Dicle, Yalçın
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Dicle, Y.
Job Title
Dr. Öğr. Üyesi
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yalcindicle@hotmail.com
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Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
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Current Staff
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Sustainable Development Goals
3
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5
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6
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3
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9
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16
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1
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5
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10
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15
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7
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12
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8
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14
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4
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17
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11
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4
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2
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13
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8
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58
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4
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6
Citations
54
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13
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11
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1/2
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21
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20
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2
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2
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WoS Citations per Publication
1.62
Scopus Citations per Publication
1.54
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8
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0
| Journal | Count |
|---|---|
| Dicle Tıp Dergisi | 4 |
| Central Nervous System Infections | 2 |
| Journal of Burn Care & Research (JBCR) | 1 |
| Kafkas Tıp Bilimleri Dergisi | 1 |
| Muş Alparslan Üniversitesi Sağlık Bilimleri Dergisi | 1 |
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13 results
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Now showing 1 - 10 of 13
Article A Study on The Presence of Legionella pneumophila in Hospital Water Samples from Eastern Turkey(Dicle Üniversitesi Tıp Fakültesi, 2023) Aydın, Elif; Dicle, Yalçın; Tuna, Duygu KübraObjective: Legionnaires' disease is a fatal form of pneumonia brought on by an infection mostly caused by the 60 different species of Legionella pneumophila. Legionnaires' illness is caused by Legionella spp.-contaminated water systems. In this work, we sought to analyze Legionella species, serogroups (SG), and contamination in the water sources of hospitals in five regions in eastern Turkey. Methods: Between January 2017 and December 2018, a total of 1008 samples were examined, including 2 cooling towers, 62 hot water tanks, 104 cold water tanks, and 840 faucet shower heads. Samples were collected by the standard culture method L. pneumophila SG 1, it was analyzed for L. pneumophila SG 2-16 and Legionella spp. The samples were inoculated into BCYE and GVPC medium, and the colonies were assessed using a latex agglutination test, followed by species- and serotype-level identifications. Results: In our study, a total of 1008 water samples were examined, of which 35.31% (356) belonged to 2017, while 64.68% (652) belonged to 2018. 83.33% of the water samples were taken from faucets and shower heads, 10.32% from the cold water tank, 6.15% from the hot water tank, and 0.2% from the cooling tower, and the highest positivity rate was observed in the hot water tank with 12.60%. 7.04% (71) of the samples were positive, and 16.9% (12) of the positive samples were L. pneumophila SG 1, 77.46% (55) L. pneumophila SG 2-14 was detected, while 5.63% (4) were nonpneumophila (Legionella spp) it has been determined as. Conclusions: Legionella disease remains a significant public health threat. The water tanks of hospitals and hotels should be investigated more thoroughly, the necessary disinfection procedures should be carried out frequently. All hospitals should have water management policies, and towns and large buildings should establish comprehensive water system management programs that decrease Legionella growth and transmission. To enhance prevention measures and clinical diagnosis, we also need quicker ways of detecting Legionella in water systems and clinical samples.Article Citation - WoS: 9Citation - Scopus: 8Investigation of the Protective Activity