Ebelik Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/225

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Citation - WoS: 17
Citation - Scopus: 15
Alpha-lipoic acid may ameliorate testicular damage by targeting dox-induced altered antioxidant parameters, mitofusin-2 and apoptotic gene expression
(Andrologia, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Tektemur, Ahmet; Department of Midwifery/ Ebelik Bölümü
In the study, the ameliorating effects of alfa lipoic acid (ALA) against doxorubicin-induced testicular apoptosis, oxidative stress and disrupted mitochondrial fusion were investigated in male rats. Rats were divided into four groups as control, doxorubicin (DOX), DOX + ALA and ALA. A single dose of 15 mg/kg DOX was administered i.p to the DOX and DOX + ALA groups. 50 mg/kg ALA was given to the DOX + ALA and ALA groups by oral gavage every other day. After 28 days, rat testes and serum samples were collected and analysed. Administration of DOX alone caused a decrease in body and relative testicular weights, seminiferous tubule diameter and germinal epithelium thickness, Johnsen's score and serum testosterone levels. DOX treatment led to severe testicular damage such as tubular degeneration, and atrophic tubules. Also, the activities of superoxide dismutase and glutathione peroxidase were reduced, while the level of malondialdehyde was increased in the testis. The mRNA levels of apoptotic-related genes (CASP3, TP53, BAX, BCL2) and apoptotic index were increased, while mitofusin-2 decreased. DOX caused an increase in CASP3 and a decrease in mitofusin-2 immunoreactivities. Treatment with ALA markedly improved all of DOX-induced biochemical, histochemical and molecular alterations in rat testis. Consequently, ALA has a therapeutic role in ameliorating DOX-induced testicular damage in rats.
Citation - WoS: 8
Citation - Scopus: 11
The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats
(Wiley, 2021) Erdem Güzel, Elif; Acay, Hilal; Yıldırım, Ayfer; Acay, Hilal; Yıldırım, Ayfer; Department of Midwifery/ Ebelik Bölümü; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
This study was conducted to evaluate the protective role of Pleurotus eryngii extract (PE) and Pleurotus eryngii extract-loaded chitosan nanoparticles (PE-CSNP) against doxorubicin (DOX)-induced testicular toxicity in rats. Male rats were divided into six groups: control (DMSO/ethanol), PE (200 mg/kg PE), PE-CSNP (30 mg/kg PECSNP), DOX (10 mg/kg DOX, a single dose, i.p), DOX+PE (10 mg/kg DOX+200 mg/ kg PE) and DOX+PE-CSNP (10 mg/kg DOX+30 mg/kg PE-CSNP). PE and PE-CSNP were administered by oral gavage every other day for 21 days. DOX-treated rats showed histopathological impairment compared with the control group. There was an increase in the apoptotic index, caspase 3 (CASP3), BCL2-associated X apoptosis regulator (BAX), dynamin-related protein 1 (DRP1) expression and total oxidative status (TOS) in the DOX group, while mitofusin-2 (MFN2), total antioxidative status (TAS) and serum testosterone levels of the DOX group reduced when compared with the other groups. PE and PE-CSNP treatments provided significant protection against DOX-induced oxidative stress by reducing TOS levels and increasing TAS levels. CASP3, BAX, apoptotic index and DRP1-MFN2 expressions were restored by PE and PE-CSNP. However, the PE-CSNP showed higher antioxidant and anti-apoptotic efficacy compared with PE. Thus, our results provide evidence that CSNP and PE could synergistically have a potent antioxidant and anti-apoptotic therapy against DOX-induced testicular damage in male rats.
