PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Acute Cyanide Intoxication Due To Apricot Seed Ingestion
(Soc Argentina Pediatria, 2024) Talay, Mehmet N.; Gungor, Emre; Orhan, Ozhan
Introduction : Cyanide poisoning, whether it be accidental or intentional, remains a significant danger to adults and children, especially in societies where agriculture is a primary source of income. We examined the clinical follow-up, complications, and results of cyanide poisoning cases that occurred after eating the pits and seeds of plants containing cyanide glycosides, such as apricot kernels and almonds. Methods : Between 01/01/2017 and 01/08/2022, 14 children aged 1-18 years who were followed up with a prediagnosis of cyanide poisoning in our Paediatric Intensive Care Unit (PICU) were retrospectively analysed. Results : Eight of the patients followed with a preliminary diagnosis of cyanide poisoning were female and six were male. The most common admission month was July (42.8%) coinciding with the agricultural season. The most common symptoms at presentation were weakness and fatigue (n = 7). In the PICU, 4 patients presented lip cyanosis; 3, altered level of consciousness. Vomiting, seizure, headache, dizziness and palpitatons were less frequent. Four patients were treated with hydroxocobalamin (Cyanokit (R) ) as an antidote due to acidosis in their blood gases. All patients treated for cyanide poisoning were discharged. Conclusions : Cyanide poisoning should be considered in paediatric patients with suspicious findings, sudden loss of consciousness, increased anion gap acidosis and lactic acidosis. The history of eating the seeds of plants such as apricot and almonds should be investigated .
Anatolian Medicinal Plants as Potential Antiviral Agents: Bridging Traditional Knowledge and Modern Science in the Fight Against Covid-19 and Related Viral Infections
(Tubitak Scientific & Technological Research Council Turkey, 2024) Tilkat, Engin; Jahan, Israt; Hoser, Ayse; Kaplan, Alevcan; Ozdemir, Oguzhan; Onay, Ahmet
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the cause of the coronavirus 2019 (COVID-19), commonly known as the coronavirus pandemic. Since December 2020, COVID-19 vaccines have been extensively administered in numerous countries. In addition to new antiviral medications, the treatment regimen encompasses symptom management. Despite sustained research efforts, the outbreak remains uncontrolled, with affected patients still lacking proper treatment. This review is a valuable asset for researchers and practitioners aiming to delve into the yet unexplored potential of Anatolian flora in the fight against COVID-19 and other viral infections. Numerous medicinal plants in Anatolia, such as thyme, sage, cannabis, oregano, licorice root, and Origanum sp., contain bioactive compounds with proven antiviral properties that have been used in the region for centuries. The rich legacy of traditional Anatolian medicine (TAM), has significantly influenced modern medicine; thus, the profusion of medicinal plants native to Anatolia holds promise for antiviral drug development, making this review essential for researchers and practitioners.
Antioxidant, anticancer and anticholinesterase activities of flower, fruit and seed extracts of hypericum amblysepalum HOCHST
(Asian Pacific Organization for Cancer Prevention, 2015) Keskin, Cumali
Background: Cancer is an unnatural type of tissue growth in which the cells exhibit unrestrained division, leading to a progressive increase in the number of dividing cells. It is now the second largest cause of death in the world. The present study concerned antioxidant, anticancer and anticholinesterase activities and protocatechuic, catechin, caffeic acid, syringic acid, p-coumaric acid and o-coumaric concentrations in methanol extracts of flowers, fruits and seeds of Hypericum amblysepalum. Materials and Methods: Antioxidant properties including free radical scavenging activity and reducing power, and amounts of total phenolic compounds were evaluated using different tests. Protocatechuic, catechin, caffeic acid, syringic acid, p-coumaric acid and o-coumaric concentrations in extracts were determined by HPLC. Cytotoxic effects were determined using the MTT test with human cervix cancer (HeLa) and rat kidney epithelium cell (NRK-52E) lines. Acetyl and butyrylcholinesterase inhibitory activities were measured by by Ellman method. Results: Total phenolic content of H. amblysepalum seeds was found to be higher than in fruit and flower extracts. DPPH free radical scavenging activity of the obtained extracts gave satisfactory results versus butylated hydroxyanisole and butylated hydroxytoluene as controls. Reducing power activity was linearly proportional to the studied concentration range: 10-500 µg/mL LC50 values for H. amblysepalum seeds were 11.7 and 2.86 respectively for HeLa and NRK-52E cell lines. Butyryl-cholinesterase inhibitory activity was 76.9 ± 0.41 for seed extract and higher than with other extracts. Conclusions: The present results suggested that H. amblysepalum could be a potential candidate anti-cancer drug for the treatment of human cervical cancer, and good source of natural antioxidants.