of Baicalein on the Lungs via Regulation of Various Cellular Responses in Rats Exposed to Experimental Sepsis(Oxford University Press, 2023) Dicle, Yalçın; Aydın, Elif; Şeker, UğurBackgrounds In the present study, a cecal ligation and puncture (CLP)-induced experimental sepsis rat model was used to explore the effects of baicalein on inflammatory cytokine levels and oxidative stress as well as the possible regulatory role of nuclear factor-kappa B (NF-κB). Methods For that purpose, 42 Wistar albino rats were equally divided into control, sham, sepsis, B50 + S, B100 + S, S + B50, and S + B100 groups. The B50 + S and B100 + S groups received baicalein before the induction of sepsis, while the S + B50 and S + B100 groups received baicalein afterwards. Experimental sepsis in related groups is generated through ligation of cecum and a puncture in cecal wall. Serum samples were used for tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) analyses, and tissue Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione (GSH), IL-6, and NF-κB levels were measured. Results Compared to the control group, there were significantly increases in the serum TNF-α, IL-6, tissue MDA, and NF-κB levels and decreases in the tissue SOD and GSH levels in the septic group (P < 0.05). Compared to the septic group, inflammation and oxidative stress were reduced in the baicalein-treated groups. Although all of the pre- and post-treatment protocols alleviated inflammation and oxidative stress to varying degrees, pre-treatment with 100 mg/kg was the most successful. Conclusions Findings of this study indicated that baicalein has the potential to reduce sepsis-related oxidative stress and inflammation in the lungs and that pathological outcomes could be regulated via NF-κB transcription factor activity.Article Bir Flavonoid Olan Gossypin'in, Standard Bakteri ve Maya Suşları Üzerindeki Antibakteriyel, Antifungal, Antibiyofilm, Antiadherent ve Antiinvazif Aktivitelerinin İn Vitro Olarak Araştırılması(2023) Karamese, Murat; Çınar, İrfan; Özgür, Didem; Dıcle, YalçınAmaç: Planlanan çalışmamızda Hibiscus vitofolius isimli bitkinin majör komponentlerinden biri olan gossypin isimli etken maddenin mikroorganizmalar ve onların virülans özellikleri (biyofilm oluşturma, adezyon ve invazyon yeteneği gibi) üzerine olan etkilerinin araştırılması amaçlanmıştır. Yöntemler: Çalışmamızda, gossypin isimli maddenin 5 farklı türdeki mikroorganizmalar (2 gram pozitif bakteri, 2 gram negatif bakteri ve 1 maya) üzerine olan antibakteriyel ve antifungal etkinlikleri bir mikrodilüsyon yöntemi olan Sıvı Mikrodilüsyon Yöntemi (SMD) ile tespit edilmiştir. Ardından, biyofilm oluşumu; kristal viyole ve MTT testleri uygulanmıştır. Gossypin’in antibiyofilm aktivitesi mikroplaka yöntemi ile tespit edilip, MTT deneyleri ile doğrulanmıştır. Son olarak ise, gossypin’in antiinvazif etkinliğini ölçmek amacıyla Adherent-Invasive Escherichia coli bakterisi ile Caco-2 insan kolon hücreleri enfekte edilerek, AEIC suşunun invazyonu indüklenmiş ve etken maddenin invazyon üzerine olan inhibe edici etkisi araştırılmıştır. Sonuç: Elde edilen sonuçlara göre, gossypin’in doza bağlı olarak antibakteriyel, antifungal ve antibiyofilm etkinliği olduğu saptanmıştır (MİK değerleri 40-80 μg/ml arasındadır). Buna ilave olarak, gossypin dozuna bağlı olarak bakterilerin Caco-2 hücrelerine olan adezyon ve invazyon süreçleri üzerine etkili olduğu saptanmıştır. 160 μg/ml gossypin uygulaması bakteri adezyonunu %67 oranına kadar ve bakteri invazyonunu %38 oranına kadar düşürmektedir. Yapılan in-vitro çalışmalar sonucunda gossypin’in IC50 dozunun 28,20 μg/ml olduğu tespit edilmiştir. Tartışma: Elde edilen veriler, gossypin'in birden fazla antimikrobiyal aktiviteye sahip olduğunu ve bu etkilerin mekanizmalarının saptanması için gelecekte detaylı moleküler çalışmaların yapılması gerektiğini gösterdi.Article Citation - WoS: 1Citation - Scopus: 1The distribution and the antimicrobial susceptibility features of microorganisms isolated from the burn wounds; a ten-year retrospective analysis(Oxford University Press, 2023) Özkaçmaz, Ayşe; Dicle, Yalçın; Bayram, Yasemin; Parlak, Mehmet; Akış, Feride; Çallı, İskan; Aklş, Feride; Çalll, İskanIn this study we aimed to evaluate the distribution features and antimicrobial susceptibility test results of the microorganisms isolated from the wounds of pediatric and adult burn patients. The culture and susceptibility test results of the microorganisms isolated from the wound swabs of the patients hospitalised in a tertiary burn care center in 10-years period, were retrospectively screened on the microbiology department databases. Their distribution of isolated microorganisms regarding species and susceptibility test results were compared with previous studies. A total of 367 microorganisms isolated from the burn wounds of 293 patients (13± 18.9 years, F/M: 0.93) (73 adult and 220 pediatric patients), were included in this study. A solitary agent was isolated in 239 (81.6%) patients, while two were isolated in 43 (14.7%) and three or more agents in 11 (3.8%). From these, 