WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

Browse

Now showing 1 - 20 of 1422

Foreign and Local Construction Practices and the Formation of Ottoman Engineering in the Hejaz Railway Construction (1900-1908)
(Vdf Hochschulverlag Ag An der Eth Zurich, 2024) Boluk, Habibe Tuba; Rinke, Mario; Mascarenhas-Mateus, Joao
Infrastructure projects were one of the most important elements of the reform processes in the Ottoman Empire in the 19th century. One of the central projects was the Hejaz railway line (1900-1908), which ran from Damascus to Medina through the Hejaz region in present-day Saudi Arabia and had a branch line to Haifa on the Mediterranean. For many of these technically demanding projects, foreign companies were engaged who were obliged to collaborate with local experts and labourers. This paper focuses on the Haifa-Dara line characterized by ambitious structures due to the rugged topography. A key person here was German engineer August Heinrich Meissner who facilitated the inclusion of Ottoman engineers (some graduates of the Hendese-i Mtilkiye and others educated in European schools). Meissner's apprenticeship model for Muslim and non-Muslim laborers played a crucial role in shaping the Hejaz railway project. The research investigates the Project's catalyzing role in the development of Ottoman civil engineering in the empire. It aims at a better understanding of how, rather than by whom, new technical knowledge of modern engineering practice was established in the empire. Archival research into diplomatic documents and foreign companies sheds light on the intertwined connections with European enterprises, particularly German ones. The discussion traces construction knowledge and organization, offering a better understanding of the technical, economic, and cultural impact of Ottoman control over foreign enterprises and highlighting the multifaceted implications of infrastructure projects in the complex execution of Ottoman railway projects.
Cryogel-Immobilized Catalase as a Biocatalyst with Enhanced Stability Against Microplastics
(MDPI, 2025) Erol, Kadir; Alkan, Mehmet Huseyin; Alacabey, Ihsan
Catalase is a pivotal antioxidant enzyme that decomposes hydrogen peroxide and reduces oxidative stress. However, its low thermal and operational stability limits applications in challenging environments, particularly those contaminated with emerging pollutants such as polystyrene-based microplastics (PS-MPs). In this study, cryogels composed of Poly(2-hydroxyethyl methacrylate-co-allyl glycidyl ether) [Poly(HEMA-co-AGE)] were synthesized and evaluated as immobilization matrices to enhance catalase stability. Cryogels containing varying AGE concentrations were characterized using FT-IR, SEM, TEM, TGA, and BET analyses. The formulation with 250 mu L AGE exhibited optimal physicochemical properties, including improved water retention, increased surface area, and high immobilization capacity (356.3 mg center dot g(-1)). Immobilized catalase maintained superior activity under PS-MP-induced stress across a range of concentrations (0-1.0 mg center dot mL(-1)), temperatures (4-60 degrees C), and exposure times (up to 5 h). Kinetic modeling revealed a significant improvement in substrate affinity, with Km decreasing from 54.9 to 17.1 mM, while Vmax decreased moderately. Long-term stability tests showed that immobilized catalase retained similar to 80% activity after 70 days at 4 degrees C and 55% after 15 reuse cycles. Desorption studies confirmed the reusability of the cryogel system. These findings suggest that Poly(HEMA-co-AGE) cryogels provide a robust and reusable platform for catalase stabilization, offering potential for applications such as wastewater treatment and biosensing in microplastic-contaminated systems.
Vulnerable Newborns: Disparities in Pediatric Emergency Department Admissions Between Refugee and Non-Refugee Newborns
(Lippincott Williams & Wilkins, 2025) Solmaz, Murat; Demir, Devran; Gungor, Emre; Orhan, Ozhan
The conflicts that began in the Middle East and Syria in 2011 resulted in many people seeking refuge in neighboring countries. Due to irregular migration, many newborns were born far from their homelands, in foreign countries. This study aims to compare the clinical characteristics and outcomes of non-refugee and refugee newborns to assess potential disparities in their healthcare experiences. The present study examined the applications of newborns who were admitted to the third level pediatric emergency clinic on the Syrian border of Turkey between January 1, 2024, and December 31, 2024. The most prevalent presenting complaint among both non-refugee and refugee newborns was jaundice, occurring in 23.9% and 21.4% of cases, respectively. Fast breathing was significantly more common in refugee newborns than in non-refugee newborns (11% vs 2.6%, P = .021). Poor feeding was significantly more prevalent among non-refugee newborns than among refugee newborns (9.8% vs 3.8%, P = .008). Additionally, 7.1% of non-refugee newborns had significant medical complications, compared to 25.2% of refugee newborns. This difference was statistically significant (P =.001). Despite the availability of universal, free healthcare at all levels for all newborns, refugee babies continue to utilize inferior healthcare facilities, resulting in elevated mortality rates. Consequently, addressing the health concerns of refugee newborns necessitates a comprehensive strategy. This strategy should encompass programs that bolster maternal and infant health, nutritional support, vaccination services, mental health services, and the provision of secure living environments.
