WoS İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 24
Citation - Scopus: 29
Fungal Pathogens Associated with Crown and Root Rot of Wheat in Central, Eastern, and Southeastern Kazakhstan
(Journal of Fungi, 2022) Bozoğlu, Tuğba; Derviş, Sibel; Imren, Mustafa; Amer, Mohammed; Özdemir, Fatih; Paulitz, Timoth; Morgounov, Alexey; Dababat, Abdelfattah A.; Özer, Göksel
Kazakhstan is the fourteenth largest wheat producer in the world. Despite this fact, there has not been a comprehensive survey of wheat root and crown rot. A quantitative survey was conducted for the purpose of establishing the distribution of fungi associated with root and crown rot on wheat (Triticum spp.). During the 2019 growing season, samples were taken from the affected plants’ roots and stem bases. A total of 1221 fungal isolates were acquired from 65 sites across the central (Karagandy region), eastern (East Kazakhstan region), and southeastern (Almaty region) parts of the country and identified using morphological and molecular tools. The internal transcribed spacer (ITS), translation elongation factor 1-alpha (EF1-α), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) sequences were successfully used to identify the species of fungal isolates. It was found that Bipolaris sorokiniana (44.80%) and Fusarium acuminatum (20.39%) were the most predominant fungal species isolated, which were present in 86.15 and 66.15% of the fields surveyed, respectively, followed by F. equiseti (10.16%), Curvularia spicifera (7.62%), F. culmorum (4.75%), F. oxysporum (4.10%), F. redolens (2.38%), Rhizoctonia solani AG2-1 (1.06%), Nigrospora oryzae (0.98%), C. inaequalis (0.90%), F. pseudograminearum (0.74%), F. flocciferum (0.74%), Macrophomina phaseolina (0.66%), F. cf. incarnatum (0.33%), Fusarium sp. (0.25%), and F. torulosum (0.16%). A total of 74 isolates representing 16 species were tested via inoculation tests on the susceptible Triticum aestivum cv. Seri 82 and the results revealed that F. culmorum and F. pseudograminearum, B. sorokiniana, Fusarium sp., R. solani, F. redolens, C. spicifera, C. inaequalis, and N. oryzae were virulent, whereas others were non-pathogenic. The findings of this investigation demonstrate the presence of a diverse spectrum of pathogenic fungal species relevant to wheat crown and root rot in Kazakhstan. To the best of our knowledge, this is the first report of F. pseudograminearum, Fusarium sp., C. spicifera, and C. inaequalis as pathogens on wheat in Kazakhstan.
Evaluation of the Neurodevelopmental Status for Urea Cycle Disorders: Based on Clinical Experience
(Galenos Publ House, 2023) Bozaci, Ayse Ergul; Goksoy, Emine; Unal, Aysel Tekmenuray; Albayrak, Hatice Mutlu; Tas, Ibrahim; Kanar, Berat; Kose, Melis
Aim: Urea cycle disorders (UCD) still have poor neurological outcomes despite early diagnosis and treatment. We aimed to present the neurological outcomes of UCD patients and to determine the main simple and accessible factors affecting these outcomes. Materials and Metkods: This was a descriptive cross-sectional study conducted in two pediatric metabolism centers on 29 patients from 25 unrelated families who were diagnosed and followed with UCD based on clinical presentation, neurological parameters, biochemical measurements, and molecular analysis.Results: Within the study population, the most common diagnosis was argininosuccinate synthase deficiency in 13 (44.82%) patients, followed by N-acetylglutamate synthase deficiency in five patients (17.24%), ornithine transcarbamylase deficiency in four patients (13.79%), arginase 1 deficiency in three patients (10.34%), carbamoyl phosphate synthase 1 deficiency in three patients (10.34%), and argininosuccinate lyase deficiency in one patient (3.44%). Peak ammonia levels were observed to be significantly higher in those patients with delayed milestones and patients who had Denver II <-2 standard deviation score results (p=0.032, p=0.026). Effect sizes were large in both groups. Delayed milestones were noted in 17 (94.4%) of the cases with peak ammonia >500 mu mol/L (n=18). Those patients with abnormal neurological parameters had a significantly higher mean number of hyperammonemic episodes per year. Extracorporeal detoxification was given to eight patients, in combination with therapeutic hypothermia in two patients. Rapid regression was observed in brain edema in those who underwent therapeutic hypothermia.Conclusion: Our study emphasizes the effect of peak ammonia levels and the frequency of hyperammonemic episodes on neurological outcomes. There were still poor neurocognitive outcomes despite extracorporeal detoxification. This highlights the need to reassess current treatment strategies, including the threshold for starting extracorporeal detoxification if ammonia levels exceed 500 mu mol/L. The use of therapeutic hypothermia by experienced teams may be promising due to its brain edema-reducing effects.
