PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Citation - WoS: 2
Citation - Scopus: 2
Biological Evaluation and Molecular Docking Studies of Novel Aza-Acyclic Nucleosides as Putative Antimicrobial, Anticancer, and Antioxidant Agents
(BioMed Central Ltd, 2025) Alhilal, M.; Alhilal, S.; Gomha, S.M.; Farag, B.; Sabancilar, I.; Ouf, S.A.
This study aimed to synthesize new aza-acyclic nucleosides (aza-acyclovir) and evaluate the efficacy of these synthetic compounds as potential antimicrobial, anticancer, and antioxidant agents. We prepared two novel aza-acyclic nucleosides via two reactions. The first reaction involved trichloroisocyanuric acid and dibenzosulphonyl diethylamine, and the second reaction involved trichloroisocyanuric acid and diethanolamine. We then used one-dimensional nuclear magnetic resonance (NMR) spectroscopy, two-dimensional NMR spectroscopy, infrared spectroscopy, and mass spectrometry to determine the structures of the resulting compounds. In this regard, we first tested the antimicrobial activity of these compounds against various bacteria, including Bacillus cereus, B. subtilis, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa, and against fungal pathogens, including Aspergillus fumigatus, Candida tropicalis, and Alternaria solani. Next, the precise mode for the interaction between synthesized aza-acyclic nucleosides and the target protein 8HQ5 was elucidate using molecular docking analysis. Subsequently, we tested the synthesized compounds for putative anticancer activity at different concentrations (i.e., 12.5, 25, 50, 100, and 200 µg/mL) against A549 cell (Human epithelial lung carcinoma) and human umbilical vein endothelial cell (HUVEC) lines. In addition, compounds antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl-based and cupric reducing antioxidant capacity-based methods at different concentrations (i.e., 31.25, 62.5, 125, 250, and 500 µg/mL). Results revealed that both aza-acyclic nucleosides inhibited both bacterial and fungal strains, although toxicity toward bacterial strains was generally greater than toward fungal strains. We also observed that the molecular docking results were consistent with the results of in vitro antimicrobial assessments. Further, both aza-cyclic nucleosides exhibited cytotoxic effects against both the A549 cell and HUVEC lines. Despite exhibiting lower radical scavenging activity than ascorbic acid (an antioxidant compound used as a standard), Compound 1 from the novel synthetic aza-acyclic nucleosides showed a higher reduction capacity, which was dose-dependent. Overall, we report newly synthesized compounds that show promising antimicrobial, anticancer, and antioxidant effects. © 2025 Elsevier B.V., All rights reserved.
Citation - WoS: 1
A Cross-Sectional Study of Emergency Care Services During the Covid-19 Pandemic: A Multicenter Study of Healthcare Staff Perspectives
(Springernature, 2024) Butun, Ahmet; Yesil, Yesim; 09.01. Department of Nursing / Hemşirelik Bölümü; 09.02. Department of Midwifery/ Ebelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted various aspects of healthcare services, including emergency care services. Healthcare staff face mental issues and physical exertion when caring for patients potentially infected with COVID-19. Understanding the experiences and perspectives of emergency department (ED) healthcare staff during the COVID-19 pandemic is essential to inform evidence-based interventions and strategies to mitigate the impact on emergency care services. This study aims to investigate the experiences of ED healthcare staff regarding emergency care services during the COVID-19 pandemic, thus providing valuable insights into the challenges faced. Materials and methods: This study utilized a cross-sectional study design. Data were collected from 256 ED healthcare staff working in nine different hospitals located in Turkey between November 15, 2021, and December 30, 2021. Data were analyzed using descriptive statistics. Results: A total of 256 participants were included in the study. Of the participants, 58.6% were nurses, 19.5% were ED doctors, and 21.9% were emergency medical technicians. In addition, 67.2% of the participants were infected with COVID-19, and almost all of them (94.1%) were psychologically affected by the pandemic process. It was found that 85.2% of ED healthcare staff felt excluded by society due to being healthcare staff and 71.9% had to be separated from their families. Nurses were separated from their families at the highest rate (78%) during this period. Conclusion: More than half of the ED healthcare staff had problems accessing protective equipment and were separated from their families during the pandemic due to the risk of COVID-19 transmission. Although the number of ED visits decreased because of restrictions at the beginning of the pandemic, ED visits increased again with the abolition of restrictions.
Effect of Tissue Fragments Remain in the Karman Cannula on the Histopathological Diagnosis of Abnormal Uterine Bleeding
(College of Physicians and Surgeons Pakistan, 2024) Tammo, Omer; Celik, Elif; Celik, Enes; Bayramoglu, Denizhan; Yıldız, Süleyman
The aim of this study was to perform histopathological analysis of residual material in the cannula by endometrial sampling using a Carmen injector, and to compare the results. The study was conducted in the Department of Gynaecology, Mardin Training and Research Hospital, Artuklu/Mardin, Turkiye, from December 2021 to June 2022. The study group consisted of 104 patients who presented to the outpatient clinic with complaints of abnormal uterine bleeding. Endometrial curettage material was collected from all patients using a Carmen injector. The collected material was discharged into the pathology container (Group 1). Subsequently, the residual material remaining in the injector was placed in a separate pathology container (Group 2). Specimens were sent to the pathology laboratory with buffered formol. The pathological evaluation was performed by the same pathologist without revealing the patients’ names. Comparative histopathological results of the patients in Group 1 and Group 2 were found to be fully compatible in 64.4% of the patients. In 35.6% of the patients, the histopathological results were different from each other between Group 1 and Group 2. Pathological results were different from each other in 21.2% of patients with incompatible pathology results. In Group 1, 16.7% of the patients were over-diagnosed, while 7.7% of the patients were over-diagnosed in Group 2. It would be beneficial to carefully remove the material remaining in the cannula and send it for pathological examination as it may affect the histopathological results. © 2024 Elsevier B.V., All rights reserved.
