PubMed İndeksli Yayınlar Koleksiyonu
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Article Citation - WoS: 6Citation - Scopus: 7Antioxidant, Ache Inhibitory, and Anticancer Effects of Verbascum Thapsus Extract(CMB Assoc, 2023) Zhang, Na; Baran, Ayse; Valioglu, Ferzane; Teng, Lei; Atalar, Mehmet Nuri; Keskin, Cumali; Beilerli, AferinVerbascum thapsus (Mullein) is a medicinal plant used in folk medicine to treat various ailments. For this study, the biological functions of Verbascum thapsus (VT) methanol extract were determined in vitro. The plant's methanol extract was created through the maceration process. The phytochemical composition of plant extracts was investigated using liquid chromatography-electrospray ionization tandem mass spectrometry. The antioxidant capacity of the extract was determined using the 2,2-diphenyl-1-picrylhydrazil (DPPH radical) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS radical). Cell lines Caco-2 (human colorectal adenocarcinoma cells), LNCaP (Lymph Node Carcinoma of Prostate), and HEK293 (Human embryonic kidney 293 cells) were used to model colon, prostate, and non-cancerous cells. The cytotoxic activity of the plant extract on the proliferation of these cells was determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) assay protocol. VT extract showed moderate DPPH and ABTS radical scavenging activities at 30 mg/ml concentration. With this, VT extract was determined to inhibit acetylcholinesterase (AChE) enzyme and had strong cytotoxic activity on cancerous cell lines. In addition, our findings clearly showed that the plant extract had greater cytotoxic activity on the viability of cancerous cells compared to non-cancerous (Human embryonic kidney cells; HEK293) cells. The current findings showed that V. thapsus might be a promising anti-cancer medication candidate for the treatment of human colorectal adenocarcinoma and colon cancer, as well as a good source antioxidans. Copyright: (c) 2023 by the C.M.B. Association. All rights reserved.Article Citation - WoS: 2Citation - Scopus: 2Biological Evaluation and Molecular Docking Studies of Novel Aza-Acyclic Nucleosides as Putative Antimicrobial, Anticancer, and Antioxidant Agents(BioMed Central Ltd, 2025) Alhilal, M.; Alhilal, S.; Gomha, S.M.; Farag, B.; Sabancilar, I.; Ouf, S.A.This study aimed to synthesize new aza-acyclic nucleosides (aza-acyclovir) and evaluate the efficacy of these synthetic compounds as potential antimicrobial, anticancer, and antioxidant agents. We prepared two novel aza-acyclic nucleosides via two reactions. The first reaction involved trichloroisocyanuric acid and dibenzosulphonyl diethylamine, and the second reaction involved trichloroisocyanuric acid and diethanolamine. We then used one-dimensional nuclear magnetic resonance (NMR) spectroscopy, two-dimensional NMR spectroscopy, infrared spectroscopy, and mass spectrometry to determine the structures of the resulting compounds. In this regard, we first tested the antimicrobial activity of these compounds against various bacteria, including Bacillus cereus, B. subtilis, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa, and against fungal pathogens, including Aspergillus fumigatus, Candida tropicalis, and Alternaria solani. Next, the precise mode for the interaction between synthesized aza-acyclic nucleosides and the target protein 8HQ5 was elucidate using molecular docking analysis. Subsequently, we tested the synthesized compounds for putative anticancer activity at different concentrations (i.e., 12.5, 25, 50, 100, and 200 µg/mL) against A549 cell (Human epithelial lung carcinoma) and human umbilical vein endothelial cell (HUVEC) lines. In addition, compounds antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl-based and cupric reducing antioxidant capacity-based methods at different concentrations (i.e., 31.25, 62.5, 125, 250, and 500 µg/mL). Results revealed that both aza-acyclic nucleosides inhibited both bacterial and fungal strains, although toxicity toward bacterial strains was generally greater than toward fungal strains. We also observed that the molecular docking results were consistent with the results of in vitro antimicrobial assessments. Further, both aza-cyclic nucleosides exhibited cytotoxic effects against both the A549 cell and HUVEC lines. Despite exhibiting lower radical scavenging activity than ascorbic acid (an antioxidant compound used as a standard), Compound 1 from the novel synthetic aza-acyclic nucleosides showed a higher reduction capacity, which was dose-dependent. Overall, we report