The Effect of Cardiopulmonary Bypass on Hemogram Parameters in Patients Operated for Tetralogy of Fallot

Abstract

Background: Tetralogy of Fallot (TOF) constitutes 10% of congenital heart diseases. Cardiopulmonary bypass (CPB) is a procedure where the heart pump function and the lungs' gas exchange function are temporarily suspended, and circulation is carried out by the heart-lung machine. Blood is exposed to abnormal physical and chemical trauma during cardiopulmonary bypass. In this study, we aimed to determine the duration of cardiopulmonary bypass on hemogram parameters in patients undergoing corrective surgery for tetralogy of Fallot. Material and Method: Age, sex, operative time, cardiopulmonary and cross-clamp time, length of stay in hospital and intensive care unit, mortality rate, and blood parameters of patients operated for tetralogy of Fallot were retrospectively evaluated. A total of 28 patients were included in the study. Result: There was a significant difference between the preoperative and postoperative neutrophil lymphocyte levels (p<0.001, p<0.001, respectively). There was a significant difference between the Neutrophil/Lymphocyte ratios and Platelet/Lymphocyte ratios measured at different times at the preoperative and postoperative periods (p=0.001, p=0.029). The analysis of the distribution of the N/L ratio at the preoperative and postoperative periods showed that the N/L first increased and then decreased. The P/L ratio was measured at 54.1 (34.1-67.3) during the preoperative period; the highest P/L ratio was measured at 67 (46.5-11.3) at the 48th hour of the postoperative period. Conclusion: The results of this study demonstrated statistically significant differences between WBC, hemoglobin, hematocrit, neutrophil, lymphocyte, N/L and P/L ratio, urea, creatinine, CRP, lactate values measured in the preoperative period and postoperative 24, 48 and 72 hours