Tıbbi Hizmetler ve Teknikler Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/159

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Citation - WoS: 6
Citation - Scopus: 14
Adsorptive Performance of Magnetic Nano-Biosorbent for Binary Dyes and Investigation of Comparative Biosorption
(Springer Nature, 2019) Tarhan, T.; Tarhan, Tuba; Tural, B.; Boga, K.; Tural, S.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The individual and competitive biosorption capacities of Metanil Yellow (MY) and Reactive Black 5 (RB5) by glutaraldehyde cross-linked magnetic chitosan nanoparticles (GMCNs) were studied. Competitive biosorption of the MY and RB5 dyes by the GMCNs has never been reported previously. Fourier transform infrared technique has been used to show the biosorbed MY and RB5 dyes onto GMCNs. During the studies, various essential factors influencing the biosorption, like adsorbate concentration, pH of the solution and contact time have been monitored. The equilibrium was achieved within 17 h for single dyes and 3 h for binary mixture at pH 3. The biosorption capacities were 620 mg/g for dye MY and 2549 mg/g for dye RB5 at pH 3, 30 °C. The second-order kinetic model has good compatibility with the dynamical biosorption behavior of a single dye and binary mixture. In order to study the competition biosorption of the RB5 and MY dyes in mixture solutions, the intraparticle diffusion model was used. Competition biosorption through analysis of the intraparticle diffusion model apparently favored the RB5 dye more than the MY dye on the GMCNs in mixture solutions. The biosorbent was regenerated efficiently through the alkaline solution and was then reused ten times for biosorption–desorption cycles. © 2018, Springer Nature Switzerland AG.
Citation - WoS: 8
Citation - Scopus: 3
Cardioprotectiveeffectsof Hypericumtriquetrifoliumturra. Against Cyclophosphamide Related Cardiotoxicity in Rats
(2018) Çetik Yıldız, Songül; Keskin, Cumali; Ayhanci, Adnan; Şahintürk, Varol; Yıldız, Songul Cetık; Keskin, Cumali; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Cyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifoliumTurra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino ratswererandomlydividedinto9groups,eachincluded7animals.Serumcreatinekinase-MB(CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.
Citation - Scopus: 0
Comparison Of Different Life Stages Of Total, Phospholipid And Triacylglycerol Fatty Acids Of Lucilia Sericata
(ABADER (Adıyaman Bilimsel Arastırmalar Dernegi), 2021) Kizmaz, V.
Lucilia sericata, which belongs to the Calliphoridae family (Diptera), is used as a debridement tool in open necrotic wounds that do not respond to conventional treatments. Knowing the total, phospholipid (PL), and triacylglycerol (TAG) fatty acid content of L. sericata fly, which is important for health, in its different stages is important both in terms of taxonomy and physiology. After L. sericata samples used in the study were obtained commercially, they were bred under laboratory conditions and then the fatty acids in different stages were analyzed by gas chromatography. Sixteen fatty acids are determined as a result of the analysis. When individual fatty acids are considered, Palmitic acid (16:0), Palmitoleic Acid (16:1n-7), oleic acid (18:1n-9) and Linoleic Acid (18:2n-6) were found to be major ones, while the others are detected in trace amounts. It is determined that, out of total, PL and TAG, saturated fatty acids (SFA) are found at a high percentage in the eggs, monounsaturated fatty acids (MUFA) are the highest in the larvae, and polyunsaturated fatty acids (PUFA) are the highest in fly and pupa. Furthermore, out of total, PL and TAG, ∑PUFA is at a low percentage in the egg and the larval stages. Different results are found at different stages in this study. This may be because fatty acid percentages that change during metamorphosis meet different physiological needs at different phases. © 2021, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.
