PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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  • Article
    Workload, Compassion Fatigue, Family Harmony, and Life Satisfaction among Social Workers: A Moderated Mediation Model
    (Oxford Univ Press Inc, 2026) Aslan, Yavuz; Koçak, Orhan; Doğan, Sait; Ceylan, Harun; Kesen, Hesna
    This study investigates the relationships among quantitative workload (QWL), compassion fatigue (CF), family harmony (FH), and life satisfaction (LS) among social welfare workers in Türkiye. Employing a cross-sectional design, data were collected from 453 participants and analyzed using structural equation modeling and moderation analysis with the PROCESS Macro. The results showed that QWL significantly predicted CF (β = .358, p < .001). CF, in turn, negatively predicted both FH (β = -.325, p < .001) and LS (β = -.332, p < .001), while FH positively predicted LS (β = .284, p < .001). Mediation analyses revealed that QWL indirectly affected FH via CF (β = -.116, p < .001) and sequentially affected LS through both CF and FH (β = -.143, p < .001). Additionally, CF indirectly influenced LS via FH (β = -.092, p < .001). Moreover, gender, work experience, and decision-making authority significantly moderated several of these relationships. These results underscore the importance of addressing emotional exhaustion and work‒life balance to support the well-being of social service professionals.
  • Article
    Turkish Cross-Sectional survEy of Glycemic and Other Metabolic Parameters in Patients with Type 2 Diabetes in 2023: Comparison with 2018 Nationwide Data (TEMD-2 Study)
    (Elsevier Inc., 2026) Cetinarslan, Berrin; Gonen, Mustafa Sait; Sonmez, Alper; Akbas, Emin Murat; Cantürk, Zeynep; Haymana, Cem; Demirci, Ibrahim
  • Article
    The Effect of Listening to Surah Al-Inshirah on Depression, Anxiety, Stress, and Mental Well-Being in Hemodialysis Patients
    (SAGE Publications Ltd, 2026) Tanrverdi, Ömer; Tanrıverdi, Ömer
    Chronic renal failure and hemodialysis are common conditions frequently associated with psychological symptoms such as depression, anxiety, and stress, which can significantly impact patients’ quality of life and psychosocial adjustment. This quasi-experimental study investigated the effects of listening to Surah Al-Inshirah on depression, anxiety, stress, and mental well-being in hemodialysis patients. A total of 60 eligible patients were allocated to an intervention group ( n = 30) and a control group ( n = 30) according to dialysis scheduling. Patients in the intervention group listened to Surah Al-Inshirah during dialysis sessions over a 4-week period. Outcomes were assessed using the Depression, Anxiety, and Stress Scale-21 (DASS-21) and the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). The results suggested that listening to Surah Al-Inshirah may be associated with reduced symptoms of depression, anxiety, and stress in hemodialysis patients. Given the cultural context of the study setting, Qur’anic recitation may represent a culturally acceptable complementary intervention.
  • Article
    Relationship between Acute Coronary Syndrome and Coronavirus Disease 2019 Infection and Vaccination Type: A Retrospective Observational Study
    (BMC, 2026) Gökdemir, Gül Şahika; Gökdemir, Mehmet Tahir
    BACKGROUND: Studies have reported that the Coronavirus Disease 2019 (COVID-19) vaccine causes other serious health problems, including myocarditis, pericarditis, neurological problems, and problems resulting from the reactivation of chronic infections. There are no satisfactory studies on the relationship between late-stage COVID-19 disease and cardiovascular diseases, or even Acute coronary syndrome (ACS). Our study primarily aimed to compare the frequency of emergency department (ED) visits and mortality rates of patients diagnosed with acute coronary syndrome (ACS) before and after the COVID-19 pandemic. Secondly, we aimed to evaluate differences in demographic and laboratory characteristics between pre-pandemic and post-pandemic ACS patients. Finally, we aimed to investigate the association between COVID-19 vaccination status (unvaccinated, inactivated vaccine, and mRNA vaccine) and mortality outcomes in post-pandemic ACS patients. METHODS: Data from 1,856 patients over the age of 18 diagnosed with ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina pectoris (USAP) in 2023, post-pandemic, and 1,450 patients diagnosed in 2018, pre-pandemic, were analyzed. The incidence of ACS before and after the pandemic, its relationship with the presence of viral vector-based vaccination and mRNA vaccination, and demographic and laboratory results were retrospectively examined. RESULTS: Although the number of emergency department visits nearly doubled after the pandemic, mortality rates were similar (P = 0.595). Troponin I (P < 0.001), creatine kinase-MB (CK-MB) (P < 0.001), and prothrombin time (PT) (P = 0.016) levels were significantly increased in post-pandemic patients. Univariable analysis showed that being unvaccinated was associated with 2.88-fold higher odds of mortality (95% CI: 1.23-6.70), while in the multivariable analysis this association remained significant with 3.77-fold higher odds (95% CI: 1.04-13.65) (p = 0.014 and p = 0.043). Inactivated vaccine [OR 0.60 (95% CI: 0.36-1.01) and p = 0.054] and mRNA vaccine [OR 1.42 (95% CI: 0.85-2.36) and p = 0.177] did not have a significant effect on mortality. CONCLUSIONS: Post-pandemic mortality rates were similar to those before the pandemic. Being unvaccinated was found to be a significant associated with higher mortality. Vaccination type did not affect mortality. Cardiac and inflammatory marker levels were increased in post-pandemic ACS patients compared to pre-pandemic ACS patients.