Citation - WoS: 8
Citation - Scopus: 9
Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat
(Taylor & Francis Online, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Tektemur, Ahmet; Etem Önalan, Ebru; Department of Midwifery/ Ebelik Bölümü
Carbamazepine (CBZ) is the antiepileptic drug used in epilepsy and some psychiatric disorders. Besides its widely used, many adverse effects have been reported including hematotoxicity, hepatotoxicity, endocrine disorders, and testicular damages due to oxidative stress. However, the role of CBZ on renal toxicity is not fully known. In this study, we attempted to explain the connected mechanisms by focusing on the metabolism of CBZ-induced renal toxicity in rats. Twenty male Wistar-Albino rats were randomized into 2 groups (n = 10); control (1 mL/day distilled water, orally) and CBZ (25 mg/kg/day CBZ, orally) groups. After 60 days, TAS (total oxidant status) and TOS (total oxidant status) levels, histopathological features, some genes involved in apoptosis, 8-hydroxy-2-deoxyguanosine (8-OHdG) activity, and apoptotic cells were assessed of kidney tissue. The oxidative stress index (OSI) was measured from TAS and TOS levels. TOS levels and OSI significantly increased, while TAS levels decreased in the CBZ group relative to the control group. Histopathological observations, Caspase-3 (Casp3), Poly [ADP-ribose] polymerase-1 (PARP-1), 8-OHdG immunoreactivities, and apoptotic cells markedly raised in the CBZ group compared with the control group. Also, mRNA expression of Cytochrome c (Cytc) and CASP3 significantly increased in the CBZ group compared to the control group. In conclusion, long-term use of CBZ may promote renal damage in rats by inducing oxidative stress and apoptosis.
Citation - WoS: 3
Citation - Scopus: 3
Chronic effects of maternal tobacco-smoke exposure and/or α-lipoic acid treatment on reproductive parameters in female rat offspring
(Taylor & Francis Online, 2020) Erdem Güzel, Elif; Nalan Kaya, Ahmet Tektemur, Nazife Ulker, Ahmet Yardimci, Ramazan Fazil Akkoc, Sinan Canpolat & Ibrahim Enver; Department of Midwifery/ Ebelik Bölümü
Prenatal tobacco-smoke exposure negatively affects the reproductive functions of female offspring and oxidative stress plays a major role at this point. Alpha-lipoic acid (ALA), well known as a biological antioxidant, has been used as a nutritional supplement and as a therapeutic agent in the treatment of certain complications during pregnancy. We aimed to investigate the effects of maternal tobacco-smoke exposure and/or ALA administration on puberty onset, sexual behavior, gonadotrophin levels, apoptosis-related genes, apoptotic cell numbers and oxidative stress markers in the adult female rat offspring. Sprague-Dawley rats were divided into four groups; control, tobacco smoke (TS), TS+ALA and ALA groups. Animals were exposed to TS and/or ALA for 8 weeks before pregnancy and throughout pregnancy. All treatments ended with birth and later newborn female rats were selected for each experimental group. The experiment ended at postnatal day 74-77. Maternal tobacco smoke advanced the onset of puberty in the female offspring of the TS group (p < 0.05). In all treatment groups; the mean number of anogenital investigations and lordosis quality scores showed a decline, serum luteinizing hormone levels significantly increased (p < 0.05) and several histopathological changes in ovaries were observed compared to the control group. In addition, an increase in apoptotic marker levels and apoptotic cell numbers was detected in the ovaries of all treatment groups. Decreased TAS and increased TOS levels were detected in all treatment groups compared to control. These findings suggested that maternal tobacco smoke and/or ALA administration may be leading to the impaired reproductive health of female offspring. Abbreviations: ALA: alpha-lipoic acid; LH: luteinizing hormone; FSH: follicle-stimulating hormone; TAS: total antioxidant status; TOS: total oxidant status; Apaf1: apoptotic protease-activating factor 1; Casp3: caspase 3; Casp9: caspase 9; CF: cyst follicles; 4-HNE: 4-Hidroxynonenal; 8-OHdG: 8-hydroxydeoxyguanosine; TUNEL: terminal deoxynucleotidyl transferase-mediated deoxyuridine-biotin nick end labeling; ROS: reactive oxygen species; GnRHR: gonadotropin-releasing hormone receptor; HPG: hypothalamic-pituitary-gonadal; AMPK: AMP-activated protein kinase; ELISA: enzyme-linked immunosorbent assay; cDNA: complementary DNA; qPCR: quantitative real-time PCR; FC: follicular cysts; PF: primary follicle; SF: secondary follicle; GF: graafian follicle; CL: corpus luteum; DF: degenerated follicle; AF: atretic follicle.
