Durucu, Cengiz

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https://hdl.handle.net/20.500.12514/8127
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Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
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Bratislava Medical Journal-Bratislavske Lekarske Listy1
Saudi Medical Journal1
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  • Thumbnail Image
    Article
    Role of Oxidative Stress in Serous Otitis Media and Myringosclerosis
    (Springer Nature, 2025) Sari, Neslihan; Savas, Hasan Basri; Ugras, Seda; Durucu, Cengiz
    Background Ventilation tube insertion (VTI) is the surgical treatment of serous otitis media (SOM). Myringosclerosis (MS) commonly appears after ventilation tube insertion (VTI). The exact etiology of both MS and SOM remains unclear. Objective The role of oxidative stress (OS) markers-total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON1), arylesterase (ARES), and zinc (Zn) levels-in the advancement of SOM and MS in patients following VTI was examined. Methods The study comprised 100 children aged six to thirteen, categorized into MS + SOM (n = 34), MS-SOM (n = 34), and control (n = 32) groups. Serum levels of TAS, TOS, OSI, PON1, ARES, and Zn were evaluated. ANOVA, independent t-test, and Receiver Operating Characteristic (ROC) analysis were used for statistical analysis (p < 0.05). Results For SOM, the means of TOS and OSI were greater than those of the control group, whereas ARES and Zn were found to be lower than those of the control group (p < 0.05). ANOVA results for MS revealed that TOS (p = 0.026), OSI (p = 0.009), PON1 (p = 0.047), ARES (p = 0.00), and Zn (p = 0.00) levels differed among the groups. In ROC analysis, TOS (AUC = 0.697, p = 0.0002), OSI (AUC = 0.701, p = 0.0002), ARES (AUC = 0.777, p = 0.0001), and Zn (AUC = 0.817, p = 0.0001) are predictive for SOM. No predictive parameters of OS for MS were identified (p > 0.05). Conclusion Serum TOS, OSI, ARES, and Zn can serve as diagnostic indicators in SOM. None of the serum OS markers is predictive of MS. More research is needed to support these conclusions.
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    Article
    Can Inflammatory Indices Predict Myringosclerosis
    (Saudi Med J, 2025) Sari, Neslihan; Savas, Hasan Basri; Ugras, Seda; Durucu, Cengiz
    Objectives: To examine the relationships between the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) in myringosclerosis after ventilation tube insertion (VTI). Methods: We conducted this descriptive case-control study between March 2022 and September 2024. A total of 75 children aged 6 to 12 years with a history of VTI were enrolled. Myringosclerosis+ (n=43) included children with myringosclerosis, while Myringosclerosis-(n=32) included children without myringosclerosis. Preoperative values for NLR, PLR, and SII were collected by hematological testing and calculations. Demographic factors, prognostic risk factors and discrimination power of parameters were determined by statistical methods. Results: Compared to the myringosclerosis-, the myringosclerosis+ had significantly higher NLR, PLR, and SII values (p=0.00, p=0.04, and p=0.01, respectively). Receiver operating characteristic (ROC) curve area of NLR is 0,76 (95% CI: 0.65-0.87, p=0.00). Area under curve of SII is 0,62 (95%CI: 0.57-0.81, p=0.01). Neutrophil-to-lymphocyte ratio affects myringosclerosis development at 1.34 with sensitivity=0.63, specificity=0.78. Neutrophilto-lymphocyte ratio(NLR) and systemic immune inflammation index(SII) show myringosclerosis development at different powers of predictivity. The ROC area of NLR is highest of all parameters but is moderately predictive (<0.80). It is slight for SII. The NLR may be a marker of prediction of myringosclerosis OR=0.182 (95%CI:0.067-0.496). Conclusion: Neutrophil-to-lymphocyte ratio and SII are systemic inflammatory prognostic markers in myringosclerosis, and elevated NLR values are a predictor of myringosclerosis with modest affect. Other parameters should be sought in myringosclerosis development.