widespread worldwide and can present with many different clinical conditions, ranging from asymptomatic to serious and fatal conditions. Brucellosis may be linked to renal tubular and acute kidney damage, nephrotic syndrome, and various types of nephropathies. Objective: Our research was carried out prospectively to investigate the relationship between brucellosis and various biochemical markers and particularly to investigate the role of renal tubular damage biomarkers. Methods: Demographic and biochemical data from 60 controls and 60 brucellosis patients were included in the study. Kidney injury molecule-1 (KIM-1) and Neutrophil gelatinase-associated lipocalin (NGAL) were analyzed by. The diagnostic accuracy of KIM-1 and NGAL for brucellosis was assessed using receiver operating characteristic (ROC) curve analysis. Results: According to our findings, significant differences of KIM-1 and NGAL were observed between brucellosis and healthy patients. A high AUC (area under the curve) value of 0.742 (95% CI: 0.616-0.868) and 0.835 (95% CI: 0.729-0.941) was observed for KIM-1 and NGAL, respectively. Conclusion: Serum levels of KIM-1 and NGAL, which are renal tubular damage markers, where higher in Brucellosis than in healthy patients. These biomarkers can contribute to the rapid and accurate diagnosis of brucellosis regarding the involvement of nephropathies and to the standardization of comprehensive diagnostic warning indicators.
Citation - WoS: 1
Citation - Scopus: 1
Safety Analysis of Different Intensities of ELF-PEMF in Terms of Apoptotic, Inflammatory, and Transcription Factor NF-κB Expression Levels in Rat Liver
(Kare Publ, 2024) Seker, Ugur; Gökçe, Yasin; Özöner, Merve Pekince
Background and Aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF- PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats. Materials and Methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Con- trol, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the de- vice was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field applica- tion was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed. Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group. Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apop- tosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.

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