WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Why Universal Design Fails: A Convergent Appreciation / Divergent Activation (CADA) Model for Culturally Diverse Cities
(Taylor & Francis Ltd, 2026) Azhar, Jasim; Zami, Mohammad Sharif; Aydin, Serdar; Delledonne, Nicola
Urban leftover spaces represent significant potential, yet universal design (UD) approaches often struggle to meet the needs of diverse multicultural contexts. Through constructivist grounded theory analysis of a participatory design charrette with 12 culturally diverse participants in Wellington, New Zealand, this study proposes the Convergent Appreciation/Divergent Activation (CADA) model. While all participants agreed that spatial problems such as safety, neglect and underutilized space potential were present (94-100% agreement in problem agreement) their solutions diverged radically along five emergent orientations: Systems-Harmony (n = 3), Efficiency-Quantification (n = 2), Social-Collective (n = 3), Place-Stewardship (n = 2) and Practical-Utilitarian (n = 2). A bootstrap resampling procedure (10,000 iterations) was used as a descriptive robustness check on orientation consistency, yielding 95% confidence intervals spanning 0.87 to 1.00. Participants' design choices showed high orientation consistency (81-94%), indicating non-random alignment with the five orientations. The CADA model demonstrates that inconsistent solution logics in multicultural urban development present challenges to uniform evaluation. Given the confounding role of professional training in isolating cultural variables, this research frames itself as exploratory theory building rather than hypothesis testing. A provisional pluralistic design framework is proposed to structure how multiple spatial logic systems might be integrated in future validation studies.
Virtual Rainforest and Portable Water Wall Application, Patient Satisfaction, Comfort, Anxiety, and Vital Signs Before Colonoscopy: Response to the Letter to the Editor
(Elsevier Science Inc, 2026) Genc, Hasan; Atay, Kadri; Tanriverdi, Seher
Underutilization of Bacteriological Testing in Extrapulmonary Tuberculosis: A Retrospective Single-Center Study from Mardin, Türkiye
(Galenos Publ House, 2026) Kabak, Mehmet; Bodur, Mehmet Sinan; Cil, Baris
OBJECTIVE: Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the low bacillus burden of the disease and the limited use of bacteriological tests. The aim of this study was to evaluate bacteriological confirmation rates, diagnostic methods, and sampling practices among patients diagnosed with tuberculosis (TB) in a southeastern province of Türkiye. MATERIAL AND METHODS: This retrospective study included a total of 456 TB cases diagnosed between 2014 and 2019. The cases were classified as pulmonary tuberculosis (PTB), EPTB, and cases with both types of involvement. Bacteriological and histopathological confirmation rates were compared between the groups. RESULTS: 41.0% of all cases were classified as EPTB. The most commonly involved site was lymph node TB (22.4%). Bacteriological confirmation rates were significantly lower in EPTB cases: acid-fast bacilli (AFB) smear positivity was 3.2% and culture positivity was 4.3%, whereas the histopathological confirmation rate was 88.8%. No bacteriological samples were taken from 63.1% of patients in the EPTB group. Among PTB cases, AFB smear positivity (71.4%) and culture positivity (66.5%) were significantly higher (P < 0.001). CONCLUSION: The findings suggest that bacteriological tests are both underused and of low diagnostic efficiency in EPTB cases. Most diagnoses are based on histopathology rather than on bacteriological confirmation. Strengthening sampling strategies and promoting the use of rapid molecular testing are critical for enhancing bacteriological validation in EPTB.
Therapeutic Philosophy: An Ontological Inquiry into Well-Being
(Beytulhikme Felsefe Cevresi, 2026) Kara, Zulkuf; Oral, Seher
This study approaches the rise of therapeutic culture not merely as a sociological transformation but as a reduction of well-being to normative adaptation. In contemporary therapeutic discourse, well-being is predominantly defined through balance, functionality, and resilience, while therapy functions as a regulatory practice that minimizes the individual's conflict with prevailing social conditions. Such a framework confines well-being to normative stability and obscures its existential dimension. The article distinguishes philosophical therapy from modern therapeutic culture and reconsiders the ontological ground of wellbeing. Drawing on Spinoza's ontology of power and theory of affects alongside Deleuze's philosophy of difference, well-being is redefined not as adaptation but as an increase in the capacity to act. Within this perspective, therapeutic intervention is conceptualized not as a restorative model of equilibrium but as a model of encounter and composition. The study aims to contribute conceptually to emerging discussions on philosophical therapy in Turkey by proposing an ontological reconfiguration of well-being.
