WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Evaluation of the Neurodevelopmental Status for Urea Cycle Disorders: Based on Clinical Experience
(Galenos Publ House, 2023) Bozaci, Ayse Ergul; Goksoy, Emine; Unal, Aysel Tekmenuray; Albayrak, Hatice Mutlu; Tas, Ibrahim; Kanar, Berat; Kose, Melis
Aim: Urea cycle disorders (UCD) still have poor neurological outcomes despite early diagnosis and treatment. We aimed to present the neurological outcomes of UCD patients and to determine the main simple and accessible factors affecting these outcomes. Materials and Metkods: This was a descriptive cross-sectional study conducted in two pediatric metabolism centers on 29 patients from 25 unrelated families who were diagnosed and followed with UCD based on clinical presentation, neurological parameters, biochemical measurements, and molecular analysis.Results: Within the study population, the most common diagnosis was argininosuccinate synthase deficiency in 13 (44.82%) patients, followed by N-acetylglutamate synthase deficiency in five patients (17.24%), ornithine transcarbamylase deficiency in four patients (13.79%), arginase 1 deficiency in three patients (10.34%), carbamoyl phosphate synthase 1 deficiency in three patients (10.34%), and argininosuccinate lyase deficiency in one patient (3.44%). Peak ammonia levels were observed to be significantly higher in those patients with delayed milestones and patients who had Denver II <-2 standard deviation score results (p=0.032, p=0.026). Effect sizes were large in both groups. Delayed milestones were noted in 17 (94.4%) of the cases with peak ammonia >500 mu mol/L (n=18). Those patients with abnormal neurological parameters had a significantly higher mean number of hyperammonemic episodes per year. Extracorporeal detoxification was given to eight patients, in combination with therapeutic hypothermia in two patients. Rapid regression was observed in brain edema in those who underwent therapeutic hypothermia.Conclusion: Our study emphasizes the effect of peak ammonia levels and the frequency of hyperammonemic episodes on neurological outcomes. There were still poor neurocognitive outcomes despite extracorporeal detoxification. This highlights the need to reassess current treatment strategies, including the threshold for starting extracorporeal detoxification if ammonia levels exceed 500 mu mol/L. The use of therapeutic hypothermia by experienced teams may be promising due to its brain edema-reducing effects.
Sectarian Diplomacy and the Transformation of Ottoman Statecraft: Yâsincizâde Abdülvehhâb Efendi's Embassy to Qajar Iran (1810-1813)
(MDPI, 2025) Tan, Hasan
At the beginning of the 19th century, Ottoman-Iranian relations entered a new diplomatic phase shaped by Russia's expansion in the Caucasus and Britain's growing influence in the Persian Gulf. This shared perception of external threats led to the establishment of a more structured and representative diplomatic framework between the two empires. This study examines the embassy of Y & acirc;sinciz & acirc;de Abd & uuml;lvehh & acirc;b Efendi, who was appointed as Ottoman ambassador to Iran between 1810 and 1813, in the context of a shifting diplomatic mindset. Y & acirc;sinciz & acirc;de's mission is analyzed not merely as a temporary diplomatic engagement, but as a form of ideological, sectarian, and cultural representation by a figure from the ulema class. Based on archival sources, the study reveals that his diplomatic reports and observations provided critical input to the central administration, contributing to the development of more institutionalized and long-term strategies in Ottoman policy toward Iran. By focusing on the transitional character of his embassy, the paper reassesses the evolving role of religious scholars in Ottoman foreign relations and situates this case between the classical sefaretn & acirc;me tradition and emerging modern diplomatic practices.
