PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Factors Affect Progressive Sperm Motility
(Permanyer Publications, 2025) Sagir, S.; Tunçekin, A.
Objective: In this study, it was aimed to investigate the effects of age, body mass index, and diet factors on sperm parameters and developing a novel index (Artuklu Sperm Quality Index [ASQI]). Method: The study incorporated a total of 115 patients who sought medical attention due to infertility and underwent semen analysis (spermiogram). The ASQI score was developed. Results: About 73% reported eating three meals daily, while 62% consume fruits a few times a week. When considering grain consumption, 30% rarely do, mirroring the 25% who never do. Carbonated drinks are consumed a few times in 15 days by 39% of respondents. Salt consumption showed 47% taking very little, whereas 42% consume caffeine very minimally. Sausage/ salami is minimally consumed by 44%, and 32% of participants reported never being exposed to air pollution. ASQI score ranges from 6 to 61 point. A lower score indicates good nutrition and quality of life, while a higher score suggests deteriorating nutrition and increasing unhealthy habits. Cronbach alfa value was noted as 0.72. A negative correlation was found between ASQI and sperm progressive motility (p < 0.001, r = −0.405). Conclusions: This study revealed a clear negative correlation between the ASQI score, which signifies deteriorating nutrition and escalating unhealthy habits, and sperm progressive motility. © 2024 Academia Mexicana de Cirugía.
Association Between Abo Blood Group, Peripheral Artery Disease Lesion Severity, and Coronary Artery Disease Coexistence
(Elsevier Inc., 2025) Evsen, A.; Aktan, A.; Kılıç, R.; Özbek, M.
Background: This study aims to investigate the relationship between ABO blood groups and the severity of peripheral artery disease (PAD) lesions, the coexistence of coronary artery disease (CAD) with PAD, and to identify which blood groups may be more predisposed to these conditions. Methods: This study, which has a single-center and retrospective design, includes 305 patients diagnosed with peripheral artery disease (PAD) between 2015 and 2021. The patients were selected from those with at least 50% stenosis detected by computed tomography (CT) angiography. The severity of PAD lesions was evaluated according to the TransAtlantic Inter-Society Consensus (TASC-II) classification, and the presence of CAD was determined by simultaneous conventional coronary angiography. Demographic data, comorbidities, and laboratory results were collected, and statistical analyses were performed using chi-square tests, logistic regression, and t-tests. All of these patients were divided into 2 groups based on their ABO blood types: O and non-O blood groups. Results: This study demonstrates a significant relationship between blood group classification and both the severity of PAD and the prevalence of CAD. Patients with non-O blood groups exhibited a higher likelihood of having severe PAD lesions (TASC-C and TASC-D) compared to those with O blood groups, who more frequently had milder lesions (TASC-A and TASC-B) (P < 0.001). The prevalence of CAD was also significantly higher among patients with non-O blood groups than those with the O blood group (54.4% vs. 36.4%; P = 0.003). In the logistic regression analysis, non-O blood groups, alongside age, hypertension (HT), and chronic kidney disease (CKD), emerged as independent predictors of severe PAD (P < 0.001 for non-O blood groups). Similarly, older age and non-O blood group status were identified as significant independent predictors of CAD (P = 0.004). These findings suggest that blood group classification, particularly non-O groups, may influence the severity and coexistence of PAD and CAD. Conclusion: Our study reveals a significant association between ABO blood groups and both the severity of PAD and the association of CAD, and shows that non-O blood groups are linked to more severe forms of these conditions. These findings highlight the potential role of ABO blood groups in cardiovascular risk stratification, suggesting a need for further research to confirm these associations and understand their clinical implications. © 2025 Elsevier Inc.
Comparison of Machine Learning Algorithms for Automatic Prediction of Alzheimer Disease
(Wolters Kluwer Health, 2025) Aslan, E.; Özüpak, Y.
