PubMed İndeksli Yayınlar Koleksiyonu
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Article The Relationship Between Exam Anxiety, Depression, and Back Pain in Physicians Preparing for the Specialty Exam(verduci Publisher, 2022) Yukselmis, O.; Dönmezdil, Süleyman; Donmezdil, S.; 02.10. Department of Psychology / Psikoloji Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiOBJECTIVE: This study aims at examining the possibility of anxiety and depression in physicians preparing for the specialty exam and the back pain caused by continuous working with these depressive symptoms. PATIENTS AND METHODS: The research was started by getting approval from the local Ethics Committee of Gazi Yasargil Training and Research Hospital. Socio-demographic data form, EQ-5D general quality of life scale, Oswestry low back pain disability scale, and Hospital anxiety and depression scale (HADS) were applied to volunteers. RESULTS: Among the physicians participating in our study, both anxiety and depression scores from the HADS scale scores applied to the exam preparation group were statistically significantly higher than those of students who did not pre-pare for the exam. CONCLUSIONS: In our study, the highness of the scale scores in the exam preparation group was statistically high. It should not be ignored that there may be complaints of anxiety, depression, and low back pain during the preparation period for the specialty examination in physicians. During the exams' periods, psychosocial support mechanisms should be activated, and active exercise activities should be recommended. For more detailed data, large-scale participatory studies are needed.Article Citation - WoS: 19Citation - Scopus: 21Hyaluronic Acid as a New Biomarker To Differentiate Acute Kidney Injury From Chronic Kidney Disease(Iranian Soc Nephrolgy, 2017) Akin, Davut; Özmen, Şehmus; Ozmen, Sehmus; Yilmaz, Mehmet Emin; 09.01. Department of Nursing / Hemşirelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiIntroduction. It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. Materials and Methods. A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured. The diagnostic role of the test was investigated using the receiver operator curve curves. Results. The mean age of the patients was 54.6 +/- 17.9 years. The diagnosis was chronic kidney disease (CKD) in 41.1%, acute kidney injury (AKI) in 48.9%, AKI on CKD in 6.7% (3 died without a diagnosis). The mean serum HA was significantly higher in the CKD group (146.1 +/- 119.3 ng/mL) than the AKI group (68.9 +/- 69.1 ng/mL; P < .001). Serum HA significantly correlated with proteinuria (r = 0.717, P < .001) and serum albumin level (r = -0.599, P < .001) in the CKD group only. Serum HA cutoff level of 61 ng/dL had a sensitivity of 82% and specificity of 67% for differential diagnosis of AKI and CKD. Conclusions. Serum HA level may be used as tool to differentiate AKI from CKD. Further larger studies are warranted to clarify the definite the role of this marker.Article Is Testicular Fixation To the Scrotum Necessary in Patients With Undescended Testis ? A Comparative Study(verduci Publisher, 2023) Azizoglu, M.; Sagir, S.OBJECTIVE: This study aimed to compare the outcome of undescended testicle patients with and without transparenchymal sutures.PATIENTS AND METHODS: Patients were divided into two distinct groups for evaluation: Group 1 (Testicular Fixation +): this group comprised 41 patients who underwent a procedure that involved testicular fixation. Group 2 (Testicular Fixation-): this group included 47 patients who had not undergone any testicular fixation.RESULTS: The age difference between these groups was not statistically meaningful (p>0.05). As for the presence of hypospadias, 2 patients (4.8%) in Group 1 and 3 patients (6.4%) in Group 2 were affected, showing no significant difference (p>0.05). Post-surgical local infection was evident in 9.8% of Group 1 and 8.5% of Group 2 patients, showcasing no significant diference (p>0.05). When assessing recurrence, both groups bore almost identical rates, 7.3% for Group 1 and 6.4% for Group 2 (p>0.05). Atrophy was observed in 2.4% of Group 1 and 2.1% of Group 2, with no marked distinction (p>0.05).CONCLUSIONS: Both groups exhibited similar outcomes, suggesting that no fixation method was also a good option.Article Citation - WoS: 17Citation - Scopus: 14In-Vitro Antioxidant, Cytotoxic, Cholinesterase Inhibitory Activities and Anti-Genotoxic Effects of Hypericum Retusum Aucher Flowers, Fruits and Seeds Methanol Extracts in Human Mononuclear Leukocytes(Iranian Journal of Pharmaceutical Research, 2017) Keskin, C.; Keskin, Cumali; Aktepe, N.; Aktepe, Necmettin; Yükselten, Y.; Asuman,; Boğa, M.; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 09.01. Department