The Contribution of Trading Colonies Founded in Levant in Protodynastic and Early Dynastic Period (BC 3300-3000) to Egypt's Becoming a State
(Karabuk Univ, 2014) Civgin, Izzet
This study is the fourth of an article series dedicated to colonization as a cause of cultural change. It discusses the effects of culture contact between lower (northern) and upper (southern) Egypt and the southern Levant during so- called Naqada expansion (widespread distribution of southern material culture at sites at the northern Egypt), and Egyptian colonization of the southern Levant assumed to be founded in the last quarter of the 4th millennium B.C. The ultimate objective of this study is to examine the relationship between long-distance trade, colonization and the state formation (state ideology, emergence of early elites, specialized craft production and political economy).
Citation - WoS: 11
Citation - Scopus: 12
The Effectiveness of HALP Score in Predicting Mortality in Non-ST Myocardial Infarction Patients
(Lippincott Williams and Wilkins, 2025) Kiliç, R.; Guzel, T.; Aktan, A.; Güzel, H.; Kaya, A.F.; Çankaya, Y.
Background: The HALP score, measured based on hemoglobin, albumin, lymphocyte, and platelet levels, is regarded as a novel scoring system that indicates the status of systemic inflammation and nutritional health. Our study aimed to evaluate the relationship between HALP score and prognosis in non-ST-elevation myocardial infarction (NSTEMI) patients. Methods Between 1 January 2020 and 1 January 2022, 568 consecutive patients diagnosed with NSTEMI from a single center were included in the study retrospectively. The patients were divided into two equal groups according to the median HALP cutoff value of 44.05. Patients were followed for at least 1 year from the date of admission. Results The average age of the patients was 62.3±10.6 years and 43.7% were female. In-hospital and 1-year mortality were found to be significantly higher in the group with low HALP scores (6.0 vs. 2.1%, P=0.019 and 22.5 vs. 9.9%, P<0.001, respectively). In receiver operating characteristic curve analysis, a cutoff level of 34.6 of the HALP score predicted 1-year mortality with 71% sensitivity and 65% specificity (area under the curve: 0.707, 95% confidence interval: 0.651-0.762, P<0.001). In Kaplan-Meier analysis, higher mortality rates were observed over time in the group with lower HALP scores (log-rank test=16.767, P<0.001). In Cox regression analysis, the HALP score was found to be an independent predictor of 1-year mortality (odds ratio: 0.969, 95% confidence interval: 0.958-0.981, P<0.001). Conclusion We found that a low HALP score could predict in-hospital and 1-year mortality in patients admitted to the hospital with a diagnosis of NSTEMI. © © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Qualitative Analysis of Solutions for a Timoshenko Type Equation With Logarithmic Source Term
(Univ Nis, 2025) Dinc, Yavuz; Irkil, Nazli; Piskan, Erhan; Tunc, Cemil
This paper deals with a Timoshenko type equation with strong damping and logarithmic source terms. The global existence and the decay estimate of the solutions have been obtained. We reproduce the finite time blow up results of weak solutions by the combining of the concavity method, perturbation energy method and differential-integral inequality technique. These results extend and improve some recent results in logarithmic nonlinearity.
The Effects of Elicitor and Abiotic Stressor Molecules on Phenolic Composition of in Vitro Callus Cultures of Elecampane (Inula Helenium L.)
(Soc Stiinte Farmaceutice Romania, 2025) Battal, Peyami; Akcura, Gokhan; Turker, Musa; Dalar, Abdullah
This study focused on the effects of various stressors and elicitors on phenolic metabolism of in vitro callus cultures of Elecampane. 1 mg/L 2,4-Dichlorophenoxyacetic acid (2,4-D) + 0,3 mg/L Kinetin (KN) formulation was detected as the most proper application for callus production. Quercetin was synthesized as the dominant phenolic compound of callus cultures. The highest values of total phenolics were obtained through the combination of 6-Benzylaminopurine + 1-Naphthaleneacetic acid (BAP+NAA) in the plant growth regulators (PGR) group (169 mu g/g), 1/2 reduced Murashige and Skoog medium (MS) (108 mu g/g) in the stressor group, and both abscisic acid (140 mu g/g) and melatonin (138 mu g/g) in the elicitor group. The application of various PGRs and elicitors enhanced the level of quercetin at pronounced levels (241-388 mu g/g), but not in rutin (3-18 mu g/g). Chlorogenic acid increased under silver nitrate (19 mu g/g) and 1/4 reduced MS stressors (17 mu g/g) and melatonin (32 mu g/g) and abscisic acid (24 mu g/g) elicitors. These findings suggest that the combination of 2,4-D + KN, reduced MS, abscisic acid, and melatonin conditions stimulated the synthesis of phenolics through the biosynthetic pathway by increasing the stress resistance of Elecampane.