newly synthesized compounds that show promising antimicrobial, anticancer, and antioxidant effects. © 2025 Elsevier B.V., All rights reserved.Article Determination of Body Image and Self-Efficacy Levels in Patients After Cornea Transplantation(Elsevier Espana Slu, 2024) Genc, H.; Tanriverdi, Seher; Sen, M. A.Purpose: The study aimed to determine body image and levels after surgery in cornea transplant patients. Materials and methods: The population of this cross-sectional study was composed of 383 patients presented to the Eye Bank unit of a University Hospital after corneal transplantation. Sample size of 193 patients was calculated with 0.5 power, a margin of error of 5%, representing 95% of the universe. The data were collected through face-to-face interviews with the patients by the researcher and the study was completed with 178 patients in September - November 2022. The data were collected using a Patient Information Form, the Body Image Scale, and the General Self-Efficacy Scale. Parametric tests, Pearson Correlation, Student's T -test, and One-Way Analysis of Variance tests were performed were used in the data analysis. Results: It was determined that the mean Body Image Scale score of the transplant patients participating in the study was 159.41 +/- 36.99 and the mean Self-Efficacy Scale score was 30.37 +/- 8.31. When the comparison of the mean scores was examined, the difference between the mean scores of gender, marital status, occupation, and body image scale was statistically significant (P < .05), while the difference between the self-efficacy mean scores was not statistically significant (P > .05). There was a positive, moderately strong significant relationship between body image and the self-efficacy of the patients (P < .01) (r = .57) Conclusion: It was found that the patient's body image and self-efficacy levels were high, and self-efficacy increased as the body image increased. (c) 2023 Elsevier Espana, S.L.U. All rights reserved.Article Is Atrial Fibrillation a Risk Factor for Hearing Loss(Verduci Publisher, 2023) Can, S.; Karahan, M. Z.OBJECTIVE: In the present study, we sought to evaluate the results of hearing loss in AF patients. PATIENTS AND METHODS: This study involved 50 patients with AF, as determined by means of electrocardiogram, and 50 patients without AF. The pure-tone audiometry (PTA) threshold values were measured at low, medium and high frequencies for both ears. The signal-to-noise ratio (SNR) DPOAEs and TEOAEs were also analyzed for both ears separately. RESULTS: Both the airway and bone conduction PTA thresholds at 3, 4 and 6 kHz (kilohertz) were significantly lower in the AF group than in the control group (p<0.05). The AF patients exhibited worse hearing and worse TEO-AE results at 1, 2, 3 and 4 kHz. In fact, the TEO-AE amplitudes of the AF group were significantly lower in both the right and left ears at 2, 3 and 4 kHz when compared with the control group (p<0.05). Moreover, the DPOAE amplitudes in the AF group were statistically significantly lower at 3.4 kHz in both ears when compared with the control group (p<0.05). CONCLUSIONS: In light of these findings, we believe that AF is a risk factor for hearing.Letter The Naples Prognostic Score in TAVI Patients: a Promising Tool Requiring Further Validation. Authors' Reply(Polish Cardiac Soc, 2025) Gitmez, Mesut; Guzel, Tuncay; Kis, Mehmet; Coskun, Ferhat; Isik, Mehmet Ali; Aktan, Adem; Ertas, Faruk; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiArticle Citation - WoS: 1A Novel Determinant of Prognosis in Acute Pulmonary Edema: Intermountain Risk Score(Kare Publ, 2024) Kilic, Raif; Aktan, Adem; Guzel, Tuncay; Kaya, Ahmet Ferhat; Guzel, Hamdullah; Arslan, Bayram; Cankaya, YusufObjective: The Intermountain Risk Score (IMRS), calculated using age, gender, complete blood count (CBC), and simple laboratory analyses, is an easy-to-use and cost-effective tool developed to predict mortality. In our study, we aimed to determine whether the IMRS could predict mortality in patients admitted to the hospital with a diagnosis of acute pulmonary edema. Methods: A total of 371 patients who were admitted with a diagnosis of pulmonary edema, were included in our study. The IMRS of the patients was determined using a calculation tool, and the patients were divided into three groups based on the determined value: low, moderate, and high IMRS. Results: The patients included in our study comprised 208 women and 163 men, with an average age of 68.7 years. There was a statistically significant difference between the patient