Background: Alzheimer disease is a progressive neurological disorder marked by irreversible memory loss and cognitive decline. Traditional diagnostic tools, such as intracranial volume assessments, electroencephalography (EEG) signals, and brain magnetic resonance imaging (MRI), have shown utility in detecting the disease. However, artificial intelligence (AI) offers promise for automating this process, potentially enhancing diagnostic accuracy and accessibility. Methods: In this study, various machine learning models were used to detect Alzheimer disease, including K-nearest neighbor regression, support vector machines (SVM), AdaBoost regression, and logistic regression. A neural network was constructed and validated using data from 150 participants in the University of Washington's Alzheimer's Disease Research Center (Open Access Imaging Studies Series [OASIS] dataset). Cross-validation was also performed on the Alzheimer Disease Neuroimaging Initiative (ADNI) dataset to assess the robustness of the models. Results: Among the models tested, K-nearest neighbor regression achieved the highest accuracy, reaching 97.33%. The cross-validation on the ADNI dataset further confirmed the effectiveness of the models, demonstrating satisfactory results in screening and diagnosing Alzheimer disease in a community-based sample. Conclusion: The findings indicate that AI-based models, particularly K-nearest neighbor regression, provide promising accuracy for the early detection of Alzheimer disease. This approach has potential for further development into practical diagnostic tools that could be applied in clinical and community settings. © 2024, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license.
Dexmedetomidine Protects the Uterus Against Ischemia-Reperfusion Injury in Rats
(Verduci Editore s.r.l, 2024) Kölükçü, V.; Balta, M.G.; Tapar, H.; Karaman, T.; Karaman, S.; Unsal, V.; Katar, M.
OBJECTIVE: This study aimed to analyze the histopathological and biochemical effects of dexmedetomidine on the rat uteri exposed to experimental ischemia-reperfusion injury. MATERIALS AND METHODS: Twenty-four female rats were randomly divided into three groups. Group 1 was defined as the control group. An experimental uterine ischemia-reperfusion model was created in Group 2. Group 3 was assigned as the treatment group. Similar uterine ischemia-reperfusion models were created for the rats in Group 3, and then, unlike the other groups, 100 μg/kg of dexmedetomidine was administered intraperitoneally immediately after the onset of reperfusion. In blood biochemical analysis, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA), interleukin 1beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels were measured. In the histopathological analyses, endometrial epithelial glandular changes (leukocytosis, cell degeneration) and endometrial stromal changes (congestion, edema) were analyzed using the tissue damage scoring system. RESULTS: It was observed that IL-1β, IL-6, and TNF-α levels were significantly suppressed in Group 3 compared to Group 2 (p=0.001, p<0.001 and p=0.001, respectively). MDA level was noted as the highest in Group 2. The MDA value in Group 3 was measured at 5.37±0.82, which was significantly decreased compared to Group 2 (p<0.001). An increase in antioxidant enzyme activities (SOD and GSH-PX) was observed in Group 3 compared to Group 2 (p=0.001 and p=0.006, respectively). In our histopathological analysis, a significant improvement in endometrial epithelial glandular and endometrial stromal changes was revealed in Group 3 compared to Group 2 (p<0.001). CONCLUSIONS: In our study, it has been documented that dexmedetomidine protects the uterine tissue against ischemia-reperfusion injury. © 2024 Verduci Editore s.r.l. All rights reserved.
Deep Learning-Based Artificial Intelligence Can Differentiate Treatment-Resistant and Responsive Depression Cases With High Accuracy
(Sage Publications inc, 2025) Metin, Sinem Zeynep; Uyulan, Caglar; Farhad, Shams; Erguzel, Tuerker Tekin; Turk, Omer; Metin, Baris; Tarhan, Nevzat; Türk, Ömer
Background: Although there are many treatment options available for depression, a large portion of patients with depression are diagnosed with treatment-resistant depression (TRD), which is characterized by an inadequate response to antidepressant treatment. Identifying the TRD population is crucial in terms of saving time and resources in depression treatment. Recently several studies employed various methods on EEG datasets for automatic depression detection or treatment outcome prediction. However, no previous study has used the deep learning (DL) approach and EEG signals for detecting treatment resistance. Method: 77 patients with TRD, 43 patients with non-TRD, and 40 healthy controls were compared using GoogleNet convolutional neural network and DL on EEG data. Additionally, Class Activation Maps (CAMs) acquired from the TRD and non-TRD groups were used to obtain distinctive regions for classification. Results: GoogleNet classified the healthy controls and non-TRD group with 88.43%, the healthy controls and TRD subjects with 89.73%, and the TRD and non-TRD group with 90.05% accuracy. The external validation accuracy for the TRD-non-TRD classification was 73.33%. Finally, the CAM analysis revealed that the TRD group contained dominant features in class detection of deep learning architecture in almost all electrodes. Limitations: Our study is limited by the moderate sample size of clinical groups and the retrospective nature of the study. Conclusion: These findings suggest that EEG-based deep learning can be used to classify treatment resistance in depression and may in the future prove to be a useful tool in psychiatry practice to identify patients who need more vigorous intervention.