Citation - WoS: 3
Citation - Scopus: 3
Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats
(Elsevier, 2020) Erdem Güzel, Elif; Ramazan Fazil Akkoc, Ahmet Tektemur, Nazife Ulker, Nalan Kaya Tektemur, Elif Erdem Güzel, Sinan Canpolat, Ibrahim Enver Ozan; Department of Midwifery/ Ebelik Bölümü
Background: Tobacco use during pregnancy is known to have several negative effects on the offspring's reproductive health in the long term. The use of alpha-lipoic acid (ALA) as a dietary supplement during pregnancy has increased greatly in recent years and has been known to have positive effects on various pregnancy outcomes including miscarriage, diabetic embryopathy, preterm delivery, and congenital malformations. Aim: To evaluate the effects of tobacco smoke exposure (TSE) on sexual behavior, reproductive parameters, and testicles in adult male rats and to reveal the possible role of ALA administration on these parameters. Methods: Pregnant rats (n = 7 per group) were treated with tobacco smoke (TS), ALA (20 mg/kg), and TS + ALA for a total of 11 weeks. The following parameters were compared with 8 control rats: puberty parameters, sexual behavior; levels of serum gonadotropins and testosterone, total antioxidant status, and total oxidant status; the expression of the apoptotic protease-activating factor-1 and caspase 9 mRNA levels in the testis; and assessment of immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling assay of testis. Main Outcome Measure: Sexual behavior, changes in puberty parameters, and hormonal and genetic alterations were the outcomes analyzed in this study. Results: Maternal TSE caused a significant decrease in the number of intromissions compared to the control group. Similarly, ALA decreased erectile function in sexual behavior by decreasing the number of intromissions and intromission ratio in the ALA group compared to the control group. In addition, TSE and ALA treatment caused an impairment of some consummatory sexual behaviors. Also, in parallel with this inhibitory effect, the age of pubertal onset was significantly delayed in the TS + ALA group compared to other groups. Also, histopathological changes in testicular tissue, oxidative stress markers, apoptotic index, and mRNA levels of apoptosis-related genes increased in all treatment groups. Clinical Implications: The use of ALA and/or tobacco products during pregnancy may adversely affect the reproductive health of male newborns in the long term. Strengths & Limitations: To the best of our knowledge, this study is the first to show the effects of maternal ALA treatment and/or TSE on the sexual behavior and reproductive parameters in male rats; however, the study is based on an animal model, and the present findings partially reflect the characteristics of human sexual behavior. Conclusion: Maternal TSE and/or ALA treatment may impair sexual behavior in adulthood in male rats because of testicular damage caused by oxidative stress during gonadal development. Yardimci A, Akkoc RF, Tektemur A, et al. Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats. J Sex Med 2020;17:1835–1847.
Citation - WoS: 3
Citation - Scopus: 4
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice
(Ultrastructural Pathology, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Gül, Mehmet; Tektemur; Özcan Yıldırım, Sena; Kavak Balgetir, Merve; Ozan Kocamüftüoğlu, Gonca; Yalçın, Tuba; Ozan, & İbrahim Enver; Department of Midwifery/ Ebelik Bölümü
Acetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in worldwide. N-acetyl cysteine (NAC) is used as the APAP antidote. Cyclosporin A (CsA) is suppressed mitochondrial damage by binding cyclophilin, a mitochondrial pore transport component. The study aimed to evaluate the effects of NAC, CsA, and NAC+CsA treatments on APAP-induced hepatotoxicity in mice. Mice were randomly divided into five groups (n = 6). 400 mg/kg/ip/single dose APAP, 1200 mg/kg/i.p/single dose NAC and 50 mg/kg/i.p/single dose CsA were performed. Light and electron microscopic alterations were investigated in liver samples. Levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and liver glutathione (GSH) were analyzed. 3-nitrotyrosine and cytochrome c immunoreactivities were evaluated in liver tissue. Here, we found that APAP leads to histopathological and ultrastructural changes in mice liver. Also, APAP increased cytochrome c and 3-nitrotyrosine immunopositive staining. Besides, a significant decrease in liver GSH and an increase in serum AST and ALT levels were detected in the APAP group. Interestingly, NAC+CsA treatment improved histological alterations, cytochrome c, and 3-nitrotyrosine immunoreactivities and liver GSH, serum AST/ALT levels caused by APAP. We suggest that the combination of NAC and CsA reduces acetaminophen-induced hepatotoxicity in mice.