Citation - WoS: 1
An Empirical Investigation on Growth and Institutional Structure Relations in Central Asian and Caucasian Countries
(Ege Univ, Fac Economics & Admin Sciences, 2023) Cuhadar, Pinar; Kıran Bulgurcu, Berna
Whether economic and political institutions have an impact on countries' economic growth performances is one of the important research topics discussed in the literature. Former socialist Central Asian and Caucasian countries trying to adapt into market economy have not yet completed their transition processes, but they have managed to grow their economies in comparison to previous periods. The aim of this study is to analyse the relationship between the growth performances and institutional structures of the Central Asian and Caucasian countries of Azerbaijan, Armenia, Georgia, Kazakhstan, Kyrgyzstan and Tajikistan between the years 2000-2018 by using the decision variables of civil rights, economic freedom, political stability, rule of law and GDP per capita. According to the analysis results obtained via Grey Relational Analysis method by assigning equal importance to all variables, Kazakhstan is found to be the highest-ranking country among all examined countries for all periods. The authoritarian tendencies that these countries have shown during their market economy transitions with regards to matters related to institutional structure have been found to be the reason why countries' economic efforts have failed to yield results.
Citation - WoS: 5
Understanding of Tourists' Memorable Local Food Experiences: a Netnography Study
(Istanbul Univ, Methodology & Sociology Research Center, 2022) Kodas, Betul; Aksoy, Zekeriya
Memorable food experiences are an important factor in both the tourism business and destination marketers and managers attracting not only current tourists but also potential tourists. Recently, several studies have been performed to explore or understand memorable food experiences, as food experiences are a crucial indicator of tourist behavioural intentions and satisfaction. Thus, the purpose of the current study is to understand tourists' memorable local food experiences, food experience satisfaction, and behavioural intentions. Accordingly, data was collected through online reviews (424) posted about tourists' memorable local food experiences in Gaziantep between 9 April 2021 and 29 May 2021. A phenomenological approach and content analysis technique were used to analyse the data. In the results of the present study, a theoretical model of memorable local food experiences (MLFEs) was developed with six key components: novelty, hospitality and services, taste and food attributes, togetherness and local interactions, ambience and setting, and local culture. In addition, tourists' food experience satisfaction and behavioural intentions were found to be positive while experiencing regional local food. Based on the results of this study, practical and managerial implications are discussed, and future research recommendations are proposed.
Muslim, Alevior Kurd? Religion, Nation and Identity Conflicts
(I B Tauris & Co Ltd, 2017) Cicek, Cuma
[No Abstract Available]
Citation - WoS: 2
The Challenges of "renewed" Enlargement To the Western Balkan Countries
(University of Warsaw Centre For Europe, 2024) Yaris, Zelal Basak
In the last two decades, acting as an anchor for a transition to democracy and a market economy, the EU has given membership perspectives to the North Macedonia, Montenegro, and Croatia. At the outset, the EU triggered democratic reforms, empowered civil society organisations, and established democratic rules in those countries. However, on Croatia's joining the EU in 2013, the Union demonstrated what can be best described as apparent enlargement fatigue and took a break from the widening of Western Balkan countries for the fi ve subsequent years. However, the Russian invasion of Ukraine in February 2022 revitalised the EU enlargement policy towards Western Balkan countries for security and geostrategic considerations. In that purview, this paper seeks to explore contextual constraints associated with the EU's renewed enlargement policy towards Western Balkan countries. Using the conceptual framework of Alcaro and his co-authors (2022), it is argued that the EU renewed enlargement operates in a context driven by the following three key processes: (1) multi-actor geostrategic competition; (2) regional fragmentation; and (3) intra-EU contestation. In this context, considering international, regional, and institutional contextual constraints, the EU's leverage on the Western Balkan countries would not be taken for granted, suggesting that the EU needs to develop hybrid strategies transcending classic tools of enlargement.
