Sağlık Bilimleri Fakültesi

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Citation - WoS: 56
Citation - Scopus: 60
Adsorption and inhibition effect of 2,4-diamino-6-hydroxypyrimidine for mild steel corrosion in HCl medium: experimental and theoretical investigation
(SPRINGER HEIDELBERG, 2019) Yildiz, Resit; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
2,4-Diamino-6-hydroxypyrimidine (2D6H) was examined as corrosion inhibitor of mild steel (MS) in 0.1M HCl using potentiodynamic measurements, linear polarization resistance (LPR), scanning electron microscopy, electrochemical experiments, and quantum chemical calculations. All measurements show that the corrosion inhibition effectiveness is forthright compared to the concentration of 2D6H ranging from 0.5 to 10.0mM. Adsorption of 2D6H on the MS surface in the presence of HCl is determined to obey Langmuir adsorption isotherm. The electronic features elucidated by quantum chemical calculations were associated with the experimental inhibition productivities. The mechanism of inhibition was revealed by E-pzc measurements.
Citation - WoS: 3
Citation - Scopus: 3
Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats
(Elsevier, 2020) Yardimc, Ahmet; Ramazan Fazil Akkoc, Ahmet Tektemur, Nazife Ulker, Nalan Kaya Tektemur, Elif Erdem Güzel, Sinan Canpolat, Ibrahim Enver Ozan; 09.02. Department of Midwifery/ Ebelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background: Tobacco use during pregnancy is known to have several negative effects on the offspring's reproductive health in the long term. The use of alpha-lipoic acid (ALA) as a dietary supplement during pregnancy has increased greatly in recent years and has been known to have positive effects on various pregnancy outcomes including miscarriage, diabetic embryopathy, preterm delivery, and congenital malformations. Aim: To evaluate the effects of tobacco smoke exposure (TSE) on sexual behavior, reproductive parameters, and testicles in adult male rats and to reveal the possible role of ALA administration on these parameters. Methods: Pregnant rats (n = 7 per group) were treated with tobacco smoke (TS), ALA (20 mg/kg), and TS + ALA for a total of 11 weeks. The following parameters were compared with 8 control rats: puberty parameters, sexual behavior; levels of serum gonadotropins and testosterone, total antioxidant status, and total oxidant status; the expression of the apoptotic protease-activating factor-1 and caspase 9 mRNA levels in the testis; and assessment of immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling assay of testis. Main Outcome Measure: Sexual behavior, changes in puberty parameters, and hormonal and genetic alterations were the outcomes analyzed in this study. Results: Maternal TSE caused a significant decrease in the number of intromissions compared to the control group. Similarly, ALA decreased erectile function in sexual behavior by decreasing the number of intromissions and intromission ratio in the ALA group compared to the control group. In addition, TSE and ALA treatment caused an impairment of some consummatory sexual behaviors. Also, in parallel with this inhibitory effect, the age of pubertal onset was significantly delayed in the TS + ALA group compared to other groups. Also, histopathological changes in testicular tissue, oxidative stress markers, apoptotic index, and mRNA levels of apoptosis-related genes increased in all treatment groups. Clinical Implications: The use of ALA and/or tobacco products during pregnancy may adversely affect the reproductive health of male newborns in the long term. Strengths & Limitations: To the best of our knowledge, this study is the first to show the effects of maternal ALA treatment and/or TSE on the sexual behavior and reproductive parameters in male rats; however, the study is based on an animal model, and the present findings partially reflect the characteristics of human sexual behavior. Conclusion: Maternal TSE and/or ALA treatment may impair sexual behavior in adulthood in male rats because of testicular damage caused by oxidative stress during gonadal development. Yardimci A, Akkoc RF, Tektemur A, et al. Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats. J Sex Med 2020;17:1835–1847.