The Potential Renoprotective Effect of Sugammadex in Renal Ischemia-Reperfusion Injury
(Galenos Publ House, 2025) Kolukcu, Vildan; Bala, Mehtap Gurler; Sahin, Ahmet Tugrul; Genc, Ali; Unsal, Velid; Firat, Fatih; Gurpinar, Ahmer Burak
Objective: We aimed to evaluate the effectiveness of sugammadex on renal tissue for against ischemia-reperfusion injury. Methods: Twenty-one Wistar albino strain female rats were divided into three groups. The first group functioned as the control cohort for comparison. In Groups 2 and 3, a renal ischemia-reperfusion model was established. Moreover, following the cessation of ischemia, the rats in Group 3 were intravenously administered sugammadex at a dose of 4 mg kg-1. Blood and tissue samples were subsequently collected for analysis. Results: Biochemical analyses revealed a notable increase in the enzymatic activities of glutathione peroxidase and superoxide dismutase in Group 3 relative to Group 2 (P < 0.001 and P=0.015, respectively). Additionally, the concentration of malondialdehyde was found to be significantly reduced in Group 3 relative to Group 2 (P=0.004). Group 3 exhibited a substantial decrease in tumor necrosis factor-alpha, interleukin 6, and interleukin 1 beta levels when compared to Group 2 (P=0.021, P=0.006, and P=0.016 respectively). Group 2 exhibited the highest concentrations of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 (P < 0.001 and P=0.015, respectively). Similarly, the histopathologic tissue damage was the most prominent in Group 2 (P < 0.001). Conclusion: Sugammadex plays a protective role against ischaemia-reperfusion injury in renal tissue.
Sectarian Diplomacy and the Transformation of Ottoman Statecraft: Yâsincizâde Abdülvehhâb Efendi's Embassy to Qajar Iran (1810-1813)
(MDPI, 2025) Tan, Hasan
At the beginning of the 19th century, Ottoman-Iranian relations entered a new diplomatic phase shaped by Russia's expansion in the Caucasus and Britain's growing influence in the Persian Gulf. This shared perception of external threats led to the establishment of a more structured and representative diplomatic framework between the two empires. This study examines the embassy of Y & acirc;sinciz & acirc;de Abd & uuml;lvehh & acirc;b Efendi, who was appointed as Ottoman ambassador to Iran between 1810 and 1813, in the context of a shifting diplomatic mindset. Y & acirc;sinciz & acirc;de's mission is analyzed not merely as a temporary diplomatic engagement, but as a form of ideological, sectarian, and cultural representation by a figure from the ulema class. Based on archival sources, the study reveals that his diplomatic reports and observations provided critical input to the central administration, contributing to the development of more institutionalized and long-term strategies in Ottoman policy toward Iran. By focusing on the transitional character of his embassy, the paper reassesses the evolving role of religious scholars in Ottoman foreign relations and situates this case between the classical sefaretn & acirc;me tradition and emerging modern diplomatic practices.