The Effects of Video-Based and Blended Learning on Medication Dosage Calculation Skills of Paramedic Students: A Randomized, Quasi-Experimental Study
(Lippincott Williams & Wilkins, 2025) Baran, Leyla; Ozturk, Huri
Background:Medication dosage calculation (MDC) is a vital component of clinical competence for healthcare providers, particularly in emergency medical services, where miscalculations can lead to life-threatening outcomes. This study aimed to compare and evaluate the effects of video-based learning (VBL) and blended learning (BL) on the MDC skills of paramedic students, with the hypothesis that BL would result in higher posttest MDC performance compared to VBL.Methods:A randomized quasi-experimental design was used. A total of 151 paramedic students were randomly assigned to 2 groups. Both groups received a 2-week e-learning course that included video-based content and task-based exercises. Additionally, the BL group received an 8-hour classroom-based training session during the same 2-week period, which was scheduled as a single full-day session on the third day of the first week. Following the intervention, both groups completed a posttest assessing their MDC skills.Results:The BL group achieved significantly higher posttest scores (82.19 +/- 13.74) compared to the VBL group (72.24 +/- 21.87), with the difference being statistically significant (P = .001).Conclusion:While both methods were effective in enhancing MDC skills, BL was more effective. E-learning materials require further development to function as a fully independent instructional approach.
Parents' State and Trait Anxiety Levels During Bloodletting Attempts in the Pediatric Emergency Department
(Galenos Publ House, 2025) Butun, Ahmet; Bayraktar, Sema; Catalbas, Meltem
Introduction: Parental stress and anxiety during pediatric bloodletting in the pediatric emergency department (PED) are influenced by a complex interplay of factors, including the child's medical condition, unfamiliaritywith procedures, healthcare-provider interactions, and parental knowledge gaps. This study aimed to identify parents' state and trait anxiety levels during bloodletting procedures performed on their children in the PED and to explore factors influencing these anxiety levels. Methods: This descriptive cross-sectional study was conducted in the PED of a tertiary hospital in the southeast of Turkiye. Data were collected from 180 parents using a questionnaire that included a socio-demographic information form, and the state-trait anxiety inventory. Data were collected between 6 January 2025 and 20 February 2025. The data were analysed using the IBM SPSS statistics for Windows version 22.0. Results: Parents exhibited moderate levels of anxiety, with mean state anxiety scores of 41.494 +/- 10.322 and trait anxiety scores of 39.189 +/- 9.370. Mothers reported significantly higher trait anxiety levels compared to fathers (41.944 +/- 9.012 vs. 35.056 +/- 8.371, p<0.001). Lower maternal education levels, non-working status, and lower income were associated with higher trait anxiety. Parents who received education about their child's illness had significantly lower anxiety levels (p<0.05). Satisfaction with healthcare staff communication and information provision also correlated with reduced anxiety. Conclusion: The study highlights the significant anxiety experienced by parents during pediatric bloodletting procedures, particularly among mothers and those with lower socio-economic status. Providing educational support and improving communication between healthcare staff and parents can help to alleviate parental anxiety. These findings underscore the need for targeted interventions to support parents in PED settings.
