PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Synthesis, Spectroscopic Characterization, and Biological Evaluation of a Novel Acyclic Heterocyclic Compound: Anticancer, Antioxidant, Antifungal, and Molecular Docking Studies
(MDPI, 2025) Alhilal, Mohammad; Alhilal, Suzan; Sabancilar, Ilhan; Gomha, Sobhi M.; Elhenawy, Ahmed A.; Ouf, Salama A.
Background/Objectives: This study aimed to synthesize a novel, high-molecular-weight acyclic heterocyclic compound, compound 5, via a one-pot reaction between Trichloroisocyanuric acid (TCCA) and ethanolamine, and evaluate its anticancer, antioxidant, and antifungal activities. Methods: Its complex tetrameric structure, assembled through N-N linkages, was unequivocally confirmed by a full suite of spectroscopic techniques including IR, 1H & 13C NMR, 2D-NMR, and high-resolution mass spectrometry (LC/Q-TOF/MS). The MTT assay was used to assess the anticancer activity of compound 5 against four different human cancer cell lines. Results: The findings indicate that human colon (HT29) and ovarian (OVCAR3) cancer cells were sensitive to the treatment, whereas brain (glioblastoma) (T98G) cancer cells were resistant. The most pronounced cytotoxic effect was observed in pancreatic (MiaPaCa2) cancer cells. Notably, compound 5 exhibited potent antifungal properties, achieving 100% inhibition of the pathogenic water mould Saprolegnia parasitica zoospores at 100 mu M after 10 min. Molecular docking studies corroborated the biological data, revealing a high binding affinity for key cancer and fungal targets (Thymidylate Synthase and CYP51), providing a strong mechanistic basis for its observed activities. Conclusions: These findings establish compound 5 as a promising dual-action agent with significant potential as both a targeted anticancer lead and an eco-friendly antifungal for applications in aquaculture.
Skin Lesion Classification Using Focal Modulation Networks
(Wiley, 2025) Zan, Hasan
The automatic classification of dermoscopic images is essential for the early diagnosis and treatment of skin cancer. However, this task remains challenging due to high visual similarity among lesion types, variations in lesion appearance across progression stages, and the presence of artifacts in the images. While deep learning-based approaches have outperformed traditional machine learning methods, many existing models are computationally intensive and offer limited interpretability. These limitations hinder their integration into clinical workflows where efficiency and transparency are critical. In this study, I propose a framework based on focal modulation networks (FMNs) for skin lesion classification. FMNs are designed to efficiently capture both local and global features, addressing the limitations of transformer-based models in processing high-resolution medical images. I evaluate four FMN variants, namely, Tiny, Small, Base, and Large, on three public datasets: ISIC 2017, ISIC 2018, and ISIC 2019. The highest classification accuracy was obtained on ISIC 2019 with 97.8%, followed by 96.4% on ISIC 2018, and 88.1% on ISIC 2017. These results match or exceed those reported in several previous studies. Additionally, FMNs offer model interpretability through modulator visualization. Overall, the proposed method provides an accurate, efficient, and transparent solution for automated skin lesion classification.
