WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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The Influence of Dietary Inflammatory Index and Food Security Status on Estimated Glomerular Filtration Rate
(W B Saunders Co-elsevier inc, 2025) Ceylan, Jiyan; Laborade, Juan Andrade; Andrade, Jeanette
Attitudes of Health Sciences Students in Turkey Towards Individuals With Different Sexual Orientations
(Womens Health & Action Research Centre, 2025) Deger, Vasfiye B.; Kacan, Havva
Study was planned in a descriptive design to examine how the empathic tendencies of students in the Faculty of Health Sciences affect their attitudes toward individuals who have different sexual orientations and was conducted with seven hundred and six students. The data collected online using the Student Information Form, Empathic Tendency Scale (ETS) and Attitudes Toward Lesbian and Gay Men Scale (ATLGS). Participants' mean scores were 62.98 +/- 18.79 on the ESS and 29.02 +/- 10.75 on the ATLGS. When the correlation between ETS and ATLGS scores was analyzed, a positive and moderate (p<0.05) correlation (r = 0.62) was found between ETS and ATLGS scores. These scores were moderate and the correlation between ETS and ATLGS scores was significant (F=438.585; p<0.05). Empathic disposition explained 38.3% of the total change in ATLGS level (R2=0.383) and increased ATLGS level (B=0.620). It was found that as students' empathic skills improved, their homophobic attitudes decreased.
Gynaecological Cancer Awareness and Healthy Lifestyle Behaviors of Women Aged 20-65 Years: a Descriptive Cross-Sectional Study
(Womens Health & Action Research Centre, 2025) Yasar, Beril Nisa; Seker, Sevda Arslan
For both individual and community health, women's health is vital. In particular, gynecological cancers can be prevented or treated by adopting healthy lifestyles, raising awareness, and detecting them early. This study aimed to identify levels of gynecological cancer awareness and healthy lifestyle behaviors among women aged 20-65 years. There were 251 women in the descriptive cross-sectional study. The Gynecological Cancers Awareness Scale (GCAS), the Descriptive Characteristics Form, and the Healthy Lifestyle Behavior Scale-II (HLBS-II) were used to gather data. The data was analyzed using the Pearson's correlation test, multiple linear regression, and descriptive statistics. The average HLBS-II score was 123.53 +/- 20.75, while the average GCAS score was 149.64 +/- 21.30. The HLBS-II and GCAS scores showed a statistically significant positive correlation. Women knowledgeable about early diagnosis methods scored 10.758 times higher on the GCAS, while women familiar with vulvar self-examination scored 11.016 times higher. Employed women had a mean HLBS-II score 6.124 times higher than non-employed women (p<0.05). Women's awareness of gynecological cancer was high, but they also had moderately good lifestyle choices. To raise awareness and promote healthy lifestyle choices, healthcare professionals are advised to take part in health-promoting initiatives.
Relationship Between First Trimester Placental Thickness and Perinatal Prognosis: a Prospective Cohort Study
(Bayrakol Medical Publisher, 2025) Yilmaz, Mehmet; Aksin, Serif; Balsak, Deniz; Aboalhasan, Yasmin; Kurnuc, Fatma Zehra; Batmaz, Ibrahim
Aim: This study aims to investigate the correlation between first-trimester placental thickness and perinatal prognosis. Material and Methods: A prospective cohort study was conducted at Siirt University Faculty of Medicine from March 2022 to March 2023 of 365 pregnant women in their first trimester (11-14 weeks of gestation). Placental volume was measured using two-dimensional (2D) ultrasound, and estimated placental volume (EPV) was calculated using Merwin's EPV Calculator app. The patients were followed until delivery, and outcomes such as gestational age at delivery, mode of delivery, fetal weight, APGAR score, fetal gender, perinatal outcomes, preeclampsia (PE), premature rupture of membranes (PROM), gestational hypertension (GHT), gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), preterm birth, oligohydramnios, polyhydramnios, surmaturation, presentation anomaly, intrauterine death, fetal distress, and placental abruption were evaluated. Results: Data from 365 pregnant women were analyzed. The mean maternal age was 27.2 +/- 5.5 years. The distribution of placental location was 38.4% posterior, 43.0% anterior, 7.4% left sidewall and 11.2% right sidewall. No significant differences were found in placental volume measurements based on delivery mode, fetal gender, or conditions such as PE, GDM, IUGR, PROM, preterm birth, or other perinatal pathologies. Statistical analyses showed no significant association between first-trimester placental volume and adverse perinatal outcomes (p>0.05). Discussion: No relationship was found between first-trimester placental thickness and perinatal outcomes.
