Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole
| dc.contributor.author | Alhilal, Suzan | |
| dc.contributor.author | Alhilal, Mohammad | |
| dc.contributor.author | Gomha, Sobhi M. | |
| dc.contributor.author | Ouf, Salama A. | |
| dc.date.accessioned | 2022-10-25T05:48:58Z | |
| dc.date.available | 2022-10-25T05:48:58Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Three novel aza-acyclic nucleosides and two hydrogen complexes were isolated by flash chromatography after being produced in a reaction between indole and dibenzosulfonyl diethylamine (which had previously been prepared) in the presence of sodium and absolute ethanol as a basic catalyst. Structures of new compounds and complexes were determined by 1D-NMR: 1H NMR, 13C NMR, DEPT-135, 2D-NMR: COSY, HMQC, HSQC, HMBC, IR, and MS spectroscopy. The synthesized compounds were evaluated against a wide range of microorganisms, including Gram-positive and Gram-negative bacteria as well as fungal strains. These compounds showed good biological activity. | en_US |
| dc.identifier.citation | Alhilal, S., Alhilal, M., Gomha, S. M., & Ouf, S. A. (2022). Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole. Research on Chemical Intermediates, 48(8), 3567-3587. | en_US |
| dc.identifier.doi | 10.1007/s11164-022-04760-3 | |
| dc.identifier.issn | 0922-6168 | |
| dc.identifier.issn | 1568-5675 | |
| dc.identifier.scopus | 2-s2.0-85133290985 | |
| dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000819274600001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0AA4wPbESzeKvWLTjqIZtmj | |
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| dc.identifier.uri | https://hdl.handle.net/20.500.12514/3149 | |
| dc.language.iso | en | en_US |
| dc.publisher | SpringerLink | en_US |
| dc.relation.ispartof | Research on Chemical Intermediates | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Nitrogen-based · Indole · Aza-acyclic nucleosides · Acyclovir analogues | en_US |
| dc.title | Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.bip.impulseclass | C4 | |
| gdc.bip.influenceclass | C5 | |
| gdc.bip.popularityclass | C4 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.collaboration.industrial | false | |
| gdc.description.department | MAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü | en_US |
| gdc.description.endpage | 3587 | en_US |
| gdc.description.issue | 8 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.startpage | 3567 | en_US |
| gdc.description.volume | 48 | en_US |
| gdc.description.wosquality | Q2 | |
| gdc.identifier.openalex | W4283732779 | |
| gdc.identifier.wos | WOS:000819274600001 | |
| gdc.index.type | WoS | en_US |
| gdc.index.type | Scopus | en_US |
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| gdc.oaire.influence | 2.7604594E-9 | |
| gdc.oaire.isgreen | false | |
| gdc.oaire.keywords | Nitrogen-based · Indole · Aza-acyclic nucleosides · Acyclovir analogues | |
| gdc.oaire.popularity | 9.357868E-9 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
| gdc.oaire.sciencefields | 01 natural sciences | |
| gdc.oaire.sciencefields | 0104 chemical sciences | |
| gdc.openalex.collaboration | International | |
| gdc.openalex.fwci | 1.54753077 | |
| gdc.openalex.normalizedpercentile | 0.72 | |
| gdc.opencitations.count | 8 | |
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| gdc.scopus.citedcount | 10 | |
| gdc.virtual.author | Alhılal, Suzan | |
| gdc.virtual.author | Alhılal, Mohammad | |
| gdc.wos.citedcount | 10 | |
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