The Şika Rika 5 Project: Transition to Sedentary Life in South-Eastern Anatolia
(Cambridge Univ Press, 2026) Kodas, Charlotte Labedan; İpek, Bahattin; Kodaş, Ergül
The 2022-2023 Pleistocene and Early Holocene Archaeological Surface Survey in Mardin Province, south-eastern Türkiye, identified prehistoric settlements, includingŞika Rika 5, that provide new insights into the early stages of settlement in the Northern Khabur Region.
The Role of Technology and Digitalisation in the Sustainability of the Gastronomy Cultures of Destinations
(Elsevier, 2026) Seyitoğlu, Faruk
This study investigates how technology and digitalisation influence the sustainability of gastronomy cultures in destinations, specifically through the perspectives of chefs working in Michelin-starred restaurants in Türkiye. Adopting the qualitative research approach, semi-structured interviews were conducted with 26 chefs working in Michelin-starred restaurants. The thematic analysis of the data revealed three main themes: the supportive roles of technology and digitalisation; the potential risks and challenges of technology and digitalisation; and changes in consumer preferences and their impact on gastronomy cultures. Promotion and visibility enhancement, preservation and documentation of gastronomic heritage, and efficiency and innovation in preservation practices are among the sub-dimensions of supportive roles of technology and digitalisation. Moreover, cultural and culinary standardisation and homogenization, as well as the decline of artisanal skills and personal touch, pose potential risks and challenges. Finally, changes in consumer preferences include shifting toward trendy, visual experiences over culinary appreciation, and increased transparency and awareness of food origins. This research contributes to understanding how technology and digitalisation affect the sustainability of gastronomy cultures, specifically by addressing existing theoretical gaps and providing context-specific insights. By offering significant implications for policymakers and practitioners to integrate relevant technologies and digital tools effectively, the study aims to strengthen culinary identities and sustain gastronomic cultures in the digital era.
The Relationship of City-Individual in Zazaki Literature: Missing Bodies, Narrowing Roads, Expanding Imagination
(Istanbul Univ Press, Istanbul Univ Rectorate, 2021) Akman, Ilyas
According to UNESCO'S language report (Atlas of the World's Languages in Danger), Zazaki/ Zazaish, Turkey's third most spoken language, is endangered.The Zaza language is shown as one of 2,500 languages that are endangered on the 40th page of the report. It is extremely important to produce literary works in this language in order for the language to survive. Authors who write works in Zazaki are aware of the importance of their work. When the authors create content, they attach great importance to village life, where Zazaki is spoken in its pure form. Villages, with their isolated structures, maintain homogeneity of language and culture by ensuring continuity between generations. On the other hand, cities don't have pure languages and cultures because of their heterogeneous structures. The city phenomenon is often portrayed negatively in Zazaki literature such that some of the works have characters afraid of the word city. In some works written in Zazaki, there are many negative adjectives for cities, such as cemetery, hole, and curse. People keep a distance from the city because of marginalization, cultural difference, linguistic adaptation, and income inequality between classes. The biggest source of consolation for the individuals who struggle with the city is to return to the old, happy days they lived in their villages through dreams. In this study, we will focus on the city-individual relationship through the novels, poetry, and stories written in Zazaki. We will attempt to analyze the aforementioned relationship through cultural, economic, and linguistic factors.