Expanded Pilot Newborn Screening for Lysosomal Disorders: First Results From Turkey
(Academic Press inc Elsevier Science, 2025) Okur, Ilyas; Oktem, Murat R.; Inci, Asli; Ozbek, Mehmet N.; Akgun, Abdurrahman; Yildirimd, Gonca Kilic; Tumera, Leyla
Anatolian Livestock Trade in the Late Ottoman Empire
(Routledge Journals, Taylor & Francis Ltd, 2025) Ciftci, Erdal
The Performance of the Naples Prognostic Score in Predicting One-Year Mortality and Major Adverse Cardiovascular Events After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis
(Polish Cardiac Soc, 2025) Gitmez, Mesut; Guzel, Tuncay; Kis, Mehmet; Coskun, Ferhat; Isik, Mehmet Ali; Aktan, Adem; Ertas, Faruk
Background: Existing risk scores for transcatheter aortic valve implantation (TAVI) may not fully capture patient complexity. Combining nutritional and inflammatory markers, the NPS (the NAPLES prognostic score) might improve outcome prediction. Aims: This study investigated the associations of the NPS with one-year mortality and major adverse cardiovascular events (MACEs) in TAVI patients. Material and methods:This retrospective analysis included 222 patients with severe aortic stenosis who underwent TAVI. The NPS was calculated based on the serum alb & uuml;min concentration, cholesterol concentration, lymphocyte/monocyte ratio, and neutrophil/lymphocyte ratio. The patients were subsequently categorized into two groups: the low-NPS group (NPS 0-2) and the high-NPS group (NPS 3-4). Results: A high NPS was significantly associated with increased one-year mortality (4.8% vs. 23.7%; P <0.001) and MACE rates (7.2% vs. 35.9%; P <0.001). Cox regression analysis demonstrated that a high NPS was an independent predictor of both mortality (HR, 5.94; 95% CI, 2.03-17.37; P = 0.001) and MACEs (HR, 5.09; 95% CI, 2.15-12.02; P <0.001). Conclusions: The NPS emerged as a potential predictor of long-term mortality and MACEs in TAVI patients. Further validation through larger, multicenter, studies is warranted.This research contributes valuable data on the role of the NPS in TAVI risk stratification.
Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential
(Dove Medical Press Ltd, 2025) Keskin, Cumali; Aslan, Seyhan; Baran, Mehmet Firat; Baran, Ayse; Eftekhari, Aziz; Adican, Mehmet Tevfik; Mohamed, Ali Jimale
Objective: Anchusa officinalis L. (A. officinalis) is a herbaceous traditional medicinal plant used in the treatment of some diseases. The presence of its medicinal properties suggested that A. officinalis (AO) leaf extract could be used as a coating agent for the environmentally friendly production of silver nanoparticles (AgNPs). Methods: The synthesized biogenic silver nanoparticles (AO-AgNPs) were characterized using different techniques. The antimicrobial activity of AgNPs against common bacterial pathogenic strains was determined by the minimum inhibitory concentration (MIC) method. The presence of phytochemicals was determined by LSMS/MS. The MTT assay was used to investigate AO-AgNPs' cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines. Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. Biogenic AO-AgNPs exhibited effective inhibition of the growth of pathogenic microorganisms at low concentrations. The most effective antimicrobial activity was measured as 0.5 mu g/mL MIC against S. aureus, E. coli, and C. albicans. Moreover, AO-AgNPs showed significant inhibition on the growth of cancerous cell lines, especially at a concentration of 25 mu g/mL. On the contrary, it was determined that the inhibition rate decreased in the growth of healthy cell lines due to the increase in concentration. The lowest EC50 values were determined as 15.15 mu g/mL in A549 cells. Conclusion: The obtained results showed that AO could be an important source for the synthesis of AgNPs. Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AOAgNPs can be used as biomedical agents in various areas. Moreover, their suppressive effect on cancerous cell lines showed that they have the potential to be used as an anticancer agent, but due to their proliferative effect on healthy cell lines, care should be taken in determining the appropriate dose.