Comparison of Different Fixatives Effects in Histochemical Stainings of Peripheral Nerve Tissue
(Cellular and Molecular Biology Association, 2024) Dörtbudak, M.B.; Demircioğlu, M.; Şeker, U.; Demircioğlu, İ.
A pathological condition in the peripheral nerve tissue, which provides the connection between the organism and the external environment, negatively affects the standard of living. The nerve tissue histotechnology is of serious importance both for scientific studies and for clinical diagnosis. The fixation, which is one of the leading procedures for histological examination of tissues, aims to preserve tissue morphology. Another essential part of the histological examination is staining process. This study, it was aimed to determine the fixative that provides optimal histological appearance in peripheral nerve tissue. Therefore, various histochemical stainings of tissues fixed with some fixatives used in practice were compared. Sciatic nerves from each rat (n=7) used in the study were fixed with different fixatives and histochemical staining was performed. In histological examination, cellular (nucleus-cytoplasm) and intercellular morphological details, staining intensity and distribution were evaluated. At the end of the study, formaldehyde was found to be the most ideal fixing agent for all stains. Although Bouin and Carnoy fixatives differed according to the staining type, their fixation quality was similar in general. Glutaraldehyde did not give as good results as other fixatives in all stainings. This study is an important technical reference for clinical and experimental studies. © 2024 Cellular and Molecular Biology Association. All rights reserved.
The Effect of Aortic Angulation on Clinical Outcomes of Patients Undergoing Transcatheter Aortic Valve Replacement
(Soc Brasil Cirurgia Cardiovasc, 2024) Aktan, Adem; Demir, Muhammed; Guzel, Tuncay; Karahan, Mehmet Zulkuf; Aslan, Burhan; Kilic, Raif; Ertas, Faruk
Introduction: The aim of this study was to assess the impact of aortic angulation (AA) on periprocedural and in -hospital complications as well as mortality of patients undergoing Evolut (TM) R valve implantation. Methods: A retrospective study was conducted on 264 patients who underwent transfemoral-approach transcatheter aortic valve replacement with self-expandable valve at our hospital between August 2015 and August 2022. These patients underwent multislice computer tomography scans to evaluate AA. Transcatheter aortic valve replacement endpoints, device success, and clinical events were assessed according to the definitions provided by the Valve Academic Research Consortium -3. Cumulative events included paravalvular leak, permanent pacemaker implantation, new-onset stroke, and in -hospital mortality. Patients were divided into two groups, AA <= 48(degrees) and AA > 48(degrees), based on the mean AA measurement (48.3 +/- 8.8) on multislice computer tomography. Results: Multivariable logistic regression analysis was performed to identify predictors of cumulative events, utilizing variables with a P-value < 0.2 obtained from univariable logistic regression analysis, including AA, age, hypertension, chronic renal failure, and heart failure. AA (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 0.89-3.38, P=0.104), age (OR: 1.04, 95% CI: 0.99-1.10, P=0.099), hypertension (OR: 1.66, 95% CI: 0.82-3.33, P=0.155), chronic renal failure (OR: 1.82, 95% CI: 0.92-3.61, P=0.084), and heart failure (OR: 0.57, 95% CI: 0.27-1.21, P=0.145) were not found to be significantly associated with cumulative events in the multivariable logistic regression analysis. Conclusion: This study demonstrated that increased AA does not have a significant impact on intraprocedural and periprocedural complications of patients with new generation self-expandable valves implanted.