Citation - WoS: 2
Citation - Scopus: 2
Roles of Loneliness and Life Satisfaction in the Relationship Between Perceived Friend Social Support, Positive Feelings About the Future and Loss of Motivation
(Elsevier, 2025) Aslan, Yavuz; Kocak, Orhan; Kaya, Aysel Basmaci; Alkhulayfi, Abdulmohsen Mohammed Abdullah; Gomez Salgado, Juan; Yildirim, Murat
Purpose: University students often face psychological challenges, particularly loneliness and hopelessness, which are exacerbated by factors such as limited social interactions, economic uncertainty, lack of employment opportunities, and the increasing prevalence of online education. This study aims to investigate the relationships among perceived friend social support, loneliness, life satisfaction, and the sub-dimensions of hopelessness, which are positive feelings about the future and loss of motivation. Design/methodology/approach: This cross-sectional quantitative study was conducted with 420 university students who completed a series of self-reported measures, including the Multidimensional Perceived Social Support Scale, the UCLA Loneliness Scale, the Satisfaction with Life Scale, and the Beck Hopelessness Scale. Findings: The findings revealed that perceived friend social support was positively associated with life satisfaction and positive future feelings and negatively associated with loneliness and loss of motivation. Both loneliness and life satisfaction individually and serially mediated the relationships between social support and the dimensions of hopelessness. Conclusion: These results highlight the crucial role of friend-based social support in alleviating loneliness and improving life satisfaction, thereby fostering optimism and preventing motivational decline among students. The findings provide valuable insights for designing interventions to enhance emotional well-being and psychological resilience among university populations.
Citation - WoS: 1
Violence in Zeki Demirkubuz's Cinema: Innocence and Destiny
(ANKARA UNIV, FAC COMMUNICATION, 2015) Aytekin, Pelin Erdal
This article focuses on how Zeki Demirkubuz approaches to the phenomenon of violence in his movies. The study aims at making the world transformed by violence comprehensible, rather than using the film narrative only as a means to discover the concept of violence. The phenomena of violence in Innocence (1997), in which Demirkubuz views violence as "a way of human nature", and Destiny (2006) are subjected to detailed film analysis The cinematographic language created by Demirkubuz in the above mentioned movies is examined through auteur analysis. The diversifying appearances of violence in Demirkubuz's movies are revealed by an analysis informed by mise-en-scene criticism. Thus, the article suggests that Demirkubuz, is one of the significant directors of Turkish cinema who make violence visible through the atmosphere he creates with his characters. It is observed that Demirkubuz's embittered and resigned characters unfold the phenomenon of violence in the movies analysed.
The Contribution of Trading Colonies Founded in Levant in Protodynastic and Early Dynastic Period (BC 3300-3000) to Egypt's Becoming a State
(Karabuk Univ, 2014) Civgin, Izzet
This study is the fourth of an article series dedicated to colonization as a cause of cultural change. It discusses the effects of culture contact between lower (northern) and upper (southern) Egypt and the southern Levant during so- called Naqada expansion (widespread distribution of southern material culture at sites at the northern Egypt), and Egyptian colonization of the southern Levant assumed to be founded in the last quarter of the 4th millennium B.C. The ultimate objective of this study is to examine the relationship between long-distance trade, colonization and the state formation (state ideology, emergence of early elites, specialized craft production and political economy).
Citation - WoS: 2
Citation - Scopus: 2
Architecture After Crisis a Journey Through Contemporary Commoning Practices
(Pontificia Univ Catolica Chile, Escuela Arquitectura, 2015) Tan, Pelin
After the economic crisis of 2008 many architects have devoted to the search of an alternative and communal production model capable of exploring diverse parallel platforms without having to cave in to the pressures of a capitalist economy. This text presents a journey through several contemporary examples, analyzing the possibilities that arise when commonality replaces professionalization in architecture.
Decarbonizing Buildings With Autoclaved Aerated Concrete (AAC): Climate-Specific Meta-Analysis of Global Performance
(Taylor & Francis Ltd, 2025) Azhar, Jasim; Aydin, Serdar; Zami, Mohammad Sharif
The building sector, which accounts for 40% of global energy consumption and 36% of CO2 emissions, requires immediate access to scalable low-carbon materials. The theoretical thermal advantages of Autoclaved Aerated Concrete (AAC) remain incomplete because field performance reports show inconsistent results between 15% and 50% energy savings, and multiple unaddressed implementation challenges have prevented its strategic adoption. The systematic review used worldwide climate-based empirical data to resolve existing performance discrepancies and develop practical implementation strategies. The meta-analysis of 12 studies comprising 847 dwelling units, assessed using CASP and ROBINS-I quality tools, showed that energy savings depend on climate zone: hot-arid zones achieving 48.3% (95% CI: 42.1-54.5%), cold-temperate zones 32.7% (27.3-38.1%), and hot-humid zones 28.4% (22.9-33.9%). The strongest predictor of performance was cooling degree days (beta = 0.0089, p < 0.001), while implementation quality explained 26% of performance variation. Economic modelling revealed median payback periods from 4.2 years (hot-arid) to 9.7 years (cold-temperate), with a 78-92% probability of positive lifetime returns. Carbon pricing at $50/tCO(2) reduces payback by 23%. The research develops a climate-oriented analytical system that analyses performance variations to help designers and policymakers achieve maximum AAC decarbonization results by combining environmental data with system information and financial metrics. [GRAPHICS] .