Citation - WoS: 13
Citation - Scopus: 10
Determination of Essential Oil Composition, Antimicrobial and Antioxidant Properties of Anise (Pimpinella Anisum L.) and Cumin (Cuminum Cyminum L.) Seeds
(Ankara University, 2014) Haşimi, N.; Tolan, Veysel; Tolan, V.; Kizil, S.; Kilinç, E.; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü
In this research, the essential oil components, antimicrobial and antioxidant properties of anise (Pimpinella anisum L.) and cumin (Cuminum cyminum L.) seed oils were investigated. The essential oil components determined by GC/MS instrument. The antimicrobial activity determined by disc diffusion method against the gram negative bacteria, namely Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, the gram positive bacteria namely Staphylococcus aureus ATCC 25923, Streptococcus pyogenes ATCC19615 and Candida albicans ATCC10231 as the yeast. The antioxidant activities of essential oils were carried out by DPPH free radical scavenging activity method. It was determined that the main components of the anise essential oil were trans-anethole (52.94%) followed by iso-anethole (13.89%), caryophllene oxide (8.55%) and caryophyllene (29.4%); the main components of the cumin essential oil were β-pinene (15.77%), α-terpinene (15:52%), 1-Phenyl-1-butanol (15:13%), cumic aldehyde (12.74%) respectively. Anise essential oil showed weak antimicrobial activity and cumin essential oil showed moderate antimicrobial activity against test microorganisms. Cumin essential oil showed strong antimicrobial activity against C. albicans with 22±0.9 mm inhibition zone diameter. P. aeruginosa showed resistance to both essential oils. The antioxidant activity of cumin essential oil (75.60%) was observed closer to ascorbic acid (78.75%), higher than BHA (50.45%) and BHT (23.54%). Although anise essential oil exhibited low activity, it has the similar activity with BHT. The scavenging activity of the samples decreasing order was ascorbic acid> cumin >BHA>BHT> anise. © Ankara Üniversitesi Ziraat Fakültesi.
Citation - WoS: 4
Citation - Scopus: 5
Determination of zinc in dried nuts by slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS) with citric acid-coated magnetic nanoparticle (CAMNP) based solid phase extraction (SPE)
(Taylor & Francis inc, 2025) Umaz, Adil; Umaz, Adil; Aydin, Isil; Aydin, Firat; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
This study reports a sensitive method for trace zinc using slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS) with citric acid-coated magnetic nanoparticle-solid phase extraction (CAMNP-SPE). To increase the efficiency, we univariately optimized the pH, buffer volume, CAMNP mass, eluent concentration and volume, mixing type and time, temperature, and interaction time. The study identified the limits of detection and quantification values for CAMNP-SPE-SQT-FAAS under the specified optimum conditions to be 12.30 and 41.00 mu g L-1, respectively. The newly developed method improved the detection power of traditional FAAS by 13.25 times. The findings of this study report a sensitive and accurate method to determine trace zinc in complex matrices.
Citation - WoS: 4
Citation - Scopus: 3
A Histopathological, Immunohistochemical and Biochemical Investigation on the in Vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum Triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity
(Inst Tecnologia Parana, 2019) Keskin, Cumali; Yildiz, Songul Cetik; Keskin, Cumali; Çetik Yıldız, Songül; Sahinturk, Varol; Ayhanci, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The aim of this study was to investigate in vitro antioxidant properties and in vivo protective effects of the methanol extract of the Hypericum triquetrifolium Turra (HT) seed against acute hepatotoxicity, myelotoxicity and hematotoxicity in rats induced by cyclophosphamide (CP). In order to investigate in vivo protective effects of the HT extract on rat tissues, the rats were divided into nine groups. The toxic effects of CP and the protective effects of HT extract on nucleated cells that are produced by bone marrow, serum alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and oxidative stress index (OSI) levels were investigated biochemically. Additionally, liver tissue samples were examined for histopathological changes and apoptosis by Bcl-2, Bax and caspase-3 immunohistochemistry. The results of this study show that HT seed methanol extract has high total phenolic content (179.52 mu g GAE/mg) and antioxidant activity (87.48% in 500 mu g/mL concentration). CP administration caused hepatotoxicity, myelotoxicity and hematotoxicity in the rats. Whereas, the groups of rats that were injected with different concentrations of HT (25, 50 and 100 mg/kg) and CP (150 mg/kg) showed significant protective effects on bone marrow nucleated cells and important decreases on serum ALT, ALP, LDH and OSI levels were observed when compared with the CP injected group.
