TR-Dizin İndeksli Yayınlar Koleksiyonu
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Article Kün Aftare Settlements: First Reports on the Neolithization Process in the Northern Habur Valley(Istanbul Univ, 2024) Kodas, Ergul; Ciftci, Yunus; Ipek, Bahattin; San, Mehmet; Dinc, Onur; Mentese, Devrim HasanThe Neolithization process in southeastern Anatolia has been the subject of many studies over the years. However, these have primarily been concentrated & Scedil;anl & imath;urfa region provide important information on the Neolithization process in the mountainous region between these two rivers. The 2023 Archaeological Survey of the Pleistocene and Early Holocene Period in the Artuklu, K & imath;z & imath;ltepe, Ye & scedil;illi, and Neolithic Period in the Northern Habur Valley. In this context, the settlements the unique Neolithization process of the Northeastern Habur Valley, a key area to both southeastern Anatolia and northern Mesopotamia.Article Citation - WoS: 18Citation - Scopus: 17Evaluation of the Antioxidant Potency of Seseli L. Species (Apiaceae)(Turkish Journal of Pharmaceutical Sciences, 2020) Önder, Alev; Çınar, Ahsen Sevde; Yılmaz Sarıaltın, Sezen; İzgi, Mehmet Necat; Çoban, TülayObjectives: In the present study, the antioxidant potency of ethyl acetate (AcOEt) and methanol (MeOH) extracts from the aerial parts of Seseli L. species was investigated for the first time. Materials and Methods: Seseli species L. such as Seseli andronakii Woronow ex Schischk., S. campestre Besser, S. corymbosum Boiss. & Heldr., S. gummiferum subsp. gummiferum Pall. ex Sm., S. hartvigii Parolly & Nordt, S. libanotis (L.) W.Koch, S. petraeum M.Bieb., S. peucedanoides (M.Bieb.) Koso-Pol., S. resinosum Freyn & Sint., and S. tortuosum L. growing in Turkey were collected and evaluated for their antioxidant capacity by using 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and lipid peroxidation (LPO) inhibition methods. Results: The highest activities as a scavenger of DPPH radicals were found in the AcOEt extracts of S. peucedanoides (M.Bieb.) Koso-Pol (IC50=0.49 mg/mL), and S. libanotis (IC50=0.75 mg/mL); α-tocopherol was used as a positive control. On the other hand, in the LPO assay, the highest activities were determined in AcOEt and MeOH extracts (at 5 mg/mL) of S. tortuosum and S. libanotis (84-94%). Conclusion: This report gives important information about the antioxidant capacity of Seseli L. species. This research on antioxidant capacity proves that the use of some species used in Eastern Anatolia (in salads) is correct. With this screening study performed in Seseli L. species growing in Turkey, in the future, it is planned to isolate antioxidant compounds from the most active strains of Seseli L.Article Citation - WoS: 2Citation - Scopus: 1Effects of Ketamine on Penile Tissues in an Experimental Priapism Model in Rats(Turkish Assoc Trauma Emergency Surgery, 2024) Gevrek, Fikret; Fırat, Fatih; Unsal, Velid; Tapar, Hakan; Karaman, Tugba; Karaman, Serkan; Yalçın, KenanBACKGROUND: This study aimed to evaluate the histopathological and biochemical effects of ketamine on penile tissues following ischemia-reperfusion injury induced by priapism. METHODS: Twenty-four male rats were randomized into three groups. Group 1 served as the control group. Group 2 underwent the priapism model to induce ischemia-reperfusion injury. Group 3, the treatment group, experienced a similar ischemia-reperfusion model as Group 2; additionally, 50 mg/kg of ketamine was administered intraperitoneally just before reperfusion. Blood biochemical analyses and penile histopathological evaluations were performed. RESULTS: In Group 3, significant improvements were observed in all histopathological scores, including desquamation, edema, inflammation, and vasocongestion compared to Group 2 (p<0.001). Blood biochemical analyses showed that the malondialdehyde (MDA) levels were recorded as 10 in Group 2, with a significant decrease in