Günbegi Çalışkan, Cemile
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Name Variants
Caliskan, Cemile Gunbegi
Çalışkan, Cemile Günbegi
Çalışkan, Cemile Günbegi
Job Title
Öğretim Görevlisi
Email Address
cemilegc@artuklu.edu.tr
Main Affiliation
Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
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Scholarly Output
5
Articles
6
Citation Count
2
Supervised Theses
0
5 results
Scholarly Output Search Results
Now showing 1 - 5 of 5
Article Citation - WoS: 3Citation - Scopus: 2Comparison of chemical and antimicrobial properties of different nanoparticles synthesized from Verbascum x calcicolum Hub.-Mor. Hybrid(Elsevier, 2024) Günbegi Çalışkan, Cemile; Caliskan, Cemile Gunbegi; Kilic, Murat; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüRecent advances in nanoparticle synthesis have led to an increase in the use of environmentally acceptable plantderived nanoparticles, given their wide range of applications. Due to their stability and several advantageous characteristics, selenium nanoparticles also stand out in these investigations in addition to metallic nanoparticles like silver, gold, iron, and zinc. These nanoparticles' favorable qualities for human health, such as antioxidant and antibacterial activities, are being studied in addition to their chemical characteristics. This investigation aimed to produce zinc oxide nanoparticles (VcZnO) and selenium nanoparticles (VcSe) from hybrid Verbascum x calcicolum Hub.-Mor. And to examine their antioxidant and antimicrobial properties. Utilizing the disk diffusion method and well methods, its antibacterial capabilities were studied. In vitro antioxidant capabilities were also assessed utilizing the DPPH, FRAP, and CUPRAC techniques. As a result, it emerged that zinc oxide nanoparticles synthesized from hybrid Verbascum x calcicolum were effective on gram-positive bacteria and gram-negative bacteria such as Staphylococcus aureus (MIC = 160 mg/ml for VcZnO), Pseudomonas aeruginosa (MIC = 80 mg/ml for VcZnO), Klebsiella pneumoniae (MIC = 40 mg/ml for VcZnO and, MIC = 120 mg/ml for VcSe), Escherichia coli (MIC = 20 mg/ml for VcZnO). While selenium nanoparticles are more favorable in terms of antioxidant capabilities, zinc nanoparticles demonstrate stronger antibacterial properties than selenium nanoparticles. Thus, it has been discovered that the use of different nanoparticles of various plants can be more efficient in different applications. It has also been found that Verbascum x calcicolum is a material that can be used successfully in nanoparticle synthesis.Article Citation - WoS: 4Citation - Scopus: 4Evaluation of Extra Virgin Olive Oil Compounds Using Computational Methods: in Vitro, Admet, Dft, Molecular Docking and Human Gene Network Analysis Study(Bmc, 2025) Unsal, Velid; Yildiz, Resit; Korkmaz, Aziz; Mert, Basak Dogru; Caliskan, Cemile Gunbegi; Oner, Erkan; Yıldız, Reşit; Unsal, Velid; Korkmaz, Aziz; Günbegi Çalışkan, Cemile; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüThis study investigates the phenolic compounds (PC), volatile compounds (VC), and fatty acids (FA) of extra virgin olive oil (EVOO) derived from the Turkish olive variety "Sar & imath; Ulak", along with ADMET, DFT, molecular docking, and gene network analyses of significant molecules identified within the EVOO. Chromatographic methods (GC-FID, HPLC) were employed to characterize FA, PC, and VC profiles, while quality parameters, antioxidant activities (TAC, ABTS, DPPH) were assessed via spectrophotometry. The analysis revealed a complex composition of 40 volatile compounds, with estragole, 7-hydroxyheptene-1, and 3-methoxycinnamaldehyde as the primary components. Hydroxytyrosol, tyrosol, oleuropein, apigenin, ferulic acid, and vanillic acid emerged as main phenolic constituents, with hydroxytyrosol and apigenin exhibiting high bioavailability. Molecular docking highlighted oleuropein and pinoresinol as compounds with strong binding affinities, though only hydroxytyrosol, apigenin, and pinoresinol fully met Lipinski and other drug-likeness criteria. DFT analysis showed that oleuropein and pinoresinol have notable dipole moments, reflecting polar and asymmetrical structures. KEGG enrichment analysis further linked key molecules like oleuropein and apigenin with pathways related to lipid metabolism and atherosclerosis, underscoring their potential bioactivity and relevance in health-related applications.Article Citation - WoS: 0Comparison of Antioxidant and Antimicrobial Properties of Zinc Oxide and Selenium Oxide Nanoparticles Using Verbascum Kotschyi Boiss. & Hohen(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2025) Günbegi Çalışkan, Cemile; Caliskan, Cemile Gunbegi; Kilic, Fatma M. U. N. G. A. N.