Fakülteler
Permanent URI for this communityhttps://hdl.handle.net/20.500.12514/14
Browse
Browsing Fakülteler by WoS Q "Q1"
Now showing 1 - 20 of 104
- Results Per Page
- Sort Options
Article Citation - WoS: 32Citation - Scopus: 36Health literacy, health perception and related factors among different ethnic groups: a cross-sectional study in southeastern Turkey(BMC Health, 2021) Yiğitalp, Gülhan; Bayram Değer, Vasfiye; Çifçi, SemaBackground: Low levels of health literacy are associated with increased hospitalization rates, problems regarding the proper intake of medications, poor general health and increased mortality rates. It is a well-known fact that health literacy differs among ethnic groups and ethnic minorities, in particular, are known to have a low level of health literacy. The present study aimed to reveal the levels of health literacy among different ethnic groups and the affecting factors as well as the relationship between health literacy and health perceptions. Methods: This cross-sectional study was carried out with different ethnic groups (Kurdish, Arab, Turkish and Assyrian origin), between 18 and 65 years old in the province of Mardin in Turkey. The study was conducted with a total of 600 people. The European Health Literacy Scale-Turkish Adaptation (EHLS-TR) and Health Perception Scale (HPS) were used for measurement. Descriptive analysis, Mann Whitney U Test, Kruskal Wallis Test and Spearman correlation were used in the data analysis. Results: It was found that 80.7% of the participants had relatively low levels of health literacy. The lowest levels of health literacy were among those of Kurdish origin. There were correlations between sufficient levels of health literacy and several factors including being of Assyrian origin, being 50–65 years old, living in a nuclear family, being a secondary school graduate, having a high financial status, being retired, evaluating one’s own health status as good, obtaining health information from healthcare professionals, preferring to visit a state hospital to seek medical assistance first, smoking and drinking alcohol. A positive correlation was also identified between the levels of health literacy and health perception. Conclusions: It is essential to develop programs to increase health literacy for the public and, in particular, for the ethnic groups that are disadvantaged in many aspects in the context of health literacy.Article Identity development of Assyrian/Syriac youth: Narratives of becoming a self(Elsevier, 2022) Ergün, NaifThis study aims to analyze the narrative identities of a group of Assyrian/Syriac youth, in particular, to investigate the role of their intergenerational narratives on their narrative identities. Accordingly, interviews were conducted with eight male Assyrian/Syriac young people and the families of four of them who lived in Mardin, Turkey. The narratives of each participant were examined through a holistic approach, analyzing their lives in the context of their personal and intergenerational narratives throughout their lifelines. In the analysis, the turning points of individuals are depicted on the figures, and three lifeline figures were mapped. Findings indicated that although the participants lived under similar living conditions and grew up in the same area, they each narrated their identities differently. For example, one participant described his identity as victimic, communion and burden, while another participant described his identity as agentic, communion, and benefit, and yet another narrated his identity as agentic, agency, and benefit. The individual analysis that emerged in the narratives of all participants was discussed in the context of the literature on identity and narrative identity.Article Citation - WoS: 42Citation - Scopus: 61Critical success factors for tourist destination governance in times of crisis: a case study of Antalya, Turkey(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2018) Cakar, KadirThe aim of this paper is to identify the critical success factors for the development of crisis management and strategy for the governance of the tourist destination of Antalya, Turkey. Data was obtained from in situ interviews, participant observation, and documentation. Interviews were conducted with the main tourism stakeholders representing both public and private sectors in Antalya. Findings show that the critical success factors of responsiveness, shared roles, strategy formation, and collaboration are vital for effective crisis management. The study also highlighted the fact that in the area of shared roles and collaboration, encompassing the characteristics of coordination, communication, cooperation, and knowledge transfer, stakeholders are proving ineffectual, thereby obstructing the development of necessary strategies for crisis management and the recovery process. Further, ineffective governance, adopted by local stakeholders, has had a substantial negative impact