Determination of Bioactive and Anti-Inflammatory Molecules of Thymbra Spicata L. from Mardin by GC-MS and LC-Orbitrap HRMS: A DFT, Molecular Docking, ADMET, Biological Target and Activity Study
(BMC, 2025) Unsal, Velid; Ercan, Leyla; Caliskan, Cemile Gunbegi
Objectives In this study, phenolic compounds (PC), volatile compounds (VC), antioxidant, anti-inflammatory, and antimicrobial properties of the Thymbra spicata L. plant grown in the Mardin Yesilli region were investigated. The properties of compounds such as rhoifolin, leucoside, naringenin, rosmarinic acid, gamma-terpinene, and carvacrol, which were found to be higher than other compounds as a result of PC and VC analysis of Thymbra spicata L. plant, and the properties of non-steroidal anti-inflammatory drugs diclofenac and ketoprofen were compared with computer-based calculations. In this context, the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiles of the mentioned molecules were calculated, Density Functional Theory (DFT)-based quantum chemical calculations were performed, and molecular docking analyses were performed. In addition, the pharmacological properties, biological targets, and biological activities of these compounds were comprehensively evaluated. This study provides important data for understanding the therapeutic potential of these plant components. Materials and methods Chromatographic methods (GC-MS and LC-Orbitrap HRMS) were used to look at PC and VC profiles, spectrophotometry (ABTS, DPPH, CUPRAC) to look at antioxidant activities, and the disk diffusion method to look at antimicrobial properties. Results While the most detected volatile compounds were gamma-terpinene (35.34%), carvacrol (17.55%), caryophyllene (10.53%), and p-cymene (9.15%), the most detected phenolic compounds were rosmarinic acid (3334.9 ng/mL), naringenin (2610.00 ng/mL), leucoside (1956.42 ng/mL), and rhoifolin (1288.55 ng/mL). The ethanol extract of Thymbra spicata L. stopped the growth of K. aerogenes in particular. The IC50 value for DPPH was 158.01 mu g/mL, the IC50 value for ABTS was 185.03 mu g/mL, and the C0.5A value was 87.13 for the ethanol extract of Thymbra spicata L. The molecular docking results that the strongest binding energy was between TNF-alpha and naringenin (-6.77 kcal/mol), IL-6 and rosmarinic acid (-5.55 kcal/mol), and NLRP3 and carvacrol (-6.88 kcal/mol). Naringenin, rosmarinic acid, diclofenac, and ketoprofen completely violated the restrictions established by Lipinski, Ghose, Veber, Egan, and Muegge. Rosmarinic acid is the most reactive antioxidant compound with low energy deficit (Eg) and high softness (S). gamma-terpinene and carvacrol, on the other hand, are more stable and durable wit high hardness (eta) and low softness. Conclusion Naringenin, rosmarinic acid, and carvacrol demonstrate significant anti-inflammatory and immunomodulatory properties owing to their high binding affinity for TNF-alpha, IL-6, and NLRP3, positioning them as promising candidates for the treatment of inflammatory disorders. Naringenin and rosmarinic acid effectively target TNF-alpha, whereas carvacrol demonstrates potential in the management of NLRP3 inflammasome-associated diseases. The strong binding of rosmarinic acid to IL-6 shows that it can change the immune system. Thymbra spicata L., abundant in bioactive compounds, may provide benefits compared to conventional NSAIDs and exhibit potential as monotherapy or adjunctive therapies. Their strong anti-inflammatory, antioxidant, antimicrobial, and pharmacological properties, along with their safety, make naringenin, rosmarinic acid, and carvacrol good candidates for more preclinical and clinical research.
Comparison of Ultrasound-Guided Quadratus Lumborum Plane Block and External Oblique Intercostal Plane Block for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Two-Center Randomized Controlled Trial
(MDPI, 2025) Kacar, Cem Kivilcim; Dedeoglu, Andac; Tosun Soner, Hulya; Celik, Enes; Andic, Okan; Acil, Fatma; Gokcek, Erhan
Background and Objectives: Although various regional anesthesia techniques are commonly used for laparoscopic cholecystectomy (LC), to date, no randomized controlled trial has compared the effectiveness of Quadratus Lumborum Plane Block (QLB) and External Oblique Intercostal Plane Block (EOIPB) in LC. Our aim was to compare the effectiveness of ultrasound-guided QLB and EOIPB in providing postoperative analgesia after LC. Materials and Methods: In this two-center, randomized controlled trial, patients undergoing LC were divided into QLB and EOIPB groups. Our primary outcome was the postoperative pain scores measured using the Numerical Rating Scale (NRS) at predetermined intervals. Secondary outcomes included opioid consumption, Riker Sedation-Agitation Scale (RSAS) score, and patient satisfaction. Results: The NRS pain scores at postoperative 30th minute, 4th, 12th, and 24th hours were significantly lower in the QLB group (p < 0.05). Patients in the QLB group required significantly less tramadol compared to the EOIPB group (p < 0.000). The QLB group also demonstrated lower RSAS scores (p = 0.005), indicating a smoother recovery process. Patient satisfaction scores were markedly higher in the QLB group (p < 0.000). Although both blocks were well-tolerated with no differences in side effects, EOIPB was associated with higher opioid consumption, indicating its relatively limited effectiveness. Conclusions: To conclude, this study highlights that QLB is a more effective option for postoperative analgesia and improves patient satisfaction after LC. EOIPB may serve as a viable alternative for some patients; however, given the advantages of QLB in pain control and recovery, it stands out as a more preferable method.
