Şeker, Uğur
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Seker, Ugur
Şeker, U.
Şeker, U.
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Dr. Öğr. Üyesi
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Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
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Current Staff
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Sustainable Development Goals
3
GOOD HEALTH AND WELL-BEING
8
Research Products
6
CLEAN WATER AND SANITATION
0
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9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
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16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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1
NO POVERTY
0
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5
GENDER EQUALITY
0
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10
REDUCED INEQUALITIES
0
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15
LIFE ON LAND
0
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7
AFFORDABLE AND CLEAN ENERGY
0
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12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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8
DECENT WORK AND ECONOMIC GROWTH
0
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14
LIFE BELOW WATER
0
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17
PARTNERSHIPS FOR THE GOALS
0
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11
SUSTAINABLE CITIES AND COMMUNITIES
0
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4
QUALITY EDUCATION
0
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2
ZERO HUNGER
0
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13
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Scholarly Output
23
Articles
21
Views / Downloads
6/0
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
60
Scopus Citation Count
59
WoS h-index
5
Scopus h-index
5
Patents
0
Projects
1
WoS Citations per Publication
2.61
Scopus Citations per Publication
2.57
Open Access Source
10
Supervised Theses
0
| Journal | Count |
|---|---|
| Çukurova Anestezi ve Cerrahi Bilimler Dergisi | 2 |
| Artuklu International Journal of Health Sciences | 1 |
| Cellular and Molecular Biology | 1 |
| Current Issues in Molecular Biology | 1 |
| Drug and Chemical Toxicology | 1 |
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23 results
Scholarly Output Search Results
Now showing 1 - 10 of 23
Article Citation - WoS: 1Neuroprotective Potential of a Novel Soluble Guanylate Cyclase Stimulator the Riociguat Alone or in a Combination Manner With Resveratrol in Experimental Stroke Model in Rats(Soc Chilena Anatomia, 2024) Aslanoglu, Baris; Kaya, Seval; Gunara, Sezer Onur; Atlas, Burak; Seker, Ugur; Guzel, Baris Can; Turan, YahyaIn this study we aimed to examine the effect of novel vasodilatory drug Riociguat co-administration along resveratrol to recover neurodegeneration in experimental stroke injury. For that purpose, thirty-five adult female rats were divided into groups five (Control, MCAO, MCAO + R, MCAO + BAY, MCAO + C) of seven animals in each. Animals in Control group did not expose to any application during the experiment and sacrificed at the end of the study. Rats in the rest groups exposed to middle cerebral artery occlusionO) (MCAinduced ischemic stroke. MCAO + R group received 30 mg/kg resveratrol, and MCAO + BAY group received 10 mg/kg Riociguat. The MCAO + C group received both drugs simultaneously. The drugs were administered just before the reperfusion, and the additional e doses weradministered 24h, and 48h hours of reperfusion. All animals in this study were sacrificed at the 72nd hour of experiment. Total brainsreceived were for analysis. Results of this experiment indicated that MCAO led to severe injury in cerebral structure. Bax, IL-6 and IL-1 ss levelstissue were upregulated, but anti-apoptotic Bcl-2 immunoexpression was suppressed (p<0.05). In resveratrol and Riociguat treated animals, the neurodegenerations and apoptosis and inflammation associated protein expressions were improved compared to MCAO group, mosbut the success was obtained in combined treatment exposed animals in MCAO + C group. This study indicated that the novel solubleate guany cyclase stimulator Riociguat is not only a potent neuroprotective drug in MCAO induced stroke, but also synergistic administratio of