on the process of developing future effective crisis management strategies.Article Citation - WoS: 3Citation - Scopus: 3Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats(Elsevier, 2020) Yardimc, Ahmet; Ramazan Fazil Akkoc, Ahmet Tektemur, Nazife Ulker, Nalan Kaya Tektemur, Elif Erdem Güzel, Sinan Canpolat, Ibrahim Enver OzanBackground: Tobacco use during pregnancy is known to have several negative effects on the offspring's reproductive health in the long term. The use of alpha-lipoic acid (ALA) as a dietary supplement during pregnancy has increased greatly in recent years and has been known to have positive effects on various pregnancy outcomes including miscarriage, diabetic embryopathy, preterm delivery, and congenital malformations. Aim: To evaluate the effects of tobacco smoke exposure (TSE) on sexual behavior, reproductive parameters, and testicles in adult male rats and to reveal the possible role of ALA administration on these parameters. Methods: Pregnant rats (n = 7 per group) were treated with tobacco smoke (TS), ALA (20 mg/kg), and TS + ALA for a total of 11 weeks. The following parameters were compared with 8 control rats: puberty parameters, sexual behavior; levels of serum gonadotropins and testosterone, total antioxidant status, and total oxidant status; the expression of the apoptotic protease-activating factor-1 and caspase 9 mRNA levels in the testis; and assessment of immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling assay of testis. Main Outcome Measure: Sexual behavior, changes in puberty parameters, and hormonal and genetic alterations were the outcomes analyzed in this study. Results: Maternal TSE caused a significant decrease in the number of intromissions compared to the control group. Similarly, ALA decreased erectile function in sexual behavior by decreasing the number of intromissions and intromission ratio in the ALA group compared to the control group. In addition, TSE and ALA treatment caused an impairment of some consummatory sexual behaviors. Also, in parallel with this inhibitory effect, the age of pubertal onset was significantly delayed in the TS + ALA group compared to other groups. Also, histopathological changes in testicular tissue, oxidative stress markers, apoptotic index, and mRNA levels of apoptosis-related genes increased in all treatment groups. Clinical Implications: The use of ALA and/or tobacco products during pregnancy may adversely affect the reproductive health of male newborns in the long term. Strengths & Limitations: To the best of our knowledge, this study is the first to show the effects of maternal ALA treatment and/or TSE on the sexual behavior and reproductive parameters in male rats; however, the study is based on an animal model, and the present findings partially reflect the characteristics of human sexual behavior. Conclusion: Maternal TSE and/or ALA treatment may impair sexual behavior in adulthood in male rats because of testicular damage caused by oxidative stress during gonadal development. Yardimci A, Akkoc RF, Tektemur A, et al. Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats. J Sex Med 2020;17:1835–1847.Article Citation - WoS: 80Citation - Scopus: 114Bibliometric mapping of mobile learning(Telematics and Informatics, 2021) Göksu, İdrisThis study aims to reveal the tendency towards research in the field of mobile learning with the analysis of co-authorship, bibliographic coupling, co-occurrence, and citation by taking into consideration of author, publication, keyword, journal, country, university and citation variables. As of September 2019, the meta-data of a total of 5167 studies in the Web of Science database constituted the scope of this study. VOSviewer and sciMAT were used for the bibliometric analysis while Harzing's Publish and Perish software was used for the h-index. As a result of the bibliometric analysis, it was concluded that the most effective countries in mobile learning are Taiwan, USA, China, and England. According to the keyword co-occurrence analysis, mobile devices, higher education, mobile technologies, tablet, and smartphone keywords stand out in the field of mobile learning. Within the period of 2015–2019, trending topics were broadly educational technologies and, more specifically, tablets, mobile phones, MOOCs and learning strategies. It was found that G. J. Hwang is the most influential researcher and National Taiwan University of Science and Technology is the most influential university. It can be concluded that the most effective researches are augmented reality, higher education, and smartphone oriented mobile learning researches. According to the analyses conducted in the context of journals, Computers & Education, British Journal of Educational Technology and Educational Technology & Society were the most contributing journalsArticle Citation - WoS: 4Citation - Scopus: 4Early puberty paradox: an investigation of anxiety levels of mothers and children, children's