Evaluation of Serum Levels of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) as Potential Biomarkers of Renal Tubular Damage in Brucellosis Patients
(Dove Medical Press Ltd, 2025) Dundar, Ahmet; Irmak, Halit; Ayhanci, Tugba; Yildiz, Songul Cetik
Background: Brucellosis is a zoonotic and multisystemic disease that is widespread worldwide and can present with many different clinical conditions, ranging from asymptomatic to serious and fatal conditions. Brucellosis may be linked to renal tubular and acute kidney damage, nephrotic syndrome, and various types of nephropathies. Objective: Our research was carried out prospectively to investigate the relationship between brucellosis and various biochemical markers and particularly to investigate the role of renal tubular damage biomarkers. Methods: Demographic and biochemical data from 60 controls and 60 brucellosis patients were included in the study. Kidney injury molecule-1 (KIM-1) and Neutrophil gelatinase-associated lipocalin (NGAL) were analyzed by. The diagnostic accuracy of KIM-1 and NGAL for brucellosis was assessed using receiver operating characteristic (ROC) curve analysis. Results: According to our findings, significant differences of KIM-1 and NGAL were observed between brucellosis and healthy patients. A high AUC (area under the curve) value of 0.742 (95% CI: 0.616-0.868) and 0.835 (95% CI: 0.729-0.941) was observed for KIM-1 and NGAL, respectively. Conclusion: Serum levels of KIM-1 and NGAL, which are renal tubular damage markers, where higher in Brucellosis than in healthy patients. These biomarkers can contribute to the rapid and accurate diagnosis of brucellosis regarding the involvement of nephropathies and to the standardization of comprehensive diagnostic warning indicators.
Citation - WoS: 14
Citation - Scopus: 16
Inclusive Mental Health Support for International Students: Unveiling Delivery Components in Higher Education
(Cambridge Univ Press, 2024) Sakiz, Halis; Jencius, Marty
This study examines the delivery components of inclusive mental health services in higher education, centering on international university students. Through interviews with 32 participants at a state university in the United States, including students, counseling staff, and faculty, six key themes emerged: mental health professionals' multicultural self-awareness, focus on reparative services, mainstream mental health theories and approaches, professionals' cultural background, faculty involvement and physical space and confidentiality. These findings underscore the importance of training for professionals, expansive mental health offerings, incorporation of diverse approaches, confidentiality, active faculty participation and suitable physical environments. By addressing these components, universities can enhance the quality of mental health support for international student populations, promoting their overall well-being and academic success.
Citation - WoS: 1
Citation - Scopus: 1
Safety Analysis of Different Intensities of ELF-PEMF in Terms of Apoptotic, Inflammatory, and Transcription Factor NF-κB Expression Levels in Rat Liver
(Kare Publ, 2024) Seker, Ugur; Gökçe, Yasin; Özöner, Merve Pekince; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background and Aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF- PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats. Materials and Methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Con- trol, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the de- vice was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field applica- tion was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed. Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group. Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apop- tosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.
Citation - WoS: 2
Citation - Scopus: 3
Unmet Need for Family Planning Among Syrian Migrant Women Living in Turkey and Its Determinants
(Bmc, 2024) Cifci, Sema; Icke, Sibel; Hakimi, Sevil; 09.01. Department of Nursing / Hemşirelik Bölümü; 09.02. Department of Midwifery/ Ebelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Introduction Migrant women might be cannot benefit from health services sufficiently. The unmet need for family planning is among the pivotal indicators for measuring progress toward improving maternal and child health. The aim of this study was to identify the unmet need for family planning (UMNFP) among Syrian migrant women living in Mardin and its determinants.Material and methods The study was conducted in Mardin. Data were gathered during home visits Data collection tools were socio-demographic and reproductive health questionnaires. The statistical analysis was performed using SPSS software. Qualitative variables were presented by number and percentage. Quantitative variables were presented by means (standard deviation). To determine, the determinants of UMNFP binary logistic regression was used.Results The result of this study showed that prevalence of UMNFP was 35%. Woman's low educational level (OR:5.42, CI95%:2.43-8.94), history of un intended pregnancy(OR:1.43, CI95%:1.1-1.94) and induced abortion (OR:1.76, CI95%: 1.41-2.21), not having husband's regular job(OR: 2.24, CI95%:1.92-3.78) and lack of woman`s autonomy in decision related to use of contraception methods(OR:3.21, CI95%: 1.78-6.12) were determinants of UMNFP.Conclusion The prevalence of UMNFP among Syrian immigrants living in Mardin was considerable. Understanding the challenges and the barriers impacting use of contraception including cultural norms as well, as social and language obstacles are essential to decrease UMNFP.

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