Citation - WoS: 1
The Effect of a Gender Course on the Gender Attitudes, Critical Thinking Dispositions, and Media Literacy Skills of University Students
(Yükseköğretim Dergisi, 2021) Koç, Gülten; Yücel Özçırpan, Çiğdem; Terzioğlu, Füsun; Şimşek Çetinkaya, Şahika; Uslu-Şahan, Fatma; Akın Işık, Rabiye; Evrenol Öçal, Simge; Cansu Akdağ Topal, Merve Mert Karadaş, Sevda Yıldırım Hamurcu, Pınar Uzunkaya Öztoprak , Ayşe Sevim Akbay Kıs, İlknur Atasever, Safiye Özkan, Beril Nisa Yaşar, Esra Başkaya
This study aims to determine the effect of a university elective course focusing on gender on students' gender attitudes, critical thinking dispositions, and media literacy skills. The research design was quasi-experimental, and the study was conducted with a pretest/posttest control group. The sample of the study consisted of 74 students who took a course on gender during the fall semester of the 2016-2017 academic year and 70 students who had similar characteristics but did not receive the course. In the pretest and posttest evaluation conducted in the first week and the last week of the semester, respectively, the Student Information Form, the Gender Roles Attitude Scale (GRAS), the Critical Thinking Dispositions Scale (CTDS), and the Media Literacy Scale (MLS) were administered to the students in both groups. The Course Satisfaction Assessment Form was administered at the end of the term to the students who enrolled for the gender course. The GRAS scores of the experimental group increased at the end of the course (p<0.05). The GRAS total mean scores of both the groups were similar in the pretest, but there was a statistically significant difference between their total mean scores in the posttest (p<0.05). This study recommends more comprehensive and long-term studies on integrating a gender course into the university curriculum, which will help develop students' critical thinking disposition and media literacy skills and raise awareness of gender equality among students.
Citation - WoS: 1
Citation - Scopus: 1
Effect of Auricular Acupressure in Management of Constipation in Palliative Care Patients
(Sage Journals Home, 2023) Bıçak Ayık, Derya; Can, Gülbeyaz; Department of Midwifery/ Ebelik Bölümü
Objectives: This experimental randomized-controlled study was performed to define the efficacy of auricular acupressure (AA) in the management of constipation developing in palliative care patients. Methods: According to the pre-prepared randomization list, 44 patients were included in the experimental group and 46 patients were included in the control group. Routine clinical treatment and care implementation were maintained in the patients in both groups. AA was performed for 4 weeks in patients in the experimental group. During the study, to determine the complaints of the patients regarding constipation, the information in the daily patient chart was examined at least 5 times by interviewing with the patient/patient's relative in the clinic and/or via phone call, and the results were recorded in the patient chart and data collection forms. The independent variable of the study is AA application, and the dependent variables are constipation and quality of life. Results: It was determined that there was no statistically significant difference between the daily defecation frequency of the 2 groups during the first 11 days. However, after the 12th day, the daily stool frequency of the experimental group was higher compared to the control group and this difference obtained between the 2 groups was statistically significantly different. AA was effective in decreasing laxative use. Conclusion: This intervention increased stool frequency, reduced physical and psychosocial symptoms, anxieties, and improved stool satisfaction and it was an effective approach to improving the quality of life. It is recommended that the daily use of AA should be evaluated. The healthcare providers including nurses, patients, and patient relatives should be trained regarding AA.
Citation - WoS: 0
Citation - Scopus: 0
Effect of Delivery Method on Breastfeeding Status in Primiparous Mothers Within the First 24 Hours
(Springer Publishing Co, 2024) Yeşil, Yeşim; Bay, Habibe; Celik, Gulbiye Dinc; Bay, Habibe; Eksioglu, Aysun; Turfan, Esin Ceber; Department of Midwifery/ Ebelik Bölümü; Department of Nursing / Hemşirelik Bölümü
Objective: This study aims to evaluate the effect of the delivery method on breastfeeding status of primiparous mothers during the first 24 hours. Methods: In this descriptive and analytical study, the sample consisted of 126 primiparous mothers with vaginal (n = 54) and cesarean (n = 72) deliveries. The research data were collected in a hospital through a personal information form and LATCH. Breastfeeding was assessed at the 6th, 12th, and 24th hours within the first 24 -hour period after the delivery. Results: A total of 83.3% of mothers with vaginal delivery started out breastfeeding in the first hour, while the rate was 43.1% for mothers with cesarean delivery. A total of 94.4% of mothers who had vaginal birth gave their babies colostrum, whereas the rate was 80.6% for mothers who had a cesarean birth. While there were no statistically significant differences in Applications 1 and 3 between the LATCH scores of mothers with vaginal and cesarean deliveries, Application 2 produced a significant difference (p < .05). Conclusions: Delivery method influenced the breastfeeding behavior and had an impact particularly on initiation of breastfeeding in the first hour.