Inspiratory Muscle Training in Natural Bodybuilders: Adaptations in Diaphragm Muscle Thickness and Maximal Strength
(Frontiers Media Sa, 2025) Guler, Iskender; Yilmaz, Coskun; Soylu, Hakan Hueseyin; Birinci, Muersit Ceyhun; Arslan, Ayla; Ocak, Hakan; Ceylan, Levent
Background: The effect of inspiratory muscle training on diaphragm muscle thickness (DT) and one repetition maximal (1RM) in professional natural bodybuilders is still unclear. The aim of the study was to investigate the effect of inspiratory muscle training on diaphragm muscle thickness and 1RM in professional natural bodybuilders. Methods: The study comprised a total of 22 athletes who participated in bodybuilding competitions. Each athlete had undergone a minimum of 5 years of training, with a minimum weekly commitment of 5 hours. Participants were randomly divided into two groups: inspiratory muscle training (IMT) and control (CON). The CON continued their normal training regime, while the IMT group also performed inspiratory muscle training with a 10% weekly increase by setting the resistance setting of the PowerBreathe (R) Classic device to 40% of the participant's maximum inspiratory pressure (MIP). Prior to and during the 4-week training period, 1RM bench press measurements and diaphragm muscle thickness measurements were obtained. Results: In the comparison of 1RM power values before and after training, it was determined that the IMT group (%: 11.20) had 6.3% more post-activation performance enhancement compared to the CON group (%: 4.9) (p < 0.001). In the study, it was determined that a higher level of significant post-activation performance enhancement was obtained in the IMT group compared to the CON group in the diaphragm muscle thickness inspiratory phase (DT ins) and ekspiratory phase (DT eks) parameters at 20.36% and 19.46%, respectively. Conclusion: In conclusion, we determined that the addition of progressive loading inspiratory muscle training to preparation programmes in natural bodybuilders will improve diaphragm muscle thickness, 1RM physical performance. In particular, it shows that the diaphragm muscle should be considered not only as a muscle that supports respiration, but also as a muscle that contributes to power generation by optimising intra-abdominal pressure.
Effects of Combined Supervised and Telerehabilitation Exercise Programs on Pain and Disability in Dentists with Chronic Neck Pain: A Randomized Controlled Trial
(BMC, 2025) Alkan, Emrullah; Gelecek, Nihal; Oz, Ilke Kara; Akcali, Aliye
Background: This study was conducted to determine the effects of combined exercises applied with supervised and telerehabilitation methods on pain intensity, pain pressure threshold, muscular endurance, grip strength, neck and upper extremity disabilities in dentists with chronic neck pain (CNP). Methods: Fifty-five dentists with CNP were included in the study and randomly divided into three groups as supervised group (n = 19), telerehabilitation group (n = 19) and control group (n = 17). The participants had a mean age of 35.20 +/- 4.16 years, with ages ranging from 30 to 44 years and of the participants, 43 were female (78%) and 12 were male (22%). Combined exercises consisting of resistance, stretching and postural alignment exercises were applied with supervised and telerehabilitation methods three days a week for 12 weeks. The control group received a non-resistance exercise sheet matching the other protocols. Initially, all patients were assessed for pain intensity (VAS), pain pressure threshold, grip strength (hand, lateral and pinch grip), muscular endurance (deep neck flexors, scapular, static and dynamic core), neck and upper extremity disability. The assessments were repeated after 12 weeks of training. Results: The telerehabilitation group demonstrated positive changes in pain intensity, pain pressure threshold, and neck disability that were statistically significant (p < 0.05). Supervised group has improved all assessments except dynamic core endurance and grip strength (p < 0.05). There was also a decrease in pain intensity and neck disability index in the control group (p < 0.05). When the changes resulting from exercise training were compared between the groups, it was seen that the changes in the supervised group were superior (p < 0.05). Conclusions: The results showed that combined exercises applied under supervision were more effective than telerehabilitation or home exercises in dentists with CNP, and telerehabilitation was more effective than home program. Although the telerehabilitation method is not as effective as supervised exercise training, it can be an alternative method to reduce pain and disability for dentists who cannot participate in a regular exercise program due to their working conditions. Long-term follow-up studies are needed to determine how long the effect of exercise training applied with telerehabilitation continues in dentists with CNP.
The Role of Statins in Modulating Subclinical Inflammatory Markers in Coronary Slow Flow Phenomenon
(Lippincott Williams & Wilkins, 2025) Demirci, Murat; Mustafayev, Urfan; Atas, Halil; Oguz, Mustafa; Kilic, Raif; Sunbul, Murat
Coronary slow flow phenomenon (CSFP) is characterized by slow coronary blood flow in the absence of significant stenosis, and its pathophysiology is associated with endothelial dysfunction, microvascular abnormalities, and inflammation. This study aimed to investigate the effects of statin therapy on subclinical inflammatory markers in CSFP patients. This retrospective cohort study included patients diagnosed with CSFP by using coronary angiography. The patients were divided into statin and control groups based on the initiation of statin therapy. Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were assessed at baseline and 3 months later. At baseline, NLR, PLR, SII, and SIRI levels were comparable between the 2 groups. After 3 months, these markers were significantly lower in the statin group. In the statin group, the NLR, PLR, SII, and SIRI levels significantly decreased from baseline, whereas no significant changes were observed in the control group. The reduction in inflammatory marker levels was more pronounced in patients receiving high-dose statins. Statin therapy is associated with reduced subclinical inflammation in CSFP, supporting the inflammatory basis and therapeutic value of statins.