groups concerning both 1-month and 1-year mortality rates. Additionally, there was a significant difference in IMRS between patients who developed in-hospital, 1-month, and 1-year mortality and those who survived. In the Receiver Operating Characteristic (ROC) analysis, a cutoff value of 15.5 for the IMRS predicted both 1-year and 1-month mortality. In the Kaplan-Meier analysis, the highest mortality risk was observed in the high IMRS group and the lowest mortality risk in the low IMRS group. Conclusion: Our research results show that the IMRS strongly predicts both short-term and long-term mortality in patients hospitalized with a diagnosis of acute pulmonary edema.Article Citation - WoS: 1Pelvic Floor Muscle Strength and Dysfunctions in Women With Pes Planus: a Case-Control Study(Elsevier, 2024) Celenay, Seyda Toprak; Yardimci, Fatma Betul; Altay, HafizeBackground/aim: Distal extremity misalignment may give rise to pelvic floor dysfunctions (PFDs). This study aimed to compare pelvic floor muscle strength (PFMS) and dysfunctions in women with and without pes planus. Materials and methods: Women with (pes planus group, n = 30) and without pes planus (control group, n = 30) were included. The presence of PFDs questioned. Pes planus with the Feiss Line Test, PFMS with the Modified Oxford Scale, and the severity of PFDs with the Pelvic Floor Distress Inventory-20 (PFDI-20), including three subscales (Pelvic Organ Distress Inventory-6 (POPDI-6) for pelvic organ prolapse, Colorectal-Anal Distress Inventory-8 (CRADI-8) for colorecto-anal symptoms, and Urinary Distress Inventory-6 (UDI-6) for urinary symptoms, were assessed. Results: It was seen that no difference was found between groups in terms of PFMS (p > 0.05). However, urinary incontinence and anal incontinence were higher in women with pes planus than in women without pes planus (p < 0.05). Only the PFDI-20, CRADI-8, and UDI-6 scores were higher in women with pes planus compared to controls (p < 0.05). There was no difference was found between groups in terms of POPDI-6 scores (p > 0.05). Conclusion: The PFMS did not change according to the presence of pes planus. However, the prevalence of PFDs and their severity were higher in women with pes planus in comparison to controls. Posture assessments of individuals with PFDs, especially examination of foot posture, and pelvic floor assessments of individuals with posture disorders should be considered.Article Citation - WoS: 6Citation - Scopus: 6The Performance of the Naples Prognostic Score in Predicting One-Year Mortality and Major Adverse Cardiovascular Events After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis(Polish Cardiac Soc, 2025) Gitmez, Mesut; Guzel, Tuncay; Kis, Mehmet; Coskun, Ferhat; Isik, Mehmet Ali; Aktan, Adem; Ertas, Faruk; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiBackground: Existing risk scores for transcatheter aortic valve implantation (TAVI) may not fully capture patient complexity. Combining nutritional and inflammatory markers, the NPS (the NAPLES prognostic score) might improve outcome prediction. Aims: This study investigated the associations of the NPS with one-year mortality and major adverse cardiovascular events (MACEs) in TAVI patients. Material and methods:This retrospective analysis included 222 patients with severe aortic stenosis who underwent TAVI. The NPS was calculated based on the serum alb & uuml;min concentration, cholesterol concentration, lymphocyte/monocyte ratio, and neutrophil/lymphocyte ratio. The patients were subsequently categorized into two groups: the low-NPS group (NPS 0-2) and the high-NPS group (NPS 3-4). Results: A high NPS was significantly associated with increased one-year mortality (4.8% vs. 23.7%; P <0.001) and MACE rates (7.2% vs. 35.9%; P <0.001). Cox regression analysis demonstrated that a high NPS was an independent predictor of both mortality (HR, 5.94; 95% CI, 2.03-17.37; P = 0.001) and MACEs (HR, 5.09; 95% CI, 2.15-12.02; P <0.001). Conclusions: The NPS emerged as a potential predictor of long-term mortality and MACEs in TAVI patients. Further validation through larger, multicenter, studies is warranted.This research contributes valuable data on the role of the NPS in TAVI risk stratification.Article Citation - WoS: 1Citation - Scopus: 1Psychological Resilience and Trait Anxiety as Mediators in the Relationship Between Perceived Family Social Support and Life Satisfaction Among Youth(Taylor & Francis Inc, 2025) Kocak, Orhan; Aslan, Yavuz; Bezirkan, Havva SenaPurposeThis study examines the impact of perceived