Peer Education Versus Traditional Education on Psychomotor Skills and Self-Efficacy in Nursing Students: A Single-Blind Randomized Controlled Trial
(BMC, 2025) Baran, Leyla; Ozdemir, Handan
Background Peer education (PE) refers to the process of individuals being educated by their peers, that is, people with similar experiences or statuses. This study aimed to evaluate the effects of PE on the psychomotor skills and self-efficacy of nursing students. Methods This single-blind randomized controlled trial was conducted with 63 undergraduate nursing students. Data were collected using the "Individual Descriptive Information Form", "Intramuscular Injection Knowledge Level Assessment Form", "Intramuscular Injection Psychomotor Skills Assessment Form", and the "General Self-Efficacy Scale". Descriptive statistics (numbers, percentages, means, standard deviations, and min-max values) were used. The independent samples t-test and Mann-Whitney U test were used to analyze differences between groups. Results The mean age of the participants was 21.22 +/- 0.85 years (range: 20 - 23), and 52.4% were female. No statistically significant differences were found between the groups in pretest, posttest, or self-efficacy scores (p > 0.05). However, the psychomotor skill levels differed significantly between the groups (p < 0.001), with the intervention group scoring higher than the control group. Conclusions Nursing students who received PE demonstrated significantly better psychomotor skills than those taught using traditional methods. It is recommended to integrate interactive learning strategies such as PE, where students can express themselves more freely and actively engage in the learning process, especially in nursing education areas requiring the development of psychomotor skills.
Identifying the Needs of Parents Admitted to the Paediatric Emergency Department
(BMC, 2025) Butun, Ahmet; Yesil, Ahmet
Introduction The paediatric emergency department (PED) represents a vital entry point into the healthcare system, particularly for children experiencing acute health issues. However, despite playing a pivotal role in the paediatric care process, the experiences and needs of parents accompanying their children during these visits are often overlooked. Understanding these needs is essential for improving the quality of care provided in PEDs. This study aimed to identify the needs of parents of children admitted to the PED and examine how these needs vary according to demographic and experiential factors, including satisfaction with care. Methods This study is a descriptive cross-sectional study. This study was conducted in the PED of a 700-bed tertiary public hospital in southeastern Turkey. The study population consisted of 406 parents of children admitted to the PED. Data were collected between October 7, 2024, and November 15, 2024, using structured questionnaires, including: (1) a socio-demographic form and, (2) the Critical Care Family Needs Inventory - Emergency Department. Data analyses were conducted using SPSS 22.0 with significance set at p < 0.05. Results Parents rated "family member participation in care" significantly higher than other needs (mean difference = 0.11-0.21, all p < 0.05). This suggests that PED staff should prioritise: (1) involving parents in care decisions, (2) providing real-time updates, and (3) creating opportunities for hands-on participation when clinically appropriate. 'Communication with family members' showed significantly higher mean scores (2.89 +/- 0.75) than both 'comfort' (2.79 +/- 0.78; p = 0.03) and 'supporting family members' (2.80 +/- 0.80; p = 0.02), with small but clinically meaningful effect sizes (Cohen's d = 0.31 and 0.29 respectively). This study revealed that 64% of parents were satisfied with the healthcare staff. In addition, 65.3% of parents were satisfied with the communication of the healthcare staff. Moreover, the rate of satisfaction with the information provided by the healthcare staff was 61.8%. The total scores on the Critical Care Family Needs Inventory - Emergency Department were significantly higher among parents who reported being satisfied with the healthcare staff, communication, and information provision (p < 0.001). Conclusion This study suggested that addressing parental needs for family participation in care and communication may enhance parents' experiences in paediatric emergency settings. However, further research is needed to evaluate specific interventions. Clear communication is a fundamental need for families, influencing satisfaction, understanding, and involvement in care.
