PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Citation - WoS: 11
Citation - Scopus: 12
The Effectiveness of HALP Score in Predicting Mortality in Non-ST Myocardial Infarction Patients
(Lippincott Williams and Wilkins, 2025) Kiliç, R.; Guzel, T.; Aktan, A.; Güzel, H.; Kaya, A.F.; Çankaya, Y.
Background: The HALP score, measured based on hemoglobin, albumin, lymphocyte, and platelet levels, is regarded as a novel scoring system that indicates the status of systemic inflammation and nutritional health. Our study aimed to evaluate the relationship between HALP score and prognosis in non-ST-elevation myocardial infarction (NSTEMI) patients. Methods Between 1 January 2020 and 1 January 2022, 568 consecutive patients diagnosed with NSTEMI from a single center were included in the study retrospectively. The patients were divided into two equal groups according to the median HALP cutoff value of 44.05. Patients were followed for at least 1 year from the date of admission. Results The average age of the patients was 62.3±10.6 years and 43.7% were female. In-hospital and 1-year mortality were found to be significantly higher in the group with low HALP scores (6.0 vs. 2.1%, P=0.019 and 22.5 vs. 9.9%, P<0.001, respectively). In receiver operating characteristic curve analysis, a cutoff level of 34.6 of the HALP score predicted 1-year mortality with 71% sensitivity and 65% specificity (area under the curve: 0.707, 95% confidence interval: 0.651-0.762, P<0.001). In Kaplan-Meier analysis, higher mortality rates were observed over time in the group with lower HALP scores (log-rank test=16.767, P<0.001). In Cox regression analysis, the HALP score was found to be an independent predictor of 1-year mortality (odds ratio: 0.969, 95% confidence interval: 0.958-0.981, P<0.001). Conclusion We found that a low HALP score could predict in-hospital and 1-year mortality in patients admitted to the hospital with a diagnosis of NSTEMI. © © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Evaluation of Serum Levels of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) as Potential Biomarkers of Renal Tubular Damage in Brucellosis Patients
(Dove Medical Press Ltd, 2025) Dundar, Ahmet; Irmak, Halit; Ayhanci, Tugba; Yildiz, Songul Cetik
Background: Brucellosis is a zoonotic and multisystemic disease that is widespread worldwide and can present with many different clinical conditions, ranging from asymptomatic to serious and fatal conditions. Brucellosis may be linked to renal tubular and acute kidney damage, nephrotic syndrome, and various types of nephropathies. Objective: Our research was carried out prospectively to investigate the relationship between brucellosis and various biochemical markers and particularly to investigate the role of renal tubular damage biomarkers. Methods: Demographic and biochemical data from 60 controls and 60 brucellosis patients were included in the study. Kidney injury molecule-1 (KIM-1) and Neutrophil gelatinase-associated lipocalin (NGAL) were analyzed by. The diagnostic accuracy of KIM-1 and NGAL for brucellosis was assessed using receiver operating characteristic (ROC) curve analysis. Results: According to our findings, significant differences of KIM-1 and NGAL were observed between brucellosis and healthy patients. A high AUC (area under the curve) value of 0.742 (95% CI: 0.616-0.868) and 0.835 (95% CI: 0.729-0.941) was observed for KIM-1 and NGAL, respectively. Conclusion: Serum levels of KIM-1 and NGAL, which are renal tubular damage markers, where higher in Brucellosis than in healthy patients. These biomarkers can contribute to the rapid and accurate diagnosis of brucellosis regarding the involvement of nephropathies and to the standardization of comprehensive diagnostic warning indicators.
GC–MS and LC–MS/MS-Based Phytochemical Profiling and Bioactivities of Salvia Montbretii and S. Hydrangea: Antioxidant, Cytotoxic and Enzyme Inhibitory Potential
(John Wiley and Sons Ltd, 2026) Kolak, U.; Cavusoglu, M.; Akdeniz, M.; Yener, I.; Yılmaz, P.; Fırat, M.; Ertaş, A.; Koseoglu-Yilmaz, Pelin
Salvia species are valuable natural resources due to their rich essential oils and bioactive compounds with applications in medicine, food, and cosmetics. In this study, essential oils and aroma components of S. montbretii and S. hydrangea were analyzed using GC–MS/FID and headspace GC–MS. Terpenoids were identified by GC–MS, while phenolic and flavonoid compounds were quantified by LC–MS/MS. Total phenolic and flavonoid contents, antioxidant capacities, and enzyme inhibitory activities were also evaluated. Caryophyllene was the dominant compound in S. montbretii essential oil and aroma samples, and camphor in S. hydrangea. GC–MS results indicated high levels of ursolic (54,675.22–1583.23 μg/g) and oleanolic acids (100,567.85–2592.11 μg/g), while LC–MS/MS revealed abundant rosmarinic acid (up to 27,0857–587.85 μg/g). All extracts exhibited moderate to strong antioxidant activities and notable inhibitory effects against urease and cholinesterase. Cytotoxic effects were observed on colon (Caco-2) and ovarian (SkOV3) cancer cell lines, along with toxicity in healthy cells (PDF). In conclusion, S. montbretii and S. hydrangea may serve as potential natural sources for pharmaceutical and cosmetic applications; however, detailed safety and dosage assessments are required prior to practical use due to the observed cytotoxic effects. © 2026 John Wiley & Sons Ltd.
