Browsing by Author "Cavusoglu, M."

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GC–MS and LC–MS/MS-Based Phytochemical Profiling and Bioactivities of Salvia Montbretii and S. Hydrangea: Antioxidant, Cytotoxic and Enzyme Inhibitory Potential
(John Wiley and Sons Ltd, 2026) Kolak, U.; Cavusoglu, M.; Akdeniz, M.; Yener, I.; Yılmaz, P.; Fırat, M.; Ertaş, A.
Salvia species are valuable natural resources due to their rich essential oils and bioactive compounds with applications in medicine, food, and cosmetics. In this study, essential oils and aroma components of S. montbretii and S. hydrangea were analyzed using GC–MS/FID and headspace GC–MS. Terpenoids were identified by GC–MS, while phenolic and flavonoid compounds were quantified by LC–MS/MS. Total phenolic and flavonoid contents, antioxidant capacities, and enzyme inhibitory activities were also evaluated. Caryophyllene was the dominant compound in S. montbretii essential oil and aroma samples, and camphor in S. hydrangea. GC–MS results indicated high levels of ursolic (54,675.22–1583.23 μg/g) and oleanolic acids (100,567.85–2592.11 μg/g), while LC–MS/MS revealed abundant rosmarinic acid (up to 27,0857–587.85 μg/g). All extracts exhibited moderate to strong antioxidant activities and notable inhibitory effects against urease and cholinesterase. Cytotoxic effects were observed on colon (Caco-2) and ovarian (SkOV3) cancer cell lines, along with toxicity in healthy cells (PDF). In conclusion, S. montbretii and S. hydrangea may serve as potential natural sources for pharmaceutical and cosmetic applications; however, detailed safety and dosage assessments are required prior to practical use due to the observed cytotoxic effects. © 2026 John Wiley & Sons Ltd.
Citation - WoS: 4
Citation - Scopus: 4
Crystal structure, IR and NMR spectra of (E)-2‑methoxy-4-(2-morpholinovinyl)phenol molecule and its DFT calculations
(ScienceDirect, 2023) Arici, K.; Altınoz, D.E.; Cavusoglu, M.; Diken, S.
In this study; molecular structure, IR and NMR spectroscopic properties of (E)-2–methoxy-4-(2- morpholinovinyl)phenol are investigated both experimentally and theoretically for the first time. The structural characterization of the compound was carried out by X-ray diffraction technique. The bond lengths, bond angles and dihedral angles of the compound were optimized using DFT with the B3LYP 6–311G(dp) base set. Using the optimized results, the infrared vibration frequencies and intensities of the compound as well as the 1H and 13C chemical shift values in the NMR spectrum were calculated with the B3LYP 6–311G(dp) basis set. In addition, the potential energy distributions (PED) of the structure were calculated to determine some characteristic vibrational frequencies of the compound. It is found that the theoretically calculated data support the experimental results. As a result, there is a good agreement between the experimentally determined structural parameters, vibrational frequencies, chemical shifts and theoretically calculated data of the compound.