Riociguat along with resveratrol have potential to increase the neuroprotective effect of resveratrol in experimental cerebral strokeosed rats.Article Citation - Scopus: 1Comparison of Different Fixatives Effects in Histochemical Stainings of Peripheral Nerve Tissue(Cellular and Molecular Biology Association, 2024) Dörtbudak, M.B.; Demircioğlu, M.; Şeker, U.; Demircioğlu, İ.A pathological condition in the peripheral nerve tissue, which provides the connection between the organism and the external environment, negatively affects the standard of living. The nerve tissue histotechnology is of serious importance both for scientific studies and for clinical diagnosis. The fixation, which is one of the leading procedures for histological examination of tissues, aims to preserve tissue morphology. Another essential part of the histological examination is staining process. This study, it was aimed to determine the fixative that provides optimal histological appearance in peripheral nerve tissue. Therefore, various histochemical stainings of tissues fixed with some fixatives used in practice were compared. Sciatic nerves from each rat (n=7) used in the study were fixed with different fixatives and histochemical staining was performed. In histological examination, cellular (nucleus-cytoplasm) and intercellular morphological details, staining intensity and distribution were evaluated. At the end of the study, formaldehyde was found to be the most ideal fixing agent for all stains. Although Bouin and Carnoy fixatives differed according to the staining type, their fixation quality was similar in general. Glutaraldehyde did not give as good results as other fixatives in all stainings. This study is an important technical reference for clinical and experimental studies. © 2024 Cellular and Molecular Biology Association. All rights reserved.Article Protective Effects of Trolox on Ketamine-Induced Memory Impairments and Morphological Changes in the Brain(Asian Network Scientific Information-Ansinet, 2025) Uyar, Emre; Erdinc, Meral; Kelle, Ilker; Erdinc, Levent; Seker, Ugur; Nergiz, YusufBackground and Objective: Ketamine has demonstrated potential in treating various neuropsychiatric disorders at low doses. However, its memory-impairing and neurotoxic effects and abuse potential present limitations to its use. This study aimed to investigate ketamine's effects on memory functions, brain morphology and lipid peroxidation in a time- and dose-dependent manner and the protective effects of Trolox. Materials and Methods: Forty-eight male BALB/c mice were administered low and high doses of ketamine (10, 30 mg/kg/day, respectively) sub-chronically and chronically (7 and 21 days, respectively). A subgroup also received Trolox (20 mg/kg/day) for 21 days combined with high-dose ketamine. Following the drug administrations, behavioral tests were performed, including a modified elevated plus maze, a novel object recognition and a passive avoidance test. In the brain, malondialdehyde levels and morphology were examined. The results were analyzed using a one-way analysis of variance followed by a post hoc Tukey's test. Results: Chronic high-dose ketamine impaired spatial, emotional and recognition memory. Subchronic high-dose ketamine did not affect emotional and recognition memory but did impair spatial memory. Low-dose ketamine did not produce impairments. Malondialdehyde levels were elevated and morphological changes were evident in the chronic high-dose ketamine-applied group. These alterations were attenuated with Trolox. Conclusion: The memory-impairing and neurotoxic effects of ketamine are linked to increased oxidative stress. Antioxidant molecules like Trolox can be practical against the toxicity of ketamine.Article Ectoine-Loaded Solid Lipid Nanoparticles Enhance the Protection of Lacrimal Glands and Corneal Tissues in Dry Eye Disease Through Modulating NF-κB Mediated Signaling Pathway(Elsevier, 2026) Toksoy, Mahmut Ozan; Seker, Ugur; Guzel, Baris CanDry eye disease (DED) is a multifactorial disorder associated with tear film instability, inflammation, and ocular surface damage. This study aimed to develop and evaluate Ectoine-loaded solid lipid nanoparticles (Ect-SLNs) as a novel ocular drug delivery system to improve corneal penetration, retention, and therapeutic efficacy. Ect-SLNs were formulated using a Box-Behnken design and characterized for particle