Koç Direk, Figen

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Profile URL
https://hdl.handle.net/20.500.12514/7588
Name Variants
Direk, F. Koc
Job Title
Dr. Öğr. Üyesi
Email Address
figenkocdirek@artuklu.edu.tr
Main Affiliation
Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
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Current Staff
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0000-0002-4748-2110
Scopus Author ID
57203556111
Turkish CoHE Profile ID
382461
Google Scholar ID
zoePUJ0AAAAJ
WoS Researcher ID
JPL-0697-2023
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cv_A-1733_ingilizce.pdf (415.43 KB)
cv_A-1733_turkce.pdf (417.91 KB)

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Akdeniz Tıp Dergisi1
Duzce Medical Journal1
Medical Records-International Medical Journal (Online)1
Polish Journal of Veterinary Sciences1
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Now showing 1 - 4 of 4
  • Thumbnail Image
    Article
    Investigation of Demographic Characteristics and General Appearance of Individuals with Angelman Syndrome
    (2025) Canbay, Ali; Dağ, Selma Solgun; Direk, Figen Koç; Durmaz, Sevda Canbay; Güven, Ümran; Özmutlu, Pınar
    Aim: Angelman syndrome (AS) is an autosomal dominant neurogenetic condition seen in 1 in 10000-22000 as a result of UBE3A gene dysfunction and microdeletion of the 15q11-13 region. The aim of this study is to determine the differences and similarities between individuals with AS by evaluating the demographic characteristics and general appearance of patients diagnosed with AS. Material and Method: Age, gender, weight, height, BMI, weight, height and head circumference at birth, age of parents, type of birth, mother's gestation period, relationship status of mother and father, presence of genetic disease, dead or miscarried siblings number, parental smoking status, first appearance of clinical signs of the disease, epilepsy, scoliosis, sleep, nutrition, and speech problems, laughing attacks, tongue size, gait status, hair and eye color of 79 cases with genetic diagnosed AS case were evaluated. Results: Of the individuals with AS who participated in the study, 40 (50.6%) were boys and 39 (49.4%) were girls. 43 of the patients (54.4%) were walking. The earliest walker among these patients started walking at the age of 3, and the latest walker started walking at the age of 13. 31 (40.5%) of our patients started walking between the ages of 3 and 4. When we asked the families when they noticed the first symptoms, all families realized that there were developmental problems before the child was 24 months old and consulted a physician. In fact, 70 of the families (88.6%) understood the problem before 12 months. When the time of onset of symptoms in boys and girls was compared, it was seen that the onset of symptoms was on average 2.82 months earlier in boys than in girls (p=0.004). The majority of cases with AS were thin, fair-skinned and blue-eyed individuals. Conclusion: The parameters evaluated in our study revealed general and current data about the characteristics of individuals with AS.
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    Article
    Investigation of the Protective Effect of Thymbra Spicata L. var Spicata and Cyclotrichium Origanifolium on Bladder in Experimental Traumatic Spinal Cord Injury
    (2025) Deveci, Engin; Nas, Cemal; Keşim, Dilek Aygün; Direk, Figen Koç; Yokus, Beran; Karabaş, Sibel Ateşoğlu; Tuncer, Mehmet Cudi
    Amaç: Spinal kord yaralanmaları, genellikle travma sonrası vertebral kolonda meydana gelen kırıklar, çıkıklar, bağ yaralanmaları ve yırtılmalar sonucunda oluşan hasarları kapsamaktadır. Bu yaralanmalarda komplikasyonların en sık görüldüğü organlardan biri mesanedir. Thymbra spicata L. var spicata (zahter) ve Cyclotrichium origani- folium (dağ nanesi) bitkilerinin yüksek biyolojik potansi- yele sahip olduğu; ekstraktlarının antioksidan özellikleri sayesinde oksidatif stresin neden olduğu hastalık riskini azalttığı ve tedavide önemli bir rol oynadığı bilinmek- tedir. Bu çalışmada, zahter ve dağ nanesi ekstraktlarının spinal kord yaralanması sonrası mesane disfonksiyonları üzerindeki potansiyel tedavi edici ve koruyucu etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmada, ağırlıkları 250-300 g arasında değişen toplam 36 adet Wistar Albino erkek sıçan, her grupta altı sıçan ola- cak şekilde altı gruba ayrılmıştır: Grup 1 (kontrol), Grup 2 (zahter), Grup 3 (dağ nanesi), Grup 4 (travma), Grup 5 (travma + zahter), Grup 6 (travma + dağ nanesi). Trav- ma gruplarında omuriliğe ağırlık düşürme yöntemi uygu- lanarak travma modeli oluşturulmuştur. Bir haftasının sonunda, tüm sıçanlardan idrar örnekleri alındıktan sonra, ketamin anestezisi altında sakrifiye edilerek mesane doku- ları alınmıştır. Mesane dokularında histopatolojik değişik- likler incelenmiştir. Bulgular: Deneysel araştırma sonucunda, zahter ve dağ nanesi eks- traktlarının spinal kord yaralanmasına bağlı gelişen me- sane hasarına karşı kısmen etkili olduğu saptanmıştır. Zahterin etkinliğinin, biyokimyasal ve histopatolojik bulgular doğrultusunda, oksidatif stres ve inflamatuar be- lirteçler üzerindeki etkisinin dağ nanesine kıyasla daha yüksek olduğu gözlemlenmiştir. Sonuç: Sonuç olarak, deneysel modellerin artmasıyla birlikte bitki ekstraktlarının tedavi amaçlı kullanımının yaygınlaşabi- leceği ve insan sağlığı üzerinde olumlu etkiler sağlayabi- leceği düşünülmektedir.