Citation - WoS: 26
Citation - Scopus: 37
The effect of ethnocentrism and moral sensitivity on intercultural sensitivity in nursing students, descriptive cross-sectional research study
(Nurse Education Today, 2021) Yaşar, Beril Nisa; Kaya, Yunus; Arslan, Sevda; Erbaş, Atiye; Küçükkelepçe, Gürhan Erkuş; Department of Midwifery/ Ebelik Bölümü
Background: Factors affecting intercultural sensitivity and care are becoming an increasingly important issue due to ethnic diversity. Nurses play a crucial role in care and therefore should keep up with this trend and improve their intercultural sensitivity. Objective and design: This descriptive cross-sectional study investigated the effects of ethnocentrism and moral sensitivity on intercultural sensitivity in nursing students. Methods and participants: Data were collected using a demographic characteristics questionnaire and the Intercultural Sensitivity Scale, Generalized Ethnocentrism Scale, and Moral Sensitivity Scale. The sample consisted of 1343 nursing students. The Pearson correlation coefficient was used to determine correlations between scale scores. Multiple linear regression was used to determine the effects of ethnocentrism, moral sensitivity, and demographic characteristics on intercultural sensitivity. Results: Intercultural sensitivity was found to be negatively correlated with ethnocentrism and positively correlated with moral sensitivity. Ethnocentrism predicted intercultural sensitivity more than moral sensitivity. Ethnocentrism and moral sensitivity explained 16.8% of the total variance of intercultural sensitivity. However, ethnocentrism affected intercultural sensitivity more than moral sensitivity did (beta = −0.406). Conclusion: Nursing education should adopt strategies to reduce ethnocentrism by helping students develop cultural competence and intercultural sensitivity. Such education can equip nurses to provide higher quality care to patients of different cultural backgrounds.
Citation - WoS: 4
Citation - Scopus: 5
Effect of Foot Massages on Postpartum Comfort and Pain Level of Mothers after Vaginal Delivery: A Randomized Trial
(Holistic Nursing Practice, 2021) İçke, Sibel; Genç, Rabia; Department of Midwifery/ Ebelik Bölümü
This study conducted on 66 mothers aimed to investigate the effect of foot massages postpartum using an introductory information form, the Postpartum Comfort Scale, the visual analog scale, and a drug follow-up card. It was concluded that foot massages positively improved comfort, reduced pain levels, and reduced unnecessary medications.
Citation - Scopus: 5
The effect of hospital-based breastfeeding group education given early perinatal period on breastfeeding self-efficacy and breastfeeding status
(ScienceDirect, 2022) Yeşil, Yeşim; Ekşioğlu, Aysun; Ceber Turfan, Esin; Department of Midwifery/ Ebelik Bölümü
Aim: This study was conducted to examine the effect of hospital-based group breastfeeding education provided to mothers before discharge from the hospital on mothers’ self-efficacy and on the increase of breastfeeding rates. Methods: This randomized controlled educational research was conducted in the hospital is located in the West of Turkey. Ninety mothers who had healthy and term babies, and an intent to breastfeed their babies participated in the study. The questionnaire forms were collected by the researcher using face to face interview technique. Chi-square, dependent and independent groups t-test and ANOVA analysis were used along with descriptive statistics in analyzing the data. Results: Compared to the control group, the scores obtained from the Breastfeeding Self-Efficacy Scale were higher in the education group in all the follow-ups. Similarly, status of exclusive breastfeeding was higher in the education group compared to the control group. In the twelfth week, the rate of exclusive breastfeeding was 80.0% in the education group, while it was 47.5% in the control group. Conclusion: These results show that breastfeeding group education and follow-up counseling given before discharge from the hospital were effective. This is evidence in favor of increasing the use of group education. This RCT was registered NCT04515862 with www.clinicaltrials.gov on 2020.
