WoS İndeksli Yayınlar Koleksiyonu

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Acute Effects of Combined and Isolated Caffeine and Theanine Supplementation on Physical and Cognitive Performance in Competitive Athletes: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
(Frontiers Media SA, 2026) Erkan, Dilara; Gundem, Mehmet Can; Sari, Cengizhan; Akca, Firat; Ozdenk, Serhat; Yildirim, Ulas Can; Tuncer, Selin Yildirim
Introduction Modern athletic performance is driven not only by physical capacity but also by rapid decision-making, attentional control, and visuomotor coordination. Evidence regarding the acute effects of caffeine (CAF), L-theanine (TEA), and their combination remains inconsistent, particularly with respect to their combined influence on physical and cognitive performance in athletic populations. This study examined the acute effects of isolated and combined CAF and TEA supplementation on maximal strength, intermittent aerobic endurance, and eye-hand coordination in competitive athletes. It was hypothesized that the combined ingestion of CAF and TEA would differentially affect physical performance and eye-hand coordination outcomes compared with isolated CAF or TEA intake.Methods Twenty trained athletes completed four randomized, double-blind, placebo-controlled crossover conditions: CAF (3 mgkg-1), TEA (200 mg), CAF+TEA (COM), and placebo (CON), with >= 72 h washout. Outcomes included isometric leg, back, and handgrip strength; Yo-Yo Intermittent Endurance Test Level 1 performance; and visuomotor coordination (CogniFit (R)). Data were analyzed using repeated-measures ANOVA with Bonferroni corrections (alpha = 0.05).Results Condition effects were found for leg strength (p = 0.004, eta p2 = 0.24) and back strength (p = 0.008, eta p2 = 0.19). In the COM condition, no additional or synergistic effect on maximal strength was observed. Additionally, no significant difference was found between the conditions in aerobic endurance, maximum isometric handgrip strength, and hand-eye coordination results. Caffeine ingestion did not differ from placebo for any strength outcome under the present conditions. Finally, acute ingestion of TEA was associated with reduced maximal isometric leg and back strength compared with CAF and CON.Discussion Findings challenge the prevailing assumption of CAF + TEA synergy and underscore the need for task-specific interpretation of co-supplementation strategies. Future studies should evaluate dose-response interactions, habitual caffeine intake, sex-specific responses, and broader cognitive domains beyond visuomotor control. The randomized controlled trial was registered at ClinicalTrials.gov, under the registration number NCT07268573.Clinical Trial Registration ClinicalTrials.gov, NCT07268573.
Alternaria Alternata Causing Inner Black Rot of Lemon (Citrus Limon) Fruits in Turkey: Genetic Diversity and Characterisation
(Academic Press Ltd- Elsevier Science Ltd, 2023) Gunen, Tacettin Utku; Ozer, Goksel; Dervis, Sibel; Guney, Inci Guler; Tekin, Fatih
The market sales of symptomless lemons in 2020 revealed a persistent and severe internal black rot with browning of the membrane wall and juice sac. To investigate the causal agent, externally symptom-free lemons from Mediterranean locations were sampled from supermarkets, local markets, and bazaars in three southeastern Turkish provinces. Internal black rot symptoms were observed in 13.69% of the 1300 externally symptomless fruits, and Alternaria was isolated from 96.63% of those exhibiting these symptoms. Morphological analysis confirmed the identity of Alternaria alternata in 26 representative isolates collected from various markets and bazaars. To examine genetic diversity or polymorphisms, start codon targeted (SCoT) markers were used. Species identification was based on the sequences of translation elongation factor 1-alpha (TEF 1-alpha), RNA polymerase second largest subunit (RPB2), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). SCoT 29 exhibited the highest amount of polymorphic amplicons, with 18 polymorphic bands scored when compared to the other six scoreable markers. The 26 representative isolates from various markets and bazaars were divided into four clades by SCoT 29. However, multilocus sequence analyses confirmed the identification of a single species, A. alternata. In terms of virulence and the impact of temperature on growth, representative isolates from four SCoT clusters were evaluated. Data suggests that SCoT markers can be used to evaluate virulence-based polymorphism in A. alternata; nonetheless, all clades showed comparable temperature responses, with 25 degrees C being the optimum. There was also no association between individual morphotypes and SCoT clade membership. Due to the lack of obvious signs on lemon fruits, producers, merchants, and consumers are unable to identify black rot, and the widespread presence of A. alternata in lemons may pose a significant risk that must be avoided at all costs.