of Nursing / Hemşirelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiThe present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of Hypericum retusum AUCHER. The amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by HPLC. Total phenolic content of H. retusum seed extract was found more than fruit and flower extracts. The DPPH free radical scavenging activity of flower and seed methanol extracts showed close activity versus BHT as control. Among three extracts of H. retusum only flower methanol extract was exhibited considerable cytotoxic activities against to HeLa and NRK-52E cell lines. Moreover, seed methanol extract showed both acetyl and butyrl-cholinesterase inhibitory activity. The highest anti-genotoxic effects were seen 25 and 50 μg/mL concentrations. In this study, the extracts showed a strong antioxidant and anti-genotoxic effect. The seed extract was more efficient- than extracts of fruit and flowers. Our results suggest that the antioxidant and anti-genotoxic effects of extracts depend on their phenolic contents. Further studies should evaluate the in-vitro and in-vivo the benefits of H. retusum seed methanol extracts. © 2017 by School of Pharmacy.Article Comparison of the Transobturator Tape and Minisling Methods in the Treatment of Stress Urinary Incontinence(Iniestares, S.A., 2025) Sagir, Süleyman; Basgut, Ozlem; Tuncekin, Adem; Ergün, Müslüm; Turgut, OmerBackground: This study aims to evaluate and compare the transobturator tape and minisling surgical techniques in the treatment of stress urinary incontinence, focusing on their effectiveness and postoperative outcomes. Methods: This retrospective analysis included 113 patients who underwent midurethral sling surgery for stress urinary incontinence at Islahiye State Hospital between January 2016 and October 2022. The patients were divided into two groups: Those treated with transobturator tape (Group 1, n = 70) and those treated with minisling (Group 2, n = 43). Data were collected from medical records and follow-up interviews. The variables assessed included demographics (age and body mass index), preop-erative and postoperative Urinary Incontinence Quality of Life Scale scores, and postoperative pain details. Operative details, such as procedure duration and hospital stay length, were recorded. Patients were also asked about postoperative symptoms, including groin pain and dyspareunia. Additionally, the duration of symptom-free months following surgery was documented. Binary logistic regression analysis was conducted to evaluate the effect of surgical methods on long-term well-being. Results: The transobturator tape and minisling techniques demonstrated similar improvements in postoperative Urinary Incontinence Quality of Life Scale scores (p = 0.213). However, the minisling procedure had significantly shorter operative time (29.2 min vs. 52.2 min, p < 0.001) and hospital stay (1.33 days vs. 1.96 days, p = 0.003) than transobturator tape. Postoperative complications were notably higher in the transobturator tape group, with significantly more patients reporting groin pain (28.6% vs. 4.7%, p = 0.002) and dyspareunia (20.0% vs. 0.0%, p = 0.002). Logistic regression analysis identified surgical method as the primary predictor of long-term well-being beyond one year (p = 0.040). Conclusions: While the transobturator tape and minisling surgeries are effective for treating stress urinary incontinence, the minisling method offers advantages, such as shorter operative time, reduced hospital stay, and fewer postoperative complica-tions, over the transobturator tape method. These findings suggest that the minisling approach may provide a more favorable patient experience, particularly due to reduced postoperative pain and quick recovery, than the transobturator tape method. © 2025 Elsevier B.V., All rights reserved.Article Impact of Almond Milk Fortified with Vitamin D3-Loaded Soy Protein Nanoparticles on Serum 25(OH)D3 Concentrations in Adults with CKD: A Pilot Double-Blind Randomized Controlled Trial(Springer Science and Business Media Deutschland GmbH, 2025) Kuo, Liying; Casta֘neda, Blanca Nuria; Luo, Yangyi E.; Aslan Ceylan, Jiyan; Andrade, Juan E.; M Andrade, Jeanette MaryBackground: Chronic kidney disease (CKD) impairs the activation of vitamin D, leading to deficiencies that exacerbate disease progression and metabolic complications. This pilot study investigated the effects of consuming almond milk fortified with vitamin D3 nanoparticles on 25(OH)D3 among adults with advanced stages of CKD. Methods: A 21-day, double-blind randomized controlled pilot study was conducted. Participants (n = 18) were randomly assigned to consume 4 oz (118 ml) of almond milk daily with 4000 IU of vitamin D3 dispersed in soy protein nanoparticles (intervention