Ebelik Bölümü Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/225
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Article Citation - WoS: 4Citation - Scopus: 6The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice(Ultrastructural Pathology, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Gül, Mehmet; Tektemur; Özcan Yıldırım, Sena; Kavak Balgetir, Merve; Ozan Kocamüftüoğlu, Gonca; Yalçın, Tuba; Ozan, & İbrahim EnverAcetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in worldwide. N-acetyl cysteine (NAC) is used as the APAP antidote. Cyclosporin A (CsA) is suppressed mitochondrial damage by binding cyclophilin, a mitochondrial pore transport component. The study aimed to evaluate the effects of NAC, CsA, and NAC+CsA treatments on APAP-induced hepatotoxicity in mice. Mice were randomly divided into five groups (n = 6). 400 mg/kg/ip/single dose APAP, 1200 mg/kg/i.p/single dose NAC and 50 mg/kg/i.p/single dose CsA were performed. Light and electron microscopic alterations were investigated in liver samples. Levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and liver glutathione (GSH) were analyzed. 3-nitrotyrosine and cytochrome c immunoreactivities were evaluated in liver tissue. Here, we found that APAP leads to histopathological and ultrastructural changes in mice liver. Also, APAP increased cytochrome c and 3-nitrotyrosine immunopositive staining. Besides, a significant decrease in liver GSH and an increase in serum AST and ALT levels were detected in the APAP group. Interestingly, NAC+CsA treatment improved histological alterations, cytochrome c, and 3-nitrotyrosine immunoreactivities and liver GSH, serum AST/ALT levels caused by APAP. We suggest that the combination of NAC and CsA reduces acetaminophen-induced hepatotoxicity in mice.Article Effect of Delivery Method on Breastfeeding Status in Primiparous Mothers Within the First 24 Hours(Springer Publishing Co, 2024) Yesil, Yesim; Oner, Serap; Celik, Gulbiye Dinc; Bay, Habibe; Eksioglu, Aysun; Turfan, Esin CeberObjective: This study aims to evaluate the effect of the delivery method on breastfeeding status of primiparous mothers during the first 24 hours. Methods: In this descriptive and analytical study, the sample consisted of 126 primiparous mothers with vaginal (n = 54) and cesarean (n = 72) deliveries. The research data were collected in a hospital through a personal information form and LATCH. Breastfeeding was assessed at the 6th, 12th, and 24th hours within the first 24 -hour period after the delivery. Results: A total of 83.3% of mothers with vaginal delivery started out breastfeeding in the first hour, while the rate was 43.1% for mothers with cesarean delivery. A total of 94.4% of mothers who had vaginal birth gave their babies colostrum, whereas the rate was 80.6% for mothers who had a cesarean birth. While there were no statistically significant differences in Applications 1 and 3 between the LATCH scores of mothers with vaginal and cesarean deliveries, Application 2 produced a significant difference (p < .05). Conclusions: Delivery method influenced the breastfeeding behavior and had an impact particularly on initiation of breastfeeding in the first hour.Article Citation - WoS: 2Citation - Scopus: 3Effects of Concomitant Use of N-Acetylcysteine and Cyclosporine a on Acetaminophen-Induced Acute Kidney Injury in Mice(Agricultural Research Communication Centre, 2024) Kocamueftueoglu, Gonca Ozan; Tektemur, Nalan Kaya; Guzel, Elif Erdem; Tektemur, Ahmet; Ozan, Ibrahim EnverBackground: Acetaminophen (APAP), a commonly used analgesic, causes acute kidney injury (AKI) in overdose although it is rare. Mitochondrial dysfunction plays a major role in the pathophysiology of renal damage, although the exact molecular mechanism is unknown. This study aimed to evaluate the potential therapeutic effect of cyclosporin A (CsA), a mitochondrial membrane permeability Methods: Male BALB/c mice were divided into Control, APAP, APAP+NAC, APAP+CsA and APAP+NAC+CsA groups (n=6). A single dose of APAP (400 mg/kg) was administered intraperitoneally. All other treatments (1200 mg/kg NAC, 50 mg/kg CsA) were performed intraperitoneally 3 h after APAP administration. All animals were decapitated and blood samples and kidney tissue samples were collected for evaluation. Serum creatinine (Cr) and blood urea nitrogen (BUN) levels were measured. The kidney tissue 8-hydroxydeoxyguanosine (8-OHdG), cytochrome c (Cytc) and 3-nitrotyrosine (3-NT) levels and cytochrome c (Cytc) expressions were determined. Result: Increased Cr and BUN levels, histopathological examinations and expressions of 8-OHdG, 3-NT and Cytc were detected in the APAP group. Combined NAC+CsA treatment sufficiently reversed oxidative stress, serum Cr and BUN levels and histopathological alterations induced by APAP. Moreover, cytc levels and renal tubular injury were remarkably reduced by combined drug treatment compared to the APAP+NAC group. These data suggest that the therapeutic effect of combined NAC+CsA treatment in mice with APAP-induced nephrotoxicity can be related to the combination of the antioxidant effect of NAC and the mitochondrial MPTP inhibitor effect of CsA.Article Factors Affecting the Burden and Quality of Life of Caregivers for Gynecological Cancer Patients(Archives of Health Science and Research, 2022) Yaşar, Beril Nisa; Terzioğlu, FüsunObjective: The aim of this study is to evaluate the care burden and quality of life of caregivers of patients with gynecologic cancer. Material and Methods: This descriptive study was conducted with 251 individuals who provided care to patients with gynecologic cancer in gynecologic oncology services of a university hospital and a state oncology hospital. The data were collected by a semi-structured questionnaire form, Caregiver Burden Inventory (CBI), and Quality of Life Family Version. Results: The mean age of the participants was 39.76 ± 14.20; 79.3% of them were female, 65.3% were married, 28.7% were high school graduates, 57.4% were employed and 56.2% were unemployed before starting care, 91.2% had health insurance, 58.6% perceived their income as moderate, and 57% had relatives of the patient receiving care. Care burden was statistically significant in terms of gender, marital status, educational level, and degree of affinity with the patient (P < .005). The correlation between caregivers’ quality of life, gender, health insurance, income status, and the degree of affinity with the patient was statistically significant (P < .005). Conclusion: As a result of this study, it was determined that some socio-demographic characteristics of the caregivers of patients with gynecologic cancer affected the care burden and quality of life.Article Investigation of the effects of Alfa lipoic acid on changes in maternal rat kidney caused by tobacco smoke exposure in pregnancy [Gebelikte Tütün Dumani Maruziyetinin Anne Siçan Böbrek Dokusunda Meydana Getirdigi Degişiklikler Üzerine Alfa Lipoik Asitin Etkilerinin İncelenmesi](Ataturk Universitesi, 2019) Erdem Güzel E.; Kaya N.; Ozan Kocamüftüoglu G.; Dabak D.Ö.; Temizer Ozan P.S.; Ozan I.E.Çalışmada gebelikte tütün dumanına maruz kalan anne sıçanların böbrek dokusunda meydana gelen histopatolojik sonuçlar üzerine Alfa lipoik asitin etkilerinin deneysel olarak araştırılması amaçlandı. 28 adet dişi Sprague-Dawley cinsi sıçan kullanıldı. Gebe sıçanlar; Kontrol grubu, Tütün dumanı (TD) grubu, Tütün dumanı + Alfa lipoik asit (TD+ALA) grubu ve Alfa lipoik asit (ALA) grubu olmak üzere rastgele dört eşit gruba ayrıldı. TD ve TD+ALA grubundaki sıçanlar çiftleşmeden önce sekiz hafta ve gebelik süresince günde iki saat tütün dumanına maruz bırakıldı. TD+ALA ve ALA grubundaki sıçanlara ise çiftleşmeden önce sekiz hafta ve gebelik süresince gün aşırı gavaj yolu ile 20 mg/kg ALA verildi. Deney sonunda çıkarılan böbrek dokuları histolojik, immünohistokimyasal ve MDA düzeyi tayini metotları kullanılarak incelendi. TD grubuna ait böbrek kesitlerinde inflamatuar hücre artışı, Bowman boşluğunda artış, tübül lümeninde hiyalin birikimi gibi histopatolojik bulgulara rastlandı. ALA uygulaması ile histopatalojik bulguların büyük bir çoğunluğunda azalma gözlendi. TD grubunda VEGF immünreaktivitesinin kontrol grubuna göre anlamlı artış gösterdiği, TD+ALA grubunda ise TD grubuna göre anlamlı derecede azaldığı belirlendi. MDA seviyelerinde ise TD grubunda, kontrol grubuna göre anlamlı artış olduğu tespit edildi. Sonuç olarak, gebelik boyunca tütün dumanı maruziyetinin böbrek dokularında histopatolojik hasara ve damarlanmada artışa neden olduğu, ALA’nın ise bu etkilere karşı kısmen koruma sağladığı belirlendi.