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüNanoparticle applications have been studied in many fields in recent years. Among these studies, the synthesis of nature-friendly and healthfriendly nanoparticles through green synthesis attracts much attention. These investigations also highlight the significance of several plant species, many of whose worth and traits remain unknown. The goal of this work is to create zinc oxide and selenium nanoparticles from Verbascum kotschyi Boiss. & Hohen., a plant species that hasn't received much attention, and to ascertain the antioxidant and antibacterial qualities of these nanoparticles. To accomplish this, three distinct techniques (DPPH, CUPRAC, and FRAP) were used to assess the produced nanoparticles' in vitro antioxidant capabilities after SEM, EDX, and FTIR analyses. Furthermore, the disk diffusion technique was utilized to ascertain the antibacterial efficacy of these nanoparticles against both gram-positive and gram-negative bacteria and fungus. In conclusion, V. kotschyi-derived zinc oxide nanoparticles outperformed selenium nanoparticles in terms of antibacterial activity. But when it came to antioxidant activity, selenium nanoparticles outperformed zinc oxide nanoparticles. Thus, it was determined that the products created by nanoparticle synthesis from Verbascum kotschyi have properties that can be used in different fields.Article Citation - WoS: 0Citation - Scopus: 0Phytochemical Profile, Antimicrobial, Antioxidant, Anti-Xanthine Oxidase, and Anti-Elastase Activities of Centaurea Hyalolepis: an in Silico and in Vitro Analysis(Wiley-v C H verlag Gmbh, 2025) Günbegi Çalışkan, Cemile; Caliskan, Cemile Gunbegi; Akan, Hasan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüThis study aimed to examine the antibacterial, antioxidant, and enzyme activity of Centaurea hyalolepis, as well as the total phenolic and carotenoid contents, and volatile and phenolic components. Gas chromatography-mass spectrometry was used for the volatile component analysis of C. hyalolepis, while liquid chromatography-mass spectrometry was used for the phenolic component analysis. Furthermore, the antimicrobial activity was evaluated using disc diffusion and microdilution techniques. The antioxidant capacity was investigated in vitro using four distinct methods (2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, cupric ion-reducing antioxidant capacity, and N,N-dimethyl-p-phenylene diamine). Additionally, both in vitro and in silico studies were carried out to determine the inhibitory effect on xanthine oxidase and elastase. Consequently, it was determined that C. hyalolepis has antioxidant properties and is a highly efficient antibacterial agent against Bacillus megaterium, Pseudomonas aeruginosa, Bacillus subtilis subsp. spizizenii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Klebsiella aerogenes, and Candida albicans. Additionally, C. hyalolepis contains many volatile compounds, such as 2-methyl propanoic acid, 3,5-octadien-2-one, 2,6-dimethyl cyclohexanol, hexanal, pentanal, anethole, and beta-cyclocitral. It also has a large number of phenolic components, including chlorogenic acid, apigenin 7-glucuronide, quinic acid, and 4-hydroxybenzoic acid. Moreover, C. hyalolepis was shown to inhibit xanthine oxidase and elastase.Article Şanlıurfa İlindeki Çeşitli Konakçılardan Echinococcus Granulosus İzolatlarının Moleküler Özelliklerinin Değerlendirilmesi(2024) Günbegi Çalışkan, Cemile; Zeyrek, Fadile Yıldız; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüEchinococcus granulosus larvalarının neden olduğu kistik ekinokokozis (KE), hem insanları hem de hayvanları etkileyen dünyadaki en önemli zoonozlardan birisidir. Suşlar arasındaki ara konak farklılıkları ve gelişimsel farklılıklar parazitle mücadeleyi ve kontrol çalışmalarını olumsuz yönde etkileyebilmektedir. Bu çalışmada Şanlıurfa’nın farklı bölgelerinden ve farklı ara konaklardan elde edilen kist hidatik materyallerinden moleküler yöntemlerle genotiplendirme yapılması amaçlanmıştır. Türkiye'nin Şanlıurfa ilindeki hastanemizde tanısı önceden konulmuş 40 tane parafinli insan numunesi ve mezbahanemizden alınan 140 koyun ve 17 sığır numunesi olmak üzere 197 hidatik kist örnekleri toplanmıştır. Bu izolatlarda fertil olan 33 parafinli insan izolatı ve 80 koyundan alınan kist sıvısında mikroskobik inceleme sonrası 250 üzeri protoskoleks ve/veya skoleks çengeli olduğundan fertil kabul edildi. Echinococcus granulosus G1 suşu referans metaryali olarak kullanıldı. Bu izolatların genetiğini belirlemek amacıyla örneklerin ribozomal DNA internal transcribed spacer gene 1 (rDNA-ITS1) bölgesi PCR-RFLP tekniğiyle incelenmiştir. Aynı band profiline sahip olması sonucu izolatların hepsinin yaygın koyun suşu (G1) olduğu belirlenmiştir. Bu çalışma ile Şanlıurfa’da E. granulosus 'un evcil koyun suşunun baskın genotip olduğu gösterilmiştir. Elde edilen sonuçların bu bölge ve komşu ülkelerde hayvanlardaki parazitlerin epidemiyolojisi ve ekolojisi ile ilgili ileri çalışmalara yol göstereceği düşünülmektedir.