group), or almond milk without vitamin D (control group). The primary outcome was the change in serum 25(OH)D3 levels, while secondary outcomes included changes in serum calcium and parathyroid hormone (PTH). Results: From baseline to end of intervention, there was a significant decrease in serum 25(OH)D3 in the control group (49.2 ± 23.3 nmol/L to 44.5 ± 25.6 nmol/L; p < 0.05). In the intervention group, there was a significant increase in 25(OH)D3 (33.0 ± 15.8 nmol/L to 36.4 ± 15.8 nmol/L; p < 0.05). A significant time × treatment interaction (p < 0.01) was observed, with the intervention group showing a marked increase in serum 25(OH)D3. No differences between groups were observed in serum calcium and PTH. Conclusion: The consumption of almond milk fortified with vitamin D3 dispersed in soy protein nanoparticles increased 25(OH)D3 in adults with advanced stages of CKD over 21-days. Future research should explore the metabolism and long-term efficacy of nanoparticle-based delivery of vitamin D3 in larger, more diverse populations. © 2025 Elsevier B.V., All rights reserved.Article Does Helicobacter Pylori Have a Role in the Pathogenesis of Otitis Media with Effusion, or Is It a Fallacy(Springer Science and Business Media Deutschland GmbH, 2025) Gunduz, A. Yasemin; Kalcioǧlu, Mahmut Tayyar; Celik, Serdal; Arı, Oğuz; Durmaz, R.Purpose: Helicobacter pylori, causing chronic systemic infection, may colonize in middle ear milieu and conduce to effusion collection. Many investigations on relationship between pathogenesis of otitis media with effusion (OME) and Helicobacter pylori yielded conflicting results. We investigated Helicobacter pylori presence in effusion and adenoid samples of children having OME and in middle ear and adenoid samples of children with healthy middle ears to elucidate its role on OME pathogenesis. Methods: This prospective case-control study included 300 patients aged 1–12 years. One-hundred effusion samples collected from 100 children undergoing ventilation tube insertion and adenoidectomy due to chronic OME and adenoid hypertrophy formed study group, and 100 adenoid samples collected from adenoids of these children formed Group-1. One-hundred healthy-looking middle ear irrigation solutions collected from 100 children undergoing cochlear implantation formed Group-2. One-hundred adenoid samples collected from 100 children having no effusion and only undergoing adenoidectomy formed Group-3. After DNA isolation of samples, Helicobacter pylori 16 S rRNA and 23 S rRNA gene for clarithromycin-resistance were investigated by real time-polymerase chain reaction (Rt-PCR). Results: The median age of 300 children was 5, and 179 were boys and 121 were girls. Helicobacter pylori was detected by Rt-PCR in none (%0) of the 400 samples (200 middle ear, 200 adenoid). Conclusion: In this largest sample-size study utilizing updated molecular methods to date, negative results indicate that Helicobacter pylori does not play role as an active pathogen in polymicrobiality of OME, and adenoids do not serve as a reservoir for Helicobacter pylori in this process. © 2025 Elsevier B.V., All rights reserved.Article Genotype, Phenotype Characteristics and Long-Term Follow-Up of Patients with Vitamin D-Dependent Rickets Type IA: A Nationwide Multi-Centre Retrospective Cross-Sectional Study(S. Karger AG, 2025) Çayir, Atilla; Demirbilek, Hüseyin; Türkyılmaz, Ayberk; Turan, Serap Demircioğlu; Bereket, Abdullah; Darendeli̇Ler, Feyza F.; Ökdemir, DenizIntroduction: Vitamin D-dependent rickets type IA (VDDR1A) is an autosomal recessive disorder characterized by defects in the biosynthesis of its active form 1,25-dihydroxyvitamin D due to mutations in the CYP27B1 gene, which encodes for 1α- hydroxylase. The present study aimed to evaluate the clinical characteristics, molecular genetic aetiology, and long-term outcomes of a large nationwide cohort of children with VDDR1A from Turkey. Methods: In this multi-centre retrospective cross-sectional study, we collected clinical characteristics, laboratory features, molecular genetic analysis results, and long-term follow-up of a nationwide cohort of patients with VDDR1A using a web-based research network, CEDD-NET, for paediatric endocrinology research. Results: In total, 118 patients (57 F, 61 M) with VDDR1A were recruited. The median age of the diagnosis was 1.7 years (0.2-18.3 years). The most common presenting complaints were skeletal deformity (n = 61), short stature (n = 45), and delay in walking (n = 42). The most common mutation was a splice-donor-site mutation (c.195+2T>G) (n = 42), followed by a 7-bp duplication 1319-1325dupCCCACCC (Phe443Profs∗24) (n = 25), and two missense mutations p.K192E (c.574A>G) (n = 17) and c.1474C>T (p.R492W) (n = 12). The novel c.195+2T>C and