Citation - WoS: 17
Citation - Scopus: 14
In-Vitro Antioxidant, Cytotoxic, Cholinesterase Inhibitory Activities and Anti-Genotoxic Effects of Hypericum Retusum Aucher Flowers, Fruits and Seeds Methanol Extracts in Human Mononuclear Leukocytes
(Iranian Journal of Pharmaceutical Research, 2017) Keskin, Cumali; Aktepe, Necmettin; Yükselten, Y.; Asuman,; Boğa, M.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Nursing / Hemşirelik Bölümü
The present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of Hypericum retusum AUCHER. The amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by HPLC. Total phenolic content of H. retusum seed extract was found more than fruit and flower extracts. The DPPH free radical scavenging activity of flower and seed methanol extracts showed close activity versus BHT as control. Among three extracts of H. retusum only flower methanol extract was exhibited considerable cytotoxic activities against to HeLa and NRK-52E cell lines. Moreover, seed methanol extract showed both acetyl and butyrl-cholinesterase inhibitory activity. The highest anti-genotoxic effects were seen 25 and 50 μg/mL concentrations. In this study, the extracts showed a strong antioxidant and anti-genotoxic effect. The seed extract was more efficient- than extracts of fruit and flowers. Our results suggest that the antioxidant and anti-genotoxic effects of extracts depend on their phenolic contents. Further studies should evaluate the in-vitro and in-vivo the benefits of H. retusum seed methanol extracts. © 2017 by School of Pharmacy.
Citation - WoS: 1
Citation - Scopus: 1
Investigate Nasal Colonize Staphylococcus Species Biofilm Produced
(Journal of Clinical and Analytical Medicine, 2015) Demir, Cemil; İnanç, B.B.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Aim: 127 S.aureus and 65 CoNS strains were isolated from patients noses’. To produce a biofilm ability was investigated using three different methods. Slime-positive and negative staphylococcies’ resistance were evaluated against different antibiotics. Material and Method: Swap samples puted 7% blood agar. Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates biofilm produced ability were investigated using Congo Red Agar (CRA), microplates (MP) and Standard Tube (ST) methods. In addition to that, presence of antibiotic resistance of the staphylococcal isolates are determined agar disc diffusion method. Results: The rate of biofilm produc-ing Staphylococcus spp strains was found to be 72.4%, 67.7%, and 62.9%, respectively with CRA, MP, and ST tests. There was no significant relationship among the tests (p>0.05). In addition, antibiotic resistance of Staphylococcus spp. against various antibiotics was also determined by the agar disk dif-fusion method. Resistance rates of biofilm positive (BP) Staphylococcus spp for penicilin G, ampicilin, amocycilin/clavulanic acid, tetracyclin, eritromycin, gentamycin, and enrofloxacin 71.7%, 69.7%, 6.2%, 20.7%, 21.4%, 1.4%, and 0.7%, respectively. Resistance rates of biofilm negative (BN) spp for 42.6%, 23.4%, 4.3%, 14.9%, 19.1%, 0.0%, 0.0% respectively. All Staphylococcus isolates were found to be susceptible to vancomycin and teicaplonin. Although BP strains antibiotic resistance rates were observed higher than BN strains. But resistance rates were not found statistically significant (p>0.05). Discus-sion: CRA is the reliablity and specifity method to determine Staphylococcus spp. biofilm produce ability. © 2015, Journal of Clinical and Analytical Medicine. All rights reserved.
Citation - WoS: 3
Investigation of Uroprotective Effects of Seed Methanol Extracts of Hypericum Triquetrifolium Turra. on Cyclophosphamide-Induced Bladder Hemorrhagic Cystitis and Nephrotoxicity in Wistar Albino Rats
(Cukurova Univ, Fac Medicine, 2020) Keskin, Cumali; Çetik Yıldız, Songül; Sahinturk, Varol; Ayhanci, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats. Materials and Methods: Wistar albino rats used in this study were divided into nine groups, each including seven rats. Group 1 (control) was treated with 0.5ml saline (SF) and Group 2 was treated with CYP (150 mg/kg). Groups 3, 4, 5 were treated with 25, 50, 100 mg/kg HT, respectively while groups 6, 7, 8 were treated with 25, 50, 100 mg/kg CYP + HT, respectively. Finally, Group 9 (control-2) was treated with 0.5ml-%0.2 dimethyl sulfoxide (DMSO). The serum creatinine, blood urea nitrogen (BUN), superoxide dismutase (SOD) and catalase (CAT) levels were measured in blood serum. Results: The CYP-treated rats histopathologically had mild-moderate bladder and renal injuries. The serum creatinine and BUN levels, which are the biochemical markers of renal injury, significantly increased compared to the control group. Conclusion: HT showed a protective effect on CYPrelated bladder HC and nephrotoxicity in rats by inhibiting inflammation and apoptosis.