Analysis of Microorganisms Isolated from Tracheal Aspirate Cultures and Their Antibiotic Susceptibility Profiles: A Retrospective Study from 2018 to 2022
(Frontiers Media SA, 2026) Sanmak, Erkan; Cil, Baris; Ayaydin, Zeynep; Canbaz, Hayri; Davarci, Ismail; Gokdemir, Gul Sahika; Guler, Gokhan
Background: To determine the distribution of microorganisms isolated from tracheal aspirate (TA) cultures and their antimicrobial susceptibility patterns, and to assess resistance differences between intensive care unit (ICU) - and ward-derived isolates as well as temporal trends across years. Methods: Tracheal aspirate specimens obtained at a tertiary-care center between 2018 and 2022 were retrospectively reviewed. Only growth meeting laboratory acceptance criteria for causative pathogens was analyzed (semi-quantitative culture thresholds with cytologic quality control). Bacterial identification was performed using automated systems, and antimicrobial susceptibility testing was interpreted according to EUCAST standards. In addition to descriptive analyses, annual resistance trends and a joinpoint regression analysis (annual percent change) were conducted. Results: Of all causative isolates, 83.8% were Gram-negative. The most frequent pathogens were Klebsiella spp., Acinetobacter spp., and Pseudomonas spp. For Klebsiella spp., resistance to cephalosporins and fluoroquinolones was generally >90%, meropenem >80%, whereas imipenem showed comparatively higher susceptibility. In Acinetobacter spp., resistance was very high to most agents, with amikacin showing the lowest resistance. In Pseudomonas spp., resistance rates ranged from 40% to 55%, and amikacin emerged as the most active agent. Resistance was systematically higher in ICU-derived isolates than in ward isolates. Joinpoint analysis identified a single breakpoint around 2020; resistance trajectories during 2018-2020 were heterogeneous, with increases observed for some organism-antimicrobial combinations, followed by divergent patterns thereafter. Conclusion: The predominance of Gram-negative pathogens and the high resistance burden in our center support locally tailored Gram-negative coverage for empiric therapy alongside early de-escalation. Temporal patterns underscore the need to update empiric policies using annual local surveillance data and to reinforce infection control and antimicrobial stewardship, particularly in ICUs.
Anesthesia Management in a Crisponi Syndrome Patient Undergoing Tracheotomy Surgery
(Wiley, 2025) Kursun, Osman Oguzhan; Celik, Enes; Akelma, Hakan; Ipek, Yusuf; Talay, Mehmet Nur
Increased salivation and contractions of the oropharyngeal muscles are frequently observed in Crisponi syndrome. This causes frequent recurrent lung infections. Anesthesia management can be challenging due to the frequent convulsions that occur during the intubation and extubation of the patient and subsequent cyanosis and hyperthermia attacks. Cold-induced sweating attacks may also occur due to the low operating room temperature. Hyperthermia attacks can lead to rhabdomyolysis and disseminated intravascular coagulation. Sudden deaths may occur in children with Crisponi syndrome. Hyperthermia, paroxysmal muscular contractions and trismus due to autonomic dysfunction are held responsible for sudden deaths.