Association Between Abo Blood Group, Peripheral Artery Disease Lesion Severity, and Coronary Artery Disease Coexistence
(Elsevier Inc., 2025) Evsen, A.; Aktan, A.; Kılıç, R.; Özbek, M.
Background: This study aims to investigate the relationship between ABO blood groups and the severity of peripheral artery disease (PAD) lesions, the coexistence of coronary artery disease (CAD) with PAD, and to identify which blood groups may be more predisposed to these conditions. Methods: This study, which has a single-center and retrospective design, includes 305 patients diagnosed with peripheral artery disease (PAD) between 2015 and 2021. The patients were selected from those with at least 50% stenosis detected by computed tomography (CT) angiography. The severity of PAD lesions was evaluated according to the TransAtlantic Inter-Society Consensus (TASC-II) classification, and the presence of CAD was determined by simultaneous conventional coronary angiography. Demographic data, comorbidities, and laboratory results were collected, and statistical analyses were performed using chi-square tests, logistic regression, and t-tests. All of these patients were divided into 2 groups based on their ABO blood types: O and non-O blood groups. Results: This study demonstrates a significant relationship between blood group classification and both the severity of PAD and the prevalence of CAD. Patients with non-O blood groups exhibited a higher likelihood of having severe PAD lesions (TASC-C and TASC-D) compared to those with O blood groups, who more frequently had milder lesions (TASC-A and TASC-B) (P < 0.001). The prevalence of CAD was also significantly higher among patients with non-O blood groups than those with the O blood group (54.4% vs. 36.4%; P = 0.003). In the logistic regression analysis, non-O blood groups, alongside age, hypertension (HT), and chronic kidney disease (CKD), emerged as independent predictors of severe PAD (P < 0.001 for non-O blood groups). Similarly, older age and non-O blood group status were identified as significant independent predictors of CAD (P = 0.004). These findings suggest that blood group classification, particularly non-O groups, may influence the severity and coexistence of PAD and CAD. Conclusion: Our study reveals a significant association between ABO blood groups and both the severity of PAD and the association of CAD, and shows that non-O blood groups are linked to more severe forms of these conditions. These findings highlight the potential role of ABO blood groups in cardiovascular risk stratification, suggesting a need for further research to confirm these associations and understand their clinical implications. © 2025 Elsevier Inc.
Automatic Detection of Brain Tumors With the Aid of Ensemble Deep Learning Architectures and Class Activation Map Indicators by Employing Magnetic Resonance Images
(Elsevier, 2024) Turk, Omer; Ozhan, Davut; Acar, Emrullah; Akinci, Tahir Cetin; Yilmaz, Musa; Türk, Ömer
Today, as in every life-threatening disease, early diagnosis of brain tumors plays a life-saving role. The brain tumor is formed by the transformation of brain cells from their normal structures into abnormal cell structures. These formed abnormal cells begin to form in masses in the brain regions. Nowadays, many different techniques are employed to detect these tumor masses, and the most common of these techniques is Magnetic Resonance Imaging (MRI). In this study, it is aimed to automatically detect brain tumors with the help of ensemble deep learning architectures (ResNet50, VGG19, InceptionV3 and MobileNet) and Class Activation Maps (CAMs) indicators by employing MRI images. The proposed system was implemented in three stages. In the first stage, it was determined whether there was a tumor in the MR images Tumor) were detected from MR images (Multi-class Approach). In the last stage, CAMs of each tumor group were created as an alternative tool to facilitate the work of specialists in tumor detection. The results showed that the overall accuracy of the binary approach was calculated as 100% on the ResNet50, InceptionV3 and MobileNet architectures, and 99.71% on the VGG19 architecture. Moreover, the accuracy values of 96.45% with ResNet50, 93.40% with VGG19, 85.03% with InceptionV3 and 89.34% with MobileNet architectures were obtained in the multi-class approach.