Fear of Missing Out (FoMO) and Sleep Disturbance as Sequential Mediators in the Relationship Between Excessive Screen Time and Life Satisfaction in Turkish Young Adults
(BMC, 2025) Aslan, Yavuz
Background With the increasing prevalence of digital device use among young adults, concerns have emerged about its impact on psychological well-being. This study investigates the relationship between excessive screen time and life satisfaction, with a focus on the sequential mediating roles of fear of missing out (FoMO) and sleep disturbance. Methods Data were collected from 407 young adults (mean age = 24.13 years; 77.6% female, 22.4% male) in T & uuml;rkiye using validated self-report measures. Structural equation modeling (SEM) was employed to test direct, indirect, and sequential effects among the study variables. Results Excessive screen time significantly predicted higher levels of FoMO and lower levels of life satisfaction. FoMO positively predicted sleep disturbance, and sleep disturbance negatively predicted life satisfaction. Mediation analyses revealed that FoMO mediated the relationship between excessive screen time and sleep disturbance, while sleep disturbance mediated the relationship between FoMO and life satisfaction. Additionally, a significant sequential mediation effect was found. Conclusion The findings highlight FoMO and sleep disturbance as key psychological and behavioral mechanisms linking excessive screen time to reduced well-being. Interventions targeting digital media use among young adults should focus on reducing FoMO and improving sleep hygiene to enhance life satisfaction.
The Moderating Effects of Gender and Emotional Eating on the Relationship Between Social Media Addiction and Hedonic Hunger in University Students
(Nature Portfolio, 2025) Ceylan, Jiyan Aslan
The widespread use of social media has become an important factor influencing eating behaviors, particularly among university students who are heavily exposed to digital content. The aim of this study was to examine the relationship between social media addiction and hedonic hunger and to explore the moderating roles of gender and emotional eating. This cross-sectional study was conducted online during the 2023-2024 academic years and included 930 university students from T & uuml;rkiye. Data were collected using the Social Media Addiction Scale-Adult Form (SMAS-AF) and the Power of Food Scale (PFS). Emotional eating was assessed by asking participants about their overall mood and whether their emotional state influenced their eating behavior, including changes in food intake (increased, decreased, or no change). Statistical analyses were conducted using SPSS and the PROCESS Macro, with significance set at p < 0.05. Findings revealed a significant positive relationship between SMAS-AF and PFS scores (B = 0.61, p < 0.01). Emotional eating significantly moderated this relationship (B = - 0.24, p < 0.01), while gender did not. Students who perceived their nutritional knowledge as inadequate, reported unbalanced eating habits, or viewed themselves as overweight or obese consistently exhibited higher scores on both the scales (p < 0.05). These results underscore the need for interventions that address emotional regulation, nutrition literacy, and media awareness to mitigate the impact of social media on eating behaviors in young adults.
A Randomized Trial of Inulin for Bowel Symptoms, Depression and Quality of Life in Constipation Predominant IBS
(Nature Portfolio, 2025) Akcali, Caglar; Ucar, Asli; Atay, Kadri
This study was conducted to evaluate the effect of inulin on bowel symptoms, depression and quality of life in individuals with constipation-predominant irritable bowel syndrome. This study was designed as a randomized, single-blind, placebo-controlled clinical trial with a parallel design and a 1:1 allocation ratio. Individuals (n = 34) aged between 21 and 63 years with constipation-predominant IBS were included in the study. Individuals were randomly assigned to two groups: the prebiotic group (n = 17), which received a 50%/50% mixture of inulin/oligofructose (4.6 g twice daily, for a total daily dose of 9.2 g), and the placebo group (n = 17), which total received 9.2 g of maltodextrin per day. The intervention period was 8 weeks. Bristol Stool Scale, IBS-Visual Analogue Scale (IBS-VAS), IBS-Symptom Severity Score Scale (IBS-SSS), IBS-Quality of Life Scale (IBS-QoL) and Beck Depression Scale were administered to the participants at the beginning, 1st month and 2nd month. As a result, total IBS-QoL score increased in the prebiotic group (61.0 +/- 19.4 to 77.4 +/- 15.1; p < 0.006), whereas total IBS-SSS score decreased (267.3 +/- 56.0 to 195.8 +/- 59.0; p < 0.026). In the prebiotic group, significant improvement was observed in the IBS-VAS parameters of constipation status (2.2 +/- 2.3 to 4.9 +/- 2.5; p < 0.042(groupxtime)), psychological state (7 (2-10) to 9 (5-10); p < 0.006). It is thought that inulin may have beneficial effects on reducing symptom severity and frequency and on quality of life in individuals with IBS in whom constipation is predominant.