quality of life, and psychiatric diagnoses(SpringerLink, 2023) Kardaş, Burcu; Kardaş, Ömer; Demiral, Meliha; Özbek, Mehmet NuriEarly puberty signs lead to an increase in anxiety levels of parents and children. The aim of this study was to investigate the quality of life and anxiety levels of girls and their mothers who were admitted to a pediatric endocrinology clinic with concerns about early puberty. Girls and their mothers who were admitted to endocrinology outpatient clinic with concerns about early puberty were compared to healthy control group. Screen for Child Anxiety Related Emotional Disorders (SCARED) parent form, Quality of Life for Children Scale (PedsQL) parent form, and Beck Anxiety Inventory (BAI) were administered to the mothers. Children were evaluated with the Schedule for Afective Disorders and Schizophrenia for School-Age Children (Kiddie-SADS Lifetime Version) (K-SADS-PL). The study sample consisted of 92 girls and 62 of them were administered to clinic with concerns about early puberty. There were 30 girls in early puberty group (group 1), 32 girls were in the normal development group (group 2), and 30 were in the healthy control group (group 3). The anxiety level of group 1 and group 2 was signifcantly higher, and their quality of life was signifcantly lower when compared to group 3 (p<0.001). Mother’s anxiety level was found signifcantly higher in group 2 (p<0.001). It has shown that anxiety level and quality of life of children were associated with anxiety level of mothers and the current Tanner stage (r=0.302, p<0.005). Conclusion: Mothers and children who have concerns about early puberty are negatively afected when early puberty is a possibility. For this reason, educating parents will prevent negative impacts of this situation on children. At the same time, it will decrease health burden.Article Citation - WoS: 145Citation - Scopus: 180Hotel Managers' Perceptions Towards the Use of Robots: a Mixed-Methods Approach(Springer Heidelberg, 2020) Seyitoglu, Faruk; Markova, Martina; Ivanov, StanislavAdopting a supply-side perspective, the paper analyses Bulgarian hotel managers' perceptions of service robots using a convergent mixed methods design. Structured quantitative data were collected from 79 managers using a questionnaire, while interviews were used for the collection of qualitative data from 20 managers. The findings indicate respondents feel that repetitive, dirty, dull, and dangerous tasks in hotels would be more appropriate for robots, while hotel managers would rather use employees for tasks that require social skills and emotional intelligence. The individual characteristics of respondents and the organisational characteristics of the hotels they currently worked in played little role in their perceptions of service robots. The managers considered that robots would decrease the quality of the service and were generally not ready to use robots. Additionally, the interviewees indicated that skilled and well-trained employees were more valuable and more adequate than robots for the hospitality and tourism industry. Theoretical and managerial implications are provided as well.Article Citation - WoS: 8Citation - Scopus: 7The future of restaurant labour: evidence from the U.S. restaurants(Routledge, 2023) Seyitoğlu, Faruk; Atsız, Ozan; Acar, AyşegülThis study contributes to the literature by delving into the perspectives of restaurant employees and managers in the USA about the future of restaurant labour. Through a qualitative research approach, we conducted 25 semi-structured interviews with employees and managers. The findings reveal the challenges of restaurant labour, including high turnover rates due to long hours and working during holidays and weekends, lack of work-life balance, and high levels of stress and pressure on employees. The impacts of the COVID-19 pandemic on the future of restaurant labour are extracted as restaurant operations-related, management-related, employee-related, and patron-related impacts. Finally, this research highlights the requirements for the future of restaurant labour, which are requirements to enhance the quality of working conditions and decrease the turnover rate and requirements to sustain in the restaurant industry as an employee.Article Citation - WoS: 5Citation - Scopus: 6Bronchiectasis in Türkiye: Data From a Multicenter Registry (Turkish Adult Bronchiectasis Database)(Galenos Publ House, 2024) Edis, Ebru Cakir; Cilli, Aykut; Kizilirmak, Deniz; Coskun, Ayson Sakar; Guler, Nurcan; Cicek, Sedat; Sayiner, AbdullahBackground: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry -based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in T & uuml;rkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in T & uuml;rkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non -cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 +/- 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation -related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in T & uuml;rkiye. The study results will provide important data that can guide the development of health policies in T & uuml;rkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.annotation.listelement.badge Citation - WoS: 142Citation - Scopus: 161Service robots as a tool for physical distancing in tourism(Current Issues in Tourism, 2021) Seyitoğlu, Faruk; Ivanov, StanislavCOVID-19 pandemic is affecting negatively the tourism and hospitality industry. As people must avoid physical interaction, service robots can be a useful tool to ensure a high level of physical social distance during the epidemic. This paper discusses whether the application of service robots to provide physical distance in the tourism and hospitality context is going to be beneficial or there will be side effects as well. The paper posits that service robots create a technological shield between tourists and employees that increases the physical and emotional distance between them.Article Citation - WoS: 4Citation - Scopus: 6A cat skeleton from the balatlar church excavation, sinop, Turkey(MDPI AG, 2021) Sıddıq, Abu Bakar; Onar, Vedat; Köroğlu, Gülgün; Armutak, Altan; Öncü, Öğül Emre; Chrószcz, AleksanderIn the 2015 excavation season, an east–west oriented burial (2015-Grave-14) built with large dimension stone blocks was unearthed on the south edge of “Area IVi” at the Balatlar Church in Sinop, on the northeastern Black Sea coast of Turkey. In this grave, which is dated between the end of the 6th century AD and the first half of the 7th century AD, a human skeleton was found with the head to the west and a cat skeleton was carefully placed next to the right femur. This study on the burial and the cat skeleton within it shows that, compared to the Roman period, the status of cats reached a higher level during the Byzantine period. It was found that alongside of being a pet, the Balatlar cat was a young healthy female individual that instinctively hunted rodents and birds, given that the remains of a rat and a sparrow were found in the region of the abdominal cavity, corresponding with the stomach location in the living animal. The grave presents the most significant direct archaeological evidence of a pet–human bond recorded at any Byzantine site so far.Article Equal Employment Opportunity and Diversity in Restaurant Labor: Perspectives of Restaurant Employees and Managers in the USA(Emerald Group Publishing Ltd, 2024) Seyitoglu, Faruk; Atsiz, Ozan; Acar, AysegulPurposeThis study was designed to contribute to the extant literature by discovering the perceptions of restaurant employees and managers toward equal opportunities in restaurant labor and working in a diversity-rich restaurant work environment.Design/methodology/approachA qualitative research approach was utilized. Through in-depth interviews, data were collected purposefully from restaurant workers in different positions (e.g. managers, servers, chefs and cooks) in the USA.FindingsAs a result of content analysis, different perspectives emerged on equal employment opportunity and diversity in restaurant labor. While some employees and managers believe that restaurant labor has equal employment opportunities, others think there is a lack of equal employment opportunity and partial equal employment opportunity in the industry. Most participants perceive working in a diversity-rich restaurant work environment as beneficial (an opportunity to learn about different cultures and an opportunity to learn different experiences and approaches).Originality/valueTo the best of our knowledge, this is the first paper to explore employees' and managers' perceptions of equal employment opportunity and diversity in the hospitality labor context, specifically restaurant labor. Therefore, the research findings will create value for scholars to understand the view on equal employment opportunity and diversity in restaurant labor. Further, it will assist practitioners in designing their labor structure regarding equal employment opportunity and diversity management for the future.Article Citation - WoS: 3Citation - Scopus: 3Discrimination Based on Sexual Orientation “Homophobia in Healthcare Employees”: a Cross-Sectional Study(Springer, 2025) Deger, Vasfiye Bayram; Kacan, HavvaIntroductionThe study was conducted to examine the attitudes of healthcare employees toward homosexuals and the factors affecting them, while homophobic thoughts and behaviors are based on heteronormative cultural beliefs and gender stereotypes.MethodsThis study was planned as a cross-sectional and completed with 720 healthcare employees. The Demographic Information Form and Hudson and Ricketts Homophobia Scale were used in the study. Data were collected between January 06 and January 10, 2022.ResultsThe mean homophobia total score of the employees was determined as 97,503 +/- 25,807. Homophobia levels of male healthcare employees, those who thought