  • Article
    Protective Effects of P-Coumaric Acid against Lead-Induced Hepatic Oxidative Stress, Inflammation, and Apoptosis: Integrated Molecular and Machine Learning-Based Analysis
    (Elsevier, 2026) Alhilal, Mohammad; Bozkurt, İlyas; Bolat, Smail; Karaarslan, Tuba; Demir, Yeliz; Bozkurt, Lyas; Halici, Mesut Bunyami; Bolat, İsmail
    Lead (Pb) exposure is a major environmental health concern that induces hepatic injury through oxidative stress, inflammation, and apoptosis. This study evaluated the hepatoprotective effects of p-coumaric acid (PCA), a phenolic compound, against Pb-induced liver toxicity using integrated molecular and machine-learning approaches. Male rats were allocated into experimental groups and exposed to Pb-acetate (30 mg/kg), while PCA was orally administered at 50 and 100 mg/kg for 14 days. A dataset consisting of 30 adult male rats (n = 6 per group) was analyzed using biochemical, molecular, inflammatory, and histopathological parameters. Oxidative stress markers, antioxidant and apoptotic gene expression, inflammatory protein expression, and liver tissue alterations were assessed. In addition, principal component analysis (PC analysis), correlation heatmap analysis, and Random Forest-based SHAP (Shapley Additive Explanations) analysis were applied to identify key biomarkers associated with Pb toxicity and PCA-mediated protection. Pb exposure caused a pronounced oxidative imbalance, evidenced by significant depletion of antioxidant defenses, including reduced glutathione (GSH) (p < 0.001), glutathione peroxidase (GPx) (p < 0.001), and catalase (Cat) gene expressions (p < 0.001), together with increased malondialdehyde (MDA) levels (p < 0.001). Pb also up-regulated Bax and Casp3 (p < 0.001), down-regulated Bcl-2 (p < 0.01), and activated NF-kappa B, IL-1 beta, TNF-alpha, IL-6, and COX-2 (p < 0.001). Histopathology confirmed severe hepatocellular degeneration and necrosis. PCA treatment attenuated these alterations in a dose-dependent manner, with 100 mg/kg showing the strongest protection (p < 0.05). Overall, PCA alleviates Pb-induced hepatotoxicity by restoring antioxidant defenses, suppressing inflammatory signalling, and inhibiting mitochondrial apoptotic pathways.