Citation - WoS: 3
Citation - Scopus: 4
GENDER (IN)EQUALITY AND WORK-LIFE (IM)BALANCE IN TOURISM AND HOSPITALITY LABOUR: PERSPECTIVES OF TOURISM ORGANISATIONS IN PORTUGAL
(University of Rijeka, 2023) Costa, Carlos; Seyitoğlu, Faruk; Malta, Ana Maria; Martins, Mariana
Purpose – This research note explores the perceptions of key stakeholders in tourism organisations regarding gender equality and work-life balance in the Portuguese tourism and hospitality industry. Methodology/Design/Approach – Eleven key stakeholders representing tourism organisations in Portugal were interviewed to obtain qualitative data. A content analysis was then conducted to uncover themes and sub-themes. Findings – The results show two main themes, including sub-themes: Gender inequality (partial gender equality, lack of gender salary equality, lack of women in higher positions, and gender inequality in career advancement) and work-life balance (the difficulty of balancing work and personal/family life and the need for better conditions for women accompanying children). Originality of the research – his study highlights gender equality and work-life balance in the tourism and hospitality industry from the perspective of managers of the leading tourism organisations in Portugal. The study also provides critical implications and future directions based on the findings.
Citation - WoS: 2
Citation - Scopus: 2
First report of needle blight of blue spruce (Picea pungens) caused by Neoscytalidium dimidiatum in Turkey
(SpringerLink, 2023) Derviş, Sibel; Türkölmez, Şahimerdan; Güney, İnci Güler; Alkan, Mehtap; Özer, Göksel
The blue spruce (Picea pungens Engelm.) is an exotic conifer species widely used for decorative purposes in landscaping and private gardens. In 2020, 60% of forty blue spruce trees between 20 and 25 years old planted in front of buildings in Kavaklıdere, Ankara, displayed needle blight symptoms. Needles on the lower and interior crown closest to the trunk were infected from the bottoms of branches. They showed a brown-colored or burned appearance before dropping off, starting from their tips, resulting in up to a 65% reduction of the canopy. On the surface of infected tissues, a black-colored fungal mass was observed. Fungal colonies isolated from twenty symptomatic branches and needles were initially dark gray and became black within 4 to 7 days. Zero- to one-septate dark brown conidia (4.6 to 9.8 × 3.6 to 7.5 μm) formed in arthric chains were disarticulating and cylindrical-truncate to rod-shaped, oblong, ellipsoidal, doliiform, or globose, consistent with the description of Neoscytalidium spp. (Crous et al. 2006). The internal transcribed spacer, translation elongation factor 1-α, and β-tubulin loci of a randomly selected isolate (Nd_Pp01) were sequenced using the primers ITS1/4, EF1-728 F/986R, and Bt2a/Bt2b and deposited in GenBank under the accession numbers OK643641, OK666381, and OK666382, respectively. The sequences had 99.77–100% nucleotide identity with those of the type specimen of N. dimidiatum, CBS 145.78. Phylogenetic analysis with concatenated sequences further confirmed the identification. The isolate was deposited in the Bolu Abant Izzet Baysal University Culture Collection with accession number BAIBU-179. A pathogenicity test was conducted with ten 1-year-old P. pungens plants by spraying a conidial suspension (105 conidia/ml) of the isolate Nd_Pp01 onto the needles (Türkölmez et al. 2019). Five seedlings sprayed with sterile water were used as controls. All plants were placed in a growth chamber at 28°C with 70% RH. Spray-inoculated needles initially showed yellow spots within two weeks and turned brown six weeks after inoculation, whereas the controls remained symptom-free. The pathogen was re-isolated from the inoculated needles but not from controls. To our knowledge, this is the first report of N. dimidiatum causing needle blight on P. pungens in Turkey and worldwide (Farr and Rossman 2023).