Astaxanthin Attenuates Bisphenol A-Induced Testicular Toxicity in Wistar Rats by Reducing Apoptosis and Fibrosis via Bax/Bcl-2 Balance and Collagen Gene Expression
(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2026) Savas, Hasan Basri; Kalkan, Serpil; Canbaz, Halime Tuba; Ayan, Ilknur Cinar; Sozen, Mehmet Enes; Canbaz, Furkan Adem; Arslan, Hilal
Bisphenol A (BPA), a synthetic compound widely used in plastic manufacturing, has been shown to cause testicular damage and disrupt spermatogenesis. This study aimed to investigate the potential protective effects of astaxanthin (AST) against BPAinduced testicular injury. Four experimental groups of Wistar Albino rats were established (n=8 per group): Control, Sham, BPA, and BPA+AST. At the conclusion of the study, serum samples were analyzed for total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI) [OSI=TOS/TAC], and CRP. Histopathological evaluations included measurements of tubule diameter, Johnsen scoring, and Masson's trichrome staining. The expression levels of anti-B-cell lymphoma 2 (Bcl-2) and anti-Bcl-2-associated X protein (Bax) were assessed using immunofluorescence (IF) staining and RT-qPCR in testicular tissues. Additionally, tissue collagen (COL1A1, COL3A1) expressions were quantified via RT-qPCR. Results indicated significant increases in TOS, OSI, and CRP levels in the BPA group (p<0.001, p<0.001, and p=0.042, respectively), while TAC levels remained unchanged (p=0.119). AST administration did not significantly alter these biochemical parameters. Histopathological analysis revealed decreased Johnsen scores and tubule diameters in the BPA group; however, these metrics improved in the BPA+AST group. IF analysis confirmed that AST restored the pro-apoptotic Bax/Bcl-2 imbalance induced by BPA (p<0.001), although RT-qPCR results indicated that AST normalized only Bax expression (p<0.001) while Bcl-2 levels remained unchanged (p=0.487). Moreover, COL1A1 and COL3A1 were significantly upregulated in the BPA group (p<0.001 for both), and Masson's trichrome staining corroborated the presence of fibrosis in this group. AST treatment mitigated these fibrotic changes, as evidenced by reductions in gene expression (p=0.001 for COL1A1 and p=0.005 for COL3A1) and improvements in Masson's trichrome staining. In conclusion, this study suggests that AST may confer a protective effect against BPA-induced testicular damage by reducing apoptosis and fibrosis; however, changes in oxidative stress markers did not achieve statistical significance. Furthermore, AST may enhance spermatogenesis.
Asylum Seekers in Healthcare Settings as a Human Rights Matter: Examining the Attitudes of Healthcare Professionals to Asylum Seekers in Türkiye
(Springer INT Publ AG, 2026) Zengin, Oguzhan; Tatlicioglu, Oktay; Cay, Murat; Snoubar, Yaser; Apak, Hidir
This study examines the attitudes and prejudices of healthcare professionals towards asylum seekers in Türkiye, investigating the influence of important demographic factors such as age, profession, and contact with asylum seekers. Using a quantitative, cross-sectional design, data are gathered through an online survey of 423 healthcare professionals. The results indicate professional experience and age have significant influences on attitudes, with young professionals with little experience having more positive views. In addition, healthcare professionals who have positive contact with asylum seekers have significantly decreased prejudice. The results highlight the relevance of cultural competency, exposure, and professional training in shaping equitable healthcare attitudes. The study affirms the need for formal training programs which integrate social work expertise in order to counteract prejudices and ensure culturally competent healthcare practices. The elimination of discriminatory healthcare attitudes is critical to providing equal access to healthcare for asylum seekers in accordance with the standards of human rights. The outcomes of the study add to the body of work by providing a quantitative analysis of the relationship between professional experience and implicit bias, which supports the relevance of policy interventions in healthcare training programs.