Citation - WoS: 14
Citation - Scopus: 16
Comparison of the Breastfeeding Practices of Refugee Syrian Mothers and Native Turkish Mothers
(Mary Ann Liebert, Inc, 2020) Ertem, Meliksah; Cifci, Sema; Deger, Vasfiye Bayram
Background: The World Health Organization recommends that babies be breastfed within the first hour of delivery and that they should exclusively be given breast milk in the first 6 months. The aim of this study was to ascertain the breastfeeding behaviors of refugee Syrian women and to compare their practices with those of the native mothers of the local community. Materials and Methods: This study is a cross-sectional study. The study was conducted in a Southern city in Turkey. The questionnaire was filled by face-to-face interviews. A total of 381 refugee Syrian mothers were compared with 381 native women living in the same community. Results: A significant difference was found between the two groups regarding breastfeeding. The rate of those who initiated breastfeeding within 1 hour after delivery was 61.4% for the Syrians and 71.1% for the Turkish mothers. In addition, the rates of exclusive breastfeeding (28.1 versus 34.1) and continuing breastfeeding for 12 months (55.0 versus 63.8) were lower in the Syrian refugee mothers. Maternal age and educational level were not correlated to the breastfeeding rates. Conclusions: This study is a rare study in which refugee mothers and local mothers were compared. Forced migration and refugee status are negatively associated with breastfeeding behavior.
Citation - WoS: 5
Citation - Scopus: 5
Diagnostic Performance of Erythropoietin and Erythropoietin Receptors Levels in Children with Attention Deficit Hyperactivity Disorder
(Clinical Psychopharmacology and Neuroscience, 2021) Güngör, Meltem; Ergul Belge Kurutas, Erkan Oner, Velid Unsal, Hatice Altun, Ali Erdinc Yalin, Serap Yalin, Ozlem Bozkus, Nilfer Sahin; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Objective: Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, a common childhood neurobehavioural disorder resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed to investigate the levels of Epo and and EpoR, and also their diagnostic values in children with ADHD. Methods: A total of 70 children were included in the study, 35 drug-naive patients with ADHD (age: 6−12 years; male/female: 20/15) and 35 healthy controls (age: 6−12 years; male/female: 22/13). Serum Epo and EpoR levels was determined using a commercial sandwich enzyme-linked immunosorbent assay kit. Results: The results indicated that the levels of Epo decreased in patients with ADHD compared to control (p < 0.05). On the other hand, EpoR levels increased in these patients (p < 0.05). Furthermore, the ratio of Epo/EpoR was significantly lower in ADHD patients than controls (p < 0.05). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curve were 0.980 and 1.000, respectively. Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in ADHD patients. Our results indicated that Epo may play a role in the etiology of ADHD, and Epo therapy may be beneficial in these disorders if given in addition to the routine treatment of children with ADHD. Furthermore, our results reveal possible diagnostic value of Epo and EpoR.
Citation - WoS: 5
Citation - Scopus: 6
Eating Behavior Changes of People With Obesity During the Covid-19 Pandemic
(Dove Medical Press Ltd, 2021) Deger, Vasfiye Bayram
Objective: The precautions taken during the pandemic period may cause stress-related eating behavior disorders. It was aimed to test this hypothesis, and the study was carried out to examine pandemic measures the effect of on the nutritional, depression and stress conditions of people with obesity. Methods: The individuals who participated in the study were people with obesity who received follow-up dietary therapy in a private hospital. Three separate scales were applied to the individuals, which measured the desire to overeating request, depression status and stress-fighting status. Results: This study was conducted on 368 individuals. Women had lower values of BMI (28.57 +/- 3.89 kg/cm(2)) than men ( 30.64 +/- 2.87 kg/cm(2)). When the scores of the excessive eating request scale mean scores before and during the pandemic were examined, it was seen that the scores of the individuals increased during the pandemic. In the multivariate regression model, it was seen that the increase of stress and BMI increased the FCQ score (p<0.001). Multiple regression models were created by taking into account the criteria that caused the score increase. Each variable can predict the FCQ score separately. The predictor significance order of variants on FCQ score beta values is as follows: the Patient Health Questionnaire-9 (PHQ-9) (beta=0.774), before pandemic FCQ (beta = 0.601), the Perceived Stress Scale ( PSS) (beta=-0.268), before pandemic BMIa (beta=-0.223), during pandemic BMIb (beta=0.073), and age (beta=-0.013). Conclusion: COVID-19 pandemic, making applications such as quarantine in pandemic processes has successful results in being able to combat its. However, undesirable conditions such as stress can have serious negative consequences on other health measurements. It was observed in the results of this study that excessive eating food desire developed in people with obesity.
