Sağlık Bilimleri Fakültesi

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Adsorption and inhibition effect of 2,4-diamino-6-hydroxypyrimidine for mild steel corrosion in HCl medium: experimental and theoretical investigation
(SPRINGER HEIDELBERG, 2019) Yildiz, Resit; Yıldız, Reşit
2,4-Diamino-6-hydroxypyrimidine (2D6H) was examined as corrosion inhibitor of mild steel (MS) in 0.1M HCl using potentiodynamic measurements, linear polarization resistance (LPR), scanning electron microscopy, electrochemical experiments, and quantum chemical calculations. All measurements show that the corrosion inhibition effectiveness is forthright compared to the concentration of 2D6H ranging from 0.5 to 10.0mM. Adsorption of 2D6H on the MS surface in the presence of HCl is determined to obey Langmuir adsorption isotherm. The electronic features elucidated by quantum chemical calculations were associated with the experimental inhibition productivities. The mechanism of inhibition was revealed by E-pzc measurements.
Eating Behavior Changes of People With Obesity During the Covid-19 Pandemic
(Dove Medical Press Ltd, 2021) Deger, Vasfiye Bayram
Objective: The precautions taken during the pandemic period may cause stress-related eating behavior disorders. It was aimed to test this hypothesis, and the study was carried out to examine pandemic measures the effect of on the nutritional, depression and stress conditions of people with obesity. Methods: The individuals who participated in the study were people with obesity who received follow-up dietary therapy in a private hospital. Three separate scales were applied to the individuals, which measured the desire to overeating request, depression status and stress-fighting status. Results: This study was conducted on 368 individuals. Women had lower values of BMI (28.57 +/- 3.89 kg/cm(2)) than men ( 30.64 +/- 2.87 kg/cm(2)). When the scores of the excessive eating request scale mean scores before and during the pandemic were examined, it was seen that the scores of the individuals increased during the pandemic. In the multivariate regression model, it was seen that the increase of stress and BMI increased the FCQ score (p<0.001). Multiple regression models were created by taking into account the criteria that caused the score increase. Each variable can predict the FCQ score separately. The predictor significance order of variants on FCQ score beta values is as follows: the Patient Health Questionnaire-9 (PHQ-9) (beta=0.774), before pandemic FCQ (beta = 0.601), the Perceived Stress Scale ( PSS) (beta=-0.268), before pandemic BMIa (beta=-0.223), during pandemic BMIb (beta=0.073), and age (beta=-0.013). Conclusion: COVID-19 pandemic, making applications such as quarantine in pandemic processes has successful results in being able to combat its. However, undesirable conditions such as stress can have serious negative consequences on other health measurements. It was observed in the results of this study that excessive eating food desire developed in people with obesity.
The effects of oxytocin on penile tissues in experimental priapism model in rats
(SPRINGER, 2019) Kolukçu, Engin; Kılıç, Şahin; Parlaktaş, Bekir Süha; Erdemir, Fikret; Ünsal, Velid; Atılgan, Doğan; Uluocak, Nihat
PurposeThis study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.MethodsForty Wistar Albino strain male rats were divided into four groups. The control group (n=10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30min following priapism. Rats in Group 4 rats were given oxytocin 30min before the induction of reperfusion following priapism. All rats were penectomized, and adequate amounts of blood sample were drawn. Inflammation, vasocongestion, desquamation, and edema in penile tissue were scored between 0 and 3 points (0: normal, 1: mild, 2: moderate, 3: severe) to evaluate the severity of tissue damage. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA), and nitric oxide (NO) in blood samples were determined spectrophotometrically.ResultsIn histopathological examination, statistically significant positive changes were detected in vasocongestion, inflammation, desquamation, and edema scores in Group 4 than in Group 2 and Group 3 (p<0.001). Biochemical test results revealed that NO levels were significantly lower in Group 4 than in Group 3 (p<0.001). Serum GSH-Px activities in Group 4 significantly increased when compared with the other groups 2 and 3 (p=0.002, p=0.001, respectively). There was no statistical difference among the groups regarding SOD activities and MDA levels (p>0.05).ConclusionsOxytocin protected against priapism-induced ischemia-reperfusion injury developed in cavernosal tissue as observed based on histopathological and biochemical evidence. Although this is an experimental study, oxytocin can be thought as an alternative drug in the treatment of priapism.
The investigation of effect of alpha lipoic acid against damage on neonatal rat lung to maternal tobacco smoke exposure
(ELSEVIER SCIENCE BV, 2018) Erdem Güzel, Elif; Kaya, Nalan; Ozan, Gonca; Tektemur, Ahmet; Dabak, Durrin Özlem; Ozan, İbrahim Enver
This study was carried out to determine the changes in the lungs of the rat pups exposed to tobacco smoke during pregnancy period and to investigate the protective effects of alpha lipoic acid, which is administered during pregnancy, on these changes. Spraque-Dawley female rats were divided into four groups: control, tobacco smoke (TS), tobacco smoke + alpha lipoic acid (TS + ALA) and alpha lipoic acid (ALA). The rats in control group were untreated. Rats were exposed to TS twice a day for one hour starting from eight weeks before mating and during pregnancy. 20 mg / kg of ALA was administered to rats. On 7th and 21st days 7 of the pups from each group were decapitated. Histological, morphometric, biochemical and quantitative real-time RT-PCR analyzes were performed. Histopathological and biochemical changes were observed in TS group. While a significant decrease was observed both in SP-A and VEGF immunoreactivities and mRNA levels, caspase-3 immunoreactivity and TUNEL positive cells were increased in TS group. It is suggested that prenatal TS exposure leads to morphological and histopathological changes on lung development by causing oxidative damage in lungs of neonatal rats and the maternal use of ALA can provide a limited protective effect on the neonatal lung development against this oxidative stress originating from TS. Although pregnant women are increasingly aware on health risks of smoking, environmental tobacco smoke exposure is still a widespread problem. For this reason, it is thought that this damage can be partially reduced by some antioxidant supplements in pregnancy.