Citation - WoS: 3
Investigation of Uroprotective Effects of Seed Methanol Extracts of Hypericum Triquetrifolium Turra. on Cyclophosphamide-Induced Bladder Hemorrhagic Cystitis and Nephrotoxicity in Wistar Albino Rats
(Cukurova Univ, Fac Medicine, 2020) Yildiz, Songul Cetik; Keskin, Cumali; Sahinturk, Varol; Ayhanci, Adnan
Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats. Materials and Methods: Wistar albino rats used in this study were divided into nine groups, each including seven rats. Group 1 (control) was treated with 0.5ml saline (SF) and Group 2 was treated with CYP (150 mg/kg). Groups 3, 4, 5 were treated with 25, 50, 100 mg/kg HT, respectively while groups 6, 7, 8 were treated with 25, 50, 100 mg/kg CYP + HT, respectively. Finally, Group 9 (control-2) was treated with 0.5ml-%0.2 dimethyl sulfoxide (DMSO). The serum creatinine, blood urea nitrogen (BUN), superoxide dismutase (SOD) and catalase (CAT) levels were measured in blood serum. Results: The CYP-treated rats histopathologically had mild-moderate bladder and renal injuries. The serum creatinine and BUN levels, which are the biochemical markers of renal injury, significantly increased compared to the control group. Conclusion: HT showed a protective effect on CYPrelated bladder HC and nephrotoxicity in rats by inhibiting inflammation and apoptosis.
Verbascum Kotschyi Boiss. & Hohen. Kullanılarak Sentezlenen Çinko Oksit ve Selenyum Oksit Nanopartiküllerinin Antioksidan ve Antimikrobiyal Özelliklerinin Karşılaştırılması
(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2025) Ercan, Leyla; Caliskan, Cemile Gunbegi; Kılıç, Fatma Mungan
Nanoparticle applications have been studied in many fields in recent years. Among these studies, the synthesis of nature-friendly and healthfriendly nanoparticles through green synthesis attracts much attention. These investigations also highlight the significance of several plant species, many of whose worth and traits remain unknown. The goal of this work is to create zinc oxide and selenium nanoparticles from Verbascum kotschyi Boiss. & Hohen., a plant species that hasn't received much attention, and to ascertain the antioxidant and antibacterial qualities of these nanoparticles. To accomplish this, three distinct techniques (DPPH, CUPRAC, and FRAP) were used to assess the produced nanoparticles' in vitro antioxidant capabilities after SEM, EDX, and FTIR analyses. Furthermore, the disk diffusion technique was utilized to ascertain the antibacterial efficacy of these nanoparticles against both gram-positive and gram-negative bacteria and fungus. In conclusion, V. kotschyi-derived zinc oxide nanoparticles outperformed selenium nanoparticles in terms of antibacterial activity. But when it came to antioxidant activity, selenium nanoparticles outperformed zinc oxide nanoparticles. Thus, it was determined that the products created by nanoparticle synthesis from Verbascum kotschyi have properties that can be used in different fields.