The Roles of Body Image, Drive for Muscularity, and Spiritual Well-Being in the Relationship Between Disordered Eating and Exercise Addiction Among Sports Science Students: A Moderated Model
(BMC, 2025) Sahin, Muhammed; Ayhanci, Nisa Nur; Erdem, Metin; Apak, Hidir; Parlak Ozer, Zeynep; Ilkim, Mehmet
BackgroundThis study aims to evaluate the roles of drive for muscularity, body image perception, and spiritual well-being in the relationship between exercise addiction and disordered eating.MethodsThe research was designed as a cross-sectional study and included 408 students enrolled in the Faculty of Sport Sciences at various public universities in T & uuml;rkiye. Data were collected using a socio-demographic information form, the Eating Behavior Disorder Scale, the Drive for Muscularity Scale, the Exercise Addiction Scale, the Spiritual Well-Being Scale, and the Body Image Scale.ResultsThe findings revealed that exercise addiction is linked to disordered eating through the mediating role of the drive for muscularity. This indirect relationship changes depending on levels of body image and spiritual well-being. Specifically, the effect of the drive for muscularity on disordered eating was strongest among individuals with low body image and low spiritual well-being. In contrast, when body image was at low or moderate levels and spiritual well-being was high, this effect was no longer significant.ConclusionsThe findings indicate that negative body image and spiritual well-being are key correlates of disordered eating and exercise habits. In addition, these findings emphasize the importance of maintaining psychological and physical balance, particularly in sports science students who are under high pressure in terms of athletic performance.
Mental and Physical Outcomes of Yoga Participation in Women with Spinal Disorders: A Qualitative Study
(Frontiers Media S.A., 2025) Akyol, Gamze; Ermis, Sermin Agrali; Karakullukcu, Omur Fatih; Guler, Ozkan; Karakulak, Izzet; Arslanoglu, Cansel; Kucuk, Hamza
Yoga, a holistic practice supporting both physical and mental integrity, has gained increasing attention in recent years as a public health-promoting activity. Particularly among women with spinal disorders (e.g., hernia, lordosis, scoliosis, kyphosis), yoga is recognized not only for improving physical functionality but also for contributing significantly to psychosocial parameters such as stress management, self-awareness, and life satisfaction. In this context, the present study aimed to explore the mental and physical outcomes of regular yoga practice in women diagnosed with spinal disorders, using qualitative methods. This study was conducted using a phenomenological design, as the participants had experienced the situation under investigation. It included semi-structured, in-depth interviews with 15 adult participants diagnosed with spinal disorders and with at least 3 months of yoga experience. In line with the nature of qualitative research, the number of participants was deemed sufficient, and it was accepted that data saturation was reached through the interviews conducted with 15 participants. The findings revealed multidimensional benefits, including mental and physical relaxation, improved stress management, postural enhancement, better quality of life, and increased self-compassion. Participants also highlighted the positive influence of yoga on body-mind balance, awareness of personal limits, and a deeper understanding of their condition. These results suggest that yoga functions both as a physical intervention and a psychological support mechanism for women with spinal disorders, promoting active engagement in their treatment process and enhancing public health outcomes. In conclusion, yoga practice was found to provide significant and sustainable contributions to spinal health and overall psychosocial well-being.