size, polydispersity index, zeta potential, and encapsulation efficiency. In vitro release kinetics were assessed. Ex vivo ocular retention studies were performed using bovine cornea. In vivo therapeutic efficacy was evaluated in a scopolamine-induced rat model of DED, with histological and immunohistochemical analyses of corneal and lacrimal gland tissues. The optimized Ect-SLN formulation exhibited a mean particle size, zeta potential and entrapment efficiency of 241.3 +/- 32.1 nm, -15.76 +/- -4.14 mV, and 32.84 + 3.15 % respectively. In vitro studies demonstrated that Ect-SLNs showed sustained release following Higuchi kinetics (r(2) = 0.991). Ex vivo studies confirmed 1.6-fold higher corneal retention compared to Ectoine solution. Animal studies showed that Ect-SLNs significantly improved glandular and corneal morphology, epithelial keratinization, apoptotic (Bax, Caspase-3) and pro-inflammatory (TNF-alpha, IL-1 beta) markers through NF-kappa B signaling pathway (p < 0.05). In addition, Ect-SLN formulation significantly inhibited the upregulated EGFR in corneal tissue, which is an important hallmark of neovascularization (p < 0.05). Ect-SLNs provided superior therapeutic benefits over conventional Ectoine solution by enhancing bioavailability, prolonging ocular residence, and modulating inflammatory and apoptotic responses. These findings suggest that Ect-SLNs constitute a promising nanocarrier platform for the clinical management of dry eye disease.Article Citation - WoS: 1Citation - Scopus: 1Antidepressant-Like Effects of Ashwagandha (Withania Somnifera) on Chronic Unpredictable Mild Stress-Induced Depression in Adolescent Rats(Springer, 2025) Gokdemir, Gul Sahika; Seker, Ugur; Baksi, Nazan; Baylan, Mukadder; Demirtas, Berjan; Gokdemir, Mehmet TahirRationaleAdolescent depression is often linked to biological changes associated with stress. However, new approaches and treatment strategies for early intervention and prevention of depression in children and adolescents are still limited. Ashwagandha is an Ayurvedic herb widely used in the management of anxiety and stress. However, there is no information in the current literature on its potential effect on adolescent depression.ObjectivesThis study aimed to investigate the effects of depression on proapoptotic proteins and neuroinflammation and the antidepressant effect of Ashwagandha on depression-like symptoms in adolescent rats exposed to the Chronic Unpredictable Mild Stress (CUMS) model.MethodsIn the study, CUMS model was used to induce depression in adolescent rats. Rats were treated with Ashwagandha or Sertraline. To evaluate the antidepressant effects, behavioral tests as well as biochemical and histological analyses were performed. Forced Swim Test (FST), Sucrose Test and Elevated Plus Maze Test were performed as behavioral tests. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were measured by the ELISA method in the fronto-parietal cortex. Proapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta), as well as glial fibrillary acidic protein (GFAP), were evaluated immunohistochemically in the fronto-parietal cortex.ResultsProapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta) were increased in the CUMS group. BDNF and GFAP levels were decreased. Ashwagandha treatment was more effective than Sertraline in reducing the levels of these proteins and markers. Additionally, Ashwagandha prevented weight loss.ConclusionsAshwagandha showed antidepressant-like effects in adolescent rats, reducing apoptosis, inflammation, and neuroinflammation, suggesting potential for treating adolescent depression.Article Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice(İnönü Üniversitesi Tıp Fakültesi, 2023) Uyar, Emre; Şeker, Uğur; Özhan, Onural; Açıkgül, Muhammet Burak; Çolak, Mehmet; İzci, Sevde Feyza; Parlakpınar, Hakan; Açıkgül, Muhammet Burak; Parlakpinar, Hakan; Ozhan, Onural; Çolak, Mehmet; Seker, Ugur; İzci, Sevde FeyzaAim: Opioids have indispensable roles in pain management. A strong link exists between opioid use and memory impairments, mainly with continuous use. This study investigated the effects of two opioid drugs, meperidine and fentanyl, on emotional memory functions, brain morphology, and the possible protective effects of low-dose ketamine in mice. Materials and Methods: A passive avoidance (PA) test was used to measure emotional memory functions following seven daily