Group 3 (p=0.013). Similarly, proinflammatory cytokine levels, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were found to be suppressed in Group 3 compared to Group 2 (p=0.003, p=0.022, and p=0.028, respectively). Antioxidant enzyme activities, such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.016 and p=0.024, respec- tively). CONCLUSION: Ketamine is an effective anesthetic agent in alleviating the effects of penile ischemia-reperfusion injury.Article Citation - WoS: 2Citation - Scopus: 2Yukarı Dicle Vadisi’nde Bulunan Sere Şippe Höyük üzerine ilk Gözlemler (Dargeçit/Mardin/Türkiye)(Anadolu Arastirmalari, 2022) Kodaş, Ergül2019 yılında tespit edilen Sere Şippe Höyük Mardin İli Dargeçit ilçesi Temelli Mahallesi sınırları içerisinde bulunmaktadır. Dicle Nehir yatağının yaklaşık 1500 m kuzey-batısında bulunan yerleşim yerinde, Ilısu Barajı ve HES Projesi kapsamında kazılar yapmakta olan Boncuklu Tarla kazı ekibi tarafından 2019 yılında yapılan yüzey araştırmasında çanak çömlek, yontmataş, sürtme taş, kemik alet ve parçaları ile süs eşyaları toplanarak koruma altına alınmıştır. Sere Şippe Höyük yerleşim yerinde toplanan yontmataş aletler, çanak-çömlek parçaları ve diğer buluntular yerleşimin hem Çanak-Çömleksiz Neolitik Dönem’de hem de Çanak-Çömlekli Neolitik Dönem’in başlarında iskan gördüğünü düşündürmektedir. Bilhassa bulunan çanak-çömlek parçaları Proto Hassuna çanak-çömlek geleneğine aittir ve höyüğün Çanak-Çömlekli Neolitik Dönem’in başlarında iskan gördüğüne işaret etmektedir. Ayrıca mikrolit aletlerin ve oluklu taş objelerin varlığı höyüğün Çanak-Çömleksiz Neolitik Dönem’de de iskan görmüş olabileceğini de düşündürmektedir. Höyükte toplanan parçalar arasında Halaf Dönemi çanak-çömlek parçaları ve yerleşim yerinin yakınlarında bulunan çakmaktaşı yatakları üzerinde Paleolitik Çağ’a ait aletler de bulunmaktadır.Article Citation - WoS: 2Citation - Scopus: 1Evaluation of the Results of the Patients Who Underwent Plasmapheresis in the Pediatric Intensive Care Unit(Tubitak Scientific & Technological Research Council Turkey, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Kangin, Murat; Turanli, Ese Eda; Ozbek, Mehmet NuriBackground/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Ya & scedil;argil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients' diagnosis, weight, type of procedure and type of device, where the procedure was performed, duration of the procedure, amount of blood and plasma processed, complications, number of procedures, and death during the procedure or independent of the procedure were evaluated. Results: The median age was 93.0 (14.0-167.0) months. Hemolytic uremic syndrome (HUS) was the most common TPE indication with nine patients. The most common complication related to TPE was fever (11 patients), while no complication was observed in 18 patients. When laboratory results were evaluated according to American Society for Apheresis (ASFA) categories, a significant improvement was observed in the values of platelet, AST, ALT, LDH, urea, and creatinine in ASFA1 after TPE. No significant improvement was observed in ASFA2 (p > 0.05). In ASFA3, a significant improvement was observed in INR, AST, ALT, LDH, total bilirubin, creatinine, pH, and lactate values after TPE (p < 0.05). Five patients died from ASFA1, one from ASFA2, and three patients from ASFA3. Conclusion: Since significant adjustments are observed in clinical and laboratory values in sepsis-MOF, which is in the ASFA3 category, we believe that it should be evaluated in the ASFA2 or ASFA1 category in the early treatment of these diseases. In addition, we think that MIS -C cases, which have not been in any category according to ASFA, should be included in the ASFA2 or ASFA3 category, considering our TPE results.Article Citation - Scopus: 2Van Kalesi Analıkız Yapısı: İşlev ve Kronolojisine Dair Bir Değerlendirme.