c.1215_1215+2delTGTinsCGA splice-site and c.1144C>A missense variants were firstly described in our cohort. Conclusion: The most common four mutations accounted for the underlying aetiology of VDDR1A in approximately 81% of the cohort, indicating Turkey may serve as a mutational hotspot or exhibit a founder effect for these variants. Our large cohort s results suggested no clear and clinically meaningful phenotype-genotype relationship in VDDR1A. © 2025 Elsevier B.V., All rights reserved.Article Effective Removal of Dyes from Aqueous Systems by Waste-Derived Carbon Adsorbent: Physicochemical Characterization and Adsorption Studies(Nature Research, 2025) Kuyucu, Ali Ender; Selçuk, Ahmet; Önal, Yunus; Alacabey, İhsan; Erol, KadirDue to their cost-effectiveness and high surface area, activated carbons are commonly used for the adsorption of dyes from aqueous solutions. In this study, activated carbon was synthesized from walnut shell waste via KOH activation (1:3 ratio), yielding a surface area of 2347.4 m²/g. Reactive Blue 19 and Reactive Red 195 adsorption behavior were studied under varying experimental conditions. These included natural pH values (6.8–7.2), dye concentrations between 50 and 1250 mg L⁻¹, and adsorbent dosages ranging from 0.1 to 1.0 g. Adsorption equilibrium was achieved within 150 min. The maximum adsorption capacities were found to be 1227.17 mg g⁻¹ for RB 19 and 235.74 mg g⁻¹ for RR 195. Isotherm modeling was conducted using Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich models, with Freundlich providing the best fit for both dyes, indicating multilayer adsorption on heterogeneous surfaces. Thermodynamic analysis revealed that the adsorption processes were spontaneous and endothermic, with negative Gibbs free energy (ΔG°), positive enthalpy (ΔH°), and positive entropy (ΔS°) values. These results highlight the high adsorption performance and practical potential of walnut shell-derived activated carbon for dye removal from wastewater. © 2025 Elsevier B.V., All rights reserved.Article Healthcare-Associated Infections in Patients with COVID-19: Is It Different from the Pre-Pandemic Period(Journal of Infection in Developing Countries, 2024) Solmaz, İhsan; Kavak, Şeyhmus; Arac, Songul; Akelma, Hakan; Başgöz, Bahadir Bilgin; Koyun, Sedrettin; Kaya, ŞafakIntroduction: Healthcare-associated infections (HAIs) are common in intensive care unit (ICU) patients and may cause devastating consequences. However, the prevalence of HAI and its effects on in-hospital mortality among critically ill COVID-19 patients is ambiguous. We determined the prevalence of HAI and the rate of mortality in critically ill COVID-19 patients and compared it with pre-pandemic ICU patients. Methodology: This retrospective study was conducted with adult ICU patients admitted to Gazi Yasargil Training and Research Hospital (Diyarbakir,Turkey) in April-November 2019 (defined as the pre-pandemic period) and in April-November 2020 (defined as the pandemic period). All patients in the pandemic period had COVID-19, while none in the pre-pandemic period did. Patients diagnosed with HAIs during the in-hospital follow-up period were recorded. Results: Of 4596 enrollees, 3386 (73.7%) were pandemic-period patients and 1210 (26.3%) were pre-pandemic-period patients. HAI prevalence was significantly higher at 5.9% (n = 71) in the pandemic-period patients and 2.7% (n = 91) in the pre-pandemic-period patients (p < 0.001). Comorbidities including hypertension (63.4% vs 14.2%, p < 0.001), diabetes mellitus (39.4% vs 8.8%, p < 0.001), and coronary artery disease (30.9% vs 10.9%, p = 0.002) were significantly more frequent in pandemic-period HAI-positive patients. The most common HAI was catheter-related bloodstream infection in both groups, with similar frequency (p = 0.652). In-hospital mortality rate was 85.9% versus 65.9% in pandemic- versus pre-pandemic-period HAI-positive patients (p < 0,05). Conclusions: The prevalence of HAI and the in-hospital mortality rate was significantly higher among pandemic-period patients. © 2024 Elsevier B.V., All rights reserved.Article Effect of Tissue Fragments Remain in the Karman Cannula on the Histopathological Diagnosis of Abnormal Uterine Bleeding(College of Physicians and Surgeons Pakistan, 2024) Tammo, Omer; Celik, Elif; Celik, Enes; Bayramoglu, Denizhan; Yıldız, SüleymanThe aim of this study was to perform histopathological analysis of residual material in the cannula by endometrial sampling using a Carmen injector, and to compare the results. The study was conducted in the Department of Gynaecology, Mardin Training and Research Hospital, Artuklu/Mardin, Turkiye, from December 2021 to June 2022. The study group consisted of 104 patients who presented to the outpatient clinic with complaints of