A Simplified Analytical Modeling Approach for the Structural Analysis of Massive Masonry Structures
(Univ Estadual Maringa, Pro-reitoria Pesquisa Pos-graduacao, 2025) Unay, Ali Ihsan; Kutlu, Izzettin; Soyluk, Asena
This paper, presents a simplified analytical modeling approach to determine the structural behavior of historical buildings. Analytical modeling is a digital tool for determining the behavior of masonry buildings under the influence of dynamic and static loads. In the analytical modeling process, different types of elements are involved to represent buildings. Due to the complex geometrical features of historical buildings, it is significant to the preference for convenient elements. Mardin Great Mosque was discussed and analyzed for the selection of convenient element preferences. Three different mosque models were built and analyzed by using three different element types (frame, shell, solid). In the findings of the paper, the values at the same points on the models were compared. When the first natural vibration period was examined, the first model is 0.76sec, the second model is 0.76sec, and the third model is 0.71sec. In addition, considering the base shear under dead load, 98.35% similarity was observed. As a consequence of the geometrical features of historical buildings, inappropriate definitions and inconvenient element preferences emerge the results questionable. Therefore, to be able to manage the analytical modeling process effectively requires accurate and appropriate definitions of the elements to be preferred.
Low-Intensity Extracorporeal Shock Wave Therapy and Platelet-Rich Plasma: Effective Combination Treatment of Chronic-Phase Peyronie's Disease
(Iniestares, S.a., 2025) Ergun, Muslum; Sagir, Suleyman
Objective: This study aimed to investigate the effectiveness, safety and outcomes of the combination therapy of low-intensity extracorporeal shockwave therapy (Li-ESWT) and platelet-rich plasma (PRP) for the treatment of chronic-phase Peyronie's Methods: The clinical outcomes of patients diagnosed with Peyronie's disease and treated with Li-ESWT combined with PRP at our clinic between January 2018 and January 2024 were retrospectively reviewed and analysed. Twenty-three patients were excluded based on inclusion criteria, leaving 26 patients for the retrospective analysis. Each patient received three sessions of PRP and six sessions of Li-ESWT. The treatment regimen involved sessions administered twice weekly over a period of 3 weeks, followed by 1-week post-treatment follow-up. The patients were then monitored for 24 weeks. Result: After treatment, no significant reduction in average plaque size was observed. However, a statistically significant average improvement of 10 degrees was noted for penile curvature. Among the patients, 14 (53.8%) reported satisfaction with the treatment outcome, and 12 (46.2%) expressed dissatisfaction. No significant adverse effects were observed at the injection sites or in the areas subjected to Li-ESWT post-procedure. Conclusions: The combination of Li-ESWT and PRP is effective and safe for the treatment of chronic-phase Peyronie's disease.
Breaking Misconceptions: Assessing the Quality of Youtube Videos on Penile Fracture With Validated Scoring Tool
(Mre Press, 2025) Sagir, Suleyman; Ertek, Mehmet Sirin; Toktas, Izzettin
Background: The main objective of this research was to evaluate the effectiveness of YouTube videos related to penile fracture by applying established rating systems. Methods: A descriptive investigation was carried out by browsing YouTube for videos related to "Penile fracture". Out of a total of 108 videos that were found, 47 were deemed eligible for inclusion in the analysis. The features and substance of the videos were assessed utilizing the adjusted DISCERN tool, the criteria from the Journal of the American Medical Association (JAMA), and the Global Quality Scale (GQS). Statistical analysis was performed using SPSS 22.0 software, with a significance level of p < 0.05. Results: High-quality videos, as classified by GQS, had more views, likes, and comments than lower-quality videos; however, these differences were not statistically significant (p > 0.05). In contrast, videos with detailed and accurate content had significantly higher view counts (approximately tenfold) and more likes (approximately twofold) than poor-content videos (p < 0.05). A strong positive correlation was found between content analysis scores and DISCERN (r = 0.815, p < 0.001), JAMA (r = 0.781, p < 0.001), and GQS (r = 0.722, p < 0.001). Videos made by urologists and surgeons demonstrated superior quality across all measured criteria in comparison to those crafted by individuals without healthcare backgrounds (p <0.001). Conclusions: The quality of YouTube content addressing penile fracture exhibits a wide range, with content generated by healthcare experts standing out for its high quality. It is imperative for medical professionals to actively engage in disseminating accurate health information on these platforms.
