Browsing by Author "Dogan, Serap"

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Preparation and Characterization of Silver-Loaded Magnetic Activated Carbon Produced From Crataegus Monogyna for Antimicrobial and Antioxidant Applications
(Wiley-v C H verlag Gmbh, 2025) Baran, Ayşe; Baran, Mehmet Fırat; Baran, Ayse; Baran, Mehmet Firat; Evcil, Murat; Kurt, Baris; Aslan, Kadir Sinan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Secondary metabolites from several plant species have been used to cure various illnesses. Current advances allowed green synthesis nanoparticle manufacturing of metal salts from plant sources. This study involves binding activated carbon obtained from the Crataegus monogyna plant to magnetic nanoparticles and coating the resulting magnetic activated carbon nanocomposite with Ag ions (CMAC/MNPs-Ag) to produce a biomedical nanobiological material. Various techniques such as SEM, EDX, XRD, FTIR, UV-Vis, VSM, DLS, and zeta potential were used to characterize synthesized nanocomposites. CMAC/MNPs-Ag nanocomposite demonstrated activity in several processes of antioxidant activity tests. DPPH and CUPRAC activities of CMAC/MNPs-Ag nanocomposite were measured as 90.21 +/- 0.42 and 46.73 +/- 0.108 mg TE/g, respectively, while total phenolic content was measured as 27.15 +/- 0.381 mg GAE/g. Finally, the antibacterial activity of CMAC/MNPs-Ag nanocomposite was evaluated against Escherichia coli and Staphylococcus aureus by microdilution and disk diffusion techniques. The antimicrobial activity of CMAC/MNPs-Ag nanocomposite was determined using microdilution and disk diffusion techniques. For Escherichia coli, microdilution and disk diffusion were measured as 1.17 mu g mL-1 and 12 mm, respectively, while for Staphylococcus aureus, microdilution and disk diffusion were measured as 2.34 mu g mL-1 and 10 mm, respectively.
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Citation - Scopus: 0
Silver Nanoparticles for Anticancer and Antibacterial Therapy: a Biogenic and Easy Production Strategy
(Wiley-v C H verlag Gmbh, 2025) Baran, Ayşe; Baran, Mehmet Fırat; Baran, Mehmet Firat; Eftekhari, Aziz; Khalilov, Rovshan; Aliyev, Elvin; Smutok, Oleh; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Metal nanoparticles are very valuable products due to their wide range of uses. Among these silver nanoparticles are beneficial products used in many fields, especially in medicine, due to their antibacterial properties. This research aimed to produce silver nanoparticles (Ag NPs) that are both affordable and environmentally friendly. For this purpose, Ag NPs were quickly obtained from domestic waste components of the carrot plant (Daucus carota L.). The UV-vis spectrophotometric, TEM, AFM, FE-SEM, STEM, EDX, XRD, and DLS analyses were performed to determine the properties of the obtained Ag NPs. It has been found that their surface charge is -21.8 mV, with a maximum absorbance at a wavelength of 421.37 nm, spherical appearance, and an average size distribution of 85.41 nm. The anticancer and antibacterial activities of the produced Ag NPs were investigated by MTT and microdilution. The synthesized Ag NPs showed the most significant antimicrobial effect on Pseudomonas aeruginosa ATCC 27833 with microdilution and low concentration. However, they were also determined to be effective on Bacillus subtilis ATCC 11774 and on Candida albicans ATCC 10231 pathogenic strains. In fact, the effective concentrations of Ag NPs on these strains were significantly lower than the antibiotics used. Furthermore, aside from exhibiting a superior anticancer impact on CaCO-2 cancer cells, it was established that Ag NPs also had remarkable efficacy in inhibiting U118 and Skov-3 cancer cells.
Yarı Kurak İklim Şartlarında Ekmeklik Buğday (Triticum Aestivum L.) Çeşitlerinde Verim ve Bazı Kalite Unsurlarının Belirlenmesi
(2023) Doğan, Yusuf; Doğan, Serap; Dogan, Serap; Dogan, Yusuf; Department of Plant Protection / Bitki Koruma Bölümü; Department of Irrigation / Sulama Bölümü
Bu araştırma, Mardin ili ve çevresinde yaygın olarak yetiştirilen 10 ekmeklik buğday çeşidinin verim unsurları, tane verimi ve bazı kalite faktörlerinin ortaya konulması amacıyla yapılmıştır. Çalışma, Mardin-Kızıltepe koşullarında 2019-20 ve 2020-21 yetiştirme sezonlarında yağışa dayalı şartlarda Tesadüf Blokları Deneme Desenine göre 3 tekerrürlü olarak yürütülmüştür. Varyans analiz sonuçlarına göre; bitki boyu 83.7-102.0 cm; başak uzunluğu 11.0-14.2 cm; başakta tane sayısı; yüz tane ağırlığı 30.5-38.8 g; biyolojik verim 582.5-644.1; hasat indeksi %30.1-38.9; hektolitre 72.2-80.4 kg/hl; protein oranı %13.1-15.8 ve tane verimi 176.9-247.7 kg da-1 arasında değiştiği tespit edilmiştir. Çeşitlerin incelen özellikleri bakımından önemli farklılıklar ortaya çıkmıştır. Tane verimi ve yüz tane ağırlığı bakımından en yüksek değerler Ceyhan-99 çeşidinde elde edilirken, protein oranı ve hektolitre değerleri bakımından Dinç çeşidi üstün çıkmıştır. Bu çalışmada Ceyhan 99, Pehlivan ve Sgittario çeşitleri tane verimi için Mardin ili ve çevresine önerilebilir.