Ameliorative Effects of Agomelatine Against Doxorubicin-Induced Hepatotoxicity
(BMC, 2025) Savas, Hasan Basri; Sozen, Mehmet Enes; Cuce, Gokhan; Batur, Tuba
Drug-induced hepatotoxicity is a significant impediment to the use of doxorubicin, a commonly employed chemotherapeutic agent with established efficacy in cancer treatment. The present study aimed to determine the potential protective effects of agomelatine against doxorubicin hepatotoxicity in rat toxicity models. Thirty-two rats were divided into four groups: control (with saline administration), Doxo (with 40 mg/kg doxorubicin administration), Doxo + Ago20, and Doxo + Ago40 (with 20 and 40 mg/kg agomelatine administration and 40 mg/kg doxorubicin administration). On the day of 14 rats were sacrificed, samples were collected for comparison of immunohistochemical, hematological, and biochemical analysis. There were statistically significant differences between the study groups in terms of immunohistochemical, hematological, and biochemical parameters. Agomelatine administration reduced the TNF-alpha, and caspase-3, which increased by doxorubicin, and reversed levels of oxidative stress markers altered by doxorubicin (p < 0.05). Doxorubicin induces oxidative stress, apoptosis, and hepatotoxicity. Agomelatine may be favored as a primary antidepressant to mitigate hepatic damage induced by doxorubicin.
Automated Mucormycosis Diagnosis from Paranasal CT Using ResNet50 and ConvNeXt Small
(MDPI, 2025) Toprak, Serdar Ferit; Dedeoglu, Serkan; Kozan, Gunay; Ayral, Muhammed; Can, Sermin; Turk, Omer; Akdag, Mehmet
Purpose: Mucormycosis is a life-threatening fungal infection, where rapid diagnosis is critical. We developed a deep learning approach using paranasal computed tomography (CT) images to test whether mucormycosis can be detected automatically, potentially aiding or expediting the diagnostic process that traditionally relies on biopsy. Methods: In this retrospective study, 794 CT images (from patients with mucormycosis, nasal polyps, or normal findings) were analyzed. Images were resized and augmented for training. Two transfer learning models (ResNet50 and ConvNeXt Small) were fine-tuned to classify images into the three categories. We employed a 70/30 train-test split (with five-fold cross-validation) and evaluated performance using accuracy, precision, recall, F1-score, and confusion matrices. Results: The ConvNeXt Small model achieved 100% accuracy on the test set (precision/recall/F1-score = 1.00 for all classes), while ResNet50 achieved 99.16% accuracy (precision approximate to 0.99, recall approximate to 0.99). Cross-validation yielded consistent results (ConvNeXt accuracy similar to 99% across folds), indicating no overfitting. An ablation study confirmed the benefit of transfer learning, as training ConvNeXt from scratch led to lower accuracy (similar to 85%) Conclusions: Our findings demonstrate that deep learning models can accurately and non-invasively detect mucormycosis from CT scans, potentially flagging suspected cases for prompt treatment. These models could serve as rapid screening tools to complement standard diagnostic methods (histopathology), although we emphasize that they are adjuncts and not replacements for biopsy. Future work should validate these models on external datasets and investigate their integration into clinical workflows for earlier intervention in mucormycosis.
Antifungal Potential of Endophytic Bacteria from Lavender (Lavandula angustifolia) Against Fusarium culmorum and Neoscytalidium dimidiatum Under Greenhouse Conditions
(Springer, 2025) Guney, Inci Guler; Keske, Mehmet Ata
This study investigated the antifungal potential of endophytic bacteria (EB) isolated from lavender (Lavandula angustifolia) against two phytopathogenic fungi Fusarium culmorum and Neoscytalidium dimidiatum under greenhouse conditions. Seventy EB isolates were obtained and subjected to phenotypic characterization and enzymatic activity profiling. Through 16S rRNA gene sequencing, five isolates were identified as Bacillus sp. (Lvt24, Lvt25, Lvt32, Lvt58 and Lvt62). Greenhouse experiments showed lavender plants treated with a mixture of Bacillus sp. isolates (Lvt24 + Lvt62) via root dipping and soil application grew better than other treatments and the control. Similarly, Bacillus sp. (Lvt25) application alone improved plant health and growth. Plants inoculated with N. dimidiatum had 81.07% disease incidence and 77.7% severity, while those inoculated with F. culmorum had 88.43% disease incidence and 81.6% severity, indicating a high level of infection. Inoculating with the pathogens and Lvt25 isolate reduced disease incidence and severity by 56.2 and 57.9% respectively, compared to control plants infected with N. dimidiatum, and by 57.7 and 57.8%, respectively, compared to control plants infected with F. culmorum. These findings indicate that Bacillus sp. Lvt25 isolate has a beneficial effect in reducing disease against these pathogens and has the potential to be a biological control agent.