Green Synthesis of Fe3o4-Crataegus Tanacetifolia (Lam.) Biochar Magnetic Nanocomposites for Adsorption of Naproxen
(Wiley-v C H verlag Gmbh, 2025) Solmaz, Alper; Turna, Talip; Baran, Ayse
In this study, naproxen (NPX), one of the emerging contaminants was removed by green synthesizing Fe3O4 coated magnetic biochar nanocomposites (Ct-BMNCs) synthesized from Crataegus tanacetifolia Lam. (Ct) wastes. The characteristics of Ct-BMNCs was examined by x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray (EDX), Fourier transform infrared spectroscopy (FTIR), thermogravimetry-differential thermal analysis (TGA-DTA), dynamic light scattering (DLS), zetasizer, Brunauer-Emmett-Teller (BET) UV-Vis spectroscopy, and pH point of zero charge (pHpzc). With batch adsorption tests, the effects of pH (4-11), amount of adsorbent (2.5-80 g L-1), time, and initial concentration (3.125-200 mg L-1), and thermodynamic analysis was performed. Also, kinetic and isotherm models and error functions were used. Accordingly, the pHpzc and average surface charge were 5.68 and +11.7 mV, respectively. Moreover, the reaction was exothermic, and the most suitable models were Pseudo-second-order and Freundlich (R2:0.999). Also, qmax was 30.12 mgNPX/gCt-BMNCs. Accordingly, Ct-BMNCs are quite effective in removing NPX.
The Ameliorative Effects of Hesperidin in Rats Developed Hepatotoxicity With Deltamethrin
(Mashhad Univ Med Sciences, 2025) Karabekir, Seda Cetinkaya; Sozen, Mehmet Enes; Ayan, Ilknur Cinar; Savas, Hasan Basri; Cuce, Gokhan; Kalkan, Serpil
Objective(s): Deltamethrin (DLM) is a widely used insecticide in agriculture; however, exposure to it can lead to serious health problems. This study aimed to evaluate the protective effects of hesperidin (HSP), a natural antioxidant, against DLM-induced liver toxicity. Materials and Methods: Thirty-two male Wistar Albino rats (250-300 g, 4 months old) were divided into four groups. The control group received 1 ml of corn oil via oral gavage for 30 days. The DLM group received 1.28 mg/kg DLM in corn oil for 30 days. The DLM+HSP 100 mg/kg and DLM+HSP 300 mg/kg groups received 1.28 mg/kg DLM followed by 100 mg/kg or 300 mg/kg HSP in distilled water, respectively, 30 min after DLM administration for 30 days. Liver tissues were examined histopathologically. Masson's trichrome staining and PCR assessed fibrosis. Caspase 3 and 9 expressions in liver tissues were determined by immunohistochemistry and PCR. Biochemical analyses were conducted on serum samples. Results: HSP supplementation led to a dose-dependent decrease in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. DLM exposure decreased antioxidant capacity, while HSP supplementation increased it dose-dependently. Histopathological evaluations showed increased liver damage in the DLM group, while HSP administration reduced liver toxicity. Masson's trichrome staining and analysis of collagen I (COL1A1) and collagen III (COL3A1) gene expression revealed increased fibrosis in the DLM group, which was attenuated with HSP treatment. Conclusion: The potential prevention of DLM-induced liver toxicity and apoptosis by HSP may be an alternative protective strategy.