Impact of an 8-Week High-Intensity Bodyweight Interval Training on Body Composition and Blood Lipid Metabolism in Young Women with Overweight
(Frontiers Media S.A., 2025) Yamaner, Emre; Turgut, Tuna; Aksoy, Ayse; Demirkiran, Burhan; Ucar, Mine Akkus; Basoglu, Burhan; Kucuk, Hamza
Background A physically inactive lifestyle is associated with an increased risk of obesity, dyslipidemia and metabolic disorders, especially in women. While high-intensity training methods have been extensively studied in male populations, the physiological and metabolic effects of high-intensity interval resistance training (HIIRT) in overweight women are understudied. The aim of this study was to investigate the effects of an 8-week HIIRT program on body composition and lipid metabolism in women.Methods A total of 30 women (mean age: 23.13 +/- 4.03 years, mean BMI: 31.21 +/- 2.92 kg/m2) participated in an 8-week HIIRT program. Body composition was measured before and after the intervention using bioelectrical impedance analysis (BIA), while blood lipid parameters (triglycerides, total cholesterol, LDL, and HDL) were analyzed. Paired-sample t-tests were performed to determine the significance of the changes in body composition and lipid metabolism, using Cohen's d effect size for interpretation.Results The HIIRT program led to significant improvements in body composition, with body weight decreasing by 11.4 kg (p = 0.001, d = 0.96) and fat percentage decreasing by 3.1% (p = 0.001, d = 0.92). In addition, blood lipid profiles improved significantly, with triglycerides (-8.9 mg/dL, p = 0.001, d = 0.81, medium effect), total cholesterol (-19.7 mg/dL, p = 0,020, d = 1.98, large effect), and LDL (-8.2 mg/dL, p = 0.004, d = 1.96, large effect) decreased, while HDL increased by +10 mg/dL (p = 0.006, d >= 2.0, very large effect). These results underline the positive effects of HIIRT on lipid metabolism and cardiovascular health.Conclusion The results suggest that HIIRT is an effective and time-efficient training model for improving body composition and metabolic health in women. The combination of high-intensity interval training principles with resistance exercise optimizes fat oxidation, improves fat metabolism and supports cardiovascular function. Given its efficacy, HIIRT could be a valuable strategy for treating metabolic disorders and reducing the risks of physically inactive behavior. Future research should focus on long-term adaptations and individual variability in metabolic responses to optimize HIIRT programs for broader populations.
Validity and Reliability Study of the Turkish Version of the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance: A Methodological Study
(Sage Publications Ltd, 2025) Ozbay, Hediye; Cevik Aktura, Seher
Aim: This study aimed to evaluate the validity and reliability of the Turkish version of the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance.Methods: A methodological design was employed between February and May 2025, involving a sample of 276 nurses. Participants were drawn from emergency departments, internal medicine units, surgical wards, and intensive care units across hospitals in two provinces in eastern Turkey. Data were collected using two instruments: the Nurses' Information Form and the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance. Descriptive statistics, including frequencies, percentages, means, standard deviations, medians, and minimum and maximum values, were used to describe participant characteristics. Content validity was assessed through expert review, and the Content Validity Index was calculated using the Davis technique. Item discrimination and difficulty indices were computed using Microsoft Excel. Reliability analysis involved calculation of the Kuder-Richardson Formula 20 (KR-20) coefficient, alongside item-total score correlation analysis.Results: The KR-20 coefficient for the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance was 0.974. Analysis of the test mean scores revealed that the items were generally easy but exhibited high discriminatory power.Conclusion: The Turkish version of the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance demonstrated high reliability, as evidenced by its KR-20 value. The use of this questionnaire enables the identification of knowledge gaps among nursing professionals regarding best practices in short peripheral catheter care.
Mindful Attention Awareness and Attitudes Toward Social Handwashing Among Nursing and Midwifery Students
(Univ Sao Paolo, 2025) Baran, Leyla; Ozturk, Huri; Dog, Feride
Objective: To explore the relationship between mindful attention awareness and attitudes toward social handwashing among undergraduate nursing and midwifery students. Method: A cross-sectional and correlational study was conducted with 679 undergraduate nursing and midwifery students. Data were collected using two scales: (1) the Mindful Attention Awareness Scale (MAAS) and (2) the Attitude Scale toward Social Handwashing (ASSHW). Additionally, the participants provided data on their sociodemographic characteristics and responded to an inventory of handwashing practices. Relationships between scores were examined using Spearman's rho. Results: The students' mindful attention levels (MAAS) averaged 44.97 +/- 11.46, and their attitudes toward social handwashing (ASSHW) averaged 78.32 +/- 13.67. While no direct correlation was found between overall ASSHW and MAAS scores, there were positive correlations between mindful attention levels and certain ASSHW sub-dimensions, as well as with specific handwashing behaviors such as frequency and duration. Conclusion: These findings suggest that mindful attention may support better hand hygiene practices among nursing and midwifery students.