The effect of acupressure on postoperative pain of lumbar disc hernia: A quasi-experimental study
(ELSEVIER, 2018) Tanrıverdi, Seher; Sarıtaş, Serdar; 09.06. Department of Social Services/ Sosyal Hizmet Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The effect of acupressure on postoperative pain of lumbar disc hernia Background: This study has been conducted for the purpose of examining the effect of acupressure on postoperatıve paın of lumbar disc hernia. Methods: This research was conducted between January 2015- July 2016 at the Neurosurgery Clinics of Turgut Özal İnönü University and Malatya State Hospital as a quasi-experimental research with pretest-posttest designs. The study population consisted of patients who were hospitalized in these clinics after operation of lumbar disc hernia. The sample group consisted of 112 patients selected with random sampling and stayed in these clinics after the power analysis (56 test, 56 control). This research data was collected between January 2016 - March 2016. Patient identification forms and visual analog scales (VAS) were used for data collection. Patient identification form was applied to the patients in the experimental group, after acupressure was applied to patients for 15-20 minutes, their level was determined with the VAS. When the acupressure was stopped, their pain was determined with the VAS. Whereas in the control group, their pain was determined with the VAS and taking the end of the time during which acupressure was applied to experimental group into consideration, their pain level was reevaluated in the 20th minute. Data were evaluated with percentage, arithmetic average, chi-square test and independent groups t test. Results: The research result showed that owing to the effect of acupressure the pain level of the experimental group decreased from 7.75±1.67 to 2.58±1.18. (p= .00). Conclusions: Hence this result suggests the effectiveness of acupressure on postoperatıve paın of lumbar disc hernia.
Citation - WoS: 5
Citation - Scopus: 5
Effect of Individual Psychoeducation for Primary Caregivers of Children With Autism on Internalized Stigma and Care Burden: a Randomized Controlled Trial
(Taylor & Francis Ltd, 2025) Kacan, Havva; Gumus, Funda; Deger, Vasfiye Bayram
This study aims to determine the effects of a six-week individual psychoeducation program provided to primary caregivers of children with autism on stigma and care burden. The study was conducted with 88 primary caregivers (experimental group n = 45, control group n = 43) of children diagnosed with autism. The study, prepared in an experimental design with a pretest, posttest, and control group, was performed between 17 June 2021 and 17 January 2022. In the study, a six-week individual psychoeducation was given to the experimental group. Study data were collected using a personal information form, the Internalized Stigma of Parents in Mental Illness Scale (ISPMIS), and the Caregiver Burden Scale (CBS).The mean pretest ISPMIS total score of the experimental group was X- =105.756 and the posttest total score after the psychoeducation was X- =66.489,which was a significant decrease (t = 25.571; p < 0.05). The mean CBS pretest total score of the experimental group was X- =61.067 and the posttest total score was X over bar =31.667, which was a significant decrease (t = 17.499;p < 0.05). The study revealed that the six-week individual psycho education provided to primary caregivers of children with autism decreased the participants' internalized stigma and perceived care burden.
Citation - WoS: 16
Citation - Scopus: 16
Effect of therapeutic touch on daytime sleepiness, stress and fatigue among students of nursing and midwifery: A randomized sham-controlled trial
(Complementary Therapies in Clinical Practice, 2021) Utli, Hediye; Vural Doğru, Birgül; Şenuzun Aykar, Fisun; 21.01. Department of Health and Nursing Services / Sağlık ve Bakım Hizmetleri Bölümü; 09.01. Department of Nursing / Hemşirelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Objectives: This study was conducted to assess the effect of therapeutic touch on stress, daytime sleepiness, sleep quality and fatigue among students of nursing and midwifery. Methods: 96 students were randomized into three groups: the therapeutic touch (TT) group, the sham therapeutic touch (STT) group, and the control group. In this randomized sham-controlled study, the TT group was subjected to therapeutic touch twice a week for four weeks with each session lasting 20 min. Results: When the TT group was compared to the STT and control groups following the intervention, the decrease in the levels of stress (p < 0.001), fatigue (p < 0.001) and daytime sleepiness (p < 0.001), and the increase in the sleep quality (p < 0.001) were found to be significant. Conclusion: It was found that TT, which is one form of complementary therapy, was relatively effective in decreasing the levels of stress, fatigue and daytime sleepiness, and in increasing the sleep quality of university students of nursing and midwifery.