Biosensors for the Detection of Pathogenic Bacteria: Current Status and Future Perspectives
(Taylor and Francis Ltd., 2024) Dicle, Y.; Karamese, M.
Pathogenic microorganisms pose significant threats to human health, food safety and environmental integrity. Rapid and accurate detection of these pathogens is essential to mitigate their impact. Fast, sensitive detection methods such as biosensors also play a critical role in preventing outbreaks and controlling their spread. In recent years, biosensors have emerged as a revolutionary technology for pathogen detection. This review aims to present the current developments in biosensor technology, investigate the methods by which these developments are used in the detection of pathogenic bacteria and highlight future perspectives on the subject. © 2024 Expert Publishing Medicine Ltd trading as Taylor & Francis.
Comparing the Efficacy of Manual Therapy and Exercise To Synchronized Telerehabilitation With Self-Manual Therapy and Exercise in Treating Subacromial Pain Syndrome: a Randomized Controlled Trial
(Mdpi, 2024) Celik, Erman Berk; Tuncer, Aysenur
This study aimed to investigate the efficacy of manual therapy and exercise versus synchronized telerehabilitation with self-manual therapy and exercise in treating Subacromial Pain Syndrome (SAPS). Sixty individuals diagnosed with SPS, aged 18-50 years, were randomly assigned to home exercise (HE), manual therapy (MT), and telerehabilitation (TR) groups. Treatment protocols were administered over 8 weeks and included specific exercises and therapy interventions. Outcome measures included the Visual Pain Scale (VAS), shoulder range of motion (ROM) via goniometric measurements, Quick Disability Arm-Shoulder-Hand Problems Survey (Q-DASH), and patient satisfaction. Results revealed that both MT and TR groups exhibited reduced pain, increased ROM, lower Q-DASH scores, and higher patient satisfaction than the HE group. However, no significant differences were found between the MT and TR groups regarding pain levels, ROM, Q-DASH scores, or patient satisfaction. The study concludes that both telerehabilitation and manual therapy effectively alleviate pain and are well-received by patients with SPS. Additionally, manual therapy demonstrates superiority in enhancing functional levels compared to exercise-based interventions (Registration: NCT05200130).
The Effect of Aortic Angulation on Clinical Outcomes of Patients Undergoing Transcatheter Aortic Valve Replacement
(Soc Brasil Cirurgia Cardiovasc, 2024) Aktan, Adem; Demir, Muhammed; Guzel, Tuncay; Karahan, Mehmet Zulkuf; Aslan, Burhan; Kilic, Raif; Ertas, Faruk
Introduction: The aim of this study was to assess the impact of aortic angulation (AA) on periprocedural and in -hospital complications as well as mortality of patients undergoing Evolut (TM) R valve implantation. Methods: A retrospective study was conducted on 264 patients who underwent transfemoral-approach transcatheter aortic valve replacement with self-expandable valve at our hospital between August 2015 and August 2022. These patients underwent multislice computer tomography scans to evaluate AA. Transcatheter aortic valve replacement endpoints, device success, and clinical events were assessed according to the definitions provided by the Valve Academic Research Consortium -3. Cumulative events included paravalvular leak, permanent pacemaker implantation, new-onset stroke, and in -hospital mortality. Patients were divided into two groups, AA <= 48(degrees) and AA > 48(degrees), based on the mean AA measurement (48.3 +/- 8.8) on multislice computer tomography. Results: Multivariable logistic regression analysis was performed to identify predictors of cumulative events, utilizing variables with a P-value < 0.2 obtained from univariable logistic regression analysis, including AA, age, hypertension, chronic renal failure, and heart failure. AA (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 0.89-3.38, P=0.104), age (OR: 1.04, 95% CI: 0.99-1.10, P=0.099), hypertension (OR: 1.66, 95% CI: 0.82-3.33, P=0.155), chronic renal failure (OR: 1.82, 95% CI: 0.92-3.61, P=0.084), and heart failure (OR: 0.57, 95% CI: 0.27-1.21, P=0.145) were not found to be significantly associated with cumulative events in the multivariable logistic regression analysis. Conclusion: This study demonstrated that increased AA does not have a significant impact on intraprocedural and periprocedural complications of patients with new generation self-expandable valves implanted.