The Predictive Value of the Cha2ds2-Vasc Score in the Development of Contrast-Induced Nephropathy After Endovascular Intervention in Peripheral Artery Disease
(Elsevier Science inc, 2025) Evsen, Ali; Aktan, Adem; Kilic, Raif; Isik, Mehmet Ali; Yalcin, Abdulaziz; Guzel, Tuncay; Ozbek, Mehmet
Background: Contrast-induced nephropathy (CIN) is a frequent complication of endovascular interventions for peripheral artery disease (PAD). It is linked to renal dysfunction, extended hospital stays, increased cardiovascular events, and higher mortality rates. The CHA2DS2-VASc score, widely utilized for assessing cardioembolic risk and guiding anticoagulation therapy in nonvalvular atrial fibrillation, encompasses risk factors that overlap with those of CIN. This study investigates whether the CHA2DS2-VASc score can predict CIN in PAD patients undergoing endovascular interventions. Methods: The study included 754 consecutive PAD patients who underwent endovascular procedures at 2 centers. Each patient's CHA2DS2-VASc score was calculated and categorized into low (<3) and high (>= 3) groups. Patients were retrospectively monitored for CIN development and divided into CIN-positive (CIN+) and CIN-negative (CIN-) groups. Univariate and multivariate regression analyses were performed to identify independent predictors of CIN, and a significance level of P < 0.05 was used for all statistical analyses. Results: Of the 754 patients, 178 (23.6%) developed CIN, with 151 (84.8%) occurring in the high CHA2DS2-VASc score group (P < 0.001). The CHA2DS2-VASc score was significantly higher in the CIN(+) group compared to the CIN(-) group (P < 0.001). Regression analysis identified the CHA2DS2-VASc score (odds ratio [OR]: 1.574, 95% confidence interval [CI]: 1.2981.907, P < 0.001), baseline creatinine (OR: 2.296, 95% CI: 1.580-3.335, P < 0.001), and hemoglobin (OR: 0.915, 95% CI: 0.844-0.992, P < 0.001) as independent risk factors. A CHA2DS2-VASc score cutoff of 2.5 predicted CIN with 85% sensitivity and 42% specificity. Conclusion: The CHA2DS2-VASc score is an independent predictor of the development of CIN in patients with PAD undergoing endovascular intervention.
Temporal Focal Modulation Networks for Sleep Stage Scoring
(Springer, 2025) Zan, Hasan
Accurate sleep stage scoring is crucial for diagnosing and treating sleep disorders, yet traditional manual methods are time-consuming and susceptible to variability. While recent advancements in machine learning and deep learning have enhanced automated sleep stage detection, many approaches still rely on handcrafted features and encounter limitations when processing full-night data. In this paper, we introduce a novel many-to-many classification framework that leverages a temporal focal modulation network for efficient and accurate sleep stage scoring. Our model, SleepFocalNet, processes full-night single-channel EEG signals and predicts sleep stages for all epochs simultaneously. SleepFocalNet is composed of three key components: a convolution block for local feature extraction, a focal modulation block for long-range temporal modeling, and a classification block for final predictions. We evaluated SleepFocalNet on Sleep Heart Health Study (SHHS), SleepEDF-20, and SleepEDF-78 datasets, achieving state-of-the-art performance. On SHHS, SleepFocalNet attained an accuracy of 0.888 and an F1-score of 0.815. On SleepEDF-20, it obtained an accuracy of 0.885 and an F1-score of 0.836. On SleepEDF-78, it outperformed other models with an accuracy of 0.855 and an F1-score of 0.800. This study represents the first application of temporal focal modulation networks in sleep stage scoring. Additionally, we conducted an extensive analysis of various network configurations to assess the impact of different architectural choices on performance. The results validate the potential of our approach to enhance the reliability and scalability of automated sleep stage scoring, offering a robust alternative to existing methods.
Myricetin Promotes Migration and Prevents Palmitate-Induced Apoptosis in Cultured Tenocytes Through Ampk-Dependent Pathways
(Academic Press inc Elsevier Science, 2025) Lim, Do Su; Ahn, Sung Ho; Cho, Wonjun; Gwon, Hyeon Ji; Ko, Jun Hwi; Pyo, Min Kyung; Jung, Tae Woo
Myricetin (Myr), a flavonoid present in vegetables and fruits, has been shown to ameliorate inflammation and oxidative stress in various disease models. However, the effects of Myr on hyperlipidemic tenocytes have not been studied. Herein, we aimed to investigate the effects of Myr on the features of tendinopathy in cultured tenocytes under hyperlipidemic conditions. Reactive oxygen species (ROS) were detected by DCFDA. Hydrogen peroxide (H2O2), malondialdehyde (MDA), and caspase 3 activity were quantified via matched assay kits. Apoptotic cells were detected via TUNEL staining. Proteins investigated in this study were evaluated through Western blotting. Treatment with Myr enhanced tenocyte migration and prevented apoptosis, inflammation and oxidative stress in palmitate-treated tenocytes. Myr treatment increased the phosphorylation of AMPK, and the expression of PGC1 alpha and FGF2. siRNA targeting AMPK abrogated the effects of Myr on palmitate-treated tenocytes. However, FGF2 siRNA reduced the impacts of Myr on only cell migration and ECM signaling. These in vitro results suggest that Myr promotes tenocyte migration and ECM signaling via AMPK/FGF2 signaling and attenuates apoptosis through the AMPK-mediated suppression of inflammation and oxidative stress in hyperlipidemic tenocytes. This study sheds light on therapeutic strategies for treating obesity-related tendinopathy.