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    Article
    Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study
    (Duzce Univ, Fac Medicine, 2025) Koc Direk, Figen; Tuncer, Mehmet Cudi; Deveci, Engin; Aygun Kesim, Dilek; Ozevren, Huseyin; Keşim, Dilek Aygün; Direk, Figen Koç
    Aim: Secondary tissue damage caused by oxidative stress and inflammation in spinal cord injury complicates treatment and highlights the need for novel therapeutic agents. This study aimed to evaluate the potential effects of Thymbra spicata L. var. spicata (zahter) and Cyclotrichium origanifolium (mountain mint) extracts in an experimental SCI model. Material and Methods: Thirty-six male Wistar albino rats were randomly assigned to six groups: control, zahter, mountain mint, trauma, trauma+zahter, and trauma+mountain mint. Spinal cord injury was induced in the trauma groups. Blood was collected via cardiac puncture, and spinal tissues were obtained for histopathological and immunohistochemical analyses. Serum MDA, TAS, Aand TOS levels were measured biochemically. VEGF and GFAP expressions were assessed immunohistochemically. Results: MDA and TOS levels decreased, while TAS levels increased in the treated groups compared to the trauma group, but these changes were not found statistically significant. Histopathological evaluation showed prominent neuronal degeneration, inflammation, and vascular dilatation in the trauma group, which were alleviated in the treatment groups. Greater histological improvement was observed in the trauma+mountain mint group compared to trauma+zahter (p<0.001). VEGF and GFAP expressions were elevated in the trauma group but statistically significantly reduced in the treatment groups (p<0.001). Conclusion: Zahter and mountain mint extracts exhibited therapeutic potential against trauma-induced spinal cord injury by modulating inflammation and tissue damage. Mountain mint was found to be more effective in terms of histological and immunohistochemical outcomes.
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    Article
    Citation - Scopus: 1
    Investigation of the Relationship Between Plasma Ghrelin Levels and Muscle Atrophy in Experimental Diabetic Rats
    (Polska Akad Nauk, Polish Acad Sciences, Univ Warmia & Mazury Olsztyn, 2024) Kesim, D. Aygun; Kelle, M.; Asir, F.; Kaya, H. Kayhan; Diken, H.; Gokdemir, G. S.; Direk, F. Koc; Aygün Keşim, D.; Koç Direk, F.; Kayhan Kaya, H.
    In this study, the relationship between plasma ghrelin levels and muscle atrophy was examined in an experimental diabetic rat model. 56 male Wistar albino rats, aged 8-10 weeks, were used in the study. The rats were divided into 8 groupsD1: one -week diabetes, C1: one -week control, D2: three-week diabetes, C2: three-week control, D3: six -week diabetes, C3: six -week control, D4: eight -week diabetes, C4: eight -week control. To induce diabetes, rats were injected with a single intraperitoneal dose of 45 mg/kg streptozotocin. At the end of the experiments, body weights and fasting blood sugar levels were measured. mTOR and myostatin levels of gastrocnemius muscle and plasma ghrelin levels were measured by ELISA method. Gastrocnemius muscle weight, cross-sectional area and histopathological images were examined. It was observed that the gastrocnemius weights of the D2, D3, D4 groups decreased significantly compared to their controls (p <= 0.01). Muscle cross-sectional area decreased significantly in groups D3 and D4 compared to controls (p <= 0.01). Muscle mTOR levels were found to be significantly lower in all diabetic groups compared to controls (p <= 0.01). Although muscle myostatin levels were higher in the diabetic groups, this increase was only significant in the D4 group. Plasma ghrelin levels were significantly lower in all diabetic groups compared to controls (p <= 0.01). A positive correlation was determined between plasma ghrelin levels and the final weights, muscle cross-sectional area, gastrocnemius weights and mTOR levels of the rats. Time -dependent muscle atrophy developed in diabetic rats and there was a relationship between muscle atrophy and plasma ghrelin level. We suggest that ghrelin plays a role in diabetes -induced muscle atrophy as well as cachexia and sarcopenia.