Assessment of Genetic Diversity and Fusarium Root Rot Response in Turkish Bread Wheat
(Springer, 2025) Sesiz, Ugur; Elis, Seval; Kizilgeci, Ferhat; Yildirim, Mehmet; Palacioglu, Gulsum
Understanding the genetic diversity and population structure of bread wheat germplasm is essential for effective breeding and conservation strategies. This study evaluated 96 bread wheat genotypes from Turkiye-including advanced lines, commercial cultivars, and landraces-using Start Codon Targeted (SCoT) and inter-Primer Binding Site (iPBS) retrotransposon markers. Six SCoT and four iPBS primers generated 81.32% and 75.59% polymorphic bands, respectively, producing clear and reproducible profiles. The average polymorphism information content was 0.19 for both marker systems, with resolving power values of 3.13 (SCoT) and 2.35 (iPBS). Unweighted pair group method with arithmetic mean (UPGMA) cluster analysis grouped the genotypes into two major clusters with 41% overall similarity. Principal coordinate analysis (PCoA) clearly illustrated the genetic differentiation among the genotypes. Analysis of molecular variance (AMOVA) revealed that 69% of genetic variation was distributed within populations. Pathogenicity assays revealed differential disease responses among 21 genotypes to Fusarium culmorum isolate, with the cultivar Empire exhibiting moderate resistance. SCoT and iPBS markers effectively revealed genetic variation and supported the exploitation of promising genotypes for resistance breeding. The identification of genetically distinct and moderately resistant genotypes underscores the potential of Turkish wheat germplasm to support future breeding efforts.
Short-Term Resistance Training Enhances Functional and Physiological Markers in Older Women: Implications for Biomechanical and Health Interventions in Aging
(Frontiers Media Sa, 2025) Ucar, Mine Akkus; Yilmaz, Coskun; Soylu, Hakan Huseyin; Sariakcali, Baris; Budak, Cemalettin; Kavuran, Korhan; Ceylan, Levent
Background: The impact of resistance training extends beyond the enhancement of muscle strength, encompassing improvements in physical performance, postural stability, and overall functional capacity. This study aimed to investigate the effects of a 4-week resistance training program on functional capacity, respiratory muscle strength, diaphragm thickness, and liver density in healthy older women. Methods: The study included 30 healthy women aged 60-80 years and was designed as a randomized controlled experimental trial. Participants were randomly assigned to a resistance training (RT) group or a control (CON) group. Each participant attended the laboratory on three occasions: during the initial visit, the study procedures were explained; the second visit involved baseline assessments (6MWT, diaphragm thickness and liver fat via ultrasound, and respiratory muscle strength); and final measurements were conducted after the 4-week training programme during the third visit. Results: When pre- and post-training measurements were compared, the resistance training (RT) group demonstrated a significantly greater improvement (8.02%) in the Six-Minute Walk Test (6MWT) distance compared to the control group (p < 0.001). In terms of diaphragm thickness (DT), the RT group showed a 16.66% increase, whereas the control group exhibited a 1.13% decrease (p < 0.001). Maximal inspiratory pressure (MIP) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group, indicating a 19.55% greater improvement in the RT group (p < 0.001). Regarding maximal expiratory pressure (MEP), a significant improvement of 21.48% was observed in the RT group, whereas a 0.75% decrease was recorded in the control group, resulting in a 22.23% greater enhancement in the RT group (p < 0.001). Finally, liver density (LD) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group (p < 0.001). Conclusion: As a result of resistance training, greater improvement was observed in functional capacity, respiratory muscle strength, diaphragm thickness and liver density in the training group compared to the control group.