Impact of Tumor Resection Volume on Visual Outcomes and the Need for Secondary Surgery Following Transsphenoidal Surgery in Suprasellar Extended Non-Functionial Pituitary Adenomas
(Turkish Neurosurgical Society, 2024) Gundogdu, D.K.; Gezer, B.; Sahinoglu, M.; Koktekir, E.; Karabagli, H.; Bozkurt, M.A.; Batur, A.
AIM: To investigate the surgical outcomes in patients with nonfunctional pituitary adenomas (NFPAs) exhibiting visual field defects (VFDs) in order to ascertain the impact of the volume of adenoma excised during surgery on recurrence rates and improvements in VFDs. MATERIAL and METHODS: From a cohort of 150 individuals diagnosed with NFPAs and exhibiting suprasellar extensions accompanied by VFDs, we selected 114 patients who fulfilled the inclusion criteria for further analysis after a comprehensive retrospective review. All selected patients underwent pituitary magnetic resonance imaging (MRI) examinations, and volumetric measurements were conducted on T1 contrast sequences using the Syngo.via software. Measurements were derived from MRI scans taken 24 h preoperatively, 24 h postoperatively, at 3 months, and at the end of the first year postsurgery. Volumetric values were compared between patients who underwent subsequent surgeries due to recurrence and those who did not. Similarly, the variables were evaluated in patients experiencing an improvement in VFD, those whose VFD remained stable, and those experiencing a deterioration in VFD. RESULTS: The recurrence rate was 19.3%. Among patients who underwent a second surgery due to recurrence, the presurgical adenoma volume, the adenoma volume removed based on the 24-h postoperative MRI, and the volumes recorded in the 3-month and 1-year postoperative imaging were significantly greater than those in patients who did not require a second surgery. Remarkable improvements were identified in 84.2% of patients with VFD complaints and 62.5% of those with visual acuity complaints. CONCLUSION: Adenoma volume measurements exerted a significant impact on recovery from VFDs and the need for a second surgery. Although the choice of surgical methodology does not definitively affect outcomes, an in-depth evaluation of variations in adenoma volume can provide valuable prognostic insights. © (2024), (Turkish Neurosurgical Society). All rights reserved.
The Disaster of the Century: Effects of the 6 February 2023 Kahramanmaraş Earthquakes on the Sleep and Mental Health of Healthcare Workers
(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Çifçi, S.; Kilinç, Z.
It is known that disasters can have long-term effects on the mental health of individuals. In particular, healthcare workers may be under greater stress in a time of disaster, as they are not only affected by the disaster, but they also take part in rescue efforts. This study was conducted to investigate the psychological effects of the Kahramanmaraş earthquakes on healthcare workers employed at the Adıyaman Training and Research Hospital. The sample in the cross-sectional study consisted of 299 healthcare personnel working in the Adıyaman Training and Research Hospital. The study data were collected through a questionnaire consisting of five sections. The data were analysed using SPSS 22 software. It was found that among healthcare workers, those who were women, married, individuals whose homes were damaged, injured, or lost a relative in the earthquake had experienced mental health problems such as post-traumatic stress disorder (PTSD), anxiety, depression, and poor sleep quality the most. The earthquakes that occurred on 6 February negatively affected the mental health of healthcare workers. In order to reduce these negative effects experienced by healthcare workers, various types of mental health screening should be performed, and supportive psychological services should be provided urgently. © 2024 by the authors.
Factors Affecting Maternal Satisfaction in Labor and Neonatal Outcomes: a Cross-Sectional Study
(Womens Health & Action Research Centre, 2024) Donmez, Aysegul; Yesil, Yesim
This study evaluated the factors affecting maternal satisfaction during labor and neonatal outcomes. This cross-sectional study was conducted with 319 mothers who gave birth in ahospital (01.10.2023-31.03.2024) and volunteered for the study. Data were collected using a personal information form including socio-demographic and obstetric characteristics of the mothers and the 'Birth Satisfaction Scale'. The mean age of the mothers who participated in the study was 28.07 +/- 6.44 years. The mean score of the Birth Satisfaction Scale was 22.29 +/- 5.03. The sub-dimensions of the scale were found to be significantly affected by mode of delivery, various factors (p<0.05). Positive birth experience also affects maternal satisfaction. This study showed that maternal satisfaction in labor was at a moderate level. It explains that maternal satisfaction in labor is affected by the mode of delivery and other factors. In addition, it is seen that the method of delivery has various negative effects on the newborn.