Müzakere, Hız, Politika: Uluslararası Arabuluculukta Digital Teknolojilerin Kullanımı
(Istanbul Univ, 2023) Burc, Safiye Ates
The super -accelerated (high-speed) life experiences and coercive practices of the new world order (Covid and post-Covid periods) have affected and changed the negotiation and conflict resolution skills of international actors. Today, with the pandemic and technological developments, acceleration has become a necessity in many fields. Many international mediators, especially the United Nations (UN), have also benefited greatly from digital technologies that pierce space and time during the most severe times of the Covid-19 pandemic. So, in today's world, where economic, social and technological development continues at high speed, should negotiations and policies keep pace? If so, how should accelerated and virtualised political practices be discussed over conflict resolution? What is the impact of digitalisation on international mediation? This article critically discusses the relationship between digitalisation, speed, politics and conflict resolution through content and discourse analysis of political reports on peacemaking practices of different UN missions, especially during the most traumatic period of the pandemic (March 2020 -March 2021). The study concludes that politics and negotiations need speed barriers because they need time, but they cannot be isolated from the developments and space of the high-speed society, so they need to follow the virtual space at all times and get involved when needed. As the analyses of the missions' reports show, the effective use of digital technologies, especially during the pandemic, has led to a rapid transformation in mediation (from traditional to cyber-mediation) and conflict resolution activities have been able to continue uninterrupted, but the dangers of digitalisation have not disappeared
A New Green Corrosion Inhibitor for Mild Steel in 1 M HCl Using Erodium Cicutarium (L.) Leaf Extract: Insights From Both Theoretical and Experimental Methods
(Elsevier, 2026) Ergel, Busra; Yildiz, Resit; Arslanhan, Selim; Baran, Mehmet Firat
Considering the economic and environmental conditions, corrosion appears to be a significant handicap. In this study, anti-corrosion performance of Erodium cicutarium (L.) (EC) is explored in a 1.0 M HCl using potentiaodynamic polarization (PDP), electrochemical impedance (EIS) and linear polarization resistance (LPR) spectroscopies along with morphological, structural and quantum chemical methods. FT-IR and LC-ESI-MS/MS reveal the chlorogenic acid, gentisic acid, protocatechuic acid, vanillin and salicylic acid, containing-C=O, C=C, C-H, C-H, -OH, and aromatic ring. PDP, EIS and LPR showed that at the highest concentration of the EC extract (1000 ppm), the polarization resistance and corrosion current density are measured as 974 Omega cm2 and 246 mu A cm-2, while the inhibition efficiency was found to be 98 %. Inhibition efficiencies decreased with increasing temperature and exposure times due to desorption of adsorbed inhibitor molecules from the surface. But, a notable increase in the Ea value (67.2 kJ mol-1) is observed, thereby hindering the corrosion process. While adsorption behavior is in accordance with the Langmuir isotherm, the Delta G degrees ads (-27.34 kJ mol-1) value indicates both physical and chemical adsorptions. To better understand the inhibitory mechanism, zero charge potential is determined, and quantum chemical calculations of the EC extract's components are performed.
Citation - WoS: 1
Language Teaching and Games -In the Light of Multiple Intelligence Theory
(Dinbilimleri Akad Arastirma Merkezi, 2014) Aydin, Tahirhan
This study reviews from the perspective of multiple intelligence theory certain educational games that have been used in foreign language teaching. It first underlines the significance of language teaching and goes on to mention the place of games in education in general and in language teaching in particular. Lastly, the study examines how multiple intelligence theory, which redefines human talents, views educational games with regards to language teaching.