GIS-Based FUCOM Method for Assessing Land Suitability for Almond Cultivation in Midyat, Southeastern Türkiye
(Wiley, 2025) Mercan, Cagri
Conducting land suitability assessments is essential for agricultural planning, productivity, and sustainability. This study develops a land suitability model for almond cultivation in Midyat, Turkiye, by integrating the Full Consistency Method (FUCOM) with Geographic Information Systems (GIS). Key criteria, including temperature, rainfall, elevation, slope, soil characteristics, and land use capability, were weighted using FUCOM based on expert and farmer input. The suitability map, generated via a weighted overlay method, classified land into five categories: highly suitable (512.72 ha), moderately suitable (32,783.22 ha), marginally suitable (55,295.96 ha), not suitable (342.66 ha), and restricted areas (35,204.06 ha). Validation through ROC analysis yielded an AUC value of 0.817, indicating a high level of classification performance for the suitability model, confirming substantial accuracy. To the best of our knowledge, this paper is the first application of FUCOM in almond land suitability studies, providing valuable insights for farmers and policymakers in agricultural land management.
Analysis of Adaptation Processes and Anxiety Levels of University Students Staying with Earthquake Survivor Families in State Dormitories
(BMC, 2025) Dag, Ibrahim; Olgac, Kadriye
Background This study aimed to examine the adaptation processes and anxiety levels of university students living with earthquake survivor families placed in state dormitories after recent major earthquakes.
Materials and Methods A descriptive, cross-sectional quantitative study was conducted in a state dormitory between May and August 2023. A total of 108 students participated using the snowball sampling method. Data were collected through a Descriptive Characteristics Form and the Beck Anxiety Scale. Statistical analyses included descriptive statistics and linear regression using SPSS 25.0.
Results Among the participants, 49% reported increased frequency of contact with their families after the earthquake. Sharing the same dormitory space with earthquake-affected families led to limited personal space for 56%, emotional impact for 51%, and benefits such as emotional support for 56%. Additionally, 45% noted changes in their attitudes, 46% in their social lives, and 56% in their social responsibility awareness. Regression analysis showed that sharing the same environment with families explained 33.7% of the variance in Beck anxiety scores. A significant positive relationship was found between cohabitation with families and anxiety levels (B=0.337, p<0.001), where each unit increase in cohabitation was associated with a 5.379-point increase in anxiety scores.
Conclusions The findings indicate that post-earthquake family cohabitation significantly affects students' psychological and social well-being. Living in close proximity to affected family members increases anxiety levels. Providing psychological support services for students is crucial to reduce anxiety and facilitate post-disaster recovery and adaptation.
Use of Artificial Intelligence in Planning Postoperative Nursing Care in Laparoscopic Cholecystectomy Patients: Comparison of ChatGPT and Student Practice
(Elsevier Sci Ltd, 2025) Tanriverdi, S.; Soylemez, N.
Aim: This study aims to compare student-generated nursing care plans with ChatGPT-generated care planning texts for patients undergoing laparoscopic cholecystectomy surgery. Background: Given the increasing significance of technology in nursing education, the integration of AI-driven tools into educational methodologies demonstrates potential for enhancing nursing students' preparation for clinical practice by providing access to more comprehensive and current information sources. Methods: This descriptive comparative study evaluated 14 nursing care plans developed by nursing students for laparoscopic cholecystectomy patients alongside care plans generated by ChatGPT for identical patient scenarios, using the DISCERN scale as the assessment instrument. Results: The quality of student-generated care plans was determined to be satisfactory, whereas the quality of ChatGPT-generated texts was assessed as moderate. Both student care plans and ChatGPT-generated texts demonstrated moderate reliability and information quality regarding nursing care. Students exhibited the highest accuracy rate in formulating correct nursing diagnoses (90.22 %), while ChatGPT-generated texts demonstrated superior performance in correctly establishing nursing goals (90.35 %) and developing appropriate nursing interventions (91.07 %). Conclusions: The findings indicate that while student-generated care plans demonstrated generally acceptable quality, ChatGPT's performance in this domain was moderate, particularly in formulating surgical nursing goals and interventions. Although clinical outcomes were not evaluated in this study, the results suggest that ChatGPT may serve as a valuable supplementary resource for surgical nursing education and care plan development. Further research is warranted to determine its impact on patient care quality and clinical effectiveness.