family social support on youth life satisfaction, focusing on the mediating roles of psychological resilience and trait anxiety.Materials and methodsA cross-sectional quantitative research design was employed, collecting data from 626 participants via an online survey. A convenience sampling method was used. Analyses, including confirmatory factor analysis, correlation analysis, and structural equation modeling (SEM) path analysis, were conducted using SPSS 24 and AMOS 24 softwareResultsThe findings indicate that perceived family social support positively influences psychological resilience and life satisfaction while reducing trait anxiety. Psychological resilience lowers trait anxiety; however, its direct effect on life satisfaction is insignificant. Trait anxiety, on the other hand, negatively affects life satisfaction and acts as a mediator between perceived family social support and life satisfaction. Additionally, psychological resilience plays an indirect role in the effect of perceived family social support on life satisfaction through trait anxiety.DiscussionThe results suggest that perceived family support enhances resilience and reduces anxiety among youth, contributing to greater life satisfaction. These findings underscore the complex interplay between these variables and highlight the mediating roles of psychological resilience and trait anxiety.ConclusionThis study contributes to the literature by demonstrating that perceived family support enhances life satisfaction by strengthening psychological resilience and reducing trait anxiety. In addition, the study emphasizes the importance of fostering family-based support systems to promote youth well-being.Article Citation - WoS: 1Citation - Scopus: 1Safety Analysis of Different Intensities of ELF-PEMF in Terms of Apoptotic, Inflammatory, and Transcription Factor NF-κB Expression Levels in Rat Liver(Kare Publ, 2024) Seker, Ugur; Gökçe, Yasin; Özöner, Merve Pekince; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiBackground and Aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF- PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats. Materials and Methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Con- trol, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the de- vice was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field applica- tion was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed. Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group. Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apop- tosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.Article Understanding How Sport Activity Shapes Work Attitudes: The Mediating Role of Impulsivity Among Social Welfare Professionals(Taylor & Francis inc, 2025) Aslan, Yavuz; Kocak, Orhan; Buber, Betul; Kocer, Alp; Altun, Gulnihal TurkerPurpose: This study investigates the relationships between living with sports (sport-oriented lifestyle), impulsivity, and attitudes toward working life among social welfare professionals in T & uuml;rkiye, with a specific focus on the mediating role of impulsivity.
Materials and Methods: A cross-sectional quantitative research design was employed, collecting data from 1,534 participants aged 18 and older via an online survey. The majority of the sample consisted of women (67.2%), with a mean age of 28.96 years. Data analysis was conducted using IBM SPSS for preliminary statistics and IBM AMOS for confirmatory factor analysis and structural equation modeling (SEM).
Results: Living with sports was negatively associated with impulsivity (beta = -0.072, p < .05) and positively associated with attitudes toward working life (beta = 0.064, p < .05). Impulsivity was negatively related to attitudes toward working life (beta = -0.185, p < .001) and significantly mediated the relationship between living with sports and work attitudes (beta = 0.013, p < .05). The model accounted for 5.5% of the variance in impulsivity and 4.4% in attitudes toward working life.
Discussion: The study results suggest that a lifestyle enriched by regular sports participation can reduce impulsive tendencies and support the development of more positive work attitudes among social welfare professionals.
Conclusion: This study provides novel empirical evidence on the triadic relationship between sport-oriented lifestyle, impulsivity, and work attitudes. It highlights the importance of integrating sport-based activities into organizational strategies to support emotional regulation, well-being, and sustainable professional engagement in social services.