The effect of pregnant Women's family sense of coherence on the fear of COVID-19
(Medicine Science, 2022) Filoğlu Ersü, Nilay; Filoğlu Ersu, Nilay; Department of Midwifery/ Ebelik Bölümü
This work aims to define the impact of pregnant women’s family sense of coherence on the fear of COVID-19. The population of this correlational descriptive working comprised a total of 1118 pregnant women recorded to family health centers in a city center of an eastern province of Turkey. Its sample consisted of 320 pregnant women. The data were collected using the Google form between the dates of November 2020 and May 2021. A personal information form, the Fear of COVID-19 Scale, and the Family Sense of Coherence Scale were used to collect the data. The descriptive statistics (mean, percentage, and standard deviation) were used in analyzing the data, and t-test, analysis of variance, correlation, and regression analysis were used for the independent groups. The mean age of the participants was 28.40±4.70. The study found a negative and weak correlation between the pregnant women’s fear of COVID-19 and family sense of coherence (r:-0.179; p<0.01, Table 3). It also discovered that family sense of coherence explained the fear of COVID-19 at a rate of 3% (β=-0.179; p<0.01). The study found that pregnant women’s family sense of coherence had a positive effect on against reducing fear of COVID-19.
Citation - WoS: 1
Citation - Scopus: 2
Effects of Concomitant Use of N-acetylcysteine and Cyclosporine A on Acetaminophen-induced Acute Kidney Injury in Mice
(Agricultural Research Communication Centre, 2024) Erdem Güzel, Elif; Tektemur, Nalan Kaya; Guzel, Elif Erdem; Tektemur, Ahmet; Ozan, Ibrahim Enver; Department of Midwifery/ Ebelik Bölümü
Background: Acetaminophen (APAP), a commonly used analgesic, causes acute kidney injury (AKI) in overdose although it is rare. Mitochondrial dysfunction plays a major role in the pathophysiology of renal damage, although the exact molecular mechanism is unknown. This study aimed to evaluate the potential therapeutic effect of cyclosporin A (CsA), a mitochondrial membrane permeability Methods: Male BALB/c mice were divided into Control, APAP, APAP+NAC, APAP+CsA and APAP+NAC+CsA groups (n=6). A single dose of APAP (400 mg/kg) was administered intraperitoneally. All other treatments (1200 mg/kg NAC, 50 mg/kg CsA) were performed intraperitoneally 3 h after APAP administration. All animals were decapitated and blood samples and kidney tissue samples were collected for evaluation. Serum creatinine (Cr) and blood urea nitrogen (BUN) levels were measured. The kidney tissue 8-hydroxydeoxyguanosine (8-OHdG), cytochrome c (Cytc) and 3-nitrotyrosine (3-NT) levels and cytochrome c (Cytc) expressions were determined. Result: Increased Cr and BUN levels, histopathological examinations and expressions of 8-OHdG, 3-NT and Cytc were detected in the APAP group. Combined NAC+CsA treatment sufficiently reversed oxidative stress, serum Cr and BUN levels and histopathological alterations induced by APAP. Moreover, cytc levels and renal tubular injury were remarkably reduced by combined drug treatment compared to the APAP+NAC group. These data suggest that the therapeutic effect of combined NAC+CsA treatment in mice with APAP-induced nephrotoxicity can be related to the combination of the antioxidant effect of NAC and the mitochondrial MPTP inhibitor effect of CsA.