Investigation of the Relationship Between the Viscoelastic Properties and Muscle Strength of Accessory Respiratory Muscles in Obstructive Sleep Apnea
(WB Saunders Co Ltd, 2026) Ramazanoglu, E.; Yildiz, G.; Sahin, G.E.; Kara, E.; Yaprak, F.; Bağcı, B.; Gündoǧdu, N.
BACKGROUND: The link between respiratory muscle strength and viscoelastic properties of accessory muscles offers a perspective for individualized treatment in Obstructive Sleep Apnea Syndrome (OSAS). PURPOSE: This study investigated associations between respiratory muscle strength and viscoelastic properties of the sternocleidomastoid (SCM) and rectus abdominis (RA) in OSAS. METHODS: Patients with moderate (n = 33) and severe OSAS (n = 45) diagnosed by polysomnography were included. Muscle viscoelasticity was assessed using Myoton®PRO, and respiratory strength (maximal inspiratory (MIP), maximal expiratory pressure (MEP)) was measured by spirometer at rest and during maximal efforts. RESULTS: In moderate OSAS, MEP-best correlated negatively with left SCM elasticity at rest (r = -0.622, p < 0.001), elasticity during inspiration (r = -0.401, p = 0.021), and stiffness (r = -0.357, p = 0.041). In severe OSAS, MEP-best correlated negatively with left SCM stiffness (r = -0.380), right SCM elasticity at rest (r = -0.393) and inspiration (r = -0.495), and left SCM elasticity during expiration (r = -0.323). MIP-best correlated negatively with right SCM elasticity during inspiration (r = -0.301) and left SCM elasticity during expiration (r = -0.323). Age correlated positively with SCM and RA parameters, while AHI correlated negatively with SCM and RA stiffness/elasticity, especially left RA elasticity during expiration (r = -0.544, p < 0.001). Side-specific differences were noted. CONCLUSION: Both inspiratory (SCM) and expiratory (RA) muscles are important in OSAS. With greater severity, viscoelastic properties shift from active support to passive adaptation, with RA contributing alongside SCM to functional changes. © © 2025. Published by Elsevier Ltd.
The Positive Effects of Wet Cupping Therapy on Thiol Disulfide Balance
(Pakistan Medical Association, 2025) Savaş, H.B.; Sarikan, I.; Sufyan, Ali
Objective: To explore the oxidant and antioxidant effects of wet cupping therapy on thiol disulfide balance. Method: The cross-sectional study was conducted at Alanya Training and Research Hospital, Turkey, from March 15 to September 15, 2021, and comprised volunteers who received two sessions of wet cupping therapy with an interval of four weeks. Blood samples were taken before the session and then again after the session. Total thiol, native thiol and disulfide were measured in the blood samples using the colorimetric method. Data was analyzed using SPSS 26. Results: Of the 50 subjects with mean age 47.10±15.16 years, 25(50%) were males and 25(50%) were females. There was a statistically significant difference between baseline and post-intervention levels of total thiol, disulfide, reduced thiol ratio, oxidized thiol and thiol oxidation reduction (p<0.001). Conclusion: Wet cupping therapy could remove oxidants, reduce oxidative stress and produce antioxidant effects. © (c) 2025 Journal of the Pakistan Medical Association. This work is licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by-nc-nd/4.0/.
Citation - WoS: 1
Citation - Scopus: 1
Safety Analysis of Different Intensities of ELF-PEMF in Terms of Apoptotic, Inflammatory, and Transcription Factor NF-κB Expression Levels in Rat Liver
(Kare Publ, 2024) Seker, Ugur; Gökçe, Yasin; Özöner, Merve Pekince; Pekince Ozoner, Merve
Background and Aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF- PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats. Materials and Methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Con- trol, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the de- vice was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field applica- tion was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed. Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group. Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apop- tosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.
Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Konca, E.; Yılmaz, C.; Bayrakdaroğlu, S.; Ceylan, H.İ.; Arslan, A.; Ocak, H.; Raul Ioan, R.I.; Muntean, Raul Ioan
Background: Age-related declines in respiratory muscle strength and ventilatory efficiency can impair functional capacity and metabolic health in older adults. Inspiratory muscle training (IMT) has been proposed as a practical intervention to counteract these changes, yet its systemic effects remain unclear. This study aimed to examine the effects of short-term IMT on functional capacity, diaphragm thickness, and liver tissue characteristics in healthy elderly men. Methods: Thirty community-dwelling men aged 60–80 years were randomly assigned to an IMT or control group. The IMT group performed four weeks of breathing exercises using a POWERbreathe® device at 40% of maximal inspiratory pressure, with a weekly 10% increase in pressure. Pre- and post-intervention assessments included the six-minute walk test (6MWT), diaphragm thickness and liver density via computed tomography, and quality of life (QoL; SF-12). Results: Four weeks of inspiratory muscle training significantly improved diaphragm thickness (11.7%), fatty liver density (FLD) (+16.7%), and six-minute walk performance (+5.3%), with large time × group effects favoring the IMT group. While the physical quality of life showed modest, comparable improvements, mental health outcomes demonstrated a moderate, time-dependent improvement without a significant group-by-time interaction. Conclusions: Short-term IMT improved diaphragmatic function and functional capacity in older men and was associated with favorable changes in a liver-related biomarker; however, given that only a single liver-related metric was assessed, these findings should not be interpreted as evidence of overall improvements in liver health. © 2026 by the authors.
Turkish Validity and Reliability of the Parental Competence Questionnaire in the Paediatric Hospital Emergency Setting (ECP-U)
(Elsevier Ltd, 2026) Kurt, A.; Dinç, F.; Güneş Şan, E.; Butun, A.; Catalbas Acarsoy, M.; San, Emine Gunes; Acarsoy, Meltem Catalbas
Aim: The aim of this study is to conduct Turkish validity and reliability study of the parental competence questionnaire in the paediatric hospital emergency setting. Methods: This study is a descriptive, cross-sectional, correlational and methodological study. Participants were 624 parents with children aged 0–14 who presented to the paediatric emergency department between December 2023 and July 2024. The study was carried out in the emergency department of three hospitals in three different regions of Turkey. The data were collected by using the “demographic information form” and “parental competence questionnaire in the paediatric hospital emergency setting”, “state and trait anxiety inventory”, and “parental stress questionnaire”. Explanatory and confirmatory factor analysis, Horn's parallel analysis, Catell's scree test, Cronbach's ordinal alpha coefficients and Pearson correlation were used in the data analysis. Results: The mean age of the mothers included in the study was 34.63 ± 6.94, and the mean age of the fathers was 37.88 ± 7.83. The scale consisted of 18 items and three sub-dimensions: emotional management and expression, social support, and parental agency, explaining 60 % of the total variance. It was determined that the Cronbach's ordinal alpha coefficients of the scale factors were greater than 0.745. There is a negative correlation between the parental stress questionnaire, the state and trait anxiety inventory, and the parental competence questionnaire in the paediatric hospital emergency setting. Conclusions: According to the results of this study, the parental competence questionnaire in the paediatric hospital emergency setting is a valid and reliable measurement tool for the Turkish population. © 2025 Elsevier Ltd
When Sound Fades: Depression and Anxiety in Adults with Hearing Loss—A Cross-Sectional Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Dedeoglu, S.; Toprak, S.F.; Sırma, E.; Dönmezdil, S.
Background: Hearing loss is a prevalent sensory impairment with substantial psychosocial consequences. This cross-sectional study investigated the relationship between audiometric hearing loss and mood disturbances in adults aged 18–65 years who reported hearing difficulties for at least six months. Methods: Objective hearing level was assessed using the better-ear pure-tone average (PTA), and subjective hearing handicap was measured with the Hearing Handicap Inventory for Adults (HHIA). Standardized mood assessments included the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). Results: The study found that higher HHIA scores, indicating greater perceived hearing handicap, were strongly correlated with more severe depression and anxiety (ρ ≈ 0.45 and 0.38, respectively; p < 0.001). In contrast, objective PTA showed weaker associations with mood scores. Regression analyses, adjusted for age and gender, confirmed that perceived hearing handicap (HHIA) was the strongest independent predictor of both depression (standardized β ≈ 0.37, p < 0.001) and anxiety (β ≈ 0.33, p < 0.01), accounting for about 30% of the variance in mood scores. Nearly one-third of participants had clinically significant depression (BDI-II ≥ 20), which is substantially higher than community norms. The cross-sectional design and potential selection bias are limitations. Conclusions: Even mild-to-moderate hearing loss can result in significant depressive and anxious symptoms when individuals perceive themselves as handicapped. Early identification of hearing problems, routine psychosocial screening (e.g., a simple two-question survey), and integrated care are essential for improving quality of life. © 2025 by the authors.

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