homosexuality is a disease, and those who stated that homosexuality can be caused by taking an example had increasing homophobia levels. The level of homophobia decreases in the presence of homosexual friends, those who can talk freely about homosexuality, and healthcare employees who support same-sex marriage.ConclusionsRecognition of individuals with different sexual orientations by healthcare employees will reduce homophobic attitudes toward these individuals. Examining the level of homophobia in healthcare institutions and ensuring that discriminatory attitudes or behaviors toward individuals from different sexual orientations are determined to be effective on the quality of healthcare and access to healthcare services.Policy ImplicationsThere is a healthcare system in which patients are generally assumed to be heterosexual; healthcare employees are not prepared to work with Lesbian, Gay, Bisexual, and Transsexual patients in general. Studies conducted on this subject indicate that more studies are needed on the subject to implement a healthcare policy focusing on sexual diversity in healthcare services and to discuss healthcare practices for the Lesbian, Gay, Bisexual, and Transsexual population.Editorial Citation - WoS: 4Citation - Scopus: 4Editorial: Anxiety, burnout, and stress among healthcare professionals(Frontiers, 2023) Bayram Değer, VasfiyeThe technology, informatics and social fields are experiencing continuous changes and developments day by day. Such changes and developments influence human life and expand the fields of research. One of these fields is the world of work life. Work life is an area where people spend a significant part of their lives by spending time and effort. The willingness of employees to make quality use of their time and labor significantly affects the efficiency obtained as a result of their work (Burton, 2010). The nature of the work requirements and the quantity of communication with other people in the workplace create challenging situations for employees. In this context, when it comes to health in work life, health workers are seen as an important sample group in terms of researching variables in work life, since their field requires qualified labor force, is vital and is a profession that constantly involves face-to-face interaction with people. The health sector is one of the sectors where employees have the most difficulties due to various factors. The health sector differs from other working environments due to the difficulty of serving patients with severe stress and the fact that employees in this sector often face stressful situations in their daily working environment.Article Citation - WoS: 10Citation - Scopus: 8Double-edged perspectives on service robots: working with robots and robots’ future career impacts(Taylor & Francis Online, 2022) Seyitoğlu, Faruk; Atsız, Ozan; Taş, Sedat; Kaya, FazılThis study investigates the perspectives of undergraduate tourism and hospitality students on working with robots and the influence of the widespread use of robots on future careers. Accordingly, interviews were conducted with thirty students. The findings include two main categories: working with robots in the tourism and hospitality industry (advantages of working with robots, disadvantages of working with robots, and willingness to work with or implement robots) and future career impacts of the widespread use of robots (threatening human employment, reducing the motivation toward working in the industry, unfair competition between humans and robots, negative psychological impact/feeling of being less skilled than robots, and giving up/changing the industry). This research contributes to the literature by revealing the dimensions of working with robots and the future career impacts of the widespread use of robots. A model of future career impacts of the widespread use of robots was also proposed.Article Citation - WoS: 32Citation - Scopus: 31Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia(Science, 2022) Acar, Ayşe; Lazaridis, Iosif; Alpaslan-Roodenberg, Songül; Açıkkol, Ayşen; Agelarakis, Anagnostis; Davtyan, RubenWe present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.Article Citation - WoS: 15Citation - Scopus: 22The two-way perspective of tourism undergraduates towards (post-)viral world: The future of tourism, and vocational development and career(ScienceDirect, 2022) Seyitoğlu, Faruk; Atsız, Ozan; Kaya, Fazıl; Taş, SedatThis timely paper explores the future of tourism and vocational career in the Covid-19 period from the perspective of undergraduate tourism students. The data were collected through semistructured interviews with 30 students majoring in tourism faculty departments following the qualitative methodology. The findings demonstrate that vocational development and career planning in the Covid-19 era and the future of tourism are the main dimensions identifying students’ perspectives. The vocational and psychological