Effect of pleurotus Ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteers
(Routledge Journals, Taylor & Francis Ltd, 2024) Dundar, Abdurrahman; Yalcin, Pinar; Arslan, Nurgul; Acay, Hilal; Hatipoglu, Abdulkerim; Boga, Mehmet; Yaprak, Bulent
Objective: Our aim in this study is, does 29-day regular consumption of Pleurotus ostreatus water extract by volunteer individuals who meet the study criteria have an effect on blood and cytokine values? Method: In accordance with the purpose of the study, volunteers were asked to consume 100 ml of the extract every morning for 29 days. Three tubes of blood samples were taken from the volunteers on the 15th and 29th days of the study. Biochemical and hematological analysis of the blood samples were performed and immunomodulatory effects through cytokines were examined. The values obtained from 3 tubes of blood obtained from volunteers before the use of mushroom extract were used as control. The chemical composition and beta-glucan content of 100 ml of mushroom water extract were also analyzed. Result: IL-4, IL-6, IL-10 and IL-13 could not be detected because the values were below the lowest standard value. TNF-alpha, IFN-gamma and IL-1 beta 15th and 29th day values decreased compared to the 1st day (control) values (p < 0.05). However, there was no significant difference observed between the 15th and 29th day. No abnormalities were observed in biochemical and hematological values. Also, the beta-glucan content of extract was found 38.12 mg/100 ml. Conclusion: The frequency range of kidney and liver function test results confirmed that P. osreatus is a reliable food source. Considering the cytokine values these results indicate that P. ostreatus water extract has an anti-inflammatory effect. As no significant difference was observed in 29 days of use, it is thought that 15 days of daily consumption of the extract may be sufficient for the anti-inflammatory effect to occur. However, a large number of qualified clinical trials are needed to support the issue.
The Effectiveness of Halp Score in Predicting Mortality in Non-St Myocardial Infarction Patients
(Lippincott Williams & Wilkins, 2025) Kilic, Raif; Guzel, Tuncay; Aktan, Adem; Guzel, Hamdullah; Kaya, Ahmet Ferhat; Cankaya, Yusuf
Background:The HALP score, measured based on hemoglobin, albumin, lymphocyte, and platelet levels, is regarded as a novel scoring system that indicates the status of systemic inflammation and nutritional health. Our study aimed to evaluate the relationship between HALP score and prognosis in non-ST-elevation myocardial infarction (NSTEMI) patients. Methods Between 1 January 2020 and 1 January 2022, 568 consecutive patients diagnosed with NSTEMI from a single center were included in the study retrospectively. The patients were divided into two equal groups according to the median HALP cutoff value of 44.05. Patients were followed for at least 1 year from the date of admission. Results The average age of the patients was 62.3 +/- 10.6 years and 43.7% were female. In-hospital and 1-year mortality were found to be significantly higher in the group with low HALP scores (6.0 vs. 2.1%, P = 0.019 and 22.5 vs. 9.9%, P < 0.001, respectively). In receiver operating characteristic curve analysis, a cutoff level of 34.6 of the HALP score predicted 1-year mortality with 71% sensitivity and 65% specificity (area under the curve: 0.707, 95% confidence interval: 0.651-0.762, P < 0.001). In Kaplan-Meier analysis, higher mortality rates were observed over time in the group with lower HALP scores (log-rank test=16.767, P < 0.001). In Cox regression analysis, the HALP score was found to be an independent predictor of 1-year mortality (odds ratio: 0.969, 95% confidence interval: 0.958-0.981, P < 0.001). Conclusion We found that a low HALP score could predict in-hospital and 1-year mortality in patients admitted to the hospital with a diagnosis of NSTEMI.
Effectiveness of Valproic Acid in the Treatment of Sydenham's Chorea and a Literature Review
(Sage Publications inc, 2024) Ozgun, Nezir; Akdeniz, Osman
There is still no evidence-based guideline and consensus on the treatment Sydenham's Chorea (SC). The first-line medication preference of specialists depends on personal experience and is variable. In this study, we evaluate the treatment results of pediatric patients who were treated with valproic acid (VPA). The medical records of 17 patients diagnosed with SC were reviewed retrospectively. The mean time to clinical improvement was found as approximately 5 days, the mean duration of remission as 13.60 & PLUSMN; 3.94 weeks and the mean duration of medication use was found as 17.96 & PLUSMN; 3.81 weeks. No side effects were observed in any of the patients and relapse occurred in 2 patients. A positive correlation was found between the initial C-reactive protein (CRP) level and the duration of medication use. Until evidence-based guidelines are established, VPA can be used as an effective, safe, and inexpensive first-line treatment option, especially in pediatric patients.
