Sakız, Davut

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Profile URL
https://hdl.handle.net/20.500.12514/7498
Name Variants
Sakız, D.
Sakiz, Davut
Job Title
Doç. Dr.
Email Address
davutsakiz@artuklu.edu.tr, davut.dr@hotmail.com
Main Affiliation
Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Status
Current Staff
Website
ORCID ID
0000-0003-1480-888X
Scopus Author ID
57188732974
Turkish CoHE Profile ID
109818
Google Scholar ID
NjWN2qoAAAAJ
WoS Researcher ID
ADF-0562-2022
Files
cv_A-1730_ingilizce.pdf (624.55 KB)
cv_A-1730_turkce.pdf (625.49 KB)

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Now showing 1 - 3 of 3
  • Thumbnail Image
    Article
    Comparison of Vitamin D Levels in Euthyroidindividuals With and Without Thyroid Nodule
    (2024) Kaçmaz, Huseyin; Sakız, Davut; Kulaksızoğlu, Mustafa
    Thyroid nodules are frequently observed in the thyroid gland, with a malignancy rate of less than 5%. The etiology of nodule formation remains unclear, and various hypotheses have been proposed. Vitamin D, known to influence cell turnover, may also play a role in the development of thyroid nodules. This study aims to investigate the association between vitamin D deficiency and thyroid nodule formation. Blood samples were collected from individuals categorized into two groups based on the presence of thyroid nodules. 100 patients with thyroid nodules detected by ultrasonography and 100 individuals with no thyroid nodules were included in the study. The 25-hydroxyvitamin D [25(OH)D3] levels were measured in a single session. The mean 25(OH)D3 levels were 15.39±9.1 ng/ml in the patient group and 13.33±7.1 ng/ml in the control group. Vitamin D deficiency was identified in 72% of the patient group and 82% of the control group. No significant correlation was found between 25(OH)D3 levels and the presence of thyroid nodules. Further research is needed to elucidate this relationship.
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    Article
    Serum Selenium Levels and Subacute Thyroiditis: Associations With Disease Course and Long-Term Outcomes in a Case-Control Study
    (BMC, 2025) Cakal, Erman; Sakiz, Davut; Calapkulu, Murat; Sencar, Muhammed Erkam; Unsal, Ilknur Ozturk; Hepsen, Sema; Bostan, Hayri
    BackgroundSubacute thyroiditis (SAT) is an inflammatory disease that induces thyrotoxicosis. Selenium is an essential trace element in thyroid physiology, which has anti-inflammatory and antioxidant properties. However, the relationship between serum selenium levels and SAT has not been well studied. The objective of this study was to evaluate serum selenium levels in patients with SAT compared to healthy controls and to investigate potential correlations between selenium status and clinical outcomes, including disease severity, delayed remission, recurrence, and the development of permanent hypothyroidism.MethodsThis case-control study included 59 patients with SAT and 50 healthy control subjects. Serum selenium levels were analysed using inductively coupled plasma mass spectrometry.ResultsThe serum selenium levels of patients with SAT were 69.10 (24.60-130.20) mu g/L, while those of the control group were 64.20 (39.21-106.80) mu g/L (p = 0.121). A negative correlation was detected between serum selenium levels and erythrocyte sedimentation rate, C-reactive protein, neutrophil-to-lymphocyte ratio, free thyroxine, and pain severity. Serum selenium levels did not significantly differ in terms of the response to initial treatment, recurrence, and permanent hypothyroidism.ConclusionThe study results showed no significant difference in serum selenium levels between patients with SAT and the control group. These results suggest that although lower serum selenium levels may be associated with a more severe and painful SAT course, there is no impact on the long-term prognosis.
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    Article
    Clinicopathological Predictors of Central Lymph Node Metastasis in Clinically Node-Negative Papillary Thyroid Carcinoma: A Retrospective Cohort Analysis
    (Springer, 2025) Sakiz, Davut; Calapkulu, Murat; Sencar, Muhammed Erkam; Unsal, Ilknur Ozturk; Kartal, Mehmet Zabit; Ucan, Bekir; Cakal, Erman
    PurposeThis retrospective cohort study aimed to identify clinicopathological predictors of central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC).MethodsA total of 503 patients with PTC who underwent thyroidectomy with central lymph node dissection were included. Preoperative clinical data, ultrasonographic features, and postoperative histopathological characteristics were analyzed.ResultsCLNM was detected in 209 (41.55%) patients. Male sex (odds ratio [OR] = 3.12, 95% CI: 1.82-5.35), irregular nodule borders (OR = 2.02, 95% CI: 1.25-3.26) and higher risk categories in the American Thyroid Association (ATA) ultrasonographic pattern stratification system (OR = 13.312, 95% CI: 8.623-20.551) were identified as independent preoperative predictors of CLNM. A simplified model incorporating only the ATA ultrasonographic pattern stratification system and male sex achieved 83.5% accuracy in predicting CLNM. Histopathological evaluation revealed lymphovascular invasion (OR = 4.61, 95% CI: 2.81-7.55), extrathyroidal extension (OR = 2.41, 95% CI: 1.52-3.83), and multifocality (OR = 1.58, 95% CI: 1.04-2.40) as independent predictors of CLNM, while lymphocytic thyroiditis (OR = 0.59, 95% CI: 0.39-0.89) was a protective factor.ConclusionThis study establishes that ATA ultrasonographic suspicion patterns combined with the male sex provide an accurate and simplified model for preoperative CLNM prediction in PTC, outperforming complex nomograms. Key independent predictors included male sex, irregular nodule margins, ATA high-risk patterns, lymphovascular invasion, extrathyroidal extension, and multifocality, while lymphocytic thyroiditis was protective. According to the current study, risk assessment and personalized management should favor a holistic approach, rather than focusing solely on individual risk factors.