Citation - WoS: 10
Citation - Scopus: 10
Role of 2.4 Ghz Radiofrequency Radiation Emitted From Wi-Fi on Some Mirna and Faty Acids Composition in Brain
(Taylor & Francis inc, 2022) Kızmaz, Veysi; Akdag, Mehmet Zulkuf; Bashan, Mehmet; Kizmaz, Veysi; Erdal, Nurten; Erdal, Mehmet Emin; Yegin, Korkut; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The purpose of this study is to investigate the effects of 2.4 GHz Wi-Fi exposure, which is continuously used in the internet connection by mobile phones, computers and other wireless equipment, on microRNA and membrane and depot fatty acid composition of brain cells. Sixteen Wistar Albino rats were divided equally into two groups such as sham and exposure. The rats in the experimental group (n = 8) were exposed to 2.4 GHz RFR emitted from a Wi-Fi generator for 24 h/day for one year. The animals in the control group (n = 8) were kept under the same conditions as the experimental group, but the Wi-Fi generator was turned off. At the end of the study, rats were sacrificed and brains were removed to analyze miRNA expression and membrane and depot fatty acids of brain cells. We analyzed the situation of ten different miRNA expressions and nineteen fatty acid patterns in this study. We observed that long-term and excessive exposure of 2.4 GHz Wi-Fi radiation increased rno-miR-181a-5p, phosphatidylserine (PS) and triacylglycerol (TAG) in the brain. In conclusion, 2.4 GHz Wi-Fi exposure has the potential to alter rno-miR-181a-5p expression and the fatty acid percentage of some membrane lipids such as phospholipid (PL), phosphatidylserine (PS) and triacylglycerol (TAG), which are depot fats in the brain. However, the uncontrolled use of RFRs, whose use and diversity have reached incredible levels with each passing day and which are increasing in the future, may be paving the way for many diseases that we cannot connect with today.
Citation - WoS: 2
Citation - Scopus: 10
Study of Endogenous Paramagnetic Centers in Biological Systems From Different Areas
(John Wiley and Sons Inc, 2021) Keskin, Cumali; Khalilov, R.; Abiyev, H.; Kavetskyy, T.; Trubitsin, B.; Keskin, C.; Eftekhari, A.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Plant leaves (Eldar pine (Pinus eldarica M.), fig (Ficus carica L.), and olive (Olea europaea L.)), collected in territories with different ecological conditions, of the Absheron Peninsula (Azerbaijan Republic) were studied by electron paramagnetic resonance spectroscopy (EPR). The generation of nanophase iron oxide magnetic particles in biological systems under the influence of stress factors was revealed. It was found that the process of biomineralization plays a role in the formation of biogenic iron oxide magnetic nanoparticles in plants and the generation of magnetite crystals in biological tissues, and stress factors have a stimulating effect on this phenomenon. Copyright © 2021 Aygun Nasibova et al.
Citation - WoS: 0
Citation - Scopus: 1
Synthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV)
(Elsevier Science Sa, 2024) Dündar, Abdurrahman; Ozdemir, Sadin; Dundar, Abdurrahman; Agirtas, Mehmet Salih; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In this study, bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) was obtained from the reaction of 3,4,5-trimethoxybenzyl alcohol with SiPcCl 2 . This phthalocyanine was characterized using 1 H NMR, FTIR, UV - vis and mass spectra. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, antidiabetic, deoxyribonucleic acid (DNA) cutting, biofilm inhibition, anti -microbial and antimicrobial photodynamic therapy (aPDT) activities of newly synthesized bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) molecule were studied. The best activities were 41.58 % at 100 mg/L for antioxidant and 41.66 % for antidiabetic at 400 mg/L concentration. The molecule degraded the biofilm matrix formed by Pseudomonas aeruginosa and Staphylococcus aureus as 78.61 % and 89.26 %, at 50 mg/L concentration, respectively. It was observed that E. coli , which was used as a model microorganism, was inhibited at a level close to 100 % even at the lowest concentration of 50 mg/L. While double strand break was observed at 50 mg/L DNA cutting activity, it was determined that DNA was reduced to nucleotides at 100 and 200 mg/L. The Pc also displayed effective antimicrobial and aPDT abilities against pathogens. With the application of aPDT, the effectiveness of antimicrobial activity increased 2 to 4 times. These increase rates are very important. The main conclusion of the study was that the newly synthesized compound exhibited various effective biological activities such as effective antioxidant, antidiabetic, DNA cleavage, antimicrobial, aPDT, biofilm inhibition and microbial cell viability inhibition.
