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Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice

dc.authorid https://orcid.org/0000-0002-1693-6378
dc.authorscopusid https://www.scopus.com/authid/detail.uri?authorId=55910059600
dc.authorwosid https://www.webofscience.com/wos/author/record/48480
dc.contributor.author Şeker, Uğur
dc.contributor.other Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
dc.date.accessioned 2023-12-18T09:43:03Z
dc.date.available 2023-12-18T09:43:03Z
dc.date.issued 2023
dc.department MAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı en_US
dc.description.abstract Aim: Opioids have indispensable roles in pain management. A strong link exists between opioid use and memory impairments, mainly with continuous use. This study investigated the effects of two opioid drugs, meperidine and fentanyl, on emotional memory functions, brain morphology, and the possible protective effects of low-dose ketamine in mice. Materials and Methods: A passive avoidance (PA) test was used to measure emotional memory functions following seven daily drug applications in 48 male Balb/C mice (30-35 g). Meperidine (10 mg/kg), fentanyl (0.3 mg/kg), ketamine (5 mg/kg), and combinations of ketamine with the opioids were intraperitoneally injected daily. No drugs were utilized during the testing days. Brain tissues were obtained after sacrification and put into diluted formalin solution for histopathological analysis. Results: Transfer latencies of the meperidine and fentanyl-treated groups in the PA test were lower than in the vehicle-treated group (p<0.01, p<0.05, respectively). Ketamine combined with meperidine had higher latencies than in the meperidine-treated group (p<0.05). The augmenting effects of ketamine were evident against fentanyl and meperidine-induced neurotoxicity as morphologic alterations were reduced. Conclusion: Low-dose ketamine may fend against opioid-induced neurotoxicity and emotional memory impairments, especially against meperidine, which can be a practical alternative to fentanyl in clinical settings. en_US
dc.description.citation Uyar E, Seker U, Ozhan O, Acikgul MB, Colak M, Izci SF, Parlakpinar H. Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. en_US
dc.description.sponsorship İnönü Üniversitesi BAP Koordinatörlüğü Proje No: TSA-2022-2882. en_US
dc.identifier.doi 10.5455/annalsmedres.2023.09.241
dc.identifier.endpage 1441 en_US
dc.identifier.issn 2636-7688
dc.identifier.issue 11 en_US
dc.identifier.startpage 1437 en_US
dc.identifier.trdizinid 1209348
dc.identifier.uri https://doi.org/10.5455/annalsmedres.2023.09.241
dc.identifier.uri https://hdl.handle.net/20.500.12514/4938
dc.identifier.volume 30 en_US
dc.institutionauthor Şeker, Uğur
dc.language.iso en en_US
dc.publisher İnönü Üniversitesi Tıp Fakültesi en_US
dc.relation.ispartof Annals of Medical Research en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Başka Kurum Yazarı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Ketamine en_US
dc.subject Opioids en_US
dc.subject Memory impairments en_US
dc.subject Passive avoidance en_US
dc.subject Brain morphology en_US
dc.title Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice en_US
dc.type Article en_US
dspace.entity.type Publication
relation.isAuthorOfPublication ef42fcf2-0f44-4652-ad49-6c27f2d064a3
relation.isAuthorOfPublication.latestForDiscovery ef42fcf2-0f44-4652-ad49-6c27f2d064a3
relation.isOrgUnitOfPublication ba421768-5f1e-47b4-9440-6a077f5f161d
relation.isOrgUnitOfPublication.latestForDiscovery ba421768-5f1e-47b4-9440-6a077f5f161d

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