abnormal uterine bleeding. Endometrial curettage material was collected from all patients using a Carmen injector. The collected material was discharged into the pathology container (Group 1). Subsequently, the residual material remaining in the injector was placed in a separate pathology container (Group 2). Specimens were sent to the pathology laboratory with buffered formol. The pathological evaluation was performed by the same pathologist without revealing the patients’ names. Comparative histopathological results of the patients in Group 1 and Group 2 were found to be fully compatible in 64.4% of the patients. In 35.6% of the patients, the histopathological results were different from each other between Group 1 and Group 2. Pathological results were different from each other in 21.2% of patients with incompatible pathology results. In Group 1, 16.7% of the patients were over-diagnosed, while 7.7% of the patients were over-diagnosed in Group 2. It would be beneficial to carefully remove the material remaining in the cannula and send it for pathological examination as it may affect the histopathological results. © 2024 Elsevier B.V., All rights reserved.Article Does the Presence of Chronic Lymphocytic Thyroiditis Affect Diagnostic Value of Fine Needle Aspiration Biopsy in Bethesda Category III Nodules?(Dr. Mladen Stojanovic University Hospital, 2023) Pedük, Şevki; Koçer, BelmaThis study aimed to determine the relationship between the presence of Hashimo-to’s thyroiditis (HT) and malignancy rates with prognostic factors in thyroid nodules diagnosed as Bethesda category III, and to examine the effect of HT on diagnostic value of fine-needle aspiration biopsy (FNAB). Demographic information, preoperative examination, and final pathological evaluation of patients with Bethesda category III (AUS-FLUS) nodules who had been operated on in our department over the last 6 years were analyzed. Statistical analyses were performed using the Student’s t-test, Mann-Whitney U test and χ2-test and logistic regression analysis using SPSS version 22 software. The malignancy rate on final pathology of 159 patients was 24.5%. Malignancy rates were found to be higher in patients with HT coexistence (30.7% vs. 21.5%, p=0.20). Poor prognostic factors such as multifocality, number of metastatic lymph nodes (p=0.04), and extrathy-roidal extension were more common in patients with cancer in the pathology specimen who were in the non-HT group. It cannot be said that HT decreases diagnostic value of FNAB in lesions diagnosed with AUS-FLUS. The lower incidence of poor prognostic factors in the HT group may be attributed to cytotoxic cell dominance in tumor immunity. © 2024 Elsevier B.V., All rights reserved.Article Pharmacological and Dietary-Supplement Treatments for Autism Spectrum Disorder: A Systematic Review and Network Meta-Analysis(BioMed Central Ltd, 2022) Siafis, Spyridon; Çiray, Oğulcan; Wu, Hui; Schneider-Thoma, Johannes; Bighelli, I.; Krause, Marc; Huhn, MaximilianBackground: There is still no approved medication for the core symptoms of autism spectrum disorder (ASD). This network meta-analysis investigated pharmacological and dietary-supplement treatments for ASD. Methods: We searched for randomized-controlled-trials (RCTs) with a minimum duration of seven days in ClinicalTrials.gov, EMBASE, MEDLINE, PsycINFO, WHO-ICTRP (from inception up to July 8, 2018), CENTRAL and PubMed (up to November 3, 2021). The co-primary outcomes were core symptoms (social-communication difficulties-SCD, repetitive behaviors-RB, overall core symptoms-OCS) measured by validated scales and standardized-mean-differences (SMDs). Associated symptoms, e.g., irritability/aggression and attention-deficit/hyperactivity disorder (ADHD) symptoms, dropouts and important side-effects, were investigated as secondary outcomes. Studies in children/adolescents and adults were analyzed separately in random-effects pairwise and network meta-analyses. Results: We analyzed data for 41 drugs and 17 dietary-supplements, from 125 RCTs (n = 7450 participants) in children/adolescents and 18 RCTs (n = 1104) in adults. The following medications could improve at least one core symptom domain in comparison with placebo: aripiprazole (k = 6 studies in analysis, SCD: SMD = 0.27 95% CI [0.09, 0.44], RB: 0.48 [0.26, 0.70]), atomoxetine (k = 3, RB:0.49 [0.18, 0.80]), bumetanide (k = 4, RB: 0.35 [0.09, 0.62], OCS: 0.61 [0.31, 0.91]), and risperidone (k = 4, SCM: 0.31 [0.06, 0.55], RB: 0.60 [0.29, 0.90]; k = 3, OCS: 1.18 [0.75, 1.61]) in children/adolescents; fluoxetine (k = 1, RB: 1.20 [0.45, 1.96]), fluvoxamine (k = 1, RB: 1.04 [0.27, 1.81]), oxytocin (k = 6, RB:0.41 [0.16, 0.66]) and risperidone (k = 1, RB: 0.97 [0.21,1.74]) in adults. There were some indications of improvement