Makale - Kitap Tanıtım Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/2468

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Browsing Makale - Kitap Tanıtım Koleksiyonu by Author "Keskin, Cumali"

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    Altın Nanopartiküllerin Yeşil Sentezi, Karakterizasyonu ve Biyouyumlu Yapılarının Biyomedikal Uygulamalarda (antibakteriyel, Antifungal ve Antikanser) Değerlendirilmesi
    (Kahramanmaras Sutcu Imam Univ Rektorlugu, 2023) Baran, Ayse; Keskin, Cumali
    Gold nanoparticles (AuNPs) stand out due to their low toxicity and high compatibility, and the large and modifiable surface areas they provide. In this study, the leaves of Celtis tournefortii Lam. (CT) were used for the green synthesis of gold nanoparticles (AuNPs) first time. The size, shape, surface charge, and functionality of the synthesized AuNPs are described in detail. The suggested mechanisms of action on the tested target cells are highlighted. The biological activities (antibacterial, antifungal, and anticancer) of "green" AuNPs and their further biomedical application possibilities are also discussed. Synthesized AuNPs displayed a spherical appearance, surface plasmon resonance band at 553.67 nm wavelength, and surface charge of -16.53 mV. Particle morphology, size, and surface charge were observed to be affected by the leaf extract used in the reduction reaction. FTIR and TGA-DTA data revealed that functional groups from the CT extract participate in the synthesis and stabilization of AuNPs. AuNPs showed antibacterial and antifungal effects on all the strains and yeast tested by microdilution method (MIC). AuNPs showed dose-dependent cytotoxic activity on cancerous cell lines (SKOV-3, CaCo2, and U118). The obtained results highlight a potentially low-cost green synthesis method using CT leaf extract to synthesize AuNPs showing important biological properties.
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    Citation - WoS: 56
    Citation - Scopus: 62
    Green synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extract
    (SpringerLink, 2023) Baran, Ayşe; Polat İpek, Mehmet Fırat Baran, Ayşe Baran, Abdulkerim Hatipoğlu, Cumali Keskin, Mahmut Yildiztekin, Selçuk Küçükaydin, Hatice Becerekli, Kadri Kurt, Aziz Eftekhari, Irada Huseynova, Rovshan Khalilov, William C. Cho; Baran, Mehmet Firat; Yildiztekin, Mahmut; Keskin, Cumali; Hatipoglu, Abdulkerim; Ipek, Polat; Cho, William C.
    Gold nanoparticles (Au NPs) have potentially therapeutic properties as they are synthesized via biomolecules as reducing and stabilizing agent(s). The aim of this study is to develop an easy and eco-friendly method for the synthesis of Au NPs using extracts from the Allium cepa (AC) red peel (skin) extract and investigate the antibacterial and antioxidant activity and also inhibitory efects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. UV–Vis peak at~564 nm confrmed the Au NPs absorbance. TEM images revealed the formation of Au NPs with mostly spherical shapes and sizes between 6.08 and 54.20 nm. FTIR analysis confrmed the important biological compounds responsible for the reduction of gold. The strong absorption property of Au NPs was studied by EDX. The produced Au NPs demonstrated signifcant antibacterial and antifungal activity against the bacterial and fungal strains tested, as well as efcient inhibitory activity against both AChE and BChE enzymes. The highest antimicrobial activities were found against Staphylococcus aureus (0.06° mg/ ml) and Candida albicans (0.06° mg/ml). The antioxidant test fndings revealed that AC-Au NPs had lesser activity when compared to normal antioxidants. The Au NPs showed excellent inhibitory efcacy against AChE and BChE. The proposed green technique could encourage the innocuous generation of Au NPs, implying therapeutic possibilities.