Intensive Care Nurses' Knowledge and Practices Regarding Medical Device-Related Pressure Injuries: a Descriptive Cross-Sectional Study
(John Wiley and Sons Inc, 2024) Kurtgöz, A.; Kızıltepe, S.K.; Keskin, H.; Sönmez, M.; Aşatır, İ.
This study aims to determine the levels of knowledge and practices of intensive care nurses regarding medical device-related pressure injuries (MDRPIs). This descriptive cross-sectional study was carried out between September 2023 and February 2024, involving 143 nurses working in intensive care units across three hospitals in Türkiye. The data were collected using the demographic form and the Medical Device-related Pressure Injuries Knowledge and Practice Assessment Tool (MDPI-ASSET). Of the nurses, 74.1% have encountered MDRPIs in their unit, 63.6% feel that their knowledge about MDRPIs is insufficient and 90.2% express a desire to receive training about MDRPIs. The participants' total mean MDPI-ASSET score was 11.12 (out of 21). The nurses achieved the highest mean score on the Aetiology/risk factors sub-scale and the lowest mean score on the Staging sub-scale. The analysis revealed significant differences in the mean MDPI-ASSET total scores among nurses based on the status of previous encounters with MDRPIs (t = 2.342; p = 0.021) and their feelings of responsibility for the development of MDRPIs (t = −2.746; p = 0.007). In this study, the knowledge and practices of intensive care nurses regarding medical device-induced pressure injuries were found to be inadequate. Given the frequent occurrence of MDRPIs in intensive care units, it is necessary to support nurses with continuous organizational-level training to improve the quality of care for critically ill patients. © 2024 The Author(s). International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
Comparison of Single-Incision Laparoscopic Percutaneous and Cystoscope Forceps Assisted Morgagni Hernia Repair Techniques
(W.B. Saunders, 2024) Okur, M.H.; Aydoğdu, B.; Azizoğlu, M.; Arslan, S.; Bayram, S.; basuguy, E.
Objective: Our goal was to compare single-incision laparoscopic percutaneous and cystoscope forceps-assisted Morgagni hernia repair techniques. Materials and methods: A total of 40 patients were allocated to two groups, each with 20 patients. Group 1: Single incision (port) laparoscopic surgical percutaneous Morgagni hernia repair (with a 5 mm Storz laparoscopic scope entered through the umbilicus). Group 2: Single incision (port) laparoscopic surgical percutaneous Morgagni hernia repair (with an 11 Fr [3.6 mm] cystoscope entered through the umbilicus + using forceps + sac plication, and sac cauterization). In Group 1; the sac was not removed. In group 2; we advanced the forceps through the cystoscope, caught the sac, pushed the needle through the sac, plicated the sac, and then cauterized the sac with Bugbee electrode. Results: Of the 40 patients, 70 % (n = 28) were male. The symptoms at admission included repeated chest infections (40 %), dyspnea (30 %), vomiting (22 %), and abdominal pain (22 %). No difference was found between groups in terms of age, gender symptomatology, or associated anomalies. The operation time was shorter in group 2 compared to group 1 (p < 0.05; 25 min vs 40 min). Although there was one recurrence in Group 1, no recurrence was reported in Group 2. The recurrence incidence did not differ between groups (p > 0.05). Conclusions: Cystoscope-assisted repair of Morgagni hernia was found to be superior in terms of safety and shorter operation time. Level of evidence: Type III. Type of the study: Retrospective study. © 2023 Elsevier Inc.