(İstanbul Üniversitesi Yayınevi, 2019) Genç, Bülent; Konyar, ErkanÖzet: Van Kalesi'nin kuzeydoğu yamaçlarında, ova düzeyine yakın bir yükseltide Analıkız veya Hazine Kapısı olarak adlandırılan kaya anıtı yer almaktadır. Anıt ana kayaya işlenmiş bir platform ve gerisinde yine ana kayaya açılmış iki adet anıtsal nişten oluşur. Marr ve Orbeli'nin 1916 yılında gerçekleştirdikleri kazılardan bu yana Analıkız alanının işlevi, sitadelle ilişkisi, krallık açısından önemi, inşa evreleri ve mimari tasarımı hakkında ayrıntılı bir değerlendirme yapılmamıştır. Literatürde bu alan genel olarak Açık Hava Kutsal Alanı olarak tanımlanmıştır. Lehmann-Haup'tun 1898'lerde alanın kuzeyinde yer alan drenaj kanallarını kurban kanalı olarak tanımlaması açık hava kutsal alanı tanımını yerleştirmiş ve sonraki çalışmalara referans olmuştur. Bu makalede alanla ilgili literatür ve hikayeleri ve kazı sonuçları tekrar değerlendirilerek yeniden tanımlanmaya çalışılmıştır. Minua ile başlamış olması muhtemel inşa faaliyetlerinin I. Argişti ve II. Sarduri ile devam ettiği yönündeki tespitler, bu alanın yapım evreleri de göz önüne alınarak değerlendirilmiştir. Analıkız yapısının aslında açık hava kutsal alanı olmayabileceği, krallık için sadece başkente özel ünik bir anıtsal birim olabileceği ele alınmıştır. Söz konusu birimin kralların kroniklerinin yazılı olduğu stellerinin toplu olarak bulunduğu bir alan olabileceği ve bütün çevresel özellikleriyle beraber kapalı bir alan olabileceği arkeolojik ve filolojik kanıtlar üzerinden tartışılmıştır. Abstract: On the northeast sides of the Van Fortress, an elevation nearby, stands a rock monument on the plain named Analıkız or also called Hazine Kapısı. The monument consists of a platform engraved into the rock and two monumental niches. Yet ever since the excavations conducted by Marr and Orbeli in 1916, there have been no detailed examinations or evaluations of the functions of the field, the relationship to the citadel, its importance for the kingdom, the levels of construction or architectural design. In literature, this field is generally recognized as Open Air Sanctuary or the way Lehmann-Haupt defined in 1898. In this study, we attempted to reevaluate and redefine the literature, stories and excavation outcomes. The deductions suggesting construction activities initiating with Minua then continuing with Argishti I and Sarduri II have been made considering the construction levels of the field. The possibilities of Analıkız structure not being an open-air sanctuary but rather a monumental site for the kingdom, a field in which the steles with king’s chronicles carved onto them are gathered or a closed field with all of its surroundings have been discussed with the aid of archeological and philological proofs.Article Kürtlerin Avrupa Birliği'ne Yönelimi: Düşük Bilgi Düzeyi, Yüksek İdealist Beklentiler(2016) Samur, Hakan; Demirtepe,TurgutKürt sorunu sadece uzun zamandır Türkiye'nin en önemli sorunlarından biri olmakla kalmamış aynı zamanda AB üyelik süreci bakımından da her zaman en önemli gündem maddelerinin başında yer almıştır. Bu açıdan, Kürtlerin AB ile ilgili meselelerde durdukları yer ve sahip oldukları görüşler kritik değere sahiptir. Elinizdeki çalışmada, üniversite mezunu Kürtler arasında gerçekleştirilen bir alan çalışmasından hareketle; literatürde kullanılan iki ana oryantasyon moduna, farkındalık (ilgi ve bilgi) düzeyine ve sübjektif değerlendirmelere dayalı olarak Kürtlerin AB'ye oryantasyonları (yönelimleri) analiz edilmeye çalışılmıştır.Article Yavaş gelişen etlik piliçlerin karkas özelliklerine ve et kalitesine serbest yetiştirme sisteminin etkisi(2012) Ahmet Şekeroğlu; Merve DiktaşBu çalışma, altlıklı yer sistemi, yarı açık gezinmeli serbest sistem ve gezinmeli serbest sistemin; yavaş gelişen etlik piliçlerin karkas özellikleri ve et kalitesine etkilerinin araştırılması amacıyla yapılmıştır. Denemede 270 adet yavaş gelişen Hubbard Isa Red-JA civcivi kullanılmıştır. Denemenin 61. gününde her yetiştirme sisteminden 12 adet, toplam olarak 36 adet yavaş gelişen