Citation - WoS: 0
Effects of Maternal Tobacco Smoke or Alpha Lipoic Acid on Puberty Onset, Estrous Cycle and Gonadotropin Levels in Female Rats
(KARGER, 2018) Erdem Güzel, Elif; Yardimcı, Ahmet; Kaya, Nihat; Tektemur, Ahmet; Akkoç, Ramazan Fazıl; Erdem Güzel, Elif; Canpolat, Sinan; Ozan, Enver; Department of Midwifery/ Ebelik Bölümü
Various environmental factors are known to affect puberty onset. However, there are few studies in literature about how maternal tobacco smoke (ts) or alpha lipoic acid (ala) affect the hypothalamus-pituitary-gonadal axis at peripheral or central levels in rats. This study aimed to investigate effects of maternal tobacco smoke or alpha lipoic acid on puberty onset, estrous cycle and serum gonadotropin levels in female rats. Adult female spraque-dawley rats were used. All animals were randomly divided into 4 groups (control, ts, ts+ala and ala) and each group consisted of 7 rats. All ts rats were exposed to ts (20 gram\day, for one hour twice a day) and all ala rats received daily oral ala (20 mg/kg) during 8 week. Afterwards all rats were impregnated, ts or ala treatments continued during pregnancy. All treatments ended with birth and later newborn female rats were selected for each group (n=7). Puberty onset was monitored by examination of vaginal opening in female rat pups. Subsequently, estrous cycle was conducted daily for 15 days and determined by examination of the vaginal smear cytology. Also, serum fsh and lh levels were measured using elisa method at the end of the experiment. There was significantly advanced on puberty onset day for ts group (p<0.05). There was a significantly increase in pubertal weight in ala group compared to control group (p<0.001). The mean total number of estrous cycles and average duration of metestrus, diestrus, proestrus or estrus phases were not significantly different in all treatments groups compared to control group. There was no any significant change in serum fsh levels, but serum lh levels were significantly increased in all treatment groups compared to control group (p<0.05). Present study showed that maternal tobacco smoke or alpha lipoic acid may affect hypothalamus-pituitary-gonadal axis differently in rats.
Citation - WoS: 1
Citation - Scopus: 1
Evaluation of contraceptive intentions among pregnant women in the third trimester: A cross-sectional study
(Wolters Kluwer, 2024) Yeşil, Yeşim; Dönmez, Ayşegül; Department of Midwifery/ Ebelik Bölümü
This study aims to determine contraceptive intentions of pregnant women in the third trimester. This cross-sectional study was conducted at a training and research hospital in Mardin province between March 2023 and May 2023. In total, 253 pregnant women who had the ability to communicate in Turkish and agreed to participate were included in the study. Data were collected through face-to-face interviews using a survey and the Contraceptive Intent Questionnaire (CIQ). The average age of the participants was 28.87 ± 5.35 with 30.8% of them holding a secondary school degree. It was found that there was a statistically significant difference in terms of CIQ score between categories of the following descriptive variables: education level, husband's/partner's education level, fertility plan, receiving family planning counseling during pregnancy, and paying for the contraceptive methods used (P = .046, P = .013, P < .001, P = .008, and P < .001 respectively). It was determined that pregnant women who had not received family planning counseling during pregnancy and paid for the contraceptive method had higher contraception intention.
Citation - WoS: 0
Citation - Scopus: 0
Evaluation of Nurses' and Midwives' Knowledge and Attitudes Towards Recognizing Violence Against Women
(Womens Health & Action Research Centre, 2024) Yeşil, Yeşim; Yesil, Yesim; Department of Midwifery/ Ebelik Bölümü
The study was cross-sectional research that surveyed 410 nurses and midwives from March 2020 to March 2021 in Turkey. The aim of this study was to evaluate the knowledge and attitudes of nurses and midwives towards recognizing violence against women. The "Scale for Nurses' and Midwives' Recognition of the Symptoms of Violence against Women" were used. The average total scale score was 20.3 +/- 3.2. The score of participants who are receiving postgraduate education, working in the field of gynaecology and obstetrics, and considering intervention as a professional responsibility when encountering a woman who has experienced violence was found to be significantly higher than the other groups (p<.05). It is important for midwives and nurses to be aware of signs of violence to identify violence against women. Providing education to midwives and nurses regarding signs of violence against women will contribute to the recognition, prevention, and awareness of violence. (Afr J Reprod Health 2024; 28 [2]: 116-124)
Citation - Scopus: 0
Factors Affecting the Burden and Quality of Life of Caregivers for Gynecological Cancer Patients
(Archives of Health Science and Research, 2022) Yaşar, Beril Nisa; Terzioğlu, Füsun; Department of Midwifery/ Ebelik Bölümü
Objective: The aim of this study is to evaluate the care burden and quality of life of caregivers of patients with gynecologic cancer. Material and Methods: This descriptive study was conducted with 251 individuals who provided care to patients with gynecologic cancer in gynecologic oncology services of a university hospital and a state oncology hospital. The data were collected by a semi-structured questionnaire form, Caregiver Burden Inventory (CBI), and Quality of Life Family Version. Results: The mean age of the participants was 39.76 ± 14.20; 79.3% of them were female, 65.3% were married, 28.7% were high school graduates, 57.4% were employed and 56.2% were unemployed before starting care, 91.2% had health insurance, 58.6% perceived their income as moderate, and 57% had relatives of the patient receiving care. Care burden was statistically significant in terms of gender, marital status, educational level, and degree of affinity with the patient (P < .005). The correlation between caregivers’ quality of life, gender, health insurance, income status, and the degree of affinity with the patient was statistically significant (P < .005). Conclusion: As a result of this study, it was determined that some socio-demographic characteristics of the caregivers of patients with gynecologic cancer affected the care burden and quality of life.