Citation - WoS: 3
Citation - Scopus: 4
The Effect of Virtual Rainforest and a White Noise Mobile Application on Satisfaction, Tolerance, Comfort, and Vital Signs During Arthroscopy
(Elsevier Sci Ltd, 2024) Genc, Hasan; Tanriverdi, Seher; Akar, Mehmet Sait
Background and purpose: This study was conducted to investigate the effect of Virtual Rainforest (VRF) and a White Noise (WN) mobile applications on patient satisfaction, tolerance, comfort, and vital signs during arthroscopic knee surgery. Methods: This is a randomized, controlled, interventional study. The study was completed with a total of 93 participants, 31 in the VRF group, 31 in the WN group, and 31 in the control group. Data were collected using a Patient Information Form and a Visual Analog Scale for satisfaction, tolerance, and comfort. Results: The results of study showed that there were significant increases in tolerance, satisfaction, comfort, respiratory rate, and oxygen saturation levels and significant decreases in heart rate, systolic and diastolic blood pressures in both VRF and WN groups (p < .05). In the control group, no significant difference was found between the means of the variables before and after the procedure (p > .05). Conclusion: According to the results of the study, VRF and WN applied during the arthroscopy procedure increased satisfaction, tolerance, and comfort in patients and had a positive effect on vital signs. Trial and protocol registration: ClinicalTrials.gov, NCT05992714.
Citation - WoS: 1
Citation - Scopus: 2
Effects of clinical practicum on nursing students' self-efficacy: Example of internal medicine wards
(Wiley, 2021) Kankaya, Hülya; Keskin, Hülya; Akyol, Asiye; 09.07. Department of Audiology/ Odyoloji Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Purpose: To evaluate the effects of clinical practicum on nursing students' self-efficacy (perceptions of confidence and importance) in internal medicine wards and the factors affecting it. Design and Methods: The single group pre-post descriptive study was conducted with 134 final-year nursing students practicing in internal medicine wards. Findings: At the beginning of the practicum, the mean score of confidence and importance subscales were 3.72 ± 0.77 and 4.25 ± 0.57, respectively. At the end of the practicum, the mean score of confidence and importance subscales were 3.91 ± 0.70 and 4.81 ± 0.76, respectively. We found that there was a significant improvement in both subscales at the end of the practicum (p < 0.05). Practice Implications: Clinical practicum positively affects students' self-efficacy in internal medicine wards
Electrocatalysis property of CuZn electrode with Pt and Ru decoration
(2021) Toprak Döşlü, Serap; DÖNER, ALİ; Yıldız, Reşit; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Electrocatalysis properties strongly depend on the interaction of metallic particles and this interaction enables to change the electronic structure of alloys which enhances the catalytic activity. This property is the key factor in the developing of cost-effective and efficient Hydrogen Evolution Reaction (HER) electrocatalysts for sustainable hydrogen production. In this study, novel electrocatalysts which are decorated with Pt and Ru have been developed for HER electrocatalysis. Microscopic analysis such as scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD) and atomic force microscopy (AFM) are performed to determine the morphological and compositional structures. Electrocatalysis properties are evaluated by cathodic current-potential curves, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) in 1.0 M KOH solution. Chronoamperometry (CA) and cycle tests are used for stability/durability of electrocatalysts. Results show that a small onset potential of the porous Cu/Ni/CuZnePt is obtained for HER. Exchange current density and polarization resistance are found to be 5.39 mA cm2 and 2.0 U cm2 at overpotential of 100 mV for porous Cu/Ni/CuZnePt, respectively, indicating that Cu/Ni/CuZnePt is higher electrocatalytic properties than the others. Moreover, very low overpotentials at 10 and 40 mA cm2 are obtained on porous Cu/ Ni/CuZnePt compared with porous Cu/Ni/CuZneRu and Cu/Ni/CuZn. Porous Cu/Ni/CuZn ePt also displays excellent stability/durability in test solution. The remarkable electrocatalysis properties of porous Cu/Ni/CuZnePt can be explained due to high porous structure, leaching of Zn from the deposit, intrinsic activity of Pt as well as changing in the electronic structure. It should be considered that porous Cu/Ni/CuZnePt is of high corrosion resistance in test solution for 120 h, which makes it good candidate for HER.