by carnosine, haloperidol, folinic acid, guanfacine, omega-3-fatty-acids, probiotics, sulforaphane, tideglusib and valproate, yet imprecise and not robust. Confidence in these estimates was very low or low, except moderate for oxytocin. Medications differed substantially in improving associated symptoms, and in their side-effect profiles. Limitations: Most of the studies were inadequately powered (sample sizes of 20–80 participants), with short duration (8–13 weeks), and about a third focused on associated symptoms. Networks were mainly star-shaped, and there were indications of reporting bias. There was no optimal rating scale measuring change in core symptoms. Conclusions: Some medications could improve core symptoms, although this could be likely secondary to the improvement of associated symptoms. Evidence on their efficacy and safety is preliminary; therefore, routine prescription of medications for the core symptoms cannot be recommended. Trial registration PROSPERO-ID CRD42019125317. © 2022 Elsevier B.V., All rights reserved.Article Selective Serotonin Reuptake Inhibitors and Manic Switch: A Pharmacovigilance and Pharmacodynamical Study(Elsevier B.V., 2021) Çiray, Oğulcan; Halaç, Eren; Turan, Serkan; Tunctürk, Mustafa; Ozbek, Mutlu Muhammed; Ermi̇ş, ÇağatayBackground: There is still no approved mechanism of manic switch in bipolar disorder, yet many selective serotonin reuptake inhibitors were accused for this important adverse event. Therefore, we aimed to investigate to estimate SSRI's risk for reporting mania and elevated mood using FEARS database and investigate receptor mechanisms involved. Methods: Mania and relevant side effects approved by FDA were screened in this dataset from the first quarter of 2004 to the third quarter of 2020. Disproportionality analysis were performed to estimate reporting odds ratio (ROR) and linear regressions were conducted to investigate relationship between ROR and Ki values. Receptor occupancy ratios were calculated from in vitro receptor binding profiles. The pharmacodynamical profile was extracted from the International Union of Basic and Clinical Pharmacology and the British Pharmacology Society dataset. Child and adolescent population was also investigated separately. Results: The analysis showed that the odds of a spontaneous report of mania in the FAERS database involving an SSRI were higher than the odds that such a report involved other types of drugs (ROR: 5.324 [CI: 3.773; 7.514]). The largest effect size in this estimation was found in fluvoxamine (ROR: 13.957 [CI: 10.391; 18.747]). Significant effects were found in regression analysis for Ki values of H1 and M1 receptors on ROR. Receptor occupation was not found to have an effect on ROR. Conclusion: Lower degress of Ki values on M1 and H1 may be plausible pharmacological mechanism. Further pharmacological data and clinical assessments may be important to validate this safety signal. © 2022 Elsevier B.V., All rights reserved.Article A Rare Cause of Dysphagia: Giant Lipoma in Parapharyngeal Space(Lippincott Williams and Wilkins, 2020) Aslan, Mehmet; Ozer Ozturk, Ebru; Dogukan, Fatih MertBackground: Parapharyngeal area is one of the most complex areas of head and neck anatomy. Tumors of the parapharyngeal region are very rare among head and neck tumors. Lipomas also constitute a tiny proportion of parapharyngeal tumors so parapharyngeal area lipomas are very rare in the literature. Due to anatomical location, these tumors treatment is challenging. Clinical Report: A 20-year-old male patient admitted to our department with complaints of swallowing difficulty and a mass on the right side of the neck. Magnetic resonance imaging was performed, and it was reported as a 6 4.5 cm lipoma. He underwent excision of parapharyngeal area lipoma by a transoral approach. Conclusion: Parapharyngeal lipomas are very rare, and difficult to diagnose before they turn out symptomatic. The primary treatment approach in tumors of the parapharyngeal area is surgery and the surgical approach should be chosen according to the anatomical location of the lesion. © 2021 Elsevier B.V., All rights reserved.Article Cryogel-Immobilized Catalase as a Biocatalyst with Enhanced Stability Against Microplastics(MDPI, 2025) Erol, Kadir; Alkan, Mehmet Huseyin; Alacabey, IhsanCatalase is a pivotal antioxidant enzyme that decomposes hydrogen peroxide and reduces oxidative stress. However, its low thermal and operational stability limits applications in challenging environments, particularly those contaminated with emerging pollutants such as polystyrene-based microplastics (PS-MPs). In this study, cryogels composed of Poly(2-hydroxyethyl methacrylate-co-allyl glycidyl ether) [Poly(HEMA-co-AGE)] were synthesized and evaluated as immobilization matrices