Investigation of State Anxiety Levels of Parents Admitted to the Paediatric Emergency Department
(BMC, 2025) Yesil, Ahmet; Butun, Ahmet
Introduction: The psychological well-being of parents during their child's emergency treatment can significantly influence the overall care experience and outcomes. Parental stress and anxiety may affect their ability to provide accurate information, make informed decisions, and support their child effectively during treatment. The aim of this study was to identify the levels of state anxiety experienced by parents whose children were receiving care in the Paediatric Emergency Department (PED), and related factors that contributing to parental anxiety. Methods: This study is a descriptive cross-sectional study. The setting of the study was PED at a tertiary hospital with a 700-bed capacity. Participants were parents of children who visited the PED and received least urgent code during triage. The population of the study consists of a total of 426 parents of children admitted to the PED. Data were collected face-to-face between 4 November 2024 and 15 December 2024. Data collection tools included a socio-demographic questionnaire and the State-Trait Anxiety Inventory (STAI), a validated 40-item tool measuring state and trait anxiety. The data were analysed using SPSS Statistics for Windows. Results: Majority of the visits were made by mothers (66%), while fathers were less active in this process (34%). The mean state anxiety score was 42.45 +/- 8.94 and the mean trait anxiety score was 43.70 +/- 8.12. Moreover, mothers exhibited significantly higher trait anxiety than fathers (p = 0,003). Significant differences were found in both state and trait anxiety scores according to mother's education level (p < 0.001). It was found that the trait anxiety levels of non-employed mothers were significantly higher than those of employed mothers (p = 0.046). Anxiety levels were found to be higher in those who visited the PED more frequently. In addition, a significant difference was found in state anxiety scores according to the perceived urgency of the child's condition, and it was observed that anxiety levels were higher in very urgent conditions (p < 0.001). Anxiety levels were significantly associated with maternal education (p < 0.001), non-employed status (p = 0.046), frequent PED visits, and perceived urgency of the child's condition (p < 0.001). It was determined that those who were dissatisfied and those who were partially satisfied with the communication of healthcare staff had higher anxiety levels. It was seen that the anxiety levels of those who were dissatisfied and those who were partially satisfied with providing information by healthcare staff were higher (p = 0.020). The adequacy of allocated time for care made a significant difference in both state and trait anxiety scores, and it was observed that the anxiety levels of those who were dissatisfied and those who were partially satisfied with the adequacy of allocated time for care were higher. Dissatisfaction with staff communication and allocated care time also correlated with higher anxiety (p < 0.05). Conclusion: Effectiveness of healthcare staff, the importance of communication, and the perceived quality of care provided to children in the PED were important indicators for parental anxiety. Effective communication between healthcare providers and parents could lead to increased level of parental satisfaction with healthcare staff and with the PED settings. Effective communication could reduce parental anxiety during the course of care and treatment, and thus enhancing the overall experience of families in the PED settings.
Violence and Its Effects on the Job Satisfaction of Healthcare Staff in Paediatric Emergency Departments
(BMC, 2025) Butun, Ahmet; Ozyurt, Mehmet
Background Workplace violence in healthcare settings poses significant challenges to staff safety and the quality of patient care, particularly in Paediatric Emergency Departments (PEDs), where its impact extends to psychological strain and diminished care standards. This study aimed to determine the prevalence and characteristics of workplace violence experienced by PED staff, and to examine its association with their job satisfaction. Methods This study was a descriptive cross-sectional study. Participants were PED physicians and nurses. Data collection tools were "socio-demographic and work-related questions form", "Workplace Violence Scale" and "Minnesota Job Satisfaction Short Scale". The population of the study consisted of a total of 476 PED healthcare staff who had at least 1 year working experience in two tertiary hospitals and one public hospital located in the southeast Anatolia region of Turkey. A total of 434 healthcare staff participated in this study. Data were collected face-to-face using a survey method between January 3, 2024 and May 12, 2024. The data were analysed using the statistical program SPSS 26. Results In this study, the prevalence of violence exposure was 84.33%. Major perpetrators were patients' relatives (n = 394, 53.2%), main cause of violence was waiting time (n = 302, 17.3%), and violence often occurred in the waiting room (n = 263, 24%). The most frequently reported types of verbal and physical violence were shouting (n = 395, 38.9%), and scratching-pinching (n = 268, 34.5%), respectively. The most violence occurred between 17:00-24:00 (n = 224, 51.6%). Reactions to violence included decrease in motivation-performance (n = 375, 56.7%), thinking of quitting the job (n = 127, 19.7%), and experiencing psychological problems (n = 91, 13.7%). Workplace Violence (WPV) Scale score was 14.25 +/- 4.66 and Minnesota Job Satisfaction score was 2.83 +/- 0.87. A statistically significant but weak negative correlation was found between workplace violence and job satisfaction (r:-0.125, p = 0.009). Conclusion Exposure to violence was frequent among PED staff. The level of job satisfaction among PED staff was low. This study suggests that taking measures to prevent violence in healthcare settings may contribute to fostering a safer work environment and potentially increasing job satisfaction.
