Browsing by Author "Güneş, Zübeyir"

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Determination of Volatile Organic Compounds in Different Parts of Hibiscus Syriacus L. by Spme/Gc-ms Method
(2024) Koyuncu, Mubin; Karadağ, Musa; Baran, Ayşe; Güneş, Zübeyir
Aromatic plants are plants with a wide range of traditional uses. One of the areas of medical use is their consumption for nutritional purposes. Aromatic plants have been used for thousands of years for their preservative and medicinal properties and for enhancing the aroma and flavor of foods. Hibiscus species L. are among the aromatic plants widely used in Türkiye. Studies have shown that Hibiscus species L. have antiinflammatory, antibacterial, antifertility, antifungal, antioxidative, antihypertensive, and hypoglycaemic effects. The use of aromatic plants for therapeutic purposes for centuries has made their compounds the research subject. Gas chromatography-mass spectroscopy (GC-MS) was combined with solid phase microextraction (SPME) to determine volatile organic compounds. Twenty-nine volatile organic compounds were determined from different parts of H. syriacus L. species. The compounds with the highest content are carvacrol, thymol, eucalyptol, and linalool. The compounds with the highest ratios determined in the flower, seeds, leaves, and buds of Hibiscus syriacus L. were carvacrol (57.93 %), carvacrol (31.50 %), thymol (44.53 %) and carvacrol (54.54 %), respectively.
Herbalists and herbs in Southeastern Anatolia of Turkey
(Emirates Journal of Food and Agriculture, 2021) Acıbuca, Veysi; Güneş, Zübeyir; Bostan Budak, Dilek
In this study, interview technique (face to face) was used to collect data from 56 herbalists in three provinces of the Southeastern Anatolia Region of Turkey (Mardin, Diyarbakir and Sanliurfa). The main purpose of the study was to determine the education level, learning methods of their job, professional experiences, the parts of the plants used and the problems of the herbalists. The average age of the herbalists were 41,7 and majority of them had a high school diploma. They learned this job mainly from older family members or working at the herbal shop. They mainly obtained their products from local people and wholesalers. Especially spices, food supplements, treatments, cosmetic and weight loss products were sold by herbalists.
Investigation of the Effect of Cuscuta Spp. Extract on Cell Viability
(2025) Öziç, Cem; Baran, Ayşe; Aktepe, Necmettin; Güneş, Zübeyir; Baran, Mehmet Firat
Cancer is becoming an increasingly serious health problem worldwide. While various treatment approaches exist for diseases like colorectal cancer, they have not yet been found to be fully effective. Therefore, the development of new anti-cancer drugs is crucial. Cuscuta is a plant used in functional foods and for traditional medicinal purposes in various cultures, including Ayurveda and its medicinal traditions, which are widespread throughout the world. In preclinical studies, Cuscuta spp. have demonstrated anticytotoxic and cytoprotective properties and potential anticancer effects, particularly in various cell lines and animal models. Fibroblasts are scientifically proven to be the primary normal cell type of connective tissue, typically mesenchymal in origin. This is represented by the laboratory L929 mouse fibroblast cell line. Colorectal cancer is the third most common cancer worldwide and the third most common cause of cancer-related death. Our study aimed to determine the cytotoxic effects of Cuscuta spp extract, known to have medicinal effects in various diseases in public health, on the L929 mouse fibroblast cell line and the HT-29 human colorectal adenocarcinoma cell line. For cytotoxic analysis, the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] enzymatic test was preferred. In vitro testing using Cuscuta spp extract revealed decreased viability in L929 fibroblast cell line and HT-29 human colorectal adenocarcinoma cells exposed to Cuscuta spp plant extract for 24 and 48 hours. The plant extract showed more cytotoxic effects on fibroblast cells, a normal cell line. In conclusion, this study demonstrates that Cuscuta spp. extract exhibits high cytotoxicity on normal cells and has limited effects on cancer cells. Further studies are needed for its pharmacological use.