Qualitative Analysis of Solutions for a Timoshenko Type Equation With Logarithmic Source Term
(Univ Nis, 2025) Dinc, Yavuz; Irkil, Nazli; Piskan, Erhan; Tunc, Cemil
This paper deals with a Timoshenko type equation with strong damping and logarithmic source terms. The global existence and the decay estimate of the solutions have been obtained. We reproduce the finite time blow up results of weak solutions by the combining of the concavity method, perturbation energy method and differential-integral inequality technique. These results extend and improve some recent results in logarithmic nonlinearity.
The Importance of Frontal QRS-T Angle in Predicting the Effectiveness and Success of Thrombolytic Therapy in Patients With Acute Pulmonary Embolism
(Cureus, 2023) Durgun, Mehmet; Karahan, Mehmet Zülkif
Objective: The frontal QRS-T angle (fQRS-T) is associated with myocardial ischemia and ventricular arrhythmias. On the other hand, acute pulmonary embolism (APE) is a major risk factor for cardiac adverse events. This research aimed to determine whether the fQRS-T, a marker of ventricular heterogeneity, can be used to predict successful thrombolytic therapy in patients with APE. Methods: This was a retrospective observational study. Patients diagnosed with APE and hospitalized in the intensive care unit between 2020 and 2022 were included in the research. A total of 136 individuals with APEs were enrolled in this research. The patients were divided into two groups: thrombolytic-treated (n=64) and non-treated (moderate to severe risk, n=72). An ECG was conducted for each patient, and echocardiography was performed. Results: The mean age of the thrombolytic group was 58.2±17.6 years, with 35 females (55.1% of the group) and 29 males (44.9%). The non-thrombolytic group had a mean age of 63.1±16.2, with 41 females (56.5%) and 31 males (43.5%). Respiratory rate, heart rate, and fQRS-T were higher in the thrombolytic group, and oxygen saturation ratio and systolic and diastolic blood pressure were higher in the non-thrombolytic group (p=0.006, p<0.001, p=0.021; p<0.001, p=0.015, p<0.001, respectively). In the thrombolytic therapy group, comparing pre- and post-treatment ECG data revealed a statistically significant change in the fQRS-T value (p=0.019). Conclusion: The fQRS-T may provide important clues for the successful treatment of APEs
Seasonal Variation on Phospholipid Classes, Triacylglycerols and Atherogenic, Thrombogenic Indices of Male chondrostoma Regium
(Japan Oil Chemists Soc, 2024) Kacar, Semra; Kaya, Hacer Kayhan; Bashan, Mehmet
Gas chromatography (GC) was used to determine the fatty acid (FA) compositions of total lipid, phospholipid (PL), phospholipid subclass (phosphatidylcholine (PC), phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE)), and TAG (triacylglycerol) fractions in male Chondrostoma regium. Percentages of myristic acid (14:0), palmitoleic acid (16:1n-7), oleic acid (18:1n-9), monounsaturated fatty acid (Sigma MUFA), linoleic acid (18:2n-6) and linolenic acid (18:3n-3) were found to be higher in TAG than the values determined in PL classes. Palmitic acid (16:0), eicosapentaenoic acid (EPA, 20:5n-3), docosahexaenoic acid (DHA, 20:6n-3) in the PC fraction; 16:0, 20:5n-3, 22: 6n-3 in PE; 16:0, stearic acid (18:0), arachidonic acid (AA, 20:4n-6), 20:5n-3, 22:6n-3 in PI; and 16:0, 18:0, oleic acid (18:1n-9), 22:6n-3 in PS were found to be dominant. In total lipid, the PUFA/SFA ratio was 1.37-1.83; atherogenicity index (AI) was 0.34-0.47 and thrombogenicity index (TI) was found in the range of 0.18-0.22. The n-3/n-6 ratio, which is an important index for nutritional content, was found to be between 5.15 and 11.07. It was discovered that the FA compositions of male C. regium were affected by the reproductive period and season. These findings suggest that fish oil might be a beneficial dietary source for preserving human health.