Citation - Scopus: 1
Synthesis and Characterization of Boron Nitride Nanotubes (Bnnts) With a New Method and Precursor Materials
(Gumushane University, 2021) Tarhan, T.; Tarhan, Tuba; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Boron nitride nanotubes (BNNTs) have many application areas thanks to their superior properties such as thermal and electrical insulation, resistance to oxidation, high hydrophobicity, and high hydrogen storage capacity, as well as biocompatible properties. Therefore, new synthesis methods are being searched for BNNT with increasing interest in recent years. In this study, high purity and yield BNNTs were synthesized using precursor materials and methods that were not previously tried in the literature. A chemical vapor storage (CVD) furnace was used for the synthesis, and various parameters were changed to achieve optimum conditions. The structure of the obtained BNNTs was characterized by Fourier conversion infrared spectroscopy (FTIR), Raman spectroscopy, and a UV-visible spectrophotometer. In addition, surface morphologies were illuminated using transmission electron microscopy (TEM) and scanning electron microscopy (SEM). However, it has been observed that BNNTs obtained as a result of HR-TEM (high-resolution transmission electron microscope) analysis have a single-walled structure that is difficult to synthesize. This increases the importance and quality of synthesized BNNTs. © 2021, Gumushane University. All rights reserved.
Citation - WoS: 11
Citation - Scopus: 13
Synthesis and Characterization of New Branched Magnetic Nanocomposite for Loading and Release of Topotecan Anti-Cancer Drug
(Springer, 2019) Tarhan, T.; Tarhan, Tuba; Tural, B.; Tural, S.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The purpose of this study is to synthesize the new branched magnetic nanocomposite to carry the therapeutic agents and bio-macromolecules. Although topotecan (TPT) has significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers, lactone ring opening causes a reduction in cytotoxic activity and severe side effects in physiological conditions. In order to contribute to the removal of the handicap (lactone ring opening), magnetic dextran branched with NαNα-Bis (carboxymethyl)-l-lysine hydrate (NTA) nanoparticles (MD3) were prepared. The characterization of the resulting MD3 material was done by using multi-pronged analyses. The stability and release of TPT with synthesized and characterized new material of the MD3 was studied using various essential factors like concentration, dosage, pH, and time. The entrapment efficiency and loading capacity of TPT onto MD3 was calculated as 32.2% and 1.44 mg/g, respectively, at pH 5. Release studies were performed with drug-loaded MD3 at different pH values. It was seen that the best release was obtained at the cancerous site pH. Initial drug concentration was measured as 0.118 mM. The loaded drug concentration was calculated as 0.0380 mM at pH 5 and 0.00092 mM of drug was released after 90 min at pH 5.8. Percentage released of drug was found as 2.42% during 90 min. [Figure not available: see fulltext.]. © 2019, The Author(s).