  • Article
    Proprioception and Balance in Young Adults with Pes Planus
    (2026) Yardimci, Fatma Betül; Anaforoğlu, Bahar; Yilmaz, Zeynep
    Background: Pes planus is a common foot deformity that may lead to both structural and functional consequences. This alteration in foot morphology has been associated with changes in neurosensory mechanisms such as proprioception and balance. This study aims to evaluate proprioception and balance parameters in young adults with pes planus by comparing them with healthy individuals. Methods: This case–control study, which had a quantitative and cross-sectional design, included a total of 90 volunteer university students aged 18–30. The presence of pes planus was assessed using the Navicular Drop Test. Proprioception assessment was performed using a digital goniometer to measure active and passive joint position sense, while balance assessment was performed using the Y Balance Test. Results: The groups were similar in terms of demographic and anthropometric characteristics (p &gt; 0.05). In the proprioception assessment, a significant difference was observed in active joint position sense scores in individuals with pes planus (p = 0.032). In contrast, no significant difference was found between the two groups in terms of passive joint position sense (p = 0.769). According to the Y Balance Test results, no difference was observed in the anterior and posteromedial directions (p = 0.690 and p = 0.806). At the same time, the balance performance of individuals with pes planus was significantly lower in the posterolateral direction (p = 0.045). Conclusions: Young individuals with flexible pes planus showed differences in active joint position sense and balance performance in the posterolateral direction. This situation shows that pes planus may be associated with not only structural but also neurosensory functions. The findings highlight the importance of planning protective interventions early. In the future, there is a need for longitudinal studies conducted with larger and more heterogeneous samples, including rigid type pes planus.
  • Article
    Not Just for Adults: Transient Global Amnesia Is Rare—But Possible—in Children
    (Lippincott Williams and Wilkins, 2026) Özgün, Nezir
    Transient global amnesia (TGA) is a well-characterized neurological syndrome primarily affecting adults over the age of 50. It is marked by the sudden onset of anterograde amnesia with repetitive questioning while other cognitive functions remain intact. To date, only a few pediatric cases of TGA have been documented. Here we present the case of a previously healthy 9-year-old girl who developed sudden-onset anterograde amnesia, manifesting with repetitive stereotyped questions and temporal disorientation consistent with the "broken record" phenomenon. The patient's neurological examination and routine laboratory investigations were unremarkable. Brain MRI obtained within 4 hours of symptom onset was reported as normal, although the slice thickness exceeded the optimal parameters for detecting TGA-related lesions. EEG, urine toxicology screening, and cardiologic evaluation were all normal. The amnestic episode resolved spontaneously within 11 hours, and no recurrence was observed over 21 months of follow-up. The patient met all established diagnostic criteria for TGA, with no identifiable underlying etiology. TGA should be considered as a diagnostic option in children presenting with isolated acute amnesia and the characteristic "broken record" phenomenon, particularly when no alternative explanation can be identified after thorough differential diagnostic evaluation.
  • Article
    NRS-2002–Defined Nutritional Risk and Associated Factors in Intensive Care Unit Patients: A Cross-Sectional Study
    (BMC, 2026) Bicak Ayik, Derya; Akca Dogan, Derya; Ayik, Derya Bıçak; Doğan, Derya Akça
    BACKGROUND: Malnutrition is common in intensive care units (ICUs) and is associated with adverse clinical outcomes. This study aimed to evaluate NRS-2002-defined nutritional risk in adult ICU patients and to examine factors associated with high nutritional risk. METHODS: This cross-sectional study was conducted in a tertiary-level ICU of a training and research hospital in Türkiye between April 2024 and May 2025. A total of 169 adult patients were included. Nutritional risk was assessed using the Nutritional Risk Screening-2002 (NRS-2002), and patients were classified as low (< 3) or high (≥ 3) risk. Disease severity was evaluated using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Group comparisons were performed using the Mann-Whitney U and chi-square tests. Factors associated with high nutritional risk were examined using modified Poisson regression with robust variance, and adjusted prevalence ratios (aPRs) with 95% confidence intervals (CIs) were reported. RESULTS: The median age of the patients was 74 years, and patients at high nutritional risk were significantly older than those at low nutritional risk (p = 0.018). Enteral or parenteral nutrition was more common in the high-risk group (p < 0.001). In the adjusted analysis, absence of sedative medication use (aPR: 0.800, 95% CI: 0.646-0.990) and higher hemoglobin level (aPR: 0.898, 95% CI: 0.852-0.948) were associated with a lower prevalence of high nutritional risk. CONCLUSIONS: Sedative medication use and lower hemoglobin levels were identified as clinical correlates of NRS-2002-defined high nutritional risk in ICU patients. These findings support the importance of regular nutritional risk screening in ICU settings and suggest that nutritional risk may not always be fully reflected by disease severity scores alone. Further multicenter studies with larger samples are needed to better clarify factors associated with nutritional risk in ICU populations.