to enhance catalase stability. Cryogels containing varying AGE concentrations were characterized using FT-IR, SEM, TEM, TGA, and BET analyses. The formulation with 250 mu L AGE exhibited optimal physicochemical properties, including improved water retention, increased surface area, and high immobilization capacity (356.3 mg center dot g(-1)). Immobilized catalase maintained superior activity under PS-MP-induced stress across a range of concentrations (0-1.0 mg center dot mL(-1)), temperatures (4-60 degrees C), and exposure times (up to 5 h). Kinetic modeling revealed a significant improvement in substrate affinity, with Km decreasing from 54.9 to 17.1 mM, while Vmax decreased moderately. Long-term stability tests showed that immobilized catalase retained similar to 80% activity after 70 days at 4 degrees C and 55% after 15 reuse cycles. Desorption studies confirmed the reusability of the cryogel system. These findings suggest that Poly(HEMA-co-AGE) cryogels provide a robust and reusable platform for catalase stabilization, offering potential for applications such as wastewater treatment and biosensing in microplastic-contaminated systems.Article Vulnerable Newborns: Disparities in Pediatric Emergency Department Admissions Between Refugee and Non-Refugee Newborns(Lippincott Williams & Wilkins, 2025) Solmaz, Murat; Demir, Devran; Gungor, Emre; Orhan, OzhanThe conflicts that began in the Middle East and Syria in 2011 resulted in many people seeking refuge in neighboring countries. Due to irregular migration, many newborns were born far from their homelands, in foreign countries. This study aims to compare the clinical characteristics and outcomes of non-refugee and refugee newborns to assess potential disparities in their healthcare experiences. The present study examined the applications of newborns who were admitted to the third level pediatric emergency clinic on the Syrian border of Turkey between January 1, 2024, and December 31, 2024. The most prevalent presenting complaint among both non-refugee and refugee newborns was jaundice, occurring in 23.9% and 21.4% of cases, respectively. Fast breathing was significantly more common in refugee newborns than in non-refugee newborns (11% vs 2.6%, P = .021). Poor feeding was significantly more prevalent among non-refugee newborns than among refugee newborns (9.8% vs 3.8%, P = .008). Additionally, 7.1% of non-refugee newborns had significant medical complications, compared to 25.2% of refugee newborns. This difference was statistically significant (P =.001). Despite the availability of universal, free healthcare at all levels for all newborns, refugee babies continue to utilize inferior healthcare facilities, resulting in elevated mortality rates. Consequently, addressing the health concerns of refugee newborns necessitates a comprehensive strategy. This strategy should encompass programs that bolster maternal and infant health, nutritional support, vaccination services, mental health services, and the provision of secure living environments.Article The Effects of Video-Based and Blended Learning on Medication Dosage Calculation Skills of Paramedic Students: A Randomized, Quasi-Experimental Study(Lippincott Williams & Wilkins, 2025) Baran, Leyla; Ozturk, HuriBackground:Medication dosage calculation (MDC) is a vital component of clinical competence for healthcare providers, particularly in emergency medical services, where miscalculations can lead to life-threatening outcomes. This study aimed to compare and evaluate the effects of video-based learning (VBL) and blended learning (BL) on the MDC skills of paramedic students, with the hypothesis that BL would result in higher posttest MDC performance compared to VBL.Methods:A randomized quasi-experimental design was used. A total of 151 paramedic students were randomly assigned to 2 groups. Both groups received a 2-week e-learning course that included video-based content and task-based exercises. Additionally, the BL group received an 8-hour classroom-based training session during the same 2-week period, which was scheduled as a single full-day session on the third day of the first week. Following the intervention, both groups completed a posttest assessing their MDC skills.Results:The BL group achieved significantly higher posttest scores (82.19 +/- 13.74) compared to the VBL group (72.24 +/- 21.87), with the difference being statistically significant (P = .001).Conclusion:While both methods were effective in enhancing MDC skills, BL was more effective. E-learning materials require further development to function as a fully independent instructional approach.Article Inspiratory Muscle Training in Natural Bodybuilders: Adaptations in Diaphragm Muscle Thickness and Maximal Strength(Frontiers Media Sa, 