The Relationship Between Mental Health Literacy and Psychological Support-Seeking Attitudes in Syrian Immigrant Students
(BMC, 2025) Kacan, Havva; Deger, Vasfiye Bayram; Cifci, Sema
Background The study was conducted to examine the relationship between mental health literacy and psychological support-seeking attitudes among Syrian immigrant university students. Materials and methods The population of the study consisted of 2000 Syrian immigrant students studying in different departments of a university, and the sample comprised 326 immigrant students. In the study, data were collected through Descriptive Questions, the Mental Health Literacy Scale (MHLS), and the Attitude Scale toward Receiving Professional Psychological Support-Short Form (ATSPPH-SF). Results The mean MHLS score of Syrian immigrant students was 11.804 +/- 3.434. The average score of the ATSPPH-SF was 58.245 +/- 8.131. A positive and moderate correlation was found between the total score of MHL and psychological support (r = 0.514, p < 0.01). The rate of explaining the effect of MHL on receiving psychological support was found as 26.2%. It was found that the increase in the level of knowledge positively affected the attitudes of the students to seek psychological support, and the belief-oriented dimension had a significant and positive effect on the attitude toward psychological support (B = 0.918, beta = 0.250, p < 0.001). A one-unit increase in the belief-oriented dimension provided a 0.918-unit increase in the psychological support attitude score. However, it was observed that the effect of this dimension was lower compared with the information-oriented dimension. This finding shows that belief-based approaches may positively affect the attitude toward psychological support, but their effect is limited. Conclusions It was determined that the MHL of the students was moderate and the attitudes of seeking psychological support were positive. There was a significant and positive relationship between the mental health literacy of Syrian immigrant students and seeking psychological support. It can be argued that initiatives to increase MHL can positively shape individuals' attitudes toward psychological support.
Chemical Evaluation of Arbequina Extra Virgin Olive Oil with in Silico Analysis of Its Key Phenolic Compounds Targeting LDL Metabolism
(Nature Portfolio, 2025) Korkmaz, Aziz; Unsal, Velid; Yildiz, Resit; Oner, Erkan; Atasoy, Ahmet Ferit
The chemical properties of extra virgin olive oil (EVOO) from Arbequina variety grown in T & uuml;rkiye were evaluated, and its major phenolic compounds (PC) (oleocanthal, oleacein, luteolin and tyrosol) were compared with drugs (bempedoic acid and ezetimibe) involved in LDL metabolism through in silico analyses. The fatty acids composition (FA), PC and volatile organic compound (VC) profiles of EVOO obtained from Arbequina olive were evaluated via chromatographic methods (GC-FID, HPLC). The quality parameters, including total phenolic content (TPC), pigment content, peroxide value (PV), free fatty acid levels (FFA) and absorption coefficients, were determined via spectrophotometric methods. ADMET profiles, density functional theory (DFT), molecular docking, and the biological targets and activities of oleocanthal, oleacein, luteolin, tyrosol, bempedoic acid and ezetimibe were calculated and compared. Oleocanthal, oleacein, and luteolin completely passed the rules of Lipinski, Ghose, Veber, Egan, and Muegge, whereas only luteolin met the optimum ranges of all the criteria on the radar map. All 4 PC strongly inhibited OATP1B1 and OATP1B3, whereas oleocanthal, oleacein, and luteolin inhibited CYP3A4. Additionally, luteolin, oleocanthal and ezetimibe had individual inhibitory effects on CYP1A2, CYP2C9 and CYP2D6, respectively. Oleacein had the best binding affinity for LDLR, whereas luteolin had the best binding affinity for PCSK9 and ACLY. Oleacein was biologically effective against pathogens such as Leishmania species, but showed high reactivity with a low energy gap and high malleability. In conclusion, oleacein, oleocanthal and luteolin have potential therapeutic functions in LDL metabolism, which plays a role in atherosclerosis. However, experimental and clinical studies are needed for more evidence.
Corrigendum to “The Effect of Mediterranean Diet Adherence During the Third Trimester of Pregnancy on Maternal and Newborn Health Outcomes” Nutrition 140 (2025) 112909 1-10 (Nutrition (2025) 140, (S0899900725002278), (10.1016/J.nut.2025.112909))
(Elsevier Science Inc, 2025) Ceylan, Jiyan Aslan
Investigation of Disaster Management Perceptions of School Administrators: The Case of Kahramanmaraş Earthquake
(Elsevier, 2025) Is, Engin; Karadas, Halil
This study examined the problems school administrators face during disasters and the strategies they develop to address these problems within the framework of disaster management theories. A phenomenological design was adopted, and purposive sampling was used to select 22 school administrators (8 female, 14 male). The findings show how disaster management, crisis management, and resilience theories are reflected in school management practices and highlight the need for systematic preparation. Due to the frequent occurrence of earthquakes and floods in Turkey, school administrators reported the necessity of strengthening support mechanisms related to preparedness, response, and risk reduction. The results indicate that administrators require comprehensive training on disaster preparedness, crisis response, and mitigation strategies. By linking these findings to resilience theory, the study underscores how administrators' adaptive practices contribute to organizational readiness in disaster-prone educational contexts.