Evolving Approach in Nephron-Sparing Surgery: Has Anything Changed From Open Surgery To Laparoscopy
(Iniestares, S.a., 2024) Ergun, Muslum; Sagir, Suleyman; Akyuz, Osman; Akman, Ramazan Yavuz
Objective: This study aimed to provide valuable insights into the comparative efficacy of different surgical approaches fornephron-sparing surgery (NSS) and contribute to the existing literature in this field. Materials and Methods: This study included patients who underwent NSS for small renal masses between January 2016 andMarch 2024. A total of 97 patients (41 in the open approach group, 56 in the laparoscopic approach group) with demographic,radiological, intraoperative, renal functional, and oncological follow-up data were included. Three different anatomical scoringsystems (R.E.N.A.L. nephrometry score, PADUA score and C-index) were utilised to assess tumour location and estimate prox-imity to the hilum and collecting system. Results: In the open nephron-sparing surgery (ONSS) and laparoscopic nephron-sparing surgery (LNSS) groups, the mean kid-ney tumour diameters (SD) were 5.20 +/- 2.30 and 4.90 +/- 2.10, which were similar in both surgical method groups (p= 0.061).However, tumours treated with ONSS had significantly more adverse morphometric features (p<0.05). For ONSS and LNSSgroups, the mean R.E.N.A.L. nephrometry scores (SD) were 6.15 +/- 2.04 and 5.2 +/- 1.4 (p= 0.032), respectively; The mean PADUAscores (SD) were 7.46 +/- 1.14 and 6.8 +/- 1.0 (p= 0.049), respectively; And the mean C-index (SD) scores were 1.39 +/- 0.4 and 1.37 +/- 0.5 (p= 0.062), respectively. No significant differences were found in the mean tumour diameter (cm) (Inter Quantile Range(IQR)) distribution of both groups (p= 0.058). Despite the slight increase in transfusion rate in the LNSS group, estimated bloodloss (EBL), transfusion rates, and length of hospital stay were similar in both groups. Conclusions: Although LNSS does not appear superior in terms of intraoperative blood loss, length of hospital stay and transfu-sion rate, it provides comparable long-term outcomes to ONSS. Our study suggests that when matched with nephrometry scores,LNSS can achieve similar outcomes to ONSS
The Deep Learning Method Differentiates Patients With Bipolar Disorder From Controls With High Accuracy Using Eeg Data
(Sage Publications inc, 2024) Metin, Baris; Uyulan, Caglar; Erguzel, Turker Tekin; Farhad, Shams; Cifci, Elvan; Turk, Omer; Tarhan, Nevzat; Türk, Ömer
Background: Bipolar disorder (BD) is a mental disorder characterized by depressive and manic or hypomanic episodes. The complexity in the diagnosis of Bipolar disorder (BD) due to its overlapping symptoms with other mood disorders prompted researchers and clinicians to seek new and advanced techniques for the precise detection of Bipolar disorder (BD). One of these methods is the use of advanced machine learning algorithms such as deep learning (DL). However, no study of BD has previously adopted DL techniques using EEG signals. Method: EEG signals of 169 BD patients and 45 controls were cleaned from the artifacts and processed using two different DL methods: a one-dimensional convolutional neural network (1D-CNN) combined with the long-short term memory (LSTM) and a two-dimensional convolutional neural network (2D-CNN). Additionally, Class Activation Maps (CAMs) acquired from the bipolar and control groups were used to obtain distinctive regions to specify a particular class in an image. Results: Group identifications were confirmed with 95.91% overall accuracy through the 2D-CNN method, demonstrating very high sensitivity and lower specificity. Also, the overall accuracy obtained from the 1D-CNN + LSTM method was 93%. We also found that F4, C3, F7, and F8 electrode activities produce predominant features to detect the bipolar group. Conclusion: To our knowledge, this study used EEG-based DL analysis for the first time in BD. Our results suggest that the raw EEG-based DL algorithm can successfully differentiate individuals with BD from controls. Class Activation Map (CAM) analysis suggests that prefrontal changes are predominant in EEG data of patients with BD.
Evaluation of Prenatal Care Quality of Pregnant Women: a Cross-Sectional Sample From the South-East Turkiye
(Womens Health & Action Research Centre, 2024) Icke, Sibel; Cifci, Sema; Kocaturk, Asiye
The aim of this study was to evaluate the quality of prenatal care among pregnant women in Mardin Artuklu. Study data were collected in August and September 2022. A total of 335 pregnant women participated in this descriptive research. The sociodemographic information form and Prenatal Care Quality Scale were used as data collection tools. The mean total score of the Prenatal Care Quality Questionnaire was 168.66 +/- 30.69. Results showed that prenatal visits more than 4 times, giving care from health centers, mothers educational level more than 12 years old, having health insurance are predisposing factors of quality of prenatal care (p<0.05). Although quality prenatal care is the right of every woman, there are still women who do not receive this care sufficiently and who are not aware of the care they receive. The role of midwives is important in raising awareness in women about the quality of prenatal care.