pandemic effects are shaping the future career decisions of students. Furthermore, the future of tourism includes the elements related to tourist expectations and behaviours and trends in the (post-)viral tourism.Article Citation - WoS: 7Citation - Scopus: 10On innovations of n-dimensional integral-type inequality on time scales(2021) Akın, LütfiIntegral-type inequalities and dynamic equations have an important place in time scales. In this paper, we present some innovations of n-dimensional Minkowski’s integral-type inequality on time scales via ♦α-integral.Article Citation - WoS: 28Citation - Scopus: 29Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines(Taylor & Francis Online, 2022) Aljohani, Ghadah F.; Abolibda, Tariq Z.; Alhilal, Mohammad; Al-Humaidi, Jehan Y.; Alhilal, Suzan; Ahmed, Hoda A.; Gomha, Sobhi M.One of the worst diseases, cancer claims millions of lives each year throughout the world, necessitating the creation of novel treatments. In this study, we designed a novel series of 1,3,4-thiadiazoles through the reaction of 2-(4-methyl-2-(2-(1-phenylethylidene)hydrazineyl)thiazole-5-carbonyl)-N-phenylhydrazine-1-carbothioamide (3) with the proper hydrazonoyl halides. Using the MTT assay, the newly synthesized thiadiazoles' growth-inhibitory potential against the liver cancer cell line HepG2-1 was assessed. In comparison to the standard drug doxorubicin (IC50 = 0.72 ± 0.52 µM), the results showed that two compounds, 16b and 21 (IC50 = 0.69 ± 0.41 and 1.82 ± 0.94 µM, respectively) had promising anticancer activity. The structural activity relationship (SAR) was investigated. In addition, molecular docking analysis onto quinone oxidoreductase2 (NQO2) receptor (PDB: 4ZVM) was investigated against the potent compounds to examine the reliability of the in vitro results. The newly prepared thiadiazole-thiazole hybrids are therefore regarded as potent anticancer drugs.Article Citation - WoS: 22Citation - Scopus: 25The role of trust in tourists’ motivation to participate in co-creation(Emerald, 2023) Kodaş, Betül; Resat Arıca, Cihan Cobanoglu, M. Omar Parvez, Viput Ongsakul and Valentina Della CortePurpose – Intention to re-participate in co-creation (IRCC) is an essential indication of customers to their deal proneness. Therefore, this study aims to focus on the role of trust in the relationship between tourists’ motivation for IRCC activities and the perceived service outputs in the tourism research. Design/methodology/approach – This study applies a quantitative method approach to achieve perceptions into this unfamiliar phenomenon of IRCC. A total of 305 valid questionnaires were collected from October 10 to October 30, 2020 in Istanbul, then analyzed with covariance-based structural equation modeling using the linear structural relations (LISREL) software package. Findings – The findings of the study showed that the tourists’ IRCC is categorized under four factors: learning benefit, social interaction benefit, hedonic benefit and financial benefit. In the context of IRCC, organizational trust partially mediates the relationship between tourist intention and deal proneness motivation for IRRC. Research limitations/implications – The scope of research was limited to domestic tourists visiting Istanbul. Research must be conducted on tourists visiting other destinations and who differ in terms of cultural features to make assessments on a larger scale. Furthermore, when considering that co-creation is the consequence of the collaboration between the business and the customers, researching businesses’ initiatives based on promoting the participation in co-creation will make a contribution both for the managers and to the literature to formalize the co-creation process. In addition, social networks are one of the main platforms where tourists motivation to participate in co-creation, but tourists can both create and destroy value on social media regarding the businesses and touristic experience. In this respect, future research should analyze tourists’ motivation elements that urge them to co-create and codestroy value on social networks, contributing to understanding and evaluating the co-creation process in all aspects. Practical implications – In contrast with prior research, this study offers a model that integrates the antecedents and consequences of the IRCC process. In this perception, insight tourist motivational factors to IRCC activities provides a path for tourism businesses to strategically manage their activities. This study mostly uncovers the role of organizational trust positively in effect the re-participation. Originality/value – IRCC is an issue that should be evaluated with its antecedents and outputs. In the literature, several studies evaluate co-creation outputs but research on antecedents promoting IRCC is limited. In this study, the antecedents (motivation to re-participate) and outputs of co-creation (trust and perceived benefit) are evaluated together