Traditional Care Practices Known And/Or Used by Different Ethnic Groups for Newborns During the Postpartum Period
(BMC, 2025) Deger, Vasfiye Bayram; Butun, Ahmet
BackgroundTraditional care practices play a significant role in shaping care provided to newborns across different ethnic groups. Understanding traditional care practices is crucial for integrating culturally sensitive approaches into modern healthcare systems. This study aims to fill the gap in the literature regarding the different traditional care practices across ethnic groups. The aim of this study was to determine the traditional beliefs and practices of women from different ethnic groups living in Mardin regarding newborn care.MethodsThis study is a descriptive cross-sectional study. The sample consisted of women from four ethnic groups who volunteered to participate in the study with at least one child living in Mardin, Turkey. Snowball and convenience sampling methods were used to recruit participants. The study was completed with 188 Assyrian, 197 Turkish, 181 Arab, and 175 Kurdish women. In total, 741 women participated in this study. Data were collected between 18 December 2023 and 14 June 2024. The data were collected face-to-face using a questionnaire. The data were analysed using SPSS for Windows 22.0.ResultsThis study identified significant differences in traditional care practices across four ethnic groups (Assyrian, Turkish, Arab, and Kurdish). Traditional care practices regarding umbilical cord care, swaddling the baby, alleviating gas pain, preventing neonatal jaundice, care for canker sores, and alleviating diaper rash were identified. Assyrian participants were more likely to apply salt to the umbilical cord (14.9%), while Arab participants rarely used this practice (0.6%). Traditional practices for relieving gas pain included drinking herbal teas such as anise, fennel, linden, and cumin. Rubbing and rubbing breast milk on the abdomen, patting on the back, and massaging were other practices for alleviating gas pain. Arab participants were more likely to use anise tea to alleviate gas pain (75.1%), while Kurdish participants preferred fennel tea (22.3%). Practices regarding alleviating diaper rash included applying saturated fat, olive oil, and powder. Arab participants were more likely to apply olive oil for diaper rash (45.9%), while Assyrian participants commonly used dry earth ('H & ouml;ll & uuml;k'). These results highlight the cultural diversity in newborn care practices and underscore the importance of culturally sensitive healthcare interventions.ConclusionThis study highlighted the significance of traditional care practices in newborn care across four ethnic groups. There are many differences between ethnic groups regarding traditional care practices during the postpartum period. Understanding such differences is crucial for developing culturally sensitive interventions that support maternal well-being and enhance health outcomes for both mothers and infants.