etlik piliç, karkas ve et kalitesini saptamak amacıyla seçilmiştir. Araştırma sonuçlarına göre; yetiştirme sisteminin karkas randımanı, but oranı ve kanat oranına etkisi önemli bulunurken (P<0.05), göğüs oranı, sırt ve boyun oranına etkisi önemli bulunmamıştır (P>0.05). Göğüs eti pH, renk, protein, yağ, kül, kuru madde ve su tutma kapasitesi bakımından yetiştirme sistemleri arasındaki farklılık önemli çıkmamıştır (P>0.05). Göğüs eti çoklu doymamış yağ asitleri bakımından yetiştirme sistemleri arasındaki farklılık önemli bulunmuştur (P<0.01). Yağ asitlerinden miristoleik asit bakımından yetiştirme sistemleri arasındaki farklılık önemli (P<0.05), ele alınan diğer yağ asitleri arasındaki farklılık önemsiz bulunmuştur (P>0.05). Göğüs eti besin madde içeriği, çoklu doymamış yağ asidi ve tekli doymamış yağ asitlerinden miristoleik asit bakımından yarı açık gezinmeli serbest sistem diğer sistemlere göre bir üstünlük sağlamıştır.Other Türkiye’de Yoğun Ekim Alanına Sahip Bazı Arpa (Hordeum vulgare L.) Çeşitlerinin Destek Sulamalı ve Yağışa Dayalı Koşullarda Değerlendirilmesi(2017) Aktaş, HüsnüBu çalışma Türkiye'de tescilli 10 arpa (Hordeum vulgare L.) çeşidinin tane verimi ve bazı agronomik karakterlerinin, yağışa dayalı ve destek sulamalı koşullarda araştırılması amacıyla 2011-12 ve 2012-13 yetiştirme sezonlarında Diyarbakır'ın Çınar ilçesinde yürütülmüştür. Denemeler tesadüf blokları deneme deseninde, dört tekrarlamalı olarak kurulmuştur. Elde edilen veriler varyans analizi ve GGE-biplot yöntemleri kullanılarak değerlendirilmiştir. Çalışmada kullanılan arpa çeşitleri aynı zamanda kuraklığa dayanıklılık parametreleri bakımından da değerlendirilmiştir. İki yıllık ortalamalara göre çeşitlerin destek sulu koşullardaki tane verimi (417 - 578 kg/da), yağışa dayalı koşullarda (281 391 kg/da) arasında değişirken; sulu ve yağışa dayalı koşullardaki ortalama değerler sırasıyla, bin tane ağırlığı için 41 g ve 38 g, hektolitre ağırlığı için 68 kg/hl ve 62 kg/hl ve m2'de başak sayısı için 513 adet/m2 ile 367 adet/m2 olarak kaydedilmiştir. GGE-biplot analizi sonuçlarına göre ise tane verimi bakımından G3 ve G5 en stabil çeşitler olarak belirlenmiştir. Sulu ve yağışa dayalı koşullardaki iki yılın ortalama verilerine göre tane verimi açısından G3, G9, G5 ve G10 en yüksek değerlere (sulu koşular: 578; 533; 520; 550 kg/da, yağışa dayalı şartlar: 363; 365; 391 ve 363 kg/da) sahip çeşitler olarak belirlenmiştir. GGE biplot sonuçlarına göre G9 yağışa dayalı şartlara, G3 ise sulu koşullara uygun çeşitler olarak tespit edilmiştir. Çalışmada kurağa dayanıklılık parametrelerinden olan YI (Yield index; Verim indeksi) ile yağışa dayalı şartlardaki verim (Ys) ile ilişkili bulunurken, bu parametrenin kuraklığa tolerant çeşit geliştirme çalışmalarında kullanılabileceği öngörülmüştür. Diğer kurağa dayanıklılık parametrelerinden HM (Harmonic Mean; Harmonik ortalama), GMP (Geometric Mean Productivity; Geometrik Ortalama Verim), STI (Stress tolerance index; Stres Tolerant İndeks) ve MP (Mean productivity; Ortalama verimlilik) ve TOL (Tolerans) parametreleri ise sulu koşullarda verim ile ilişkili bulunmuş, bu yüzden sulu koşullara uygun genotiplerin belirlenmesinde bu parametrelerinin kullanılabileceği tespit edilmiştirArticle High Level of Fluctuating Asymmetry in the Byzantine Dogs From the Theodosius Harbor, Istanbul, Turkey(2021) Siddiq, Abu B.; Onar, Vedat; Parés Casanova, Pere M.; Öncü, Ögül Emre; Kar, HakanAbstract: Asymmetry, the abnormality of an organism or a part of it from its perfect symmetry, is represented by three different categories: fluctuating asymmetry, directional asymmetry, and antisymmetry. Fluctuating asymmetry attributes to random developmental variation of a morphological character, whereas directional asymmetry attributes one of the body sides to be more prominent than the other. Antisymmetry appears whenever one body side of a biological body shows greater morphological appearance than the other. Since more environmental