A Novel Determinant of Prognosis in Acute Pulmonary Edema: Intermountain Risk Score
(Kare Publ, 2024) Kilic, Raif; Aktan, Adem; Guzel, Tuncay; Kaya, Ahmet Ferhat; Guzel, Hamdullah; Arslan, Bayram; Cankaya, Yusuf
Objective: The Intermountain Risk Score (IMRS), calculated using age, gender, complete blood count (CBC), and simple laboratory analyses, is an easy-to-use and cost-effective tool developed to predict mortality. In our study, we aimed to determine whether the IMRS could predict mortality in patients admitted to the hospital with a diagnosis of acute pulmonary edema. Methods: A total of 371 patients who were admitted with a diagnosis of pulmonary edema, were included in our study. The IMRS of the patients was determined using a calculation tool, and the patients were divided into three groups based on the determined value: low, moderate, and high IMRS. Results: The patients included in our study comprised 208 women and 163 men, with an average age of 68.7 years. There was a statistically significant difference between the patient groups concerning both 1-month and 1-year mortality rates. Additionally, there was a significant difference in IMRS between patients who developed in-hospital, 1-month, and 1-year mortality and those who survived. In the Receiver Operating Characteristic (ROC) analysis, a cutoff value of 15.5 for the IMRS predicted both 1-year and 1-month mortality. In the Kaplan-Meier analysis, the highest mortality risk was observed in the high IMRS group and the lowest mortality risk in the low IMRS group. Conclusion: Our research results show that the IMRS strongly predicts both short-term and long-term mortality in patients hospitalized with a diagnosis of acute pulmonary edema.
Is Testicular Fixation To the Scrotum Necessary in Patients With Undescended Testis? a Comparative Study
(Verduci Editore s.r.l, 2023) Azizoğlu, M.; Sagir, S.
OBJECTIVE: This study aimed to compare the outcome of undescended testicle patients with and without transparenchymal sutures. PATIENTS AND METHODS: Patients were divided into two distinct groups for evaluation: Group 1 (Testicular Fixation +): this group comprised 41 patients who underwent a procedure that involved testicular fixation. Group 2 (Testicular Fixation -): this group included 47 patients who had not undergone any testicular fixation. RESULTS: The age difference between these groups was not statistically meaningful (p>0.05). As for the presence of hypospadias, 2 patients (4.8%) in Group 1 and 3 patients (6.4%) in Group 2 were affected, showing no significant difference (p>0.05). Post-surgical local infection was evident in 9.8% of Group 1 and 8.5% of Group 2 patients, showcasing no significant difference (p>0.05). When assessing recurrence, both groups bore almost identical rates, 7.3% for Group 1 and 6.4% for Group 2 (p>0.05). Atrophy was observed in 2.4% of Group 1 and 2.1% of Group 2, with no marked distinction (p>0.05). CONCLUSIONS: Both groups exhibited similar outcomes, suggesting that no fixation method was also a good option. © 2023 Verduci Editore s.r.l. All rights reserved.
The Clinical and Laboratory Features of Patients With Triple a Syndrome: a Single-Center Experience in Turkey
(Springer, 2023) Yıldırım, R.; Unal, E.; Tekmenuray-Unal, A.; Taş, F.F.; Özalkak, Ş.; Çayır, A.; Özbek, M.N.