Citation - WoS: 15
Citation - Scopus: 17
Electrocatalysis property of CuZn electrode with Pt and Ru decoration
(International Journal of Hydrogen Energy, 2021) Toprak Döşlü, Serap; Döner, Ali; Yıldız, Reşit; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Electrocatalysis properties strongly depend on the interaction of metallic particles and this interaction enables to change the electronic structure of alloys which enhances the catalytic activity. This property is the key factor in the developing of cost-effective and efficient Hydrogen Evolution Reaction (HER) electrocatalysts for sustainable hydrogen production. In this study, novel electrocatalysts which are decorated with Pt and Ru have been developed for HER electrocatalysis. Microscopic analysis such as scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD) and atomic force microscopy (AFM) are performed to determine the morphological and compositional structures. Electrocatalysis properties are evaluated by cathodic current-potential curves, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) in 1.0 M KOH solution. Chronoamperometry (CA) and cycle tests are used for stability/durability of electrocatalysts. Results show that a small onset potential of the porous Cu/Ni/CuZn–Pt is obtained for HER. Exchange current density and polarization resistance are found to be 5.39 mA cm−2 and 2.0 Ω cm2 at overpotential of −100 mV for porous Cu/Ni/CuZn–Pt, respectively, indicating that Cu/Ni/CuZn–Pt is higher electrocatalytic properties than the others. Moreover, very low overpotentials at 10 and 40 mA cm−2 are obtained on porous Cu/Ni/CuZn–Pt compared with porous Cu/Ni/CuZn–Ru and Cu/Ni/CuZn. Porous Cu/Ni/CuZn–Pt also displays excellent stability/durability in test solution. The remarkable electrocatalysis properties of porous Cu/Ni/CuZn–Pt can be explained due to high porous structure, leaching of Zn from the deposit, intrinsic activity of Pt as well as changing in the electronic structure. It should be considered that porous Cu/Ni/CuZn–Pt is of high corrosion resistance in test solution for 120 h, which makes it good candidate for HER.
Citation - WoS: 17
Citation - Scopus: 20
The electrochemical synthesis and corrosion behaviour of TiO2/poly(indole-co-aniline) multilayer coating: Experimental and theoretical approach
(Arabian Journal of Chemistry, 2018) Toprak Döşlü, Serap; Doğru Mert, Başak; Yazıcı, Birgül; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 09.01. Department of Nursing / Hemşirelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The aim of this study was to protect stainless steel against corrosion via poly (indole-co-aniline) with the help of titanium dioxide pre-coating. Different monomer ratios (1:1 and 1:9) wereapplied in order to determine the suitable chain composition to synthesize the copolymer in lithiumperchlorate containing acetonitrile. The structures, morphologies, electrochemical properties andcorrosion resistances of the mono and multi-layer coatings were investigated by Fourier-transform infrared spectra, scanning electron microscope, energy dispersive X-ray spectrometer,electrochemical impedance spectroscopy and anodic polarization. Furthermore the geometric struc-ture and electronic properties of indole, aniline, and indole-co-aniline (dimmer) molecules have beeninvestigated by quantum calculations. The results indicated that corrosion protection of copolymerswas increased via titanium dioxide pre-coating. The 1:1 copolymer coating showed better corrosionprevention than 1:9 coating. The correlation was determined between experimental and theoreticalparameters.
Citation - WoS: 14
Citation - Scopus: 15
Evaluation of fatty acids, free fatty acids and textural properties of butter and sadeyag (anhydrous butter fat) produced from ovine and bovine cream and yoghurt
(ScienceDirect, 2022) Karakuş, Mehmet Şükrü; Yıldız Akgül, Filiz; Korkmaz, Aziz; Atasoy, Ahmet Ferit; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Fatty acids (FAs), free fatty acids (FFAs) and textural characteristics were determined in butter and sadeyag (anhydrous butter fat) manufactured from ovine and bovine cream and yoghurt. The samples made from cream and yoghurt had similar FA and FFA profiles and textural properties. Ovine milk fat products had higher short- and medium-chain saturated fatty acid (SFA) content, while samples made with bovine milk fat had higher long-chain SFA content. Ovine milk fat samples contained higher levels of capric, myristic, stearic and oleic acids and lower levels of butyric and caproic acids than bovine milk samples. Bovine milk fat products had firmer and poorer spreadability, and lower adhesiveness than ovine milk fat products. Polyunsaturated fatty acid (PUFA) content of butter was higher than that of sadeyag. Sadeyag was firmer and less spreadable than butter. Textural characteristics of the milk fat products depended on the FA composition of the samples.