drug applications in 48 male Balb/C mice (30-35 g). Meperidine (10 mg/kg), fentanyl (0.3 mg/kg), ketamine (5 mg/kg), and combinations of ketamine with the opioids were intraperitoneally injected daily. No drugs were utilized during the testing days. Brain tissues were obtained after sacrification and put into diluted formalin solution for histopathological analysis. Results: Transfer latencies of the meperidine and fentanyl-treated groups in the PA test were lower than in the vehicle-treated group (p<0.01, p<0.05, respectively). Ketamine combined with meperidine had higher latencies than in the meperidine-treated group (p<0.05). The augmenting effects of ketamine were evident against fentanyl and meperidine-induced neurotoxicity as morphologic alterations were reduced. Conclusion: Low-dose ketamine may fend against opioid-induced neurotoxicity and emotional memory impairments, especially against meperidine, which can be a practical alternative to fentanyl in clinical settings.Article The Involvement of the Serotonergic System in Ketamine and Fluoxetine Combination-Induced Cognitive Impairments in Mice(Ataturk Univ, 2024) Uyar, Emre; Erdinc, Meral; Kelle, Lker; Erdinc, Levent; Seker, Ugur; Nergiz, Yusuf; Kelle, İlkerBackground: Gluta mater gic N-methyl-D-aspartate (NMDA) receptors play vital roles in memory formation. Changes in the activity of these receptors influence memory processes. Ketamine is a noncompetitive NMDA receptor antagonist drug with promising mood-altering and pain-reducing effects ff ects in low doses. These effects ff ects are believed to be related to altered serotonergic transmission. Methods: The present study investigated the involvement of the serotonergic system in low-dose ketamine administrations' effects ff ects on memory acquisition, consolidation, and retrieval processes. Sixty-four male BALB/c mice were used in this experiment and separated into 8t groups. Mice were treated subchronically with a selective serotonin reuptake inhibitor, fluoxetine, and a serotonin depletion agent, p-chlorophenylalanine (pCPA). A serotonin antagonist, methiothepin, and ketamine were acutely administered 60 minutes before or after the behavioral tests. A passive avoidance (PA) test measured emotional memory acquisition, consolidation, and retrieval processes. Hippocampi malondialdehyde (MDA) levels were analyzed, and histopathological examinations were performed. Results: Ketamine alone did not significantly affect ff ect memory encoding processes in the PA test, while the ketamine-fluoxetine combination disrupted memory consolidation. Fluoxetine negatively affected ff ected the memory acquisition process, which was normalized during the consolidation and retrieval trials. Drug applications did not significantly alter hippocampal MDA levels. In all ketamine-applied groups, histopathologic alterations were evident. Conclusion: Low-dose ketamine administration induces neurodegeneration, and it also impairs memory functions when combined with fluoxetine, indicating increased serotonergic transmission may be involved in the memory-impairing and neurotoxic effects ff ects of ketamine.Other Adm and Sflt-1 Expression in Placentas With Gestational Diabetes Mellitus(2023) Söker, Sevda İpek; Aşır, Fırat; Deveci, Engin; Arslan, Necat; Kaplan, Özge; Şeker, Uğur; Başaran, Süreyya Özdemir; Necat,Amaç: Bu çalışmada gestasyonel diyabetes mellitusta (GDM) vasküler regülasyonda rolü saptanan iki yeni protein olan Adrenomedullin (ADM) ve soluble fms-benzeri tirozin kinaz (sFlt-1)’in ekspresyon seviyelerini incelemeyi, hastalığın histopatolojisinde bu proteinlerin ekspresyon seviyelerini karşılaştırmayı ve bu proteinlerin ekspresyon yoğunluğunun hastalıkla korelasyonunu gözlemlemeyi amaçladık. Gereç ve Yöntem: Çalışmamızda 20 Normotansif ve 20 GDM’li plasenta örneği alındı. Histolojik takip yöntemiyle takip edildi. Bu dokulardan 5µm kalınlığında kesitler alınarak Hematoksilen-Eozin, Periodic Acid Schiff (PAS) boyamaları yapıldı. İmmunünohistokimyasal olarak ADM ve sFlt-1 antikorları çalışıldı. Bulgular: GDM grubunda; kök villuslarındaki kan damarlarında dilatasyon ve konjesyon, endotel hücrelerinde hiperplazi görüldü. Villusların dış kısmındaki sinsitiyal köprülerde artış, mononükleer hücre infiltrasyonu, maternal bölgedeki desidual hücrelerin bazılarında piknotik nükleuslar ve sitoplazma kaybı izlendi. İmmunohistokimyasal incelemede villusların