Citation - WoS: 6
Citation - Scopus: 6
Synthesis and characterization of novel magnetic nano-catalyst (Fe3O4@SiO2@EDDHA-Fe) and their hydrogen production activity
(Elsevier Sci Ltd, 2024) Umaz, Adil; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Due to irreparable crises for nature and people, replacing fossil fuel -based energy with green energy sources is a necessity for nature and humanity. Hydrogen is considered a clean energy transport due to its high energy density, environmental friendliness, high efficiency, and recyclable nature. This study generated hydrogen through NaBH 4 ethanolysis. In hydrogen production studies, there are very few studies with magnetic nano catalysts and very few studies with cheap transition metals. In order to contribute to the literature in this field, in this study, Fe 3 O 4 @SiO 2 @EDDHA-Fe was produced for the first time and used in hydrogen production studies. Fe 3 O 4 @SiO 2 @EDDHA-Fe synthesis was successfully carried out and hydrogen production was successfully implemented. The study also utilized FT-IR, XRD, VSM, BET, and SEM-EDX methods to characterize the structural, physical, and chemical properties of MNCs. The average particle diameter and magnetization value of Fe 3 O 4 @SiO 2 @EDDHA-Fe were 12.81 nm and 30.6 emu/g, respectively. The catalysis experiment designed with 50 mg Fe 3 O 4 @SiO 2 @EDDHA-Fe and 93.75 mM NaBH 4 generated 840 mL H 2 /g NaBH 4 298 K and 947 mL H 2 /g NaBH 4 318 K in 5 -min duration, respectively. At room temperature, the hydrogen generation rate (HGR) and activation energy (Ea) of Fe 3 O 4 @SiO 2 @EDDHA-Fe reaction were calculated as 1040 mL H 2 /gcat & sdot; min and 5.39 kJ/mol, respectively. After the sixth cycle, the reusability test of Fe 3 O 4 @SiO 2 @EDDHA-Fe reaction still retained approximately 87% of the initial hydrogen production volume. The study concluded that Fe 3 O 4 @SiO 2 @EDDHA- Fe is a promising catalyst in hydrogen production from NaBH 4 ethanolysis, as it is affordable and easy to prepare compared to other expensive catalysts.
Citation - WoS: 0
Synthesis and Characterization of the Branched Magnetic Polymer for Drug Delivery Systems
(Wiley-Blackwell, 2016) Tarhan, Tuba; Tarhan, T.; Tural, B.; Tural, S.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Citation - WoS: 3
Citation - Scopus: 3
Synthesis, Characterization, Aggregation Behavior, Antioxidant Activity, and Antibacterial Activity of Metallophthalocyanines Carrying Four Phthalonitriles Group
(Editura Acad Romane, 2016) Guven, M. Emin; Dündar, Abdurrahman; Agirtas, M. Salih; Ozdemir, Sadin; Dundar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
A novel phthalonitrile derivative and zinc (II), cobalt (II), and cupper (II) phthalocyanines complexes were synthesis and characterized. The novel compounds have been characterized by using various spectroscopic data FTIR, UV/vis, NMR, elemental analysis etc. The aggregation investigations carried out in different concentrations indicate that 4- (4-(1-(4-phenoxypheny1)-1-phenylethyl)phenoxy)phthalonitrile substituted phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-5) M in tetrahydrofuran. The antioxidant properties of the phthalonitrile and its phthalocyanine compounds were evaluated in three series of in vitro tests: DPPH free radical scavenging, ferrous ion chelating activity and reducing power. Antimicrobial activities of compounds were investigated.
Citation - WoS: 1
Citation - Scopus: 1
Trace Metal Determination in the Medicinal Plant Hyoscyamus (Solanaceae) by Inductively Coupled Plasma Optical Emission Spectrometry
(Perkin - Elmer Corp., 2014) Keskin, Cumali; Kisin, E.; Yavuz, M.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The concentrations of Cd, Ni, Cu, Pb, Cr, Fe, B, and A1 were determined in four different medicinal plants of the Hyoscyamus species: Hyoscyamus reticulums L, Hyoscyamus leptocalyx STAPF, Hyoscyamus aureus L, and Hyoscyamus albus L by ICP-OES. By considering the sensitivity of ICP-OES with respect to the trace level determination of Cd, Ni, Cu, Pb, Cr, Fe, B, and Al in the studied plant samples and the limitations of sample amount possible in a microwave digestion procedure, the ashing method was applied before analysis and proved the quantitative measurements of the elements.The accuracy of the method was verified by comparison to the certified reference sample NCSZC 73014 Tea Leaves. The RSD values were between 0.14-10.4%, while the error values were in the 90-107% range. The results show that with the proposed method higher concentrations of Ni, Cr, Pb, Fe, and B were determined in H. aureus. Interestingly, the concentration of Cu in H. reticulatus was approximately 48.5 times higher than the mean Cu values of the other three Hyoscyamus species, while the Pb concentration levels in H. aureus were 17.8 times higher than in the H. reticulatus L, H. leptocalyx STAPF, and H. albus L species.

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