Citation - WoS: 3
Citation - Scopus: 3
Frequency of clinical alarms in intensive care units and nurses’ sensitivity to them: An observational study
(American Journal of Critical Care, 2021) Baran, Leyla; Ceylan, Burcu; Güneş, Ülkü Yapucu; 09.06. Department of Social Services/ Sosyal Hizmet Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background All clinical alarms require nurses to respond even if an intervention is not needed. Nurses are expected to respond appropriately to each alarm and establish priorities among their care practices accordingly. This study was conducted to examine the number and types of clinical device alarms used in intensive care units, the duration of their activation, and nurses’ degree of sensitivity to them. Methods This observational study was conducted in 4 intensive care units in a university hospital in Turkey. A total of 20 nurses (5 from each unit) were observed for a total of 80 hours. The alarms were categorized as valid, false, or technical. Results During the study observation period, the mean number of alarms sounding per hour per bed was 1.8. A total of 144 alarms were recorded, of which 70.8% were valid, 15.3% were false, and 13.9% were technical. The mean duration of alarm activation was 8 minutes for valid alarms, 14 minutes for false alarms, and 53 minutes for technical alarms. Conclusions Nurses’ responses to alarms differ depend-ing on alarm type; for alarms that do not require an emergency intervention, nurses tend to respond late or not at all. (American Journal of Critical Care. 2021;30:186-192).
Frequency of Clinical Alarms in Intensive Care Units and Nurses' Sensitivity to Them: An Observational Study
(2021) Ceylan, Burcu; Baran, Leyla; Güneş, Ülkü; 09.06. Department of Social Services/ Sosyal Hizmet Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background All clinical alarms require nurses to respond even if an intervention is not needed. Nurses are expected to respond appropriately to each alarm and establish priorities among their care practices accordingly. This study was conducted to examine the number and types of clinical device alarms used in intensive care units, the duration of their activation, and nurses’ degree of sensitivity to them. Methods This observational study was conducted in 4 intensive care units in a university hospital in Turkey. A total of 20 nurses (5 from each unit) were observed for a total of 80 hours. The alarms were categorized as valid, false, or technical. Results During the study observation period, the mean number of alarms sounding per hour per bed was 1.8. A total of 144 alarms were recorded, of which 70.8% were valid, 15.3% were false, and 13.9% were technical. The mean duration of alarm activation was 8 minutes for valid alarms, 14 minutes for false alarms, and 53 minutes for technical alarms. Conclusions Nurses’ responses to alarms differ depending on alarm type; for alarms that do not require an emergency intervention, nurses tend to respond late or not at all.
Citation - WoS: 7
Citation - Scopus: 8
Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
(MDPI, 2023) İpek, Polat; Yıldız, Reşit; Baran, Mehmet Fırat; Hatipoğlu, Abdülkerim; Baran, Ayşe; Sufianov, Albert; Beylerli, Ozal; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet-visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced from Papaver rhoeas (PR) L. leaf extract are presented. PR-AgNPs are generally spherical and have a maximum surface plasmon resonance of 464.03 nm. The dimensions of the manufactured nanomaterial are in the range of 1.47-7.31 nm. PR-AgNPs have high thermal stability and a zeta potential of 36.1 mV. The minimum inhibitory concentration (MIC) values (mg L-1) of PR-AgNPs on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans are 1.50, 0.75, 3.00, 6.00, and 0.37, respectively. In the study, the cytotoxic and proliferative effects of PR-AgNPs using the MTT (3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide) method on various cancer cell lines (CACO-2 (human colon adenocarcinoma cell), MCF-7 (human breast cancer cell), T98-G (glioblastoma multiforme cell), and healthy HUVEC (human umbilical vein endothelial cell)) cell lines are presented. After 24 and 48 h of the application, the half-maximum inhibitory concentration (IC50) values (mu g mL(-1)) of PR-AgNPs on HUVEC, CACO-2, MCF-7, and T98-G lines are 2.365 and 2.380; 2.526 and 2.521; 3.274 and 3.318; 3.472 and 3.526, respectively. Comprehensive in vivo research of PR-AgNPs is proposed to reveal their potential for usage in sectors such as nanomedicine and nanochemistry.