2025) Guler, Iskender; Yilmaz, Coskun; Soylu, Hakan Hueseyin; Birinci, Muersit Ceyhun; Arslan, Ayla; Ocak, Hakan; Ceylan, LeventBackground: The effect of inspiratory muscle training on diaphragm muscle thickness (DT) and one repetition maximal (1RM) in professional natural bodybuilders is still unclear. The aim of the study was to investigate the effect of inspiratory muscle training on diaphragm muscle thickness and 1RM in professional natural bodybuilders. Methods: The study comprised a total of 22 athletes who participated in bodybuilding competitions. Each athlete had undergone a minimum of 5 years of training, with a minimum weekly commitment of 5 hours. Participants were randomly divided into two groups: inspiratory muscle training (IMT) and control (CON). The CON continued their normal training regime, while the IMT group also performed inspiratory muscle training with a 10% weekly increase by setting the resistance setting of the PowerBreathe (R) Classic device to 40% of the participant's maximum inspiratory pressure (MIP). Prior to and during the 4-week training period, 1RM bench press measurements and diaphragm muscle thickness measurements were obtained. Results: In the comparison of 1RM power values before and after training, it was determined that the IMT group (%: 11.20) had 6.3% more post-activation performance enhancement compared to the CON group (%: 4.9) (p < 0.001). In the study, it was determined that a higher level of significant post-activation performance enhancement was obtained in the IMT group compared to the CON group in the diaphragm muscle thickness inspiratory phase (DT ins) and ekspiratory phase (DT eks) parameters at 20.36% and 19.46%, respectively. Conclusion: In conclusion, we determined that the addition of progressive loading inspiratory muscle training to preparation programmes in natural bodybuilders will improve diaphragm muscle thickness, 1RM physical performance. In particular, it shows that the diaphragm muscle should be considered not only as a muscle that supports respiration, but also as a muscle that contributes to power generation by optimising intra-abdominal pressure.Article Effects of Combined Supervised and Telerehabilitation Exercise Programs on Pain and Disability in Dentists with Chronic Neck Pain: A Randomized Controlled Trial(BMC, 2025) Alkan, Emrullah; Gelecek, Nihal; Oz, Ilke Kara; Akcali, AliyeBackground: This study was conducted to determine the effects of combined exercises applied with supervised and telerehabilitation methods on pain intensity, pain pressure threshold, muscular endurance, grip strength, neck and upper extremity disabilities in dentists with chronic neck pain (CNP). Methods: Fifty-five dentists with CNP were included in the study and randomly divided into three groups as supervised group (n = 19), telerehabilitation group (n = 19) and control group (n = 17). The participants had a mean age of 35.20 +/- 4.16 years, with ages ranging from 30 to 44 years and of the participants, 43 were female (78%) and 12 were male (22%). Combined exercises consisting of resistance, stretching and postural alignment exercises were applied with supervised and telerehabilitation methods three days a week for 12 weeks. The control group received a non-resistance exercise sheet matching the other protocols. Initially, all patients were assessed for pain intensity (VAS), pain pressure threshold, grip strength (hand, lateral and pinch grip), muscular endurance (deep neck flexors, scapular, static and dynamic core), neck and upper extremity disability. The assessments were repeated after 12 weeks of training. Results: The telerehabilitation group demonstrated positive changes in pain intensity, pain pressure threshold, and neck disability that were statistically significant (p < 0.05). Supervised group has improved all assessments except dynamic core endurance and grip strength (p < 0.05). There was also a decrease in pain intensity and neck disability index in the control group (p < 0.05). When the changes resulting from exercise training were compared between the groups, it was seen that the changes in the supervised group were superior (p < 0.05). Conclusions: The results showed that combined exercises applied under supervision were more effective than telerehabilitation or home exercises in dentists with CNP, and telerehabilitation was more effective than home program. Although the telerehabilitation method is not as effective as supervised exercise training, it can be an alternative method to reduce pain and disability for dentists who cannot participate in a regular exercise program due to their working conditions. Long-term follow-up studies are needed to determine how long the effect of exercise training applied with telerehabilitation continues in dentists with CNP.