Biomechanical Characteristics of Upper Airway Muscles and Their Association with Obstructive Sleep Apnea Risk in Industrial Workers
(Springer Heidelberg, 2026) Polat, Hakan; Ramazanoglu, Engin; Bagci, Burcu; Ergun, Nevin; Uzun, Meltem; Yilmaz, Fatma
Background Obstructive Sleep Apnea Syndrome (OSAS) is characterized by repetitive upper airway obstruction during sleep. The viscoelastic properties of accessory respiratory muscles may play a compensatory role in maintaining airway patency. This study aimed to investigate the association between OSAS risk and muscle biomechanics in industrial workers. Methods This cross-sectional study included 236 male industrial workers aged 18-55, categorized into low, moderate, and high OSAS risk groups using the STOP-BANG questionnaire. The viscoelastic properties (tone, stiffness, elasticity) of the genioglossus, sternocleidomastoid, and masseter muscles were assessed using the MyotonPRO device. Sociodemographic and occupational data were collected. Statistical analyses included Kruskal-Wallis and Spearman correlation tests and additionally, univariate and multivariate linear regression. Results A significant difference was found only in left genioglossus tone across STOP-BANG risk groups (p < 0.05). Age and BMI were moderately associated with increased muscle stiffness and reduced elasticity, particularly in the SCM and masseter muscles. In regression analyses, right SCM stiffness and BMI were significant in the univariate model; however, after adjusting for age, BMI, smoking and duration of employment, only right SCM stiffness remained an independent predictor of STOP-BANG score (beta approximate to 0.01, p < 0.05). Conclusions Muscle viscoelastic properties are influenced not only by OSAS risk but also by age, BMI, occupational exposure, and smoking. Importantly, SCM stiffness may serve as a potential biomechanical marker associated with OSAS risk. Muscle biomechanics assessments could be used as a supportive, non-invasive screening tool in high-risk occupational populations.
Chronic Ozone Exposure Does Not Alter Sexual Behavior but Modulates Oxidative Stress and Early Testicular Apoptosis in Adult Male Rats
(Elsevier, 2026) Ertugrul, Nazife Ulker; Tektemur, Ahmet; Tektemur, Nalan Kaya; Guzel, Elif Erdem; Yardimci, Ahmet; Ogeturk, Murat; Akkoc, Ramazan Fazil
Ozone (O3) has been used to treat various diseases for many years, with most preclinical studies focusing on its effects in conditions such as testicular torsion and ischemia-reperfusion injury; however, its impact on male reproductive function, particularly sexual behavior, remains largely unexplored. This study aimed to evaluate the effects of chronic O3 exposure on sexual behavior, reproductive parameters, oxidative stress, and apoptosis in adult male rats. Animals were assigned to a vehicle group (n = 7), which received saline, or an O3-treated group (n = 7), which received intraperitoneal injections of an O2/O3 mixture (1 mL containing 150 mu g/kg O3) three times per week for eight weeks. Behavioral assessments conducted at the end of the treatment period showed that chronic O3 exposure did not alter appetitive or consummatory sexual behaviors; however, it significantly reduced serum testosterone levels, increased serum total oxidant status (TOS), and decreased testicular hydrogen peroxide (H2O2) levels, suggesting a hormetic response. Additionally, O3 treatment altered apoptotic markers without causing histopathological damage, indicating the onset of early-stage apoptosis. Overall, O3 exposure did not adversely affect sexual behavior independently of testosterone levels in adult male rats, but its induction of oxidative stress and early apoptosis highlights the need for further studies to clarify underlying mechanisms and establish long-term safety.
Comparative Effects of Fermented Cattle Manure and Synthetic Fertilization on Cotton Yield and Fibre Quality
(Springer INT Publ AG, 2026) Elis, Seval; Yildirim, Mehmet
This study investigated the impact of fermented granular commercial farmyard manure on cotton yield and quality, aiming to identify optimal manure and reduced synthetic fertilizer combinations for maximizing production, lowering costs, and promoting sustainable agriculture. Conducted over two growing seasons in Diyarbakir, Turkey, the research employed a randomized block design. Ten fertilizer applications were tested, including varying amounts of processed granular commercial cattle manure (170-300 kg da- 1), commercial synthetic fertilizer (9 N + 9P/9 N kg da- 1), and a control group. Plant height, chlorophyll content, yield, and ginning percentage were measured. Fertilizer doses did not significantly affect plant height or chlorophyll content. However, they significantly impacted yield and ginning percentage. Combining farmyard manure with reduced synthetic fertilizers resulted in similar or higher yields than synthetic fertilizers alone. The highest cotton production was observed with manure applications at 260 M /0 N and 260 M/4.5 N kg da- 1. Elevated temperatures in the second year negatively affected overall yields, but manure applications provided better protection and yield outcomes compared to synthetic fertilizer treatments. Utilizing organic fertilizer, alone or with reduced synthetic fertilizer, can promote sustainable agriculture by offering economic and environmental benefits. Farmyard manure can enhance soil structure and fertility, lessening reliance on synthetic fertilizers and potentially mitigating the adverse effects of global warming on crop yields.
