Comparison of Vitamin D Levels in Euthyroidindividuals With and Without Thyroid Nodule

Abstract

Thyroid nodules are frequently observed in the thyroid gland, with a malignancy rate of less than 5%. The etiology of nodule formation remains unclear, and various hypotheses have been proposed. Vitamin D, known to influence cell turnover, may also play a role in the development of thyroid nodules. This study aims to investigate the association between vitamin D deficiency and thyroid nodule formation. Blood samples were collected from individuals categorized into two groups based on the presence of thyroid nodules. 100 patients with thyroid nodules detected by ultrasonography and 100 individuals with no thyroid nodules were included in the study. The 25-hydroxyvitamin D [25(OH)D3] levels were measured in a single session. The mean 25(OH)D3 levels were 15.39±9.1 ng/ml in the patient group and 13.33±7.1 ng/ml in the control group. Vitamin D deficiency was identified in 72% of the patient group and 82% of the control group. No significant correlation was found between 25(OH)D3 levels and the presence of thyroid nodules. Further research is needed to elucidate this relationship.