Pelvic floor muscle strength and dysfunctions in women with pes planus: A case-control study
(Churchill Livingstone, 2024) Yardımcı, Fatma Betül; Yardimci, F.B.; Altay, H.
Background/aim: Distal extremity misalignment may give rise to pelvic floor dysfunctions (PFDs). This study aimed to compare pelvic floor muscle strength (PFMS) and dysfunctions in women with and without pes planus. Materials and methods: Women with (pes planus group, n = 30) and without pes planus (control group, n = 30) were included. The presence of PFDs questioned. Pes planus with the Feiss Line Test, PFMS with the Modified Oxford Scale, and the severity of PFDs with the Pelvic Floor Distress Inventory-20 (PFDI-20), including three subscales (Pelvic Organ Distress Inventory-6 (POPDI-6) for pelvic organ prolapse, Colorectal-Anal Distress Inventory-8 (CRADI-8) for colorecto-anal symptoms, and Urinary Distress Inventory-6 (UDI-6) for urinary symptoms, were assessed. Results: It was seen that no difference was found between groups in terms of PFMS (p > 0.05). However, urinary incontinence and anal incontinence were higher in women with pes planus than in women without pes planus (p < 0.05). Only the PFDI-20, CRADI-8, and UDI-6 scores were higher in women with pes planus compared to controls (p < 0.05). There was no difference was found between groups in terms of POPDI-6 scores (p > 0.05). Conclusion: The PFMS did not change according to the presence of pes planus. However, the prevalence of PFDs and their severity were higher in women with pes planus in comparison to controls. Posture assessments of individuals with PFDs, especially examination of foot posture, and pelvic floor assessments of individuals with posture disorders should be considered. © 2024
Seasonal Variations in the Fatty Acid Composition of Phospholipid and Triacylglycerol in Gonad and Liver of Mastacembelus simack
(SPRINGER, 2015) Kaçar, Semra; Başhan, Mehmet
The seasonal effects on the fatty acid composition of triacylglycerol (TG) and phospholipid (PL) in the gonad and liver of Mastacembelus simack were determined using the gas chromatographic method. The most abundant fatty acids in the investigated seasons and tissues were palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1n-9), palmitoleic acid (C16:1n-7), arachidonic acid (C20:4n-6), eicosapentaenoic acid (C20:5n-3), and docosahexaenoic acid (C22:6n-3). The distribution proportions of aSFA (saturated fatty acids), aMUFA (monounsaturated fatty acids) and aPUFA (polyunsaturated fatty acids) were found to be different among PL and TG fractions in all seasons. The total lipid content of gonad and liver were 1.32 (November)-4.90 % (September) and 1.32 (September)-3.94 % (January), respectively. It was shown that the total lipid and fatty acid compositions in the gonad and liver of fish were significantly influenced by seasons.
Seasonal variations in the fatty acid composition of phospholipids and triacylglycerols of brown trout
(WILEY-BLACKWELL, 2015) Kaçar, Semra; Başhan, Mehmet; Kaçar, Semra
Seasonal variations on phospholipid (PL) and triacylglycerol (TG) fatty acid (FA) compositions in muscles of Salmo trutta macrostigma were investigated by gas chromatography (GC) using the method described by Folch. The total lipid of the muscle was extracted using chloroform/methanol (2: 1, v/v) and was separated into TG and PL using thin layer chromatography (TLC). A total of nineteen and sixteen different fatty acids were determined in TG and PL, respectively. The distributions of Sigma SFAs (saturated fatty acids), Sigma MUFAs (monounsaturated fatty acids) and Sigma PUFAs (polyunsaturated fatty acids) proportions were found to be different among PL and TG fractions in all seasons. TG contained a lower proportion of Sigma PUFA, but a higher proportion of Sigma MUFA and Sigma SFA than PL. The major components were palmitic acid (16: 0), oleic acid (18: 1 n-9), eicosapentaenoic acid (EPA, 20: 5 n-3) and docosahexaenoic acid (DHA, 22: 6 n-3) in PL, 16: 0, palmitoleic acid (16: 1 n-7), 18: 1 n-9, linoleic acid (LA, 18: 2 n-6), linolenic acid (ALA, 18: 3 n-3), 20: 5 n-3 and 22: 6 n-3 in TG extracted from muscle of S. trutta macrostigma in all seasons. The total lipid content varied seasonally from 1.44% to 1.90% in female muscle of wet weight for S. trutta macrostigma. N-3/n-6 ratios of PL and TG were found to be 5.19-12.0 and 1.09-2.62, respectively.

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