Period Poverty Among Women After the 2023 Kahramanmaraş Earthquake in Turkey: ACross-Sectional Study
(Inst Rural Health Lublin, Poland, 2025) Dal, Nursel Alp; Kurt, Nuray; Beydag, Kerime Derya; Aruser, Ulkin Gunduz; Nagorska, Anna; Nagorska, Malgorzata
Introduction and objective: Menstrual poverty lies at the intersection of poverty, sustainability, reproductive rights, and gender inequality. The study investigates menstrual poverty among women affected by the 2023 earthquake in Turkey.
Material and methods: A descriptive cross-sectional study was conducted between 24 April - 24 May 2023 with 400 women impacted by the earthquake. Data were collected via social media using a survey form. Chi-square tests, Bonferroni test, and binary logistic regression model were used for statistical analysis.
Results: The mean age of participants was 27.27 +/- 8.40 years; 69.5% had higher education, 57.0% lived in urban areas, and 90.5% had no chronic disease. A significant relationship was found between access to menstrual products and basic needs (clean water, toilet paper, soap, safe toilet access, and healthcare) during menstruation after the earthquake (p<0.05). A significant correlation was also observed between disruptions to the menstrual cycle and the following variables: lack of privacy, perception that lack of privacy affected menstruation, healthcare access, and difficulty obtaining menstrual products (p<0.05).
Conclusions: Most participants faced difficulties accessing menstrual products, water, hygiene supplies, privacy, and healthcare. Those living in tents or containers reported greater challenges. These barriers contributed to menstrual poverty and impacted women's cycles. As menstrual health and hygiene are basic needs and human rights, menstrual poverty must be addressed globally
Anticancer, Antioxidant and Antimicrobial Activity of Elaeagnus Angustifolia L. Leaf Extract
(Dove Medical Press Ltd, 2025) Do Gan, Serap; Mese, Ahmet; Baran, Mehmet Firat; Baran, Ayse; Aktepe, Necmettin; Ahmadian, Elham; Aktas, Husnu
Objective: This study was conducted to determine and compare the antioxidant, cytotoxic, and antimicrobial effects of spindle leaves of Elaeagnus angustifolia L. (E. angustifolia) (oleaster) leaves. Methods: Total phenolic content was measured using the Folin-Ciocalteu method, phenolic compound analysis by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and antimicrobial effect by the minimum inhibition concentration (MIC) method. The free radical scavenging activity was determined by the (2,2-Diphenyl-1-picrylhydrazyl) DPPH method, the free radical scavenging activity was determined by the ABTS method, and cytotoxicity assays were performed by the MTT method in human retinal epithelium cells (RPE-1), human osteosarcoma cells (U2OS), and prostate cancer cells (DU-145) cell lines. Results: High amounts of gallic acid, protocatechuic acid, and o-coumaric acid were identified as phenolic compounds. E. angustifolia was found to have a good antioxidant capacity and high free radical scavenging capacity. In this study, for the first time, E. angustifolia leaf extract was used to investigate cytotoxic effects on human retinal epithelium (RPE-1), human osteosarcoma cells (U2OS), and prostate cancer (DU-145) cells and antimicrobial effects on Listeria monocytogenes American Type Culture Collection (ATTC) 7644, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 11774, and Candida albicans ATCC 10231 microorganisms. The highest cytotoxic effect was observed in the DU-145 cell line, and the highest antimicrobial effect was observed in Listeria monocytogenes ATTC 7644 and Candida albicans ATCC 10231. The leaf extract of the plant contains some important phenolic compounds and has high free radical scavenging capacity, a good anticancer effect, and effective antimicrobial activity on yeast species such as C. albicans. Conclusion: Our study will contribute greatly to the search for anticancer and antimicrobial agents, especially from a pharmacological perspective, by examining biological activity using three different methods.

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