stress often produces greater effect of fluctuating asymmetry, it can be a good indicator of physiological stress in the morphological characteristic of a biological being. Applying, so far, the first geometric morphometric methods on any Byzantine fauna, this study aimed to determine the kind and direction of skull asymmetry occurred in Byzantine dog skulls. Aiming this, asymmetries in 16 adult Byzantine dog skulls unearthed form Yenikapı-Marmaray excavation (ancient Theodosius Harbor) in İstanbul, were compared with 39 adult skulls of modern pet dog breeds. Seventeen landmarks (3 midline and 14 bilateral) were selected on the digital pictures of the ventral aspect of each skull, and used for detailed analysis. The results showed a greater percentage of fluctuating asymmetry in the Byzantine dog skulls, suggesting them not to be the remains of pets or housed dogs but perhaps the labor or stray dogs in the Byzantine capital Constantinople.Key words: Byzantine dog, geometric morphometrics, fluctuating asymmetry, Theodosius Harbor, Canis familiaris, Yenikapı-Marmaray excavation, İstanbulArticle Citation - WoS: 6Citation - Scopus: 7Evaluation of patients diagnosed with phenylketonuria and biotinidase deficiency by the newborn screening program: a ten-year retrospective study(The Turkish Journal of Pediatrics, 2022) Toktaş, İzzettin; Sarıbaş, Seyfettin; Canpolat, Semih; Erdem, Özgür; Özbek, Mehmet NuriBackground. Phenylketonuria (PKU) and biotinidase deficiency (BD) are autosomal recessive diseases. If they are not identified and treated early, severe intellectual disability and developmental delay occur. This study was conducted to calculate the ten-year incidence of PKU and BD in the Diyarbakır province of Turkey. Methods. This cross-sectional study included patients born between 2011-2020 and diagnosed with PKU and BD. Patients with a clear diagnosis had their records evaluated retrospectively. Results. Between 2011 and 2020, blood was taken from 417,525 newborns’ heels in Diyarbakir province. As a result of further diagnostic testing, 53 PKU (Incidence: 1:7878) and 177 BD (Incidence: 1:2359) were detected. Of the patients with BD, 56% had profound BD and 44% had partial BD. The records of a total of 269 patients (PKU: 25; BD: 123; Hyperphenylalaninemia: 121) were examined. Parents of 65% (n=15) of the patients diagnosed with PKU and 46.6% (n=55) of the patients diagnosed with BD were consanguineous. Conclusions. The incidence of both PKU and BD was found to be high in our region. The high number of consanguineous marriages was regarded as the most important explanation for the high frequency of these illnesses.Article Citation - WoS: 1Citation - Scopus: 1Safety Analysis of Different Intensities of ELF-PEMF in Terms of Apoptotic, Inflammatory, and Transcription Factor NF-κB Expression Levels in Rat Liver(Kare Publ, 2024) Seker, Ugur; Gökçe, Yasin; Özöner, Merve PekinceBackground and Aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF- PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats. Materials and Methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Con- trol, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the de- vice was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field applica- tion was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed. Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group. Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apop- tosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.Article Hyperinsulinemic Hypoglycemia in Childhood(Pera Yayincilik Hizmetleri, 2023) Ozbek, Mehmet Nuri; Orhan, OzhanHyperinsulinemic Hypoglycemia (HH) is the most common cause of permanent hypoglycemia, especially in the neonatal period. Childhood HH is mostly related to genes encoding proteins in the insulin secretion pathways, and may also be seen in syndromes such as Beckwidth Wiedemann, Kabuki, and Turner. The majority of congenital HH cases are the result of KATP channel gene defect. Most of these cases are unresponsive to diazoxide treatment. In this review, recent genetic studies and recent updates in treatment options in childhood HH are reviewed.Article Citation - WoS: 6Citation - Scopus: 6Etomidate Alleviates Ovarian Ischemia-Reperfusion Injury in Rats(Turkish Assoc Trauma Emergency Surgery, 2024) Katar, Muzaffer; Gevrek, Fikret; Unsal, Velid; Tapar, Hakan; Karaman, Tugba; Karaman, Serkan; Balta, MehtapBACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury. METHODS: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflamma- tory cytokine levels, and antioxidant enzyme activity.Furthermore, histopathological scoring was performed to evaluate tissue damage in the ovaries. RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL- 1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p<0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p<0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were signifi- cantly increased in Group 3 compared to Group 2 (p=0.031 and p=0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p<0.001, p<0.001, p<0.001, and p=0.001, respectively). CONCLUSION: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histo- pathological and biochemical outcomes.Article Citation - WoS: 2Citation - Scopus: 2Volatile Compounds, Bioactive Properties and Chlorophylls Contents in Dried Spearmint (Mentha Spicata L.) as Affected by Different Drying Methods(Galenos Publ House, 2023) Korkmaz, Aziz; Arslan, Erhan; Kosan, MeltemThis study presents a comparison of the quality characteristics of spearmint (Mentha spicata L.) dried by a photovoltaic thermal dryer (PVT), the shade dried spearmint (SDS), and an oven dried spearmint (ODS). The obtained samples were evaluated with respect to volatile compounds (VC), total phenolic content (TPC) and flavonoid content (TFC), antioxidant capacity (AC) and chlorophylls (Chl) contents. PDS had the highest amount of TPC, TFC and AC, while SDS and ODS did not differ significantly from each other in terms of these features. SDS exhibited the highest Chl a and Chl b contents, whereas ODS showed the lowest. The composition of VC in the dried spearmints was significantly affected by the drying methods used. The total amount of terpenoids, especially carvone, responsible for spearmint's characteristic aroma in SDS was higher than those of the others, while the concentrations of most VC were lowest in ODS. According to the results, the PVT can be recommended for drying spearmint.Article Citation - WoS: 1Effect of Different Sowing Time on Yield and Yield Components of Lentil (Lens Culinaris Medic.) Varieties in Mardin Kiziltepe Conditions(Univ Namik Kemal, 2014) Dogan, Y.; Doğan, Yusuf; Togay, Y.; Togay, N.; 06.02. Department of Plant Protection / Bitki Koruma Bölümü; 06. Faculty of Agricultural Sciences and Technologies in Kızıltepe / Kızıltepe Tarım Bilimleri ve Teknolojileri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiThe aim of this work is to determine the most suitable sowing date for lentil in Mardin Kiziltepe conditions. Three cultivars of lentil (Firat-87, Sakar andYerli Kirmizi) were sown at three different sowing dates (November 10, 25 and 10 December). The trial was conducted in the experimental fields of Kiziltepe Vocational High School of Mardin Artuklu University by using split plots in randomized factorial blocks design with the three replicates in years of 2011-12 and 2012-13. Experiment was established as main plots and sowing times treatments as split plots. Effects of sowing dates on plant height, first pod height, numbers of pod per plant and numbers of seed per plant, numbers of seed per pod, 1000 grain weight, grain yield, harvest index and biological yield were investigated for three cultivars. According to the two years results; effects of varieties and sowing time on the yield and yield components of lentil were obtained significantly. While the highest grain yield per