Citation - WoS: 12
Citation - Scopus: 12
Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats
(Elsevier, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Department of Midwifery/ Ebelik Bölümü
Doxorubicin (DOX) is one of the most widely used chemotherapeutic agents. However, it causes pulmonary toxicity which decreases its clinical use in human cancer therapy. The present study was undertaken to obtain an insight into the potential protective effect of hesperetin (HES) against doxorubicin-induced pulmonary toxicity in rats. The animals were divided into 4 groups with 7 rats per group. The experimental treatments were as follows: Control, DOX, DOX + HES, and HES groups. DOX was administered at the dosage of 15 mg/kg i.p for a single dose. HES was administered at the dosage of 50 mg/kg by oral gavage every other day. After 28 days, biochemical parameters, oxidative stress status, histopathological changes, apoptosis-related genes and apoptotic index (AI) were examined of lung tissue. Histopathological changes, Poly [ADP-ribose] polymerase 1 (PARP-1), Caspase-3 (Casp3), Cytochrome c (Cytc), apoptosis-related genes, and AI significantly increased in the DOX group relative to the control group. Malondialdehyde (MDA) significantly increased, while superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased in the DOX group relative to the control group. However, histopathological findings, MDA, AI, and PAPR1, Casp3 protein expression, mRNA expression of Cytc significantly decreased, while SOD, GPx increased in the DOX + HES group relative to the DOX group. These results attested HES might be a potential agent for the treatment of DOX-induced pulmonary toxicity.
Citation - WoS: 7
Citation - Scopus: 7
The investigation of effect of alpha lipoic acid against damage on neonatal rat lung to maternal tobacco smoke exposure
(ELSEVIER SCIENCE BV, 2018) Erdem Güzel, Elif; Kaya, Nalan; Ozan, Gonca; Tektemur, Ahmet; Dabak, Durrin Özlem; Ozan, İbrahim Enver; Department of Midwifery/ Ebelik Bölümü
This study was carried out to determine the changes in the lungs of the rat pups exposed to tobacco smoke during pregnancy period and to investigate the protective effects of alpha lipoic acid, which is administered during pregnancy, on these changes. Spraque-Dawley female rats were divided into four groups: control, tobacco smoke (TS), tobacco smoke + alpha lipoic acid (TS + ALA) and alpha lipoic acid (ALA). The rats in control group were untreated. Rats were exposed to TS twice a day for one hour starting from eight weeks before mating and during pregnancy. 20 mg / kg of ALA was administered to rats. On 7th and 21st days 7 of the pups from each group were decapitated. Histological, morphometric, biochemical and quantitative real-time RT-PCR analyzes were performed. Histopathological and biochemical changes were observed in TS group. While a significant decrease was observed both in SP-A and VEGF immunoreactivities and mRNA levels, caspase-3 immunoreactivity and TUNEL positive cells were increased in TS group. It is suggested that prenatal TS exposure leads to morphological and histopathological changes on lung development by causing oxidative damage in lungs of neonatal rats and the maternal use of ALA can provide a limited protective effect on the neonatal lung development against this oxidative stress originating from TS. Although pregnant women are increasingly aware on health risks of smoking, environmental tobacco smoke exposure is still a widespread problem. For this reason, it is thought that this damage can be partially reduced by some antioxidant supplements in pregnancy.

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