33% of the isolated microorganisms were gram positive cocci, 61% were gram negative bacteria and 6% were Candida spp. The most common isolated microorganisms were Staphylococcus aureus (18.5%), Pseudomonas spp. (16.9) and Escherichia coli (%11.2), while the least common was Streptococcus spp. (2.5%). Methicillin resistance was 15% among the S. aureus strains. No resistance was observed against levofloxacin, vancomycin, teicoplanin, linezolid, daptomycin, fusidic acid and tigecycline in S. aureus strains. The highest resistance rates were observed against levofloxacin (64%), tobramycin (64%), pip/tazobactam (63%), imipenem (63%), and the lowest against colistin (5%) and ceftazidime (29%), among Pseudomonas spp. The most common causative agents in burn wound infections and their current antimicrobial susceptibility features should be well identified, in order for prevention of serious complications and optimal management the condition to occur.Article Citation - WoS: 11Citation - Scopus: 11Biosensors for the Detection of Pathogenic Bacteria: Current Status and Future Perspectives(Future Medicine Ltd, 2024) Dicle, Yalcin; Karamese, MuratPathogenic microorganisms pose significant threats to human health, food safety and environmental integrity. Rapid and accurate detection of these pathogens is essential to mitigate their impact. Fast, sensitive detection methods such as biosensors also play a critical role in preventing outbreaks and controlling their spread. In recent years, biosensors have emerged as a revolutionary technology for pathogen detection. This review aims to present the current developments in biosensor technology, investigate the methods by which these developments are used in the detection of pathogenic bacteria and highlight future perspectives on the subject. Microorganisms that cause disease are important not only to human health but also to food safety and environmental health. Therefore, it is important to detect these microorganisms quickly, easily, at a low cost and with accuracy. Biosensors have all of these features and offer a unique way to detect microorganisms. They are already being used in similar fields and are becoming increasingly portable and ergonomic devices. This paper looks at the uses of biosensors in detecting disease-causing bacteria and how their use will develop with greater technology. Outbreaks caused by pathogenic bacteria are a global concern, not only for human health but also for food safety and bioterrorism. This paper provides an overview of how biosensors can be used in the quick, easy and low-cost detection of pathogenic bacteria.Article Retrospective Evaluation of Tularemia Cases in Muş Province: 2011-2022(Mardin Artuklu University, 2023) Dicle, Yalçın; Aydın, Elif; Şen Gündoğan, Nesibe Efruz; YalçınObjective: Tularemia is a bacterial disease of humans, wild and domestic animals. Recently, an increase in human tularemia cases has been observed in many countries worldwide. This study aimed to calculate the incidence of tularemia cases in Muş, determine the seasonal distribution of cases, and describe the socio demographic and clinical characteristics of tularemia cases detected over a twelve-year period. Methods: Data from 162 patients diagnosed clinically and serologically with tularemia and admitted to health facilities in Muş province between 2011 and 2022 were retrospectively analysed. Results: In our study, among 162 tularemia patients with F. tularensis microagglutination test titres of 1/160 and above, the ratio of male and female cases was equal (50%), and the mean age was 24.51 years. In the twelve-year evaluation, there were two major epidemics, and the most cases were seen in 2018 with 37 cases. Most cases were observed in winter (38.3%) and autumn (25.3%). Oropharyngeal tularemia was the most common form (64.2%) among the cases evaluated. Similar disease was found in 33.3% of patients living in the same neighbourhood as the patients, and no mortality was observed in any of the patients. Conclusion: As the oropharyngeal form is the most common, contact with contaminated water should be questioned, rodent and tick populations should be monitored and detailed epidemiological studies should be conducted. We believe that hygiene and sanitation measures are important with regard to tularemia outbreaks.Book Part Botulism(Nova Science Publishers, Inc., 2024) Dicle, Y.Botulism is a rare but serious illness caused by a toxin produced by the Clostridium botulinum bacterium. The toxin can cause paralysis and, in severe cases, it can be fatal. Botulism can be contracted through contaminated food, wound infections, or the use of contaminated drugs. Symptoms typically appear within six to 36 hours after exposure and include blurred vision, dry mouth, difficulty swallowing, and muscle weakness. Diagnosis is typically made through laboratory testing of blood or stool samples from a patient. Treatment involves administering antitoxin medication and supportive care to manage symptoms. Prevention measures include proper food handling and preparation, wound care, and