Sağlık Hizmetleri Meslek Yüksekokulu

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Comparison Of Different Life Stages Of Total, Phospholipid And Triacylglycerol Fatty Acids Of Lucilia Sericata
(ABADER (Adıyaman Bilimsel Arastırmalar Dernegi), 2021) Kizmaz, V.
Lucilia sericata, which belongs to the Calliphoridae family (Diptera), is used as a debridement tool in open necrotic wounds that do not respond to conventional treatments. Knowing the total, phospholipid (PL), and triacylglycerol (TAG) fatty acid content of L. sericata fly, which is important for health, in its different stages is important both in terms of taxonomy and physiology. After L. sericata samples used in the study were obtained commercially, they were bred under laboratory conditions and then the fatty acids in different stages were analyzed by gas chromatography. Sixteen fatty acids are determined as a result of the analysis. When individual fatty acids are considered, Palmitic acid (16:0), Palmitoleic Acid (16:1n-7), oleic acid (18:1n-9) and Linoleic Acid (18:2n-6) were found to be major ones, while the others are detected in trace amounts. It is determined that, out of total, PL and TAG, saturated fatty acids (SFA) are found at a high percentage in the eggs, monounsaturated fatty acids (MUFA) are the highest in the larvae, and polyunsaturated fatty acids (PUFA) are the highest in fly and pupa. Furthermore, out of total, PL and TAG, ∑PUFA is at a low percentage in the egg and the larval stages. Different results are found at different stages in this study. This may be because fatty acid percentages that change during metamorphosis meet different physiological needs at different phases. © 2021, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.
Investigate Nasal Colonize Staphylococcus Species Biofilm Produced
(Journal of Clinical and Analytical Medicine, 2015) Demir, C.; İnanç, B.B.
Aim: 127 S.aureus and 65 CoNS strains were isolated from patients noses’. To produce a biofilm ability was investigated using three different methods. Slime-positive and negative staphylococcies’ resistance were evaluated against different antibiotics. Material and Method: Swap samples puted 7% blood agar. Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates biofilm produced ability were investigated using Congo Red Agar (CRA), microplates (MP) and Standard Tube (ST) methods. In addition to that, presence of antibiotic resistance of the staphylococcal isolates are determined agar disc diffusion method. Results: The rate of biofilm produc-ing Staphylococcus spp strains was found to be 72.4%, 67.7%, and 62.9%, respectively with CRA, MP, and ST tests. There was no significant relationship among the tests (p>0.05). In addition, antibiotic resistance of Staphylococcus spp. against various antibiotics was also determined by the agar disk dif-fusion method. Resistance rates of biofilm positive (BP) Staphylococcus spp for penicilin G, ampicilin, amocycilin/clavulanic acid, tetracyclin, eritromycin, gentamycin, and enrofloxacin 71.7%, 69.7%, 6.2%, 20.7%, 21.4%, 1.4%, and 0.7%, respectively. Resistance rates of biofilm negative (BN) spp for 42.6%, 23.4%, 4.3%, 14.9%, 19.1%, 0.0%, 0.0% respectively. All Staphylococcus isolates were found to be susceptible to vancomycin and teicaplonin. Although BP strains antibiotic resistance rates were observed higher than BN strains. But resistance rates were not found statistically significant (p>0.05). Discus-sion: CRA is the reliablity and specifity method to determine Staphylococcus spp. biofilm produce ability. © 2015, Journal of Clinical and Analytical Medicine. All rights reserved.
Investigation of Uroprotective Effects of Seed Methanol Extracts of Hypericum Triquetrifolium Turra. on Cyclophosphamide-Induced Bladder Hemorrhagic Cystitis and Nephrotoxicity in Wistar Albino Rats
(Cukurova Univ, Fac Medicine, 2020) Yildiz, Songul Cetik; Keskin, Cumali; Sahinturk, Varol; Ayhanci, Adnan
Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats. Materials and Methods: Wistar albino rats used in this study were divided into nine groups, each including seven rats. Group 1 (control) was treated with 0.5ml saline (SF) and Group 2 was treated with CYP (150 mg/kg). Groups 3, 4, 5 were treated with 25, 50, 100 mg/kg HT, respectively while groups 6, 7, 8 were treated with 25, 50, 100 mg/kg CYP + HT, respectively. Finally, Group 9 (control-2) was treated with 0.5ml-%0.2 dimethyl sulfoxide (DMSO). The serum creatinine, blood urea nitrogen (BUN), superoxide dismutase (SOD) and catalase (CAT) levels were measured in blood serum. Results: The CYP-treated rats histopathologically had mild-moderate bladder and renal injuries. The serum creatinine and BUN levels, which are the biochemical markers of renal injury, significantly increased compared to the control group. Conclusion: HT showed a protective effect on CYPrelated bladder HC and nephrotoxicity in rats by inhibiting inflammation and apoptosis.

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