Tükenmez Emre, Ümmügülsüm
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Tukenmez, Ummugulsum
Tukenmez Emre, U.
Tükenmez, Ümmügülsüm
Tukenmez Emre, U.
Tükenmez, Ümmügülsüm
Job Title
Doktor Öğretim Üyesi
Email Address
ummugulsumtukenmez@artuklu.edu.tr
Main Affiliation
Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
1NO POVERTY
0
Research Products
2ZERO HUNGER
0
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3GOOD HEALTH AND WELL-BEING
2
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4QUALITY EDUCATION
0
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5GENDER EQUALITY
0
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6CLEAN WATER AND SANITATION
0
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7AFFORDABLE AND CLEAN ENERGY
0
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8DECENT WORK AND ECONOMIC GROWTH
0
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9INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
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10REDUCED INEQUALITIES
0
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11SUSTAINABLE CITIES AND COMMUNITIES
0
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12RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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13CLIMATE ACTION
0
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14LIFE BELOW WATER
0
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15LIFE ON LAND
0
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16PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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17PARTNERSHIPS FOR THE GOALS
0
Research Products
Documents
3
Citations
230
h-index
3
Documents
5
Citations
217
Scholarly Output
3
Articles
3
Views / Downloads
0/31
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
60
Scopus Citation Count
64
Patents
0
Projects
0
WoS Citations per Publication
20.00
Scopus Citations per Publication
21.33
Open Access Source
1
Supervised Theses
0
| Journal | Count |
|---|---|
| JBIC Journal of Biological Inorganic Chemistry | 1 |
| JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 1 |
| South African Journal of Botany | 1 |
Current Page: 1 / 1
Scopus Quartile Distribution
Competency Cloud
3 results
Scholarly Output Search Results
Now showing 1 - 3 of 3
Article Mechanistic Insights Into the Anticancer Effects of Lavandula Stoechas L. Via Apoptosis and Autophagy Regulation(Elsevier B.V., 2026) Tukenmez Emre, U.; Nigdelioglu Dolanbay, S.; Şirin, S.; Aslím, B.; Emre, Ummugulsum Tukenmez; Dolanbay, Serap NigdeliogluThis study aimed to evaluate the chemical composition and antioxidant, genotoxic, antigenotoxic, and anticancer properties of the methanolic extract of Lavandula stoechas L. (LSME). Total flavonoid content was determined spectrophotometrically, and total phenolic content was measured using Folin–Ciocalteu reagent. The phenolic compounds were identified and quantified by high-performance liquid chromatography (HPLC). The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, metal chelation, and plasma lipid peroxidation assays. Genotoxicity/antigenotoxicity was evaluated using the comet assay, and cytotoxicity was determined using the MTT assay in MCF-7, SK-BR-3, and MCF-12A cell lines. Gene expression related to apoptosis, autophagy, and the AMPK/mTOR signaling pathway was analyzed using quantitative real-time PCR (qRT-PCR). Phytochemical analysis revealed that LSME is rich in phenolics (294.6 mg/g) and flavonoids (7.50 mg/g). HPLC profiling identified 23 phenolic constituents, with rosmarinic acid, chlorogenic acid, and luteolin as the predominant compounds. LSME exhibited strong antioxidant activity in all assays. Genotoxicity assays showed no significant DNA damage, while antigenotoxicity assays demonstrated a protective effect against H₂O₂-induced DNA damage in human lymphocytes. In vitro cytotoxicity assays revealed dose-dependent antiproliferative effects in MCF-7 and SK-BR-3 cells, without cytotoxicity toward normal breast epithelial cells (MCF-12A). Molecular analyses indicated activation of intrinsic apoptotic and autophagic pathways and modulation of the AMPK/mTOR signaling axis. Molecular docking supported interactions between major phenolic compounds and key target proteins. These findings demonstrating that LSME exerts selective anticancer effects in HER2+ and HER2- breast cancer cells and highlighting its potential as a plant-based therapeutic candidate. © 2026 SAABArticle Citation - WoS: 30Citation - Scopus: 32Structural analysis and biological functionalities of iron(III)- and manganese(III)-thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies(Springer, 2019) Kaya, Büşra; Yılmaz, Zehra Kübra; Şahin, Onur; Aslim, Belma; Tükenmez, Ümmügülsüm; Ülküseven, BahriOne iron(III) and two manganese(III) complexes based on thiosemicarbazone were synthesized and characterized using analytical and spectroscopic data. The crystallographic analysis showed the square pyramid structures of the complexes. Electronic spectra analysis was performed to determine the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were examined by gel electrophoresis (pBR322 DNA). The cytotoxicity of the complexes was determined against human cervical carcinoma (HeLa) and human colorectal adenocarcinoma (HT-29) cell lines by MTT assay. The results indicated that complex Fe1 is bound to CT-DNA via the intercalation mode, while complexes Mn1 and Mn2 are bound to CT-DNA via groove binding and/or electrostatic interactions rather than the intercalation mode. In addition, they showed good binding activity, which followed the order of Fe1 > Mn2 > Mn1. Complexes were found to promote the cleavage of DNA from supercoiled form (SC, Form I) to nicked circular form (NC, Form II) without concurrent formation of Form III, revealing the single-strand DNA cleavage. No significant cleavage was found in the presence of Mn1 and Mn2; however, it was observed at 2000 and 3000 µM concentrations of Fe1. The ability of Fe1 to cleave DNA was greater than that of other complexes and these results are in conformity with their DNA-binding affinities. Cytotoxicity determination tests revealed that the complex Fe1 on HeLa and HT-29 cells exhibited a higher anti-proliferative effect than Mn1 and Mn2 (Fe1 > Mn2 > Mn1). These studies suggested that the complex Fe1 could be a good candidate as a chemotherapeutic drug targeting DNA.Article Citation - WoS: 30Citation - Scopus: 32Structural analysis and biological functionalities of iron(III)- and manganese(III)-thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies(SPRINGER, 2019) Kaya, Busra; Yilmaz, Zehra Kubra; Sahin, Onur; Aslim, Belma; Tukenmez, Ummugulsum; Ulkusever, Bahri; Ulkuseven, BahriOne iron(III) and two manganese(III) complexes based on thiosemicarbazone were synthesized and characterized using analytical and spectroscopic data. The crystallographic analysis showed the square pyramid structures of the complexes. Electronic spectra analysis was performed to determine the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were examined by gel electrophoresis (pBR322 DNA). The cytotoxicity of the complexes was determined against human cervical carcinoma (HeLa) and human colorectal adenocarcinoma (HT-29) cell lines by MTT assay. The results indicated that complex Fe1 is bound to CT-DNA via the intercalation mode, while complexes Mn1 and Mn2 are bound to CT-DNA via groove binding and/or electrostatic interactions rather than the intercalation mode. In addition, they showed good binding activity, which followed the order of Fe1>Mn2>Mn1. Complexes were found to promote the cleavage of DNA from supercoiled form (SC, Form I) to nicked circular form (NC, Form II) without concurrent formation of Form III, revealing the single-strand DNA cleavage. No significant cleavage was found in the presence of Mn1 and Mn2; however, it was observed at 2000 and 3000 mu M concentrations of Fe1. The ability of Fe1 to cleave DNA was greater than that of other complexes and these results are in conformity with their DNA-binding affinities. Cytotoxicity determination tests revealed that the complex Fe1 on HeLa and HT-29 cells exhibited a higher anti-proliferative effect than Mn1 and Mn2 (Fe1>Mn2>Mn1). These studies suggested that the complex Fe1 could be a good candidate as a chemotherapeutic drug targeting DNA. [GRAPHICS]