area was obtained at the Sakar cultivar as 237.48kg/da and 210.34 kg/da, the lowest grain yield per area was obtained at the Yerli Kirmizi cultivar as 164.07 kg/da and 148.22 kg/da in years of 2011-12 and 2012-13 respectively. The most suitable sowing time was determined with November 25 in Mardin conditions.Article The Impact of Nano Processed Cattle Manure Combinations on the Yield and Quality Changes of Cotton(Ankara Univ, Fac Agriculture, 2025) Elis, SevalSustainable agriculture necessitates the exploration of organic fertilizers to promote both crop productivity and soil health. The objective of this two-year study was to evaluate the effects of different combinations of processed cattle manure on the yield and quality of cotton crops, with a focus on determining the optimal dosage of these fertilizers. Parameters including seed cotton yield, lint yield, ginning percentage, and physiological traits such as chlorophyll content and normalized difference vegetation index (NDVI) were analyzed. Results revealed significant differences in yield and physiological traits among fertilizer treatments. Notably, combinations involving cattle manure as base fertilizer exhibited superior performance compared to synthetic fertilizer alone. The application of 230 kg da-1 of cattle manure as base fertilizer, in particular, resulted in optimal yield and quality, highlighting the potential of organic fertilizers in enhancing crop productivity. While synthetic fertilizers tended to enhance chlorophyll content, cattle manure applications promoted a more balanced improvement in yield components without compromising plant vigor. Integrating processed cattle manure into fertilizer regimes emerges as a promising strategy for sustainable cotton production. The dose of processed manure fertilizer will provide ten times less use than the dose of normal manure fertilizer. This will make the use of manure fertilizers more active and the use of organic fertilizers more widespread.Article Citation - WoS: 2Citation - Scopus: 2Ascorbic Acid Exhibits More of a Protective Effect Than Estradiol Against Nephrotoxicity Induced by Malathion in Rats: a Histopathological and Molecular Docking Study(TUBITAK Scientific & Technological Research Council Turkey, 2025) Alhilal, Mohammad; Salem, Mahmoud E. L. S. A. Y. E. D. M. O. H. A. M. E. D.; Ali Albakoush, Ahmed; Alhilal, Suzan; Farag, Basant; Gomha, Sobhi M.Background/aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses. Materials and methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion and the effects of estradiol and ascorbic on nephrotoxicity were evaluated. After 4 weeks of treatment, the animals were sacrificed and the kidneys were examined following hematoxylin and eosin (H&E) staining. Histopathology results were supported by molecular docking studies of estradiol and ascorbic acid against a target protein (PDB ID: 2YMX), the peptide inhibitor Fab408 inhibiting acetylcholinesterase (AChE). The inhibition of AChE is the primary mechanism of the toxic effects of malathion. Results: Histopathological examination revealed a notable elevation (p < 0.001) in degeneration and necrosis within the tubular epithelium and interstitial nephritis in the malathion group compared to the sham group. Daily administration of estradiol and ascorbic acid resulted in a notable reduction (p = 0.0022) in the severity of these histopathological changes in the malathion + estradiol and malathion + ascorbic acid groups compared to the malathion group. Of these, the most significant decreases were observed in the malathion + ascorbic acid group. Docking studies of these compounds against the selected protein (PDB ID: 2YMX) revealed promising binding scores. Ascorbic acid exhibited the highest docking score (-6.44 kcal/mol), indicating a favorable binding interaction with this protein. Conclusion: Estradiol and ascorbic acid exert protective effects against malathion-induced nephrotoxicity, whereas