Determining the Relationship between the Sociodemographic Characteristics and Attachment Styles of Liver Transplant Donors: A Cross-Sectional Study
(Lippincott Williams & Wilkins, 2026) Bayrakci, Emine; Soylemez, Neslihan; Ozkan, Meral; Tanriverdi, Seher
This study aimed to determine the relationship between the sociodemographic characteristics and attachment styles of liver transplant donors. This descriptive and correlational study included a sample of 156 donors. Data were collected through face-to-face interviews using a Patient Information Form and the Relationship Scales Questionnaire. In addition to normality tests, the Mann-Whitney U test, Kruskal-Wallis test, Bonferroni-corrected P-value, and Spearman correlation coefficient were used in data analysis. The significance level was set at P <= .05. The findings revealed that the majority of donors had a dismissive attachment style. Individuals with higher income levels, those living in rural areas, and those not related to the recipient showed a higher tendency toward secure attachment compared to other groups. Donors who had undergone previous surgery exhibited stronger secure attachment and weaker dismissive attachment than those who had not. Based on these results, future studies and organ donation campaigns are recommended to focus on attachment styles and their association with sociodemographic and sociocultural characteristics. The mean age of the participating donors was 31.65 +/- 6.67 years, and 76.92% were related to the recipient. Among the donors, 93.6% exhibited a dismissive attachment style. Income level, place of residence, kinship with the recipient, and previous surgical history had a statistically significant effect on secure attachment style (P < .05), explaining 34.4% of the variance (R-2 = 0.344). Previous surgical history was found to have a statistically significant effect on the dismissive attachment style (P < .05), accounting for 14.5% of the variance (R-2 = 0.145).
Development and Implementation of a Sandwich ELISA Prototype for the Detection of Brucella Antigens in Cheese Samples
(Elsevier Sci Ltd, 2026) Dellal, Ozden; Gurbuz, Semra; Tel, Osman Yasar; Demir, Muzeyyen; Gurbilek, Sevil Erdenlig; Yucetepe, Ayfer Gullu; Keskin, Oktay
Brucellosis remains one of the most important zoonotic diseases worldwide, posing a serious threat to both public health and animal production. Unpasteurized dairy products represent a major route of transmission. Furthermore, even in regions where the disease has been eradicated, individuals may remain at risk due to travel or the illegal importation of contaminated products. Effective control therefore relies on rapid, accurate, and practical diagnostic methods. In this study, a sandwich enzyme-linked immunosorbent assay (ELISA) prototype was developed to detect Brucella antigens in cheese irrespective of bacterial viability. The assay was evaluated using 150 fresh cheese samples collected from the Central and Siverek districts of S & cedil;anlıurfa province, Türkiye. The developed test demonstrated 100% specificity and 66% sensitivity. Overall, 17.3% of the samples were positive for Brucella antigens, with similar positivity rates observed across both districts. These findings indicate a considerable public health risk associated with contaminated fresh cheese. The newly developed sandwich ELISA may serve as a practical tool for antigen detection and support brucellosis surveillance and control efforts.