Epilepsy Detection by Using Scalogram Based Convolutional Neural Network from EEG Signals
(MDPI, 2019) Türk, Ömer; Özerdem, Mehmet Siraç; Türk, Ömer
The studies implemented with Electroencephalogram (EEG) signals are progressing very rapidly and brain computer interfaces (BCI) and disease determinations are carried out at certain success rates thanks to new methods developed in this field. The effective use of these signals, especially in disease detection, is very important in terms of both time and cost. Currently, in general, EEG studies are used in addition to conventional methods as well as deep learning networks that have recently achieved great success. The most important reason for this is that in conventional methods, increasing classification accuracy is based on too many human efforts as EEG is being processed, obtaining the features is the most important step. This stage is based on both the time-consuming and the investigation of many feature methods. Therefore, there is a need for methods that do not require human effort in this area and can learn the features themselves. Based on that, two-dimensional (2D) frequency-time scalograms were obtained in this study by applying Continuous Wavelet Transform to EEG records containing five different classes. Convolutional Neural Network structure was used to learn the properties of these scalogram images and the classification performance of the structure was compared with the studies in the literature. In order to compare the performance of the proposed method, the data set of the University of Bonn was used. The data set consists of five EEG records containing healthy and epilepsy disease which are labeled as A, B, C, D, and E. In the study, A-E and B-E data sets were classified as 99.50%, A-D and B-D data sets were classified as 100% in binary classifications, A-D-E data sets were 99.00% in triple classification, A-C-D-E data sets were 90.50%, B-C-D-E data sets were 91.50% in quaternary classification, and A-B-C-D-E data sets were in the fifth class classification with an accuracy of 93.60%.
Etomidate Alleviates Ovarian Ischemia-Reperfusion Injury in Rats
(Turkish Assoc Trauma Emergency Surgery, 2024) Kolukcu, Vildan; Balta, Mehtap Gurler; Tapar, Hakan; Karaman, Tugba; Karaman, Serkan; Unsal, Velid; Katar, Muzaffer
BACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury. METHODS: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflammatory cytokine levels, and antioxidant enzyme activity RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL1 beta ), interleukin-6 (IL-6), and tumor necrosis factor -alpha (TNF- alpha ), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p<0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p<0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased in Group 3 compared to Group 2 (p=0.031 and p=0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p<0.001, p<0.001, p<0.001, and p=0.001, respectively). CONCLUSION: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histopathological and biochemical outcomes.
Evaluation of Nurses' and Midwives' Knowledge and Attitudes Towards Recognizing Violence Against Women
(Womens Health & Action Research Centre, 2024) Donmez, Ayseguel; Yesil, Yesim
The study was cross-sectional research that surveyed 410 nurses and midwives from March 2020 to March 2021 in Turkey. The aim of this study was to evaluate the knowledge and attitudes of nurses and midwives towards recognizing violence against women. The "Scale for Nurses' and Midwives' Recognition of the Symptoms of Violence against Women" were used. The average total scale score was 20.3 +/- 3.2. The score of participants who are receiving postgraduate education, working in the field of gynaecology and obstetrics, and considering intervention as a professional responsibility when encountering a woman who has experienced violence was found to be significantly higher than the other groups (p<.05). It is important for midwives and nurses to be aware of signs of violence to identify violence against women. Providing education to midwives and nurses regarding signs of violence against women will contribute to the recognition, prevention, and awareness of violence. (Afr J Reprod Health 2024; 28 [2]: 116-124)
Evaluation of Prenatal Care Quality of Pregnant Women: a Cross-Sectional Sample From the South-East Turkiye
(Womens Health & Action Research Centre, 2024) Icke, Sibel; Cifci, Sema; Kocaturk, Asiye
The aim of this study was to evaluate the quality of prenatal care among pregnant women in Mardin Artuklu. Study data were collected in August and September 2022. A total of 335 pregnant women participated in this descriptive research. The sociodemographic information form and Prenatal Care Quality Scale were used as data collection tools. The mean total score of the Prenatal Care Quality Questionnaire was 168.66 +/- 30.69. Results showed that prenatal visits more than 4 times, giving care from health centers, mothers educational level more than 12 years old, having health insurance are predisposing factors of quality of prenatal care (p<0.05). Although quality prenatal care is the right of every woman, there are still women who do not receive this care sufficiently and who are not aware of the care they receive. The role of midwives is important in raising awareness in women about the quality of prenatal care.