avoiding the use of illicit drugs. While botulism is rare, it is a serious condition that requires prompt medical attention. Early diagnosis and treatment can improve outcomes and reduce the risk of complications. © 2024 Nova Science Publishers, Inc. All rights reserved.Article Detection of Human Brucellosis by Brucellacapt and Rose Bengal Test in the Endemic Area(Fazile Nur Ekinci Akdemir, 2023) Aydın, Elif; Dicle, Yalçın; Kaçtaş, Şerif; Gümüş, Ali FurkanAbstract: Although brucellosis is the most common zoonosis in the world, it remains an infectious disease that has not received sufficient attention. There are a few tests detecting brucellosis by serum. Rose Bengal Test is an advantageous one. Our aim with this study was to compare Rose Bengal and Brucellacapt tests in serum samples and draw attention to the advantages of the test. Between June 2019 and June 2021, 7827 serum samples sent to the public health laboratory with a provisional diagnosis of brucellosis were evaluated. The Rose Bengal and Brucellacapt test (Vircell, Spain) was used to diagnose infection. Samples with antibody titer ≥1/160 were considered positive. Of the 7827 samples included in the study, 354 (4.6%) of the total 7677 serum samples tested were RBT positive, 118 (3.1%) of the 3776 samples tested were BCAP positive, and 118 (3.3%) of the 3626 samples tested were both RBT and BCAP positive. It was found that seropositivity was significantly higher in female patients (p<0.10). RBT and BCAP test positivity were most frequently observed in the 25-34 year age group. Considering brucellosis cases in terms of seasonal changes; 10.7% of cases were found in spring, 52.4% in summer, 20.9% in fall, and 16% in winter. In suspected cases, RBT is still considered the ideal detection method because it is easy to use, inexpensive, sensitive, and provides rapid results. It was concluded that the BCAP test is suitable for diagnosis due to its ability to detect blocker and high titer antibodies.Book Part Tetanus(Nova Science Publishers, Inc., 2024) Dicle, Y.Tetanus is a fatal disease caused by tetanospasmin exotoxins produced by C. tetani, an anaerobic gram-positive bacterium. Although the disease can be prevented by vaccination, it is still a serious toxic fatal infection. While tetanus is less common in developed countries, it is a common infectious agent in less developed countries. The exotoxin tetanospasmin produced by C. tetani causes severe cramps, muscle spasms, and autonomic nervous system dysfunction in humans. Tetanus is usually caused by a contaminated wound, a skin rupture with compromised integrity, inadequate perinatal hygiene, or a cord cut with inappropriate materials during labor and delivery. To prevent tetanus, it is recommended that people of all ages be vaccinated with the tetanus toxoid vaccine to ensure good immunization. The rate of developing immunity against tetanus decreases significantly and inversely with age. The rates of developing immunity are quite high, especially in people who have been vaccinated for any reason in adulthood. Tetanus treatments generally aim to prevent muscle spasms and eliminate cardiovascular problems. In addition, if there is an open wound, the skin around the wound is cleaned, antibiotics and antitoxins are applied, and supportive care is applied. © 2024 Nova Science Publishers, Inc. All rights reserved.Article COVID-19 Pandemisinden Sonra Solunum Patojenlerinin Dağılımı: Türkiye’den Tek Merkezli bir Pediatrik Çalışma(2023) Dıcle, Yalçın; Aydın, Neşet; Aydın, Elif; Renders, Duygu Perçin; Yılmaz, Güleser GüneyGiriş: Bu çalışmanın amacı, Türkiye’de salgın döneminde solunum yolu enfeksiyonu ön tanısı alan hastalarda viral ve bakteriyel pato - jenlerin sıklığını ve tiplendirmesini değerlendirmektir. Materyal ve Metot: Ekim 2022-Mart 2023 tarihleri arasında Kütahya Sağlık Bilimleri Üniversitesi Çelebıya Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniğine solunum yolu en - feksiyonu semptomları ile başvuran 0–17 yaş arası 215 hastanın solunum yolu patojenleri analiz sonuçları çalışmaya dâhil edilmiştir. Solunum panelinde 23 virüs ve altı bakterinin varlığı multipleks ger- çek zamanlı PCR kullanılarak çalışılmıştır. Örnekler entübe olmayan hastalarda nazofarengeal sürüntüden, entübe hastalarda ise trake- al aspirasyon materyalinden elde edilmiştir. Bulgular: Hastaların %92,1’inde bir veya daha fazla etken pozitif bulunurken, %7,9’unda hiçbir etken saptanmamıştır. Pozitif so - nuçlar arasında tek patojen oranı %27,3 (n=54) iken, çoklu pato- jen oranı %72,7 (n=144) idi. Respiratuvar sinsityal virüs %23,3 ve Adenovirüs %19,1 oranıyla en sık görülen viral etkenler olurken, Haemophilus influenzae (%48,8) ve Streptococcus pneumoniae (%29,3) en sık görülen bakteriyel etkenler olmuştur. Sonuç: Bu çalışmada çocuklarda viral ve bakteriyel patojenler yo - ğun olarak saptanmıştır. Bu etkenlerin eş zamanlı, hızlı ve duyarlı bir şekilde saptanması gereksiz antibiyotik kullanımının önlenmesi ve enfeksiyon kontrolü açısından önemlidir. Bu da mortalite ve morbi- dite oranlarının azaltılması açısından önemlidir.