The Relationship between Maturity Stage and Forage Yield and Quality of Field Pea (Pisum Sativum Ssp. Arvense)
(Pakistan Botanical Soc, 2026) Karadeniz, Erdal; Seydosoglu, Seyithan; Bengisu, Gulsah
The aim of the study was to determine the appropriate growth stage for the harvest of peas (Pisum sativum L., cv.Özkaynak) to obtain a better yield and quality. The study was conducted in Kızıltepe district, Mardin province in the Southern Anatolian Region of Turkey during the 2018-2019 and 2019-2020 growing seasons. Forage peas were harvested at 3 different stages: 50% flowering stage, detergent fiber (ADF), neutral detergent fiber (NDF), digestible dry matter (DDM), dry matter intake (DMI), and relative feed value (RFV) were determined. The harvest at the visible first pod stage showed the highest values for GM, DM, CP yield, ADF, DMI, and RFV. Harvesting before or after this stage resulted in a significant decrease in these parameters. However, the highest CP rate and DDM value were recorded for the harvest at the 50% flowering stage, and the highest NDF was noted when the harvest was done at the full pod stage. Therefore, it is concluded that the most appropriate maturity stage for forage pea harvest in the Mardin province of Turkey and regions with similar ecological conditions is the first visible pod stage.
The Relationship Between Dyspnea and Fatigue and Levels of Medication Adherence and Self-Efficacy in Individuals with Chronic Obstructive Pulmonary Disease
(SAGE Publications Inc, 2026) Bicak Ayik, Derya; Gurdap, Zuleyha; Cengiz, Zeliha; Oner, Ugur
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease marked by symptoms such as dyspnea and fatigue, which negatively affect patients' quality of life. Self-efficacy influences patients' ability to manage symptoms, while medication adherence is crucial for effective disease control. This study aimed to examine the impact of dyspnea and fatigue on medication adherence and self-efficacy in individuals with COPD. A descriptive, cross-sectional, and correlational study was conducted with 171 COPD patients receiving treatment in a tertiary hospital in eastern Turkiye between November 2024 and April 2025. Data were collected using validated scales measuring fatigue, dyspnea, medication adherence, and self-efficacy. Statistical analyses included correlation and regression to examine relationships and predictors. The findings revealed high levels of dyspnea and fatigue, which were significantly and negatively correlated with self-efficacy (p < .001). Both dyspnea and fatigue significantly predicted decreased self-efficacy, accounting for over 60% of the variance. Medication adherence levels were generally high; medication adherence decreased when dyspnea increased, while no relationship was observed between fatigue and medication adherence. Dyspnea and fatigue are prevalent symptoms in COPD patients that adversely affect self-efficacy. Enhancing self-efficacy may be critical in improving symptom management and quality of life. The complex nature of medication adherence requires further in-depth investigation. Nurses should prioritize interventions that strengthen self-efficacy and address symptom burden to optimize COPD management and patient outcomes.
School-Family Collaboration in Practice: Teachers’ Voices on Challenges and Solutions
(Routledge Journals, Taylor & Francis Ltd, 2026) Arar, Khalid; Karadas, Halil
This study examines the effects of school-family collaboration on educational outcomes, identifies structural and relational barriers, and proposes contextually relevant solutions. Using a phenomenological design within an interpretivist paradigm, data were collected through semi-structured interviews. Findings reveal that teacher-parent interactions are often strained due to misunderstandings, mismatched expectations, and communication gaps. Key barriers include socioeconomic disadvantage, limited access, time constraints, parents' educational levels, and negative attitudes toward schooling. Strong collaboration, however, is associated with improved student achievement, teacher motivation, parental involvement, and school climate, while weak collaboration undermines performance, institutional goals, and teacher morale. The study concludes that school-family collaboration must be strengthened through contextual, systematic, and inclusive strategies. It recommends developing culturally responsive participation models, flexible engagement practices, and sustainable interventions that enhance access and promote school belonging.