sitotrofoblast ve sinsitiyotrofoblast hücrelerinde ve sinsitiyal düğümlerde negatif ADM ekspresyonu vardı. Küçük villusların bazı sitotrofoblast hücrelerinde, damar endotel hücrelerinde ve desidual hücrelerde pozitif ADM ekspresyonu görüldü. GDM grubunda sFlt-1 ekspresyonu endotel hücrelerinde, mezenşimal bağ doku içindeki bazı Hofbauer hücrelerinde, desidual hücre nükleuslarında ve membranlarında pozitif olarak gözlendi. Sonuç: Desidual hücre membranlarında, sitotrofoblastlarda ADM pozitif ekspresyon gösterdiğinden ADM’nin glikoz yoğunluğunun belirlenmesinde ve bununla ilişkili olarak insülin regülasyonunda önemli bir düzenleyici olabileceğini düşündürmüştür. Yine sFlt-1’in maternal ve fötal bölgelerdeki endotel hücresi üzerindeki etkileri ve Hofbauer hücrelerindeki ekspresyonu, anjiyogenik etkide bu molekülün anahtar rol alabileceği kanısını uyandırmıştır.Article Normozoospermik Fertil Bireyler ile Oligozoospermik, Şiddetli-Oligozoospermik, Oligoastenozoospermik, Azoospermik ve İdiyopatik Bireylerde Natural Killer Hücre Aktivitesinin Araştırılması(Mardin Artuklu Üniversitesi, 2023) Özmen, Mehmet Ferit; Afşin, Muhammet; Şeker, Uğur; Yavuz, Dilek; Bademkıran, Muhammed Hanifi; Yıldırım, İbrahim Halil; Cirit, ÜmütGiriş: İnfertilite çiftleri ve toplumu birçok açıdan olumsuz etkileyen ve gittikçe yaygınlaşan bir sağlık problemidir. Bu problemlerin %30-40’ının erkek kaynaklı olduğu tahmin edilmektedir. Amaç: Farklı derecelerde infertilite problemi olan erkek bireyler ile normal sperm sayısı ve konsantrasyonuna sahip bireylerde (normozoospermi) doğal öldürücü (Natural Killer: NK) hücre aktivitesinin değişip değişmediğinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Sperma analizleri sonucu oligozoospermi, şiddetli-oligozoospermi, oligoastenoozospermi, azoospermi ve idiopatik olduğu belirlenen bireyler ile normozoospermi teşhisi konan bireylerden (n:120) alınan kan numunelerinden NK hücre aktiviteleri ölçüldü. Bulgular: Yapılan ölçümler sonucunda normozoospermi grubu en düşük değer (544.46 pg/ml) alırken şiddetli oligozoospermi grubundan en yüksek değer (1005.90 pg/ml) alınmıştır. NK hücre aktivitesi ise oligozoospermi, oligoastenozoospermi, azoospermi ve idiyopatik gruplarda sırasıyla 797.60 ± 428.55 pg/ml, 905.34 ± 430.60 pg/ml, 757.66 ± 541.16 pg/ml ve 639.44 ± 385.50 pg/ml olarak ölçüldü. Şiddetli oligozoospermi grubu ile diğer gruplar arasında NK aktivitesi farkı önemli (p<0.05) bulunurken diğer gruplar arasındaki farklar önemli bulunmamıştır (p >0.05). Sonuç: İnfertilite derecesi şiddetli oligozoospermi olan bireylerde NK hücre aktivitesinin normozoospermi, oligozoospermi, oligoastenozoospermi, azoospermi ve idiopatik gruplarından daha yüksek olduğu belirlenmiştir.Article Citation - WoS: 4Citation - Scopus: 7An Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathy(MDPI, 2024) Tueredi, Sibel; Celik, Hakim; Dagli, Seyda Nur; Taskin, Seyhan; Seker, Ugur; Deniz, Mustafa; Türedi, SibelThe purpose of this study was to reveal the combined effects of propolis (P) and quercetin (Q) against diabetic peripheral neuropathy developing with streptozotocin-induced diabetes in rats. Sixty-four adult male rats were divided into eight equal groups: control, P (100 mg/kg/day), Q (100 mg/kg/day), P + Q (100 mg/day for both), diabetes mellitus (DM) (single-dose 60 mg/kg streptozotocin), DM + P, DM + Q, and DM + P + Q. The rats were sacrificed, and blood and sciatic nerve tissues were collected. Blood glucose and malondialdehyde (MDA) levels increased, while IL-6 and total antioxidant status decreased in the DM group (p = 0.016 and p = 0.047, respectively). Ultrastructural findings showed degeneration of the axon and myelin sheath. The apoptotic index (AI %), TNF-alpha, and IL-1 beta immunopositivity increased significantly in the DM group (p < 0.001). Morphological structures approaching those of the controls were observed in the DM + P, DM + Q, and DM + P + Q groups. Morphometric measurements increased markedly in all treatment groups (p < 0.001), while blood glucose and MDA levels, AI (%), TNF-alpha, and IL-1 beta immunopositivity decreased. In conclusion, the combined effects of propolis and quercetin in diabetic neuropathy may provide optimal morphological protection with neuroprotective effects by reducing hyperglycemia, and these may represent a key alternative supplement in regenerative medicine.
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