ascorbic acid showed superior efficacy compared to estradiol. This result was further supported by molecular docking studies.Article Documentation of Material Deterioration on the Facades of Cultural Assets With the Use of Topographic Laser Scanning Method and Orthophotographs: Case of Mardin Mungan Mansion(Geomatik Journal, 2023) Karatas, LaleIt is of great importance to determine and understand the factors and processes that affect the material deterioration in buildings, to apply appropriate protection interventions, to know in advance of the deterioration that will occur in the structures and to take precautions. Mardin Mungan Mansion, which is the subject of the study and is a historical stone structure reflecting the characteristics of traditional houses unique to the region. It is a structure formed under the determination of regional elements such as topography and materials. The aim of the study is to investigate the stone material problems of Mardin Mungan Mansion, which is a historical mansion reflecting the characteristics of traditional houses in the province of Mardin. In the investigation of material problems, observational detection and terrestrial laser scanning methods were used. As a result of the study, it is seen that by combining the data obtained from observational detection and orthophotos obtained from terrestrial laser scanning, a deterioration map can be created quickly and easily for the detection of material deterioration and restoration analysis. In the results obtained from the deterioration maps, on the facades of the Historical Mardin Mungan Mansion, surface pollution, blooming, faulty repairs due to the use of cement, and the problems of pouring the plaster made as a result of various faulty repairs were encountered. It is seen that the most important possible causes of damage to the structure are the negative effects of user-induced deterioration.Article Citation - WoS: 1Citation - Scopus: 1Is There Any Effect of Lidocaine on Ischemia/Reperfusion Injury in Testicular Torsion? An Experimental Study(Turkish Assoc Trauma Emergency Surgery, 2024) Gevrek, Fikret; Fırat, Fatih; Unsal, Velıd; Kılınç, Fatih; Tapar, Hakan; Karaman, Serkan; Yalçın, KenanBACKGROUND: This experimental study aimed to evaluate the potential protective effects of lidocaine on ischemia-reperfusion injury resulting from testicular torsion/detorsion in rats. METHODS: A total of 18 male rats were randomized into three groups. Group 1 served as the control group. Group 2 was designed to evaluate testicular ischemia-reperfusion injury using a torsion/detorsion model. In Group 3, the treatment group, a similar ischemia- reperfusion model was used as in Group 2. Additionally, lidocaine at a dose of 15 mg/kg was administered intraperitoneally five minutes before reperfusion. Blood biochemical analyses and testicular histopathological evaluations were conducted. RESULTS: Blood biochemical analysis showed that malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly higher in Group 2 compared to the other groups (p<0.001 and p=0.008, respectively). Proinflammatory cytokine levels, including interleu- kin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), were lower in Group 3 than in Group 2 (p<0.001, p=0.007, and p=0.026, respectively). Antioxidant enzyme activities, including glutathione peroxidase (GSH-Px) and superoxide dis- mutase (SOD), were higher in Group 3 compared to Group 2 (p=0.005 and p=0.025, respectively). Histopathological evaluations revealed significant improvements in all testicular damage scores, including hemorrhage, edema, vasocongestion, and inflammation in Group 3 compared to Group 2 (p=0.015, p=0.035, p=0.015, and p=0.034, respectively). Additionally, there was a notable improvement in the Johnsen score in Group 3 compared to Group 2 (p=0.034). CONCLUSION: Lidocaine, an effective local anesthetic, significantly alleviates the effects of testicular ischemia-reperfusion injury.