The Knowledge, Attitudes, and Practices of Parents of Children Admitted to the Paediatric Emergency Department with Fever
(MDPI, 2026) Bayraktar, Sema; Türk, Gülay; Butun, Ahmet; Tay, Zeynep Olgac
Introduction: Fever is one of the most common reasons for Paediatric Emergency Department (PED) visits, often driven by parental anxiety and misconceptions about fever management. This study aimed to evaluate the knowledge, attitudes, and practices of parents regarding childhood fever to identify gaps and guide targeted educational interventions. Understanding parental behaviors is crucial for improving care outcomes and reducing unnecessary PED utilization. Methods: This study is a descriptive cross-sectional study. The sample of this study consists of a total of 440 parents of children admitted to the Paediatric Emergency Department (PED) with complaints of fever. Convenience sampling was used to select the participants. Data were collected using a questionnaire covering sociodemographics, a form surveying the parents' fever knowledge and attitude, and the validated parents' fever management scale (Turkish version). The data were analyzed using the SPSS 22.0 statistical program. Results: Most parents (95.5%) reported prior experience with childhood fever, yet 54.1% lacked a regular physician. Common fever detection methods included tactile assessment (56.4%) and thermometers (27.3%). Parental concern arose at 39 degrees C (48.6%). Cold applications (41.6%) and antipyretics (21.1%) were frequent interventions. The mean PFMS-TR score was high (34.97 +/- 4.27), indicating elevated caregiver burden. Scores varied significantly by the child's age (higher for infants, p = 0.044) and maternal education (higher for educated mothers, p = 0.008). Satisfaction with healthcare staff correlated with higher scores (p = 0.024). Negative correlations emerged between parental age, number of children, and fever management scores (p < 0.05). Conclusions: Parents exhibited high interventionist behaviors and persistent knowledge gaps, underscoring the need for targeted education programs. Educational programs targeting fever management, tailored to parental demographics and misconceptions, are essential. Healthcare providers, particularly pediatric nurses, should prioritize clear communication and evidence-based guidance to empower parents and reduce unnecessary healthcare burdens. Future research should expand to diverse geographic and cultural settings to enhance generalizability.
The Impact of Earthquake Trauma and Experience on Positive Future Expectations in Türkiye: Mediating Roles of Resilience and Religious Attitude
(Springer Nature, 2026) Yildirim, Murat; Alkhulayfi, Abdulmohsen Mohammed Abdullah; Apak, Hidir; Kocak, Orhan; Mohammed Abdullah Alkhulayfi, Abdulmohsen; Tatlicioglu, Oktay; Gomez-Salgado, Juan
Background In recent years, the occurrence of natural disasters has been on the rise globally, including in Türkiye. On February 6, 2023, a powerful earthquake with its epicentre in Kahramanmaraş, Türkiye, impacted 10 provinces, resulting in widespread devastation, significant loss of life, and deep trauma for many individuals. This study examines the mediating roles of psychological resilience and religiosity in the relationship between earthquake trauma and positive future expectancy. Methods Employing a cross-sectional design, data were collected through an online survey from 1,412 participants who completed the Post-Earthquake Trauma Level Determining Scale, the Positive Expectations Towards the Future Scale, the Religious Attitude Scale, and the Brief Resilience Scale. Results The results indicated that trauma from the earthquake was linked to increased religiosity and reduced psychological resilience. The trauma was higher in those exposed to the earthquake than in those not exposed, and positive future expectation was positively correlated with religiosity and resilience. Both religiosity and psychological resilience were found to play an indirect role in influencing the relationship between earthquake-related trauma and positive expectations for the future. Conclusions These findings highlight the potential roles of religiosity and psychological resilience in supporting the psychological well-being of trauma survivors. While the cross-sectional design limits causal inference, the results may inform future research and discussions on how these factors could be considered in recovery and intervention contexts.
The Effect of Mindfulness-Based Stress Reduction Education Given to Obese Adolescents on Eating Behaviors and Depression
(Springer, 2026) Dag, Ibrahim; Kavak Budak, Funda
This study focused on an online education program based on Mindfulness-Based Stress Reduction Education. The purpose of this research is identifying the effects of mindfulness-based stress reduction education about eating behavior and depression on obese adolescents. The research has been conducted on high schools in the province capital of Mardin, in the dates between March 2021-January 2022, as a pretest/posttest control grouped experimental study. The sample of the study was composed of 93 obese adolescents (experimental group: 45, control group: 48) determined by power analysis. Introductory Peculiarities Form, Dutch Eating Behavior Questionnaire and Kutcher's Adolescent Depression Scale has been used for information gathering. An 8-week long awareness-based stress reduction education has been given to the experimental group. No initiative has been taken on the control group. For the assessment of the data, percentage distribution, arithmetic average, standard deviation, chi-square test, t test in independent groups and t test in dependent groups methods have been used. A reduction in total depression points and eating behaviors among the obese adolescents in the experimental group after Mindfulness-Based Stress Reduction Education, and the importance of the difference between groups being statistically important has been determined (p < 0.05). The eating behaviors and the total depression points of the obese adolescents in the experimental group has been detected as lower than the obese adolescents in the control group. It has also been detected that the Mindfulness-Based Stress Reduction Education has affected the eating behaviors of the obese adolescents positively and that it is an effective method for reducing their depression levels.
