Importance of Curcumin Effect and Asprosin Level on Glucose Metabolism in Diabetic Rats

dc.contributor.author Gökdemir, Mehmet Tahir
dc.contributor.author Taşdemir, Ezel
dc.contributor.author Yokus, Beran
dc.contributor.author Atmaca, Mukadder
dc.contributor.author Gokdemir, Gul Sahika
dc.date.accessioned 2023-12-30T20:09:42Z
dc.date.accessioned 2025-09-17T14:28:34Z
dc.date.available 2023-12-30T20:09:42Z
dc.date.available 2025-09-17T14:28:34Z
dc.date.issued 2023
dc.description.abstract Asprosin is a new hormone secreted mainly from white adipose tissue. It may be associated with the pathogenesis of obesity, diabetes and some metabolic diseases. The changes in plasma asprosin levels of experimental diabetic rats and the relation of these changes with liver glucose metabolism and some diabetes parameters were investigated, and the effects of metformin, gliclazide or curcumin treatment on plasma asprosin levels were tried. The study was designed as an animal model in diabetic rats The albino rats were divided into five groups. To induce diabetes, a single dose of STZ was injected intraperitoneally. Diabetics rats were treated intragastrically with metformin (D+Metformin group), gliclazide (D+Giliclazide group) or 20 curcumin (D+Curcumin group) for eight weeks. Fasting blood glucose, insulin levels and other parameters were measured. Plasma asporsin levels of untreated diabetic rats increased significantly (P<.001). Although the plasma asprosin levels of diabetic rats treated with the rugs were significantly lower (P<.001). Fasting blood glucose levels of diabetic rats treated with the drugs were found to be remarkably lower than the diabetic control values (P<.001, respectively). There was no significant difference in the insulin levels and HOMA- IR between these three groups. Curcumin treatment provides significant improvements in plasma asprosin level and diabetes parameters. The increase in plasma asprosin level in diabetic rats may be one of the main reasons that facilitate the development of the disease or is responsible for its pathogenesis. Our findings support the idea that curcumin may be an important treatment option for diabetes. en_US
dc.identifier.doi 10.5455/medscience.2022.12.281
dc.identifier.issn 2147-0634
dc.identifier.uri https://doi.org/10.5455/medscience.2022.12.281
dc.identifier.uri https://search.trdizin.gov.tr/en/yayin/detay/1176289/importance-of-curcumin-effect-and-asprosin-level-on-glucose-metabolism-in-diabetic-rats
dc.identifier.uri https://hdl.handle.net/20.500.12514/9703
dc.language.iso en en_US
dc.relation.ispartof Medicine Science en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Farmakoloji Ve Eczacılık en_US
dc.subject Biyoloji en_US
dc.subject Endokrinoloji Ve Metabolizma en_US
dc.subject Onkoloji en_US
dc.subject Veterinerlik en_US
dc.title Importance of Curcumin Effect and Asprosin Level on Glucose Metabolism in Diabetic Rats en_US
dc.type Article en_US
dspace.entity.type Publication

Files