  • Article
    Move in Nature, Get Strong with Smart Sports: Physical Activity Habits and Health-Related Psychological Factors among Adults Exercising in Green and Smart Sports Environments
    (Frontiers Media SA, 2026) Ulukan, Mahmut; Karakulak, İzzet; Tunçer, Mehmet; Rüzgar, Kerim; Ceylan, Levent; Sari, Okan; Bingölbalı, Nisanur
    Introduction Sedentary lifestyles threaten physical and psychological well-being. Nature-integrated green sports environments and digitally supported smart sports environments may promote physical activity and sustainable health. This study examined the direct and indirect associations among green facility exposure/use, smart facility/technology interaction, physical activity, sport motivation, perceived stress, psychological resilience, and quality of life. Methods A quantitative, cross-sectional correlational design was used with 300 adults living in Türkiye (168 women and 132 men; mean age = 33.4 years, SD = 9.7). Data were collected online between 22 May and 14 November 2025 and analyzed using a hybrid structural equation model combining observed composite indices and latent psychometric constructs. Results The model showed acceptable fit ( χ 2 /d f = 2.10, CFI = 0.96, TLI = 0.95, RMSEA = 0.051, SRMR = 0.044). Physical activity was positively associated with sport motivation ( β = 0.48, p &lt; 0.001), which was positively associated with psychological resilience ( β = 0.42, p &lt; 0.001) and quality of life ( β = 0.27, p &lt; 0.001). Green facility exposure/use ( β = 0.18, p &lt; 0.05) and smart facility/technology interaction ( β = 0.12, p &lt; 0.05) were positively associated with physical activity. Perceived stress was negatively associated with psychological resilience ( β = −0.33, p &lt; 0.01) and quality of life ( β = −0.29, p &lt; 0.01). Indirect associations linked physical activity with quality of life through sport motivation and psychological resilience. Discussion Green and smart exercise contexts may support physical activity and related motivational and psychological processes. Because the study was cross-sectional, the findings should be interpreted as associations rather than causal effects. Nature-based and technology-supported opportunities may inform sports-environment planning and public-health strategies.
  • Article
    Long-Term Clinical Outcomes of Primary Adrenal Insufficiency Caused by Homozygous CYP11A1 p.R451W Variant
    (Oxford Univ Press, 2026) Demirbilek, Hüseyin; Özbek, Mehmet Nuri; Çayır, Atilla; Kurt, İlknur; Koca, Serkan Bilge; Güran, Tülay; Türkyılmaz, Ayberk
    BACKGROUND: The cytochrome P450 side-chain cleavage enzyme (P450scc), encoded by the CYP11A1 gene, regulates the first and rate-limiting step of steroidogenesis. c.1351C > T (p.R451W) is the most commonly identified pathogenic variant in the CYP11A1 gene, and is associated with a mild P450scc deficiency. Long-term follow-up data of affected individuals are insufficient. AIM: To investigate the long-term growth, pubertal development, and adrenal and gonadal functions of patients with homozygous CYP11A1 c.1351C > T (p.R451W) variant. METHOD: Retrospective follow-up data were obtained from the medical records of patients managed at tertiary pediatric endocrinology centers. RESULTS: Twenty-two patients (16 males) from 16 families were included. The median age at presentation was 4.8 ± 4.2 years (range: 1-14.6 years), and the mean follow-up period was 7.8 ± 5.2 years (range: 0.5-17.9 years). Primary adrenal insufficiency (PAI) was present in all cases. Three patients were diagnosed during family screening. Mineralocorticoid (MC) deficiency was detected in 20 patients (83%), and recovered in 2 cases during follow-up. One patient with no MC deficiency at presentation had developed a salt-wasting crisis during acute illness. None of the 46,XY cases showed atypical genitalia; 3 had micropenis, 1 had cryptorchidism, and 2 patients required sex steroid therapy because of subsequent hypergonadotropic hypogonadism later. CONCLUSION: Mild P450scc deficiency due to p.R451W variant in the CYP11A1 gene is associated with late onset PAI with variable MC and sex hormone deficiency. The growth is consistent with genetic potential, and pubertal onset and progression are normal in affected patients, while long-term follow-up is required with regard to the risk of gonadal failure.