Tartrazine-Induced Nephrotoxicity via Oxidative and Genotoxic Pathways in Rats: Regulatory Insights and the Nephroprotective Role of Curcumin
(Academic Press Inc Elsevier Science, 2026) Demirtaş, Selim; Tan, Fazile Canturk; Keskin, Cumali; Varol, Salih; Yavaş, Mehmet Cihan; Cantürk Tan, Fazile
This study evaluated tartrazine-induced nephrotoxicity and the protective effects of curcumin in rats. Thirty-five male Wistar albino rats were assigned to five groups (n = 7): control; tartrazine 10 mg/kg/day; tartrazine 100 mg/kg/day; tartrazine 10 mg/kg/day + curcumin 20 mg/kg/day; and tartrazine 100 mg/kg/day + curcumin 20 mg/kg/day. After 21 days, blood and kidney samples were analyzed for biochemical, oxidative, genotoxic, and histopathological changes. High-dose tartrazine significantly elevated serum urea and creatinine levels compared with controls (urea, p = 0.033; creatinine, p < 0.001), indicating renal dysfunction. Curcumin co-treatment mitigated these elevations. Total antioxidant status (TAS) was elevated by tartrazine exposure but decreased with curcumin supplementation (p < 0.001), total oxidant status (TOS) showed a non-significant increasing trend and was reduced by curcumin. Compared to the control group, MDA levels decreased with low-dose tartrazine and increased with high-dose tartrazine, while curcumin supplementation increased levels (p < 0.05). Comet assay and histopathological analyses confirmed dose-dependent DNA and tissue damage, both of which were alleviated by curcumin. Overall, short-term tartrazine exposure may induce renal biochemical, oxidative, and genotoxic alterations in rats under experimental conditions, particularly at doses exceeding the ADI level. The antioxidant properties of curcumin may mitigate the negative effects of food dyes.
Systemic Inflammatory Response Index as a Predictor of Inflammation and Mortality in Hemodialysis Patients
(Springer Nature, 2026) Yuksel, Enver; Danis, Ramazan; Karabay, Umut; Kilic, Jehat; Esen, Rengin
Introduction Chronic kidney disease is a global health problem with high mortality among hemodialysis patients. We evaluated the prognostic value of the systemic inflammatory response index (SIRI) in this population. Material method This retrospective cross-sectional study included 340 adult patients undergoing maintenance hemodialysis for more than three months (2015-2022). Demographic and clinical data, comorbidities, and laboratory parameters were retrieved from electronic records. The Systemic Inflammatory Response Index (SIRI) was calculated as (neutrophil & times; monocyte) / lymphocyte count, and patients were categorized into low (< 1.54) and high (>= 1.54) SIRI groups. Results A total of 340 hemodialysis patients were included (mean age 55.2 +/- 17.4 years; 52.6% female). Patients in the high-SIRI group were significantly older and more frequently female than those in the low-SIRI group. Diabetes mellitus was more prevalent, whereas obstructive and polycystic kidney diseases were less common among high-SIRI patients. Higher SIRI levels were associated with increased neutrophils, monocytes, white blood cell count, NLR, MLR, CRP, and CAR, along with lower lymphocyte counts, albumin, Kt/V, and PTH levels (all p < 0.05). Although 5-year overall survival was numerically lower in the high-SIRI group, the difference was not statistically significant. In multivariable Cox regression, only age and male sex independently predicted mortality. Conclusion High SIRI was associated with older age, increased inflammatory burden, and poorer dialysis adequacy but not with mortality. Age and male sex independently predicted death. SIRI reflects inflammation in hemodialysis patients but has limited independent prognostic value.