Citation - WoS: 1
Citation - Scopus: 1
Determination of Bioactive and Anti-Inflammatory Molecules of Thymbra Spicata L. from Mardin by GC-MS and LC-Orbitrap HRMS: A DFT, Molecular Docking, ADMET, Biological Target and Activity Study
(BMC, 2025) Unsal, Velid; Ercan, Leyla; Caliskan, Cemile Gunbegi
Objectives In this study, phenolic compounds (PC), volatile compounds (VC), antioxidant, anti-inflammatory, and antimicrobial properties of the Thymbra spicata L. plant grown in the Mardin Yesilli region were investigated. The properties of compounds such as rhoifolin, leucoside, naringenin, rosmarinic acid, gamma-terpinene, and carvacrol, which were found to be higher than other compounds as a result of PC and VC analysis of Thymbra spicata L. plant, and the properties of non-steroidal anti-inflammatory drugs diclofenac and ketoprofen were compared with computer-based calculations. In this context, the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiles of the mentioned molecules were calculated, Density Functional Theory (DFT)-based quantum chemical calculations were performed, and molecular docking analyses were performed. In addition, the pharmacological properties, biological targets, and biological activities of these compounds were comprehensively evaluated. This study provides important data for understanding the therapeutic potential of these plant components. Materials and methods Chromatographic methods (GC-MS and LC-Orbitrap HRMS) were used to look at PC and VC profiles, spectrophotometry (ABTS, DPPH, CUPRAC) to look at antioxidant activities, and the disk diffusion method to look at antimicrobial properties. Results While the most detected volatile compounds were gamma-terpinene (35.34%), carvacrol (17.55%), caryophyllene (10.53%), and p-cymene (9.15%), the most detected phenolic compounds were rosmarinic acid (3334.9 ng/mL), naringenin (2610.00 ng/mL), leucoside (1956.42 ng/mL), and rhoifolin (1288.55 ng/mL). The ethanol extract of Thymbra spicata L. stopped the growth of K. aerogenes in particular. The IC50 value for DPPH was 158.01 mu g/mL, the IC50 value for ABTS was 185.03 mu g/mL, and the C0.5A value was 87.13 for the ethanol extract of Thymbra spicata L. The molecular docking results that the strongest binding energy was between TNF-alpha and naringenin (-6.77 kcal/mol), IL-6 and rosmarinic acid (-5.55 kcal/mol), and NLRP3 and carvacrol (-6.88 kcal/mol). Naringenin, rosmarinic acid, diclofenac, and ketoprofen completely violated the restrictions established by Lipinski, Ghose, Veber, Egan, and Muegge. Rosmarinic acid is the most reactive antioxidant compound with low energy deficit (Eg) and high softness (S). gamma-terpinene and carvacrol, on the other hand, are more stable and durable wit high hardness (eta) and low softness. Conclusion Naringenin, rosmarinic acid, and carvacrol demonstrate significant anti-inflammatory and immunomodulatory properties owing to their high binding affinity for TNF-alpha, IL-6, and NLRP3, positioning them as promising candidates for the treatment of inflammatory disorders. Naringenin and rosmarinic acid effectively target TNF-alpha, whereas carvacrol demonstrates potential in the management of NLRP3 inflammasome-associated diseases. The strong binding of rosmarinic acid to IL-6 shows that it can change the immune system. Thymbra spicata L., abundant in bioactive compounds, may provide benefits compared to conventional NSAIDs and exhibit potential as monotherapy or adjunctive therapies. Their strong anti-inflammatory, antioxidant, antimicrobial, and pharmacological properties, along with their safety, make naringenin, rosmarinic acid, and carvacrol good candidates for more preclinical and clinical research.