Citation - Scopus: 1
The Effect of Health Literacy and Self-Efficacy Levels of Syrian Refugee University Students on Quality of Life
(Springer Heidelberg, 2024) Apak, Hidir; Yigitalp, Gulhan; Tatlicioglu, Oktay
AimAccording to studies, self-efficacy and health literacy impact Syrian refugees' quality of life. However, it is unclear how these factors influence quality of life for Syrian university students. This study aims to determine health literacy, self-efficacy, and quality of life for Syrian refugee students and investigate how health literacy and self-efficacy affect quality of life. MethodsThis cross-sectional study was conducted with 330 Syrian undergraduate students studying at Mardin Artuklu University in Turkey between February and May 2022. The Socio-demographic Information Form, Health Literacy Scale (HU-SOY), and World Health Organization Quality of Life (WHOQOL-BREF) Scale were used in this study as data collection instruments and all scales were administered in Arabic. The data were analyzed with t-tests, ANOVA tests, correlation, and multiple linear regression. ResultsA significant positive correlation was found between health literacy, self-efficacy, and quality of life (p < 0.05). Self-efficacy (beta = .335, t 324 = 6.65, p < .001) and perception of general health status (beta = .255, t 324 = 5.075, p < .001) predicted quality of life. ConclusionsIt is concluded that Syrian university students' quality of life might be improved by increasing their health literacy, self-efficacy, and perception of health.
The Relationship of Promising as a Speech Act With Ethics and the Fact-Value Problem
(Beytulhikme Felsefe Cevresi, 2024) Bingol, Sedat
The aim of this paper is to show how value is derived from the fact through the example of promise and to reveal the relationship of this derivation with ethics. This aim will be achieved mainly through the answers of John Searle and Paul Ricoeur to the fact-value problem. Searle tries to solve the problem of whether value can be derived from facts, within the boundaries of the philosophy of language. Ricoeur, on the other hand, thinks that if this derivation is achieved, the problem is an ethics problem. In this paper, I will try to build a bridge between philosophy of language and ethics by presenting the views of Searle and Ricoeur. This effort to establish a connection has the intention of, in a sense, violating the boundaries and distinctions between the two fundamental disciplines of philosophy.
Relationship Between First Trimester Placental Thickness and Perinatal Prognosis: a Prospective Cohort Study
(Bayrakol Medical Publisher, 2025) Yilmaz, Mehmet; Aksin, Serif; Balsak, Deniz; Aboalhasan, Yasmin; Kurnuc, Fatma Zehra; Batmaz, Ibrahim
Aim: This study aims to investigate the correlation between first-trimester placental thickness and perinatal prognosis. Material and Methods: A prospective cohort study was conducted at Siirt University Faculty of Medicine from March 2022 to March 2023 of 365 pregnant women in their first trimester (11-14 weeks of gestation). Placental volume was measured using two-dimensional (2D) ultrasound, and estimated placental volume (EPV) was calculated using Merwin's EPV Calculator app. The patients were followed until delivery, and outcomes such as gestational age at delivery, mode of delivery, fetal weight, APGAR score, fetal gender, perinatal outcomes, preeclampsia (PE), premature rupture of membranes (PROM), gestational hypertension (GHT), gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), preterm birth, oligohydramnios, polyhydramnios, surmaturation, presentation anomaly, intrauterine death, fetal distress, and placental abruption were evaluated. Results: Data from 365 pregnant women were analyzed. The mean maternal age was 27.2 +/- 5.5 years. The distribution of placental location was 38.4% posterior, 43.0% anterior, 7.4% left sidewall and 11.2% right sidewall. No significant differences were found in placental volume measurements based on delivery mode, fetal gender, or conditions such as PE, GDM, IUGR, PROM, preterm birth, or other perinatal pathologies. Statistical analyses showed no significant association between first-trimester placental volume and adverse perinatal outcomes (p>0.05). Discussion: No relationship was found between first-trimester placental thickness and perinatal outcomes.
Applying Ibn Khaldun: the Recovery of a Lost Tradition in Sociology
(Scientific Studies Assoc-ilmi Etudler dernegi-ilem, 2020) Gokdag, Kamuran
[No Abstract Available]
Eva Illouz, Modern Ruhu Kurtarmak: Terapi, Duygular ve Kişisel Gelişim Kültürü, Çev. Kadir Gülen, Fol Kitap, 2024, 368 S
(Ilem, 2025) Demir, Ali Eren; Illouz, Eva

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