Side-Blow Technique in the Hakemi Use Chipped Stone Industry: Neolithic Efficiency and Functionality (Diyarbakır/TÜRKİYE)
(Routledge Journals, Taylor & Francis Ltd, 2026) Erbil, Esref
This study examines the side-blow technique, a significant component of the chipped stone industry at the Late Neolithic settlement of Hakemi Use, from technological, typological, and functional perspectives. A total of 266 obsidian artifacts were analyzed; including 164 cores for side-blow blade-flakes and 102 side-blow blade-flakes. Morphometric data, microscopic use-wear analyses, and experimental replication demonstrate that the technique represents a standardized and controlled flaking strategy. The results show that obsidian blades were transformed into small, sharp, and functional units with minimal modification. Use-wear traces, particularly on the cores, indicate contact with soft organic materials, suggesting use in plant processing or similar activities. Experimental observations further reveal that the method is rapid, controlled, and easily applied without requiring advanced knapping skills. Overall, the findings suggest that the side-blow technique reflects deliberate, efficient, and economically conscious raw material management and production organization.
Psychiatric Comorbidity in Chronic Tinnitus: Depression and Anxiety in an Otolaryngology Outpatient Cohort
(Dove Medical Press Ltd, 2026) Sirma, Enes; Toprak, Serdar Ferit; Dedeoglu, Serkan; Donmezdil, Suleyman
Purpose: Chronic subjective tinnitus is commonly accompanied by psychological distress; however, its independent relationship with depressive and anxiety symptoms in otolaryngology outpatients has not been fully delineated. This study sought to estimate the prevalence of mood symptoms among adults with chronic tinnitus and to determine whether tinnitus severity contributes independently to psychological burden. Patients and Methods: In this cross-sectional study, 100 adults with subjective tinnitus of at least six months' duration were evaluated at a tertiary otolaryngology clinic. Participants completed the Tinnitus Handicap Inventory (THI), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI). Prevalence estimates were compared with population-level data. Associations between tinnitus severity and mood symptoms were examined using correlation analyses and multivariable linear regression adjusted for age, sex, and hearing status. Results: Mean scores were 47.2 +/- 18.3 for THI, 16.1 +/- 10.4 for BDI-II, and 19.5 +/- 11.2 for BAI. Tinnitus severity showed moderate positive associations with depressive (r = 0.50) and anxiety symptoms (r = 0.48), both p < 0.001. After adjustment, THI scores remained independently associated with higher BDI-II ((3 = 0.42, p < 0.001) and BAI scores ((3 = 0.39, p < 0.001). Severe tinnitus (THI >= 58) was linked to increased odds of moderate-to-severe depression (OR 3.10, 95% CI 1.52-6.30) and anxiety (OR 2.84, 95% CI 1.40-5.72). Clinically relevant depressive and anxiety symptoms were identified in 28% and 31% of participants, respectively. Conclusion: Greater tinnitus severity is independently associated with elevated symptom severity of depression and anxiety. These findings underscore the importance of routine mental health screening and multidisciplinary management in ENT practice.
Predicting Positive Airway Pressure Appointment Attendance Using Machine Learning and Deep Learning: The Role of Clinical and Oximetric Indicators
(Springer Heidelberg, 2026) Baran, Mehmet Tarık; Kabak, Mehmet; Çi̇l, Barış
Introduction Participation in positive airway pressure (PAP) therapy is essential for improving long-term health outcomes in individuals diagnosed with obstructive sleep apnea syndrome (OSAS). This study aimed to identify clinical, physiological, and behavioral factors influencing attendance at initial PAP appointments and to develop and compare predictive models using machine learning and deep learning techniques. Methods A total of 369 patients with obstructive sleep apnea syndrome (OSAS) were retrospectively analyzed. Among them, 39.2% attended their scheduled PAP therapy appointment and initiated treatment, whereas 60.8% did not. Correlation analyses were performed, and predictive models including logistic regression, decision trees, random forests, support vector machines, and a deep neural network were developed and compared to predict appointment attendance. Results A high Epworth Sleepiness Scale (ESS) score and greater time spent in the 80-90% nocturnal oxygen saturation range were positively associated with PAP therapy attendance. In contrast, alcohol consumption was a significant behavioral predictor of non-attendance. Hypoxemia-related metrics, such as average nocturnal oxygen saturation, were found to be stronger predictors than the apnea-hypopnea index (AHI). Anthropometric variables-waist circumference, body mass index (BMI), and neck circumference-showed only weak positive correlations with treatment participation. Conclusion This study is among the few to focus on initiation of PAP therapy, rather than long-term adherence, which is the typical focus of most existing research. The machine learning and deep learning models developed here have the potential to support clinical decision-making systems by identifying high-risk individuals early and enabling timely intervention. Integrating these tools into clinical workflows may improve patient engagement and outcomes from the very first step of treatment.