Evaluation of Prenatal Comfort, Sleep, and Quality of Life in Pregnant Women With Cholestasis: a Cross-Sectional Study
(Mdpi, 2024) Yesil, Yesim; Gunduz, Ulkin; Donmez, Aysegul; Pasa, Semir
Background: Associated with adverse pregnancy outcomes, intrahepatic cholestasis of pregnancy is the most prevalent liver disease that women typically experience during pregnancy. This study aimed to evaluate prenatal comfort, sleep, and quality of life in pregnant women with cholestasis. Methods: This cross-sectional study was implemented between November 2022 and June 2023 at Mardin Training and Research Hospital with 150 pregnant women who received a diagnosis of pregnancy-induced intrahepatic cholestasis and agreed to participate. The following tools were utilized to collect data: A personal information form exploring socio-demographic and obstetric characteristics of participants, the Prenatal Comfort Scale (PCS), the Pittsburgh Sleep Quality Index (PSQI), and the World Health Organization Quality of Life-Brief Form (WHOQOL-BREF). Results: The mean age of participants was 27.79 +/- 6.33 years. The mean PCS and PSQI scores were 61.20 +/- 5.84 and 9.52 +/- 3.02, respectively. The mean scores of "physical health, psychological health, social relationships, and environmental health" sub-dimensions in WHOQOL-BREF were 10.63 +/- 2.18, 10.48 +/- 2.10, 11.31 +/- 3.28, and 11.27 +/- 2.10, respectively. A significant difference was found for PSQI regarding hospitalization status and change in sleep quality variables (p = 0.025 and p = 0.035, respectively). Conclusions: Cholestasis of pregnancy creates problems such as pruritus, body image changes, hospitalization, and poor sleep quality in women. This study showed that pregnant women with cholestasis had low levels of sleep quality and quality of life, implying that cholestasis affects their sleep quality, prenatal comfort levels, and quality of life in general. In addition, it is seen that women with this problem do not want to fall pregnant again.
Evolving Approach in Nephron-Sparing Surgery: Has Anything Changed From Open Surgery To Laparoscopy
(Iniestares, S.a., 2024) Ergun, Muslum; Sagir, Suleyman; Akyuz, Osman; Akman, Ramazan Yavuz
Objective: This study aimed to provide valuable insights into the comparative efficacy of different surgical approaches fornephron-sparing surgery (NSS) and contribute to the existing literature in this field. Materials and Methods: This study included patients who underwent NSS for small renal masses between January 2016 andMarch 2024. A total of 97 patients (41 in the open approach group, 56 in the laparoscopic approach group) with demographic,radiological, intraoperative, renal functional, and oncological follow-up data were included. Three different anatomical scoringsystems (R.E.N.A.L. nephrometry score, PADUA score and C-index) were utilised to assess tumour location and estimate prox-imity to the hilum and collecting system. Results: In the open nephron-sparing surgery (ONSS) and laparoscopic nephron-sparing surgery (LNSS) groups, the mean kid-ney tumour diameters (SD) were 5.20 +/- 2.30 and 4.90 +/- 2.10, which were similar in both surgical method groups (p= 0.061).However, tumours treated with ONSS had significantly more adverse morphometric features (p<0.05). For ONSS and LNSSgroups, the mean R.E.N.A.L. nephrometry scores (SD) were 6.15 +/- 2.04 and 5.2 +/- 1.4 (p= 0.032), respectively; The mean PADUAscores (SD) were 7.46 +/- 1.14 and 6.8 +/- 1.0 (p= 0.049), respectively; And the mean C-index (SD) scores were 1.39 +/- 0.4 and 1.37 +/- 0.5 (p= 0.062), respectively. No significant differences were found in the mean tumour diameter (cm) (Inter Quantile Range(IQR)) distribution of both groups (p= 0.058). Despite the slight increase in transfusion rate in the LNSS group, estimated bloodloss (EBL), transfusion rates, and length of hospital stay were similar in both groups. Conclusions: Although LNSS does not appear superior in terms of intraoperative blood loss, length of hospital stay and transfu-sion rate, it provides comparable long-term outcomes to ONSS. Our study suggests that when matched with nephrometry scores,LNSS can achieve similar outcomes to ONSS
Factors Affect Progressive Sperm Motility
(Permanyer Publications, 2025) Sagir, S.; Tunçekin, A.