Aim: Triple-A Syndrome (TAS) is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia, and alacrimia. This disorder is caused by mutations in the AAAS gene. The aim of this study is to discuss the clinical, laboratory and molecular genetic analysis results of 12 patients with TAS. Method: We evaluated 12 patients from 8 families. Clinical and laboratory data were retrospectively collected from the medical records of the patients in the database for the period 2015–2020. All exons and exon-intron junctions of the AAAS gene were evaluated by next-generation sequencing method. Detected variants were classified according to American Collage of Medical Genetics criteria. Results: Alacrimia was found in all patients (100%); achalasia was found in 10 patients (83.3%) and adrenal insufficiency was found in 10 patients (83.3%). In addition, hyperreflexia(6/12), learning disability(5/12), hypernasal speech(5/12), muscle weakness(8/12), delayed walking(7/12), delayed speech(6/12), excessive sweating(7/12), optic atrophy(1/12), epilepsy(1/12), palmoplantar hyperkeratosis(5/12), multiple dental caries(9/12), atrophy of the thenar/hypothenar muscles(4/12) and short stature(4/12) were detected. The DHEA-S levels were measured in 10 patients and were found to be low in 8 of them. In all patients, the sodium and potassium levels were found to be normal. AAAS gene sequencing revealed four previously reported c.1066_1067del (p.Leu356fs*8), c.1432 C > T (p.Arg478*), c.688 C > T (p.Arg230*), and c.1368_1372del (p.Gln456fs*38) variants and two novel homozygous c.1250-1 G > A and c.398_399 + 2del variants in the AAAS gene. Conclusion: We detected two novel variants in the AAAS gene. While the classic triad is present in 66.7% of the cases, neurological dysfunction, skin and dental pathologies also occur quite frequently. The earliest and most common finding of TAS is alacrimia. Therefore, adrenal insufficiency should be investigated in all patients with alacrimia and if necessary, genetic analysis should be performed for TAS. In addition, TAS should be followed up with a multidisciplinary approach since it involves many systems. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
The Relationship Between Exam Anxiety, Depression, and Back Pain in Physicians Preparing for the Specialty Exam
(Verduci Editore s.r.l, 2022) Yükselmiş, Ö.; Dönmezdil, S.
OBJECTIVE: This study aims at examining the possibility of anxiety and depression in physicians preparing for the specialty exam and the back pain caused by continuous working with these depressive symptoms. PATIENTS AND METHODS: The research was started by getting approval from the local Ethics Committee of Gazi Yasargil Training and Research Hospital. Socio-demographic data form, EQ-5D general quality of life scale, Oswestry low back pain disability scale, and Hospital anxiety and depression scale (HADS) were applied to volunteers. RESULTS: Among the physicians participating in our study, both anxiety and depression scores from the HADS scale scores applied to the exam preparation group were statistically significantly higher than those of students who did not prepare for the exam. CONCLUSIONS: In our study, the highness of the scale scores in the exam preparation group was statistically high. It should not be ignored that there may be complaints of anxiety, depression, and low back pain during the preparation period for the specialty examination in physicians. During the exams' periods, psychosocial support mechanisms should be activated, and active exercise activities should be recommended. For more detailed data, large-scale participatory studies are needed. © 2022 Verduci Editore s.r.l. All rights reserved.
Hyaluronic Acid as a New Biomarker To Differentiate Acute Kidney Injury From Chronic Kidney Disease
(Iranian Society of Nephrology, 2017) Akin, D.; Ozmen, S.; Yilmaz, M.E.
Introduction. It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. Materials and Methods. A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured. The diagnostic role of the test was investigated using the receiver operator curve curves. Results. The mean age of the patients was 54.6 ± 17.9 years. The diagnosis was chronic kidney disease (CKD) in 41.1%, acute kidney injury (AKI) in 48.9%, AKI on CKD in 6.7% (3 died without a diagnosis). The mean serum HA was significantly higher in the CKD group (146.1 ± 119.3 ng/mL) than the AKI group (68.9 ± 69.1 ng/ mL; P <.001). Serum HA significantly correlated with proteinuria (r = 0.717, P <.001) and serum albumin level (r = - 0.599, P <.001) in the CKD group only. Serum HA cutoff level of 61 ng/dL had a sensitivity of 82% and specificity of 67% for differential diagnosis of AKI and CKD. Conclusions. Serum HA level may be used as tool to differentiate AKI from CKD. Further larger studies are warranted to clarify the definite the role of this marker. © 2017, Iranian Society of Nephrology. All rights reserved.

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