Pomiferin Protects against Sepsis-Associated Acute Liver and Kidney Injury via Inhibition of NF-κB Activation, Oxidative Stress, and Cytochrome-c
(Nature Portfolio, 2026) Koc, Murat; Alhilal, Mohammad; Erol, Huseyin Serkan; Alhilal, Suzan; Dereli, Esra; Yildirim, Serkan; Halici, Mesut Bunyami
In this study we report the first identification of the therapeutic effects of pomiferin isolated from Maclura pomifera against acute liver and kidney injury induced by sepsis. These results were obtained using a rat model of sepsis. We focused on targeting the nuclear factor kappa B (NF-kappa B) activation cascade, oxidative stress, and cytochrome-c, three key components involved in the pathophysiology of sepsis-associated acute liver and kidney injury. This assessment was conducted using biochemical, histopathological, immunohistochemical, and immunofluorescence analyses to examine parameters in liver and kidney tissues. The cecal ligation and puncture technique, used to induce sepsis, consistently caused acute liver and kidney damage. This was evidenced by significant increases (p < 0.0001), relative to untreated control rats, in the abundance of Toll-like receptor 4, NF-kappa B p65, phospho-NF-kappa B p65, 8-hydroxydeoxyguanosine, cytochrome-c, and caspase-3, higher degeneration, lipid peroxidation, and necrosis. This technique also caused significant decreases (p < 0.001) in components of the cellular antioxidant system in the hepatic and renal tissues of septic rats. Pomiferin, particularly at a dose of 300 mg/kg, showed promising pharmacological effects by reversing these pathological changes. Overall, pomiferin appears to protect liver and kidney tissues during sepsis by suppressing the NF-kappa B activation cascade, reducing oxidative stress, and lowering cytochrome-c activity. These effects suggest that pomiferin may be useful for managing sepsis patients with acute liver and kidney injury.
Phenolic Profile, Antioxidant Capacity, Enzyme Inhibitory Potential and Physicochemical Properties of Almond Milk and Date Enriched Plant-Based Ice Cream
(Springer, 2026) Kizmaz, Veysi; Cavusoglu, Mehmet; Hatipoglu, Abdulkerim
The aim of this study was to evaluate the effects of almond milk and date fruit on the functional and physicochemi-cal properties of ice cream formulations. For this purpose, four ice cream formulations with a fixed fat content of 5% were produced: IC1 (control, condensed cow's milk and refined sugar); IC2 (milk-based using dates instead of refined sugar); IC3 (plant-based containing almond milk and dates); and IC4 (plant-based containing almond milk and refined sugar). The pH, viscosity, overrun, and melting behavior of the samples were investigated, along with total phenolic and flavonoid contents and antioxidant capacities determined by DPPH, ABTS, and CUPRAC assays. In addition, inhibitory activities against alpha-amylase, alpha-glucosidase, urease, tyrosinase, elastase, collagenase, AChE, and BChE enzymes were evaluated. The results indicated that formulations containing almond milk and dates exhibited significantly higher total phenolic and flavonoid contents, as well as enhanced antioxidant capacities, particularly as measured by the CUPRAC assay (P < 0.05). These formulations also demonstrated greater inhibitory activity against alpha-amylase and alpha-glucosidase enzymes. Physicochemical evaluation revealed that IC3 exhibited superior viscosity and melting resistance, as reflected by the longest first drip time, whereas IC4 achieved the highest overrun. The highest melting speed and melting rates were observed in IC2 (P < 0.05). Overall, the findings suggest that the combined use of almond milk and dates represents an effective strategy for developing plant-based ice cream formulations with enhanced functional properties and favor-able physicochemical characteristics.

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