Objective: In this study, it was aimed to investigate the effects of age, body mass index, and diet factors on sperm parameters and developing a novel index (Artuklu Sperm Quality Index [ASQI]). Method: The study incorporated a total of 115 patients who sought medical attention due to infertility and underwent semen analysis (spermiogram). The ASQI score was developed. Results: About 73% reported eating three meals daily, while 62% consume fruits a few times a week. When considering grain consumption, 30% rarely do, mirroring the 25% who never do. Carbonated drinks are consumed a few times in 15 days by 39% of respondents. Salt consumption showed 47% taking very little, whereas 42% consume caffeine very minimally. Sausage/ salami is minimally consumed by 44%, and 32% of participants reported never being exposed to air pollution. ASQI score ranges from 6 to 61 point. A lower score indicates good nutrition and quality of life, while a higher score suggests deteriorating nutrition and increasing unhealthy habits. Cronbach alfa value was noted as 0.72. A negative correlation was found between ASQI and sperm progressive motility (p < 0.001, r = −0.405). Conclusions: This study revealed a clear negative correlation between the ASQI score, which signifies deteriorating nutrition and escalating unhealthy habits, and sperm progressive motility. © 2024 Academia Mexicana de Cirugía.
Factors Affecting Maternal Satisfaction in Labor and Neonatal Outcomes: a Cross-Sectional Study
(Womens Health & Action Research Centre, 2024) Donmez, Aysegul; Yesil, Yesim
This study evaluated the factors affecting maternal satisfaction during labor and neonatal outcomes. This cross-sectional study was conducted with 319 mothers who gave birth in ahospital (01.10.2023-31.03.2024) and volunteered for the study. Data were collected using a personal information form including socio-demographic and obstetric characteristics of the mothers and the 'Birth Satisfaction Scale'. The mean age of the mothers who participated in the study was 28.07 +/- 6.44 years. The mean score of the Birth Satisfaction Scale was 22.29 +/- 5.03. The sub-dimensions of the scale were found to be significantly affected by mode of delivery, various factors (p<0.05). Positive birth experience also affects maternal satisfaction. This study showed that maternal satisfaction in labor was at a moderate level. It explains that maternal satisfaction in labor is affected by the mode of delivery and other factors. In addition, it is seen that the method of delivery has various negative effects on the newborn.
Hyaluronic Acid as a New Biomarker To Differentiate Acute Kidney Injury From Chronic Kidney Disease
(Iranian Society of Nephrology, 2017) Akin, D.; Ozmen, S.; Yilmaz, M.E.
Introduction. It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. Materials and Methods. A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured. The diagnostic role of the test was investigated using the receiver operator curve curves. Results. The mean age of the patients was 54.6 ± 17.9 years. The diagnosis was chronic kidney disease (CKD) in 41.1%, acute kidney injury (AKI) in 48.9%, AKI on CKD in 6.7% (3 died without a diagnosis). The mean serum HA was significantly higher in the CKD group (146.1 ± 119.3 ng/mL) than the AKI group (68.9 ± 69.1 ng/ mL; P <.001). Serum HA significantly correlated with proteinuria (r = 0.717, P <.001) and serum albumin level (r = - 0.599, P <.001) in the CKD group only. Serum HA cutoff level of 61 ng/dL had a sensitivity of 82% and specificity of 67% for differential diagnosis of AKI and CKD. Conclusions. Serum HA level may be used as tool to differentiate AKI from CKD. Further larger studies are warranted to clarify the definite the role of this marker. © 2017, Iranian Society of Nephrology. All rights reserved.

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