Citation - WoS: 2
Citation - Scopus: 2
Can Quercetin Reduce Arsenic Induced Toxicity in Mouse Balb/C 3t3 Fibroblast Cells ? A Study Involving in Vitro, Molecular Docking, and Adme Predictions
(Bmc, 2025) Unsal, Velid; Keskin, Cumali; Oner, Erkan
This study aimed to investigate the protective effect of quercetin against arsenic-induced oxidative damage, inflammation, and apoptosis in mouse BALB/c 3T3 fibroblast cells (NIH-3T3). Arsenic at different concentrations of 0.05 mu M (low), 0.5 mu M (medium), 10 mu M (high) doses were used to induce toxicity, while 120 mu m quercetin was used for treatment. MTT and LDH analyses were performed to determine the effect of arsenic and quercetin on cell viability, while oxidative stress markers and antioxidant enzyme activities were measured by spectrophotometric method. TNF-alpha and IL-1 beta levels were measured by the ELISA method, Autodock programs were used for molecular docking studies. In addition, computer-based analyses of quercetin and succimer molecules were performed using SwissADME web tools. TNF-alpha (PDB ID: 2AZ5), IL-1 beta (PDB ID: 1ITB), Caspase3 (PDB ID: 2XYG), Bax (PDB ID: 4S0O), SOD (PDB ID:1CBJ), GSH-Px (PDB ID: 1GP1) and Bcl-2 (PDB ID: 1G5M) crystal structures were obtained from the Protein Data Bank. Bax and Bcl-2 levels of apoptotic genes and mRNA expression levels of Caspase-3 activity were measured using the QRT-PCR technique. TUNEL staining was performed to determine DNA fragmentations, while DAPI staining was done to visualise nuclear modifications. Quercetin has been found to significantly reduce oxidative stress, inflammation, and apoptosis in cells and exert anti-apoptotic effects. Molecular docking studies revealed quercetin shows good binding affinity with molecules with SOD, GSH-Px, Bax, Bcl-2, Caspase-3, TNF-alpha and IL-1 beta structures, and has been observed to bind with Bax and Bcl-2 with molecular docking scores of -7.5 and - 7.7 kcal/mol, respectively. These findings are supported by results showing that quercetin is effective in anti-apoptotic and anti-inflammatory processes in arsenic-induced cells under in vitro conditions. In addition, when ADME values are examined, it can be considered that quercetin is a useful and effective candidate compound in reducing arsenic toxicity, considering its higher synthetic accessibility score, better pharmacokinetic properties, and good biological transition and interaction capacities compared to succimer.
Citation - WoS: 3
Suriyeli Mülteci Ergenlerin Yaşadıkları Gelişimsel Sorunların Bazı Demografik Değişkenler Açısından İncelenmesi
(İnsan & Toplum, 2020) Apak, Hıdır; Acar, Muhammet Cevat
Bu çalışma, Suriyeli mülteci ergenlerin yaşadıkları gelişimsel sorunları; Milli Eğitim Bakanlığı okullarında okuyan öğrenci görüşleri ışığında ortaya koymayı amaçlamaktadır. Bu çalışma, tarama modelinin kullanıldığı nicel bir araştırmadır. Araştırmanın örneklemini Mardin’de okuyan 338 Suriyeli mülteci ergen öğrenci oluşturmaktadır. Bu çalışmada veri toplama aracı olarak araştırmacılar tarafından hazırlanan sosyodemografik veri formu ve Gelişimsel Sorun Alanları Ölçeği kullanılmıştır. Veriler ANOVA, t-testi, LSD testi ve çoklu regresyon ile analiz edilmiştir. Araştırma bulgularından birine göre Suriyeli mülteci ergenlerin yaşadıkları; sınav kaygısı, öfke dışavurumu ve akademik başarısızlık sorunlarının ilk sıralarda yer almasıdır. Araştırmanın sonuçlarına göre ergenlerin yaşadıkları gelişimsel sorunların cinsiyete göre sıklık düzeylerine bakıldığında kızların erkeklere oranla daha fazla sorun yaşadıkları görülmektedir. Ayrıca bir işte çalışan ve bir kamp deneyimi olan mülteci ergenlerin diğer ergenlere göre gelişimsel sorunların sıklığını daha fazla yaşadıkları tespit edilmiştir. Gelişimsel sorun alanlarının toplamına bakıldığında Suriyeli mülteci ergenlerin ekonomik durumu kötüleştikçe daha fazla sorun yaşadıkları da ifade edilebilir.
