TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/1836

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Citation - WoS: 2
Citation - Scopus: 3
Bronchiectasis in Türkiye: Data From a Multicenter Registry (Turkish Adult Bronchiectasis Database)
(Galenos Publ House, 2024) Edis, Ebru Cakir; Cilli, Aykut; Kizilirmak, Deniz; Coskun, Ayson Sakar; Guler, Nurcan; Cicek, Sedat; Sayiner, Abdullah
Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry -based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in T & uuml;rkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in T & uuml;rkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non -cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 +/- 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation -related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in T & uuml;rkiye. The study results will provide important data that can guide the development of health policies in T & uuml;rkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.
Citation - WoS: 4
Citation - Scopus: 5
Characterization and Bioremediation Potential of Heavy-Metal Resistant Bacteria Isolated From Agricultural Soil
(Tubitak Scientific & Technological Research Council Turkey, 2024) Dahnoun, Kheira; Djadouni, Fatima; Essghaier, Badiaa; Naccache, Chahnez; Zitouna, Nadia; Zehdi-Azouzi, Salwa; Bourguiba, Hedia
Heavy metal pollution is a major environmental issue that has a negative impact on soil quality and food security. As result, heavy metal removal or remediation from hazardous sites has become mandatory. Bioremediation based on microorganisms is promising method to remediate heavy metal-contaminated areas due to its ecofriendly, cost-effective, and highly efficient characteristics. This study aimed to isolate, identify, and characterize rhizospheric bacteria able to resist, reduce, and detoxify heavy metals [chromium (Cr), nickel (Ni), and aluminum (Al)] from agricultural soil. Two isolates were chosen due to their high level of heavy metal resistance and could serve as potential in situ remediation agents at the site of isolation. On the basis of morphological, cultural, biochemical, and molecular characterization, these two isolates were identified as Pseudomonas aeruginosa (S1) and Bacillus cereus (S2). The results revealed a minimum inhibitory concentrations (MICs) of the three heavy metals studied, ranging from 1000 to 1400 mu g/mL for the two bacterial isolates. Atomic absorption spectroscopy analysis was used to evaluate the degrading potential. B. cereus was able to reduce Cr and Al more than P. aeruginosa (42% and 67.78% vs. 38.44% and 58.85, respectively). On the other hand, P. aeruginosa showed a higher capacity to degrade Ni than B. cereus (62.33% and 50.76%, respectively). The findings of the analysis revealed information regarding the use of these heavy metal-resistant bacterial isolates as potential bioremediation agents in contaminated environments. Microbial bioremediation offers sustainable alternatives to the traditional physical or chemical remediation technologies of agricultural land.

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