Citation - WoS: 30
Citation - Scopus: 34
Health literacy, health perception and related factors among different ethnic groups: a cross-sectional study in southeastern Turkey
(BMC Health, 2021) Yiğitalp, Gülhan; Bayram Değer, Vasfiye; Çifçi, Sema; 09.01. Department of Nursing / Hemşirelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background: Low levels of health literacy are associated with increased hospitalization rates, problems regarding the proper intake of medications, poor general health and increased mortality rates. It is a well-known fact that health literacy differs among ethnic groups and ethnic minorities, in particular, are known to have a low level of health literacy. The present study aimed to reveal the levels of health literacy among different ethnic groups and the affecting factors as well as the relationship between health literacy and health perceptions. Methods: This cross-sectional study was carried out with different ethnic groups (Kurdish, Arab, Turkish and Assyrian origin), between 18 and 65 years old in the province of Mardin in Turkey. The study was conducted with a total of 600 people. The European Health Literacy Scale-Turkish Adaptation (EHLS-TR) and Health Perception Scale (HPS) were used for measurement. Descriptive analysis, Mann Whitney U Test, Kruskal Wallis Test and Spearman correlation were used in the data analysis. Results: It was found that 80.7% of the participants had relatively low levels of health literacy. The lowest levels of health literacy were among those of Kurdish origin. There were correlations between sufficient levels of health literacy and several factors including being of Assyrian origin, being 50–65 years old, living in a nuclear family, being a secondary school graduate, having a high financial status, being retired, evaluating one’s own health status as good, obtaining health information from healthcare professionals, preferring to visit a state hospital to seek medical assistance first, smoking and drinking alcohol. A positive correlation was also identified between the levels of health literacy and health perception. Conclusions: It is essential to develop programs to increase health literacy for the public and, in particular, for the ethnic groups that are disadvantaged in many aspects in the context of health literacy.
Citation - WoS: 12
Citation - Scopus: 13
Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats
(Elsevier, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; 09.02. Department of Midwifery/ Ebelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Doxorubicin (DOX) is one of the most widely used chemotherapeutic agents. However, it causes pulmonary toxicity which decreases its clinical use in human cancer therapy. The present study was undertaken to obtain an insight into the potential protective effect of hesperetin (HES) against doxorubicin-induced pulmonary toxicity in rats. The animals were divided into 4 groups with 7 rats per group. The experimental treatments were as follows: Control, DOX, DOX + HES, and HES groups. DOX was administered at the dosage of 15 mg/kg i.p for a single dose. HES was administered at the dosage of 50 mg/kg by oral gavage every other day. After 28 days, biochemical parameters, oxidative stress status, histopathological changes, apoptosis-related genes and apoptotic index (AI) were examined of lung tissue. Histopathological changes, Poly [ADP-ribose] polymerase 1 (PARP-1), Caspase-3 (Casp3), Cytochrome c (Cytc), apoptosis-related genes, and AI significantly increased in the DOX group relative to the control group. Malondialdehyde (MDA) significantly increased, while superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased in the DOX group relative to the control group. However, histopathological findings, MDA, AI, and PAPR1, Casp3 protein expression, mRNA expression of Cytc significantly decreased, while SOD, GPx increased in the DOX + HES group relative to the DOX group. These results attested HES might be a potential agent for the treatment of DOX-induced pulmonary toxicity.
Citation - WoS: 34
Citation - Scopus: 32
Investigation of oxidant/antioxidant and anti-inflammatory effects of apigenin on apoptosis in sepsis-induced rat lung
(Journal of Biochemical and Molecular Toxicology, 2021) Unsal, Velid; Çiçek, Mustafa; Doganer, Adem; Demir, Mehmet; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
We suppose that apigenin may inhibit the cellular process of sepsis-induced lung injury, which is considered to be a major cause of morbidity and mortality, and may improve inflammation and oxidative stress. The aim of this study was to investigate the potential protective effect of apigenin in a rat model of polymicrobial sepsis. Eight groups consisting of a total of 64 female Wistar albino rats were used for this study. Pro-inflammatory (TNF-α, IL-1-β, IL-6) and anti-inflammatory (TGF-β, IL-10) cytokine levels were measured with the enzyme-linked immunosorbent assay technique, oxidant/antioxidants parameters were measured using the spectrophotometric method and Bax and Caspase-3 immunohistochemical methods. TNF-α, TGF-β, IL-1β, and IL-6 levels significantly increased in the sepsis-induced group than in the control groups, while IL-10 levels decreased. Lipid peroxidase (LPO), an oxidative stress marker, increased, while the antioxidant defense parameters of superoxide dismutase (SOD), catalase (CAT) activities, glutathione (GSH) levels decreased. Although Bax and Caspase-3 immunoreactivity and H score levels significantly increased in the sepsis group, significant decreases were found in the groups treated with apigenin. In conclusion, we are of the opinion that apigenin treatment improves lung injury by inhibiting oxidative stress and inflammatory cell damage.

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