Citation - WoS: 1
Citation - Scopus: 1
Knowledge of Tuberculosis Among Health Higher School Students'
(DERMAN MEDICAL PUBL, 2015) Bayram Değer, Vasfiye; Inanc, Betul Battaloglu; Cifci, Sema
Aim: Aimed to determine students' tuberculosis (tbc) knowledge level and effectiveness of education. Material and Method: A questionnaire form which consisting of 10 questions was applied to Mardin Artuklu University Health School students in 18-19 April 2013 to determine their level of knowledge before and after a two-day training for tuberculosis. Results: 196 students' data were included. After training, most common right answers rate were initially 22.4% whose vaccinated necessary, 13.7% whose control after tbc patient close contact and 13.3% what was the tbc illness agent were learned by students. After training, the way of diagnosis to patient was remained basically same, right answers rate decreased 1.5% which organs influence with tbc, 0.5% increased right answer rate for risk of spread tbc but remained lowest among the other right answers. Tbc disease agent is a bacteria, smudge with airway is agreed by the students' (p= 0.0001). Whose risk of developing tbc and how was treat patients was learned increasingly by students after training (p= 0.0001). Before training, awareness of the spread of tbc to lung, lymph node and brain membrane was known and was found significantly (p= 0.0001). After training, vaccination of infants (p< 0.001), and most common symptom of pulmonary tuberculosis (p= 0.0001) is shown statistically significant. After training was thought to diagnosed tbc with skin test was statistically significant (p < 0.001). Training was not change student's knowledge and approach this two points; whose control was necessary with tbc close contact persons' (p= 0.065) and what was the directly observed treatment (p= 0.058). Discussion: Although, our students' knowledge about tuberculosis is enough but continuing education programs, and updating of information must provide.
Citation - WoS: 4
Citation - Scopus: 5
Green biosynthesis of silver nanoparticles using Prunus cerasifera pissardii nigra leaf and their antimicrobial activities against some food pathogens
(Czech Journal of Food Sciences, 2022) Hatipoğlu, Abdulkerim
In this study, silver nanoparticles (AgNPs) were synthesised using the Prunus cerasifera pissardii nigra (PC) leaf extract in an easy, low-cost and environmentally friendly way. According to the ultraviolet-visible (UV-vis) spectrophotometer analysis data, the nanocrystals demonstrated a characteristic peak at 456 nm. Scanning electron microscopy (SEM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and energy-dispersive X-ray (EDX) spectroscopy analyses revealed that the morphological structures of the biosynthesised AgNPs were mostly spherical. According to the results of X-ray diffraction (XRD) analysis, it was determined that the crystal structures of AgNPs were cubic. The size of the nanoparticles was calculated as 23.60 nm using the Debye-Scherrer equation. The zeta potential of the synthesised nanomaterial was measured as –15.5 mV. The minimum inhibitory concentration (MIC) values of AgNPs on Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 11774, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were determined to be 0.062, 0.250, 0.125, 0.500 and 0.125 µg mL–1, respectively
Citation - WoS: 4
Citation - Scopus: 4
DEVELOPING THE ONLINE PORNOGRAPHY ADDICTION SCALE AND EXAMINING ITS ASSOCIATIONS WITH PSYCHOSOCIAL FACTORS
(Fundacion VECA, 2023) Ergün, Naif
This study aims to develop the Online Pornography Addiction Scale (OPAS) using the behavioral addiction model and to explore the relationships between the scale, demographic variables, psychosocial variables, and pornography viewing behaviors. Two studies were conducted, the first of which involved two phases. The findings from Study 1a and Study 1b reveal that the OPAS comprises 23 items organized into four sub-scales: Compulsiveness-Uncontrollability, Psychosocial Effects, Sexual Effects, and Tolerance-Withdrawal. Overall, the scale demonstrates consistency and reliability. The results of Study 2 indicate that the OPAS correlates with gender, access to professional support, levels of hopelessness, communication with partners, degree of religious affiliation, engagement with sexual videos, frequency of pornography consumption, time devoted to pornography viewing, longest duration without pornography, impact of pornography on sexual experiences, and influence of pornography on daily life. Communication with partners of the opposite sex, engagement with sexual videos, impact on daily life, and religious affiliation levels are also significant predictors of the OPAS score. These findings are discussed in relation to relevant literature

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