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Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole

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dc.contributor.authorAlhılal, Suzan
dc.contributor.authorAlhılal, Mohammad
dc.contributor.authorGomha, Sobhi M.
dc.contributor.authorOuf, Salama A.
dc.date.accessioned2022-10-25T05:48:58Z
dc.date.available2022-10-25T05:48:58Z
dc.date.issued2022
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractThree novel aza-acyclic nucleosides and two hydrogen complexes were isolated by flash chromatography after being produced in a reaction between indole and dibenzosulfonyl diethylamine (which had previously been prepared) in the presence of sodium and absolute ethanol as a basic catalyst. Structures of new compounds and complexes were determined by 1D-NMR: 1H NMR, 13C NMR, DEPT-135, 2D-NMR: COSY, HMQC, HSQC, HMBC, IR, and MS spectroscopy. The synthesized compounds were evaluated against a wide range of microorganisms, including Gram-positive and Gram-negative bacteria as well as fungal strains. These compounds showed good biological activity.en_US
dc.description.citationAlhilal, S., Alhilal, M., Gomha, S. M., & Ouf, S. A. (2022). Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole. Research on Chemical Intermediates, 48(8), 3567-3587.en_US
dc.identifier.doi10.1007/s11164-022-04760-3
dc.identifier.endpage3587en_US
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85133290985
dc.identifier.startpage3567en_US
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000819274600001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0AA4wPbESzeKvWLTjqIZtmj
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85133290985&origin=resultslist&sort=plf-f&src=s&st1=10.1007%2fs11164-022-04760-3&sid=fdd1d64269c1f2a06aef897666292db7&sot=b&sdt=b&sl=31&s=DOI%2810.1007%2fs11164-022-04760-3%29&relpos=0&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12514/3149
dc.identifier.volume48en_US
dc.identifier.wosWOS:000819274600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringerLinken_US
dc.relation.ispartofResearch on Chemical Intermediatesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitrogen-based · Indole · Aza-acyclic nucleosides · Acyclovir analoguesen_US
dc.titleSynthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indoleen_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublicationfa10ac27-8c03-4573-b492-e55db820f6a6
relation.isAuthorOfPublication467d0c32-7caf-48ef-ba50-8ecf629453d2
relation.isAuthorOfPublication.latestForDiscoveryfa10ac27-8c03-4573-b492-e55db820f6a6

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