Evaluation of the Relationship Between Uric Acid Level and Urıc Acide/Albumin Ratio with Stent Thrombosis in Patients Presenting Acute Coronary Syndrome

Abstract

This study aimed to evaluate the relationship between uric acid level and urıc acide/albumin ratio (UAR) and stent thrombosis in patients with acute coronary syndrome (ACS). This single-center retrospective cohort study included 142 patients who underwent interventional treatment with stent implantation for ACS. The patients were divided into two groups: those who developed stent thrombosis within one year (n=67) and those who did not (n=75). Demographic, clinical, and laboratory data were collected from the hospital records. The uric acid/albumin ratio was calculated. Stent thrombosis is significantly associated with diabetes and hyperlipidemia.(respectively p=0,001, p=0,002) Uric acid levels were significantly higher and UAR was significantly lower in the stent thrombosis group. (respectively p= 0,001, p=0,001) The development of no reflow and post-dilatation was more frequent in the stent thrombosis group. ROC analysis revealed that a uric acid cut-off value of 5.55 had a sensitivity of 59.7% and a specificity of 64% for predicting stent thrombosis. The relationship between uric acid levels, UAR, and stent thrombosis likely involves complex processes including inflammation and oxidative stress. Understanding these relationships may contribute to the development of targeted interventions to reduce the risk of stent thrombosis and improve the outcomes of ACS patients undergoing stent implantation. © 2025 Elsevier B.V., All rights reserved.