The Relationship Between Family Nutrition and Physical Activity Practices and Physical Activity Attitudes in Children
(BMC, 2025) Butun, Ahmet
Introduction Childhood obesity and sedentary lifestyles are growing public health concerns, with familial practices playing a critical role in shaping children's physical activity attitudes. The influence of family attitudes and behaviours regarding nutrition and exercise has been highlighted as a pivotal determinant in promoting healthier choices among children. This study aims to explore the relationship between family nutrition and physical activity practices and children's attitudes toward physical activity. Methods A descriptive cross-sectional study was conducted with 633 children and their parents from a tertiary hospital in eastern Turkey. Data were collected using three tools: (1) a sociodemographic form, (2) the Family Nutrition and Physical Activity Screening Scale (FNPASS), and (3) the Youth Physical Activity Attitude Scale in Children and Young People. Data were analysed using SPSS software and statistical analyses included Pearson correlation, linear regression, and ANOVA to explore associations and group differences. Results Family nutrition and physical activity practices significantly predicted children's physical activity attitudes. Physical activity positive attitudes (mean score: 3.74 +/- 0.88) correlated strongly with healthier family practices (FNPASS mean: 52.44 +/- 7.65; r = 0.648, p < 0.01), while physical activity negative attitudes (mean: 2.46 +/- 0.92) showed inverse relationships (r = -0.596, p < 0.01). Higher parental education, urban residency, and income levels were associated with more physical activity positive attitudes (p < 0.001). Underweight children had higher positive attitude scores than overweight/obese peers (p < 0.001). Conclusion Family environments significantly influence children's physical activity attitudes, with socioeconomic factors acting as key modifiers. This study demonstrates that family nutrition and physical activity practices significantly influence children's attitudes toward physical activity. Healthier family habits correlated with more positive attitudes in children, particularly among families with higher parental education and urban residency. Public health initiatives should focus on educating parents about healthy practices while ensuring equitable access to physical activity opportunities for children.
Biological Evaluation and Molecular Docking Studies of Novel Aza-Acyclic Nucleosides as Putative Antimicrobial, Anticancer, and Antioxidant Agents
(BMC, 2025) Alhilal, Mohammad; Alhilal, Suzan; Gomha, Sobhi M.; Farag, Basant; Sabancilar, Ilhan; Ouf, Salama A.
This study aimed to synthesize new aza-acyclic nucleosides (aza-acyclovir) and evaluate the efficacy of these synthetic compounds as potential antimicrobial, anticancer, and antioxidant agents. We prepared two novel aza-acyclic nucleosides via two reactions. The first reaction involved trichloroisocyanuric acid and dibenzosulphonyl diethylamine, and the second reaction involved trichloroisocyanuric acid and diethanolamine. We then used one-dimensional nuclear magnetic resonance (NMR) spectroscopy, two-dimensional NMR spectroscopy, infrared spectroscopy, and mass spectrometry to determine the structures of the resulting compounds. In this regard, we first tested the antimicrobial activity of these compounds against various bacteria, including Bacillus cereus, B. subtilis, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa, and against fungal pathogens, including Aspergillus fumigatus, Candida tropicalis, and Alternaria solani. Next, the precise mode for the interaction between synthesized aza-acyclic nucleosides and the target protein 8HQ5 was elucidate using molecular docking analysis. Subsequently, we tested the synthesized compounds for putative anticancer activity at different concentrations (i.e., 12.5, 25, 50, 100, and 200 mu g/mL) against A549 cell (Human epithelial lung carcinoma) and human umbilical vein endothelial cell (HUVEC) lines. In addition, compounds antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl-based and cupric reducing antioxidant capacity-based methods at different concentrations (i.e., 31.25, 62.5, 125, 250, and 500 mu g/mL). Results revealed that both aza-acyclic nucleosides inhibited both bacterial and fungal strains, although toxicity toward bacterial strains was generally greater than toward fungal strains. We also observed that the molecular docking results were consistent with the results of in vitro antimicrobial assessments. Further, both aza-cyclic nucleosides exhibited cytotoxic effects against both the A549 cell and HUVEC lines. Despite exhibiting lower radical scavenging activity than ascorbic acid (an antioxidant compound used as a standard), Compound 1 from the novel synthetic aza-acyclic nucleosides showed a higher reduction capacity, which was dose-dependent. Overall, we report newly synthesized compounds that show promising antimicrobial, anticancer, and antioxidant effects.

Browse

Recent Submissions