The Role of Mid-Trimester Bun and Creatinine Assessment in Predicting Preeclampsia: Retrospective Case-Control Study
(Mdpi, 2025) Kavak, Ebru Celik; Akcabay, Cigdem; Demircan, Meryem; Batmaz, Ibrahim; Sanli, Cengiz; Senocak, Ahmet; Kavak, Salih Burcin
Background and Objectives: Preeclampsia (PE) is a major cause of adverse perinatal outcomes. Early diagnosis of pregnant women at risk of PE can facilitate disease prevention and management. However, the presence of different phenotypes of the disease complicates its prediction. In particular, the challenges in the early diagnosis of term PE cases necessitate research on PE prediction in the second and third trimesters. This study aims to examine the association between PE development and mid-trimester blood urea nitrogen (BUN), serum creatinine, and the BUN/creatinine ratio in pregnant women. Materials and Methods: This retrospective case-control study was conducted on women diagnosed with PE. Pregnant women who underwent routine biochemical blood tests between the 18th and 24th weeks of gestation and subsequently gave birth at our hospital between January 2022 and May 2023 were categorized into three groups. Accordingly, healthy women who had term deliveries were classified as Group 1 (150 cases), women diagnosed with PE were classified as Group 2 (58 cases), and those diagnosed with severe PE were classified as Group 3 (44 cases). Results: There were no significant differences in age, gravidity, parity, body mass index, or gestational week at blood sampling between the patient and control groups (p > 0.05). When comparing the mean blood urea nitrogen, serum creatinine, and BUN/creatinine ratios, a significant difference was observed between the control group and those who developed PE (p = 0.001, p < 0.001, and p = 0.031, respectively). Univariate analysis revealed a significant association between BUN levels and PE development (OR 1.083; 95% CI, 1.031-1.139; p = 0.002). A stronger association was observed between serum creatinine levels and PE development (OR 112.344; 95% CI, 11.649-1083.416; p < 0.001). However, no significant association was found between the BUN/creatinine ratio and PE in univariate analysis (OR 1.003; 95% CI, 0.979-1.028; p > 0.05). Mid-trimester BUN and serum creatinine levels were significantly higher in patients who developed PE and severe PE. The AUC value for the BUN parameter in predicting PE was 0.614 (AUC 0.614; 95% CI, 0.539-0.689; p = 0.002). A BUN cut-off value of 16.2 mg/dL predicted disease development with a sensitivity of 52.9% and a specificity of 74%. Similarly, the AUC value for the serum creatinine parameter in predicting PE was 0.644 (AUC 0.644; 95% CI, 0.574-0.751; p < 0.001). A serum creatinine cut-off value of 0.58 mg/dL was able to predict disease development with 37.2% sensitivity and 88% specificity. No significant AUC value was obtained for the BUN/creatinine ratio (p > 0.05). Conclusions: Our findings indicate that elevated BUN and serum creatinine levels measured during the mid-trimester (18-24 weeks) are associated with an increased risk of developing preeclampsia.
The Effect of Argumentation-Based Activities on the Development of Moral Reasoning
(Routledge Journals, Taylor & Francis Ltd, 2025) Isiker, Yakup; Sozer, Mehmet Akif
This study aims to investigate the effects of argumentation-based activities on moral reasoning development of 4th-grade primary school students. A concurrent nested mixed method was employed. The sample consisted of 30 fourth grade students from a primary school. Before and after the argumentation-based activities "Moral Reasoning Scenarios Inventory" was administered, then interviews were conducted with the students regarding the scenarios. It was found that there was a significant difference in favor of post-intervention results, with a decrease in students' hedonistic and punishment avoidance reasoning, and an increase in the norm and rule-based, the good-empathy of the other, social approval-based and rights and justice-based reasoning. When the students' argumentation activities and their views on moral situations were considered together, it was concluded that argumentation-based activities have a positive effect on the development of students' moral reasoning.
Evaluation of Thiol/Disulfide Homeostasis and Ischemia Modified Albumin as Potential Markers for Periodontitis
(BMC, 2025) Karci, Bilge; Savas, Hasan Basri
Background The current study aimed to assess the impact of periodontitis on oxidative stress parameters by examining serum total antioxidant capacity (TAS), total oxidant status (TOS), oxidative stress index (OSI), thiol/ disulfide homeostasis and ischemia modified albumin (IMA). Methods The study had 90 participants, categorized into 3 groups: Group 1: Periodontally healthy; Group 2: Stage II Grade B periodontitis; Group 3: Stage III and IV Grade B periodontitis. Demographic and periodontal variables were assessed. The levels of serum TAS, TOS, OSI, IMA, and thiol/disulfide were assessed. Results No significant differences in sex and age were detected among the groups (p > 0.05). When compared to Group 1, all clinical measurements were statistically significantly greater in Group 3 (p < 0.05). Statistical analysis revealed no significant differences in serum TAS, TOS, and OSI levels among the groups (p > 0.05). The highest serum IMA value was observed in Group 3 (p = 0.037), whereas native thiol (p = 0.00), total thiol (p = 0.00) and disulfide values (p = 0.023) were highest in Group 1. Conclusions These findings indicate that thiol/disulfide homeostasis and IMA could hold promise as a potential biomarker of inflammation in periodontitis.

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