Browsing by Author "Gungoren, Muhammed"

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Citation - WoS: 2
Citation - Scopus: 2
Docetaxel-Loaded, Dipeptide-Functionalized Γ-Fe2o3 Magnetic Nanoparticles: Synthesis, Characterization, and Targeting To Prostate Cancer
(Wiley-VCH Verlag GmbH, 2025) Gungoren, Muhammed; Koyuncu, Ismail; Kilinc, Ersin; Baysal, Zubeyde
A new delivery system was designed and synthesized to increase the efficiency of docetaxel. For this aim, gamma-Fe2O3 was synthesized in order to give the nanoparticle the ability to be magnetic targeted. It was functionalized with citric acid to prevent clumping and maintain stability. To increase the interaction efficiency between the delivery system and the drug, leucine-glycine dipeptide and an amphiphilic polymer, Pluronic F127, were attached to the nanoparticle. Characterization studies were carried out with XRD, ICP-MS, vibrating sample magnetometer (VSM), TEM, and zeta potential to elucidate the structure of this carrier system. After docetaxel was bound to the synthesized carrier, its therapeutic effect was measured by spectrophotometric and flow cytometric methods (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide [MTT], reactive oxygen species [ROS], and apoptosis). Docetaxel-bound nanoparticles significantly reduced the viability of the tumor cell compared to the healthy cell in a dose-dependent manner, especially at 24 (50.14 +/- 13.25 to 22.32 +/- 5.51 at 100 mu g/mL) h and 48 (41.46 +/- 2.22 to 18.80 +/- 2.81 at 100 mu g/mL) h. The rate of apoptosis and ROS in the negative sample increased from 2.7% to 15.4% and from 9.6% to 74.7%, respectively, as a result of treatment with 15 mu g/mL gamma-Fe2O3/C/LG/F127/Dotx. Thus, it can be said that the synthesized carrier system is a suitable candidate for the improvement of docetaxel transport.
Citation - WoS: 3
Citation - Scopus: 3
Phytochemical Factor Analysis of Some Extra Virgin Olive Oils (olivae Oleum) and the Effects of Storage Under Different Conditions-Simulating General Consumer Behavior
(Springer, 2024) Gungoren, Muhammed
Olive oil, one of the foods that has a wide place in production and consumption worldwide, is considered important in terms of taste and health, thanks to the components it contains. However, incorrect approaches to storing this seasonally produced food cause significant losses for many consumers. In this study, by simulating a general consumer behavior, three extra virgin olive oils (EVOO) produced annually were procured and stored under different conditions for 6 months; and the effects of time, temperature, and light parameters were examined. The phytochemical properties of olive oils were analyzed and repeated after 3 and 6 months. During the process, negative changes occurred in free fatty acid values from 0.51 +/- 0.01 to 2.04 +/- 0.01 (oleic acid%), total phenolic content amounts from 481.77 +/- 3.24 to 96.02 +/- 0.94 (mg GAE/kg oil), total antioxidant capacity from 215.93 +/- 1.67 to 11.21 +/- 0.17 (mg TE/kg oil), and peroxide values from 13.58 +/- 0.34 to 31.96 +/- 0.85 (meq O-2/kg). Oleic acid ratios were between 66.37 +/- 1.09% (Halhal & imath;) and 72.97 +/- 1.19% (Memecik) in all processes and samples. No defect was detected in sensory test results for up to 6 months. Among the most important phenolic components, hydroxytyrosol (max 33.18 +/- 0.81 mg/kg) and tyrosol (max 3.93 +/- 0.03 mg/kg) showed a fluctuating change, and oleuropein (max 7.40 +/- 0.12 mg/kg) tended to decrease. Statistical results performed with all samples and parameters using principal component analysis showed that oleic acid, linoleic acid, hydroxytyrosol, total unsaturated fatty acid values, some terpenes, and C6 volatile components were the most characteristic components for the oils studied. Additionally, the results showed that time was more effective than temperature and light variables in storage.
Güneydoğu Anadolu Bölgesindeki Üç Farklı İlin Üzümlerinin GC-FID Metoduyla Yağ Asitlerinin Karşılaştırılması
(2019) Atalar, Mehmet Nuri; Baran, Mehmet Fırat; Umaz, Adil; Gungoren, Muhammed
Bu çalışmada Mardin, Diyarbakır ve Gaziantep kuru üzümlerinin yağ asit düzeyleri belirlendi. Mardin kuru üzümünün yağ asit düzeyleri ΣPUFA % 49.60, ΣMUFA % 29.61, ΣUSFA % 79.21 ve ΣSFA % 22.02 olarak, Diyarbakır kuru üzümünün yağ asit düzeyleri ΣPUFA % 22.80, ΣMUFA % 37.72, ΣUSFA % 60.58, ΣSFA % 40.45 ve Gaziantep kuru üzümünün yağ asit düzeyleri ΣPUFA % 44.77, ΣMUFA % 27.34, ΣUSFA % 72.12, ΣSFA % 28.62 olarak tespit edildi. Mardin ve Gaziantep kuru üzümünün linoleik asit (18:2n6c) düzeyi yüksek çıkarken Diyarbakır kuru üzümünün oleik asit (18:1n9c) ve palmitik asit (16:0) düzeylerinin yüksek çıktığı gözlendi.