Diethyl Phthalate-Induced Oxidative Stress, Genotoxicity, and Thyroid Hormone Disruption in Female Wistar Rats
(Pergamon-Elsevier Science Ltd, 2026) Komurcu, Ayse; Yavas, Mehmet Cihan
Background: Diethyl phthalate (DEP), a common plasticizer in cosmetics and personal care products, is known to induce oxidative stress and endocrine disruption. Its widespread use raises concerns about thyroid toxicity. Objective: This study aimed to evaluate the genotoxic and endocrine effects of subacute DEP exposure on thyroid tissue in female Wistar albino rats using thyroid hormones, oxidative stress markers, DNA damage, and histopathology. Methods: Twenty-eight female Wistar albino rats were divided into four groups (n = 7): control, 100 mg/kg, 300 mg/kg, and 600 mg/kg DEP. DEP was administered orally for 21 days. DNA damage was assessed by Comet Assay, oxidative stress markers (TAS, TOS, OSI) were measured, and serum TSH, T3, and T4 levels were determined by ELISA. Body weights were monitored, and thyroid tissues were examined histologically. Results: Compared to the control group, T3 and T4 levels decreased (P < 0.05), TSH levels increased (p < 0.05), TAS levels decreased (p < 0.05), and TOS and OSI levels increased (p < 0.05). Comet Assay showed dose-dependent DNA damage (tail DNA%, p < 0.05). With higher DEP doses, thyroid tissue histopathology changed significantly. Conclusion: Subacute DEP exposure causes dose-dependent genotoxicity, oxidative stress, and endocrine disruption in thyroid tissue. These findings emphasize the need to limit environmental and human DEP exposure.
Dose-Dependent Hepatotoxicity of Diethyl Phthalate in Female Wistar Rats
(MDPI, 2026) Tan, Fazile Canturk; Gokdemir, Gul Sahika; Kalkan, Kubra Tugce; Varol, Salih; Yavas, Mehmet Cihan; Cantürk Tan, Fazile
Phthalates are a class of compounds commonly used as plasticizers in various industrial and consumer products. In line with the increasing environmental and biological exposure concerns regarding these compounds, this study investigated the dose-dependent effects of diethyl phthalate (DEP) on the liver in a subacute rat model. Diethyl phthalate (DEP) was given orally by gavage to female Wistar albino rats at doses of 100, 300, and 600 mg/kg body weight per day for 21 days in order to assess liver tissue and associated function test levels. Liver function was evaluated by analyzing serum biochemical data. Liver tissues were evaluated using histopathological staining (H&E and Masson's trichrome staining), immunohistochemical analysis of IL-1 beta and TGF-beta, tissue ELISA for IL-6 and TNF-alpha, and comet assay to determine DNA damage. DEP exposure was found to cause significant, dose-dependent histopathological changes in liver tissue, including hepatocyte necrosis, cytoplasmic vacuolization, sinusoidal dilation, and vascular congestion. AST levels were significantly increased compared to the control group, while no significant changes were observed in other serum biochemical parameters. Compared to the control group, the expression of pro-inflammatory cytokines (IL-6 and TNF-alpha), IL-1 beta, and TGF-beta was found to be elevated in the DEP-treated groups, and their levels increased with increasing exposure dose. DEP exposure also caused significant DNA damage in liver tissue. These findings indicate that despite an increase in AST levels observed in subacute DEP exposure, there were limited changes in serum biochemical parameters; serum liver enzymes alone may not fully reflect the extent of hepatic damage, and DEP can cause significant inflammatory, histopathological, and genotoxic effects in liver tissue.
Educational Continuity under Crisis: How School-Based Support Professionals Navigate Systemic Constraints
(Pergamon-Elsevier Science Ltd, 2026) Ergun, Naif; Bozdag, Faruk
The COVID-19 pandemic significantly disrupted educational systems worldwide, with lockdowns and school closures forcing a rapid transition to online learning. This shift posed unprecedented challenges for the delivery of educational support services in public education, revealing critical vulnerabilities in institutional readiness and professional adaptability. This study explores the lived experiences of school-based support professionals (psychological counselling and guidance [PCG]) as key institutional actors within educational systems working in public schools and Guidance Research Centres in Türkiye during and after the pandemic. Drawing on qualitative methodology, two complementary studies were conducted. The first employed a phenomenological design and involved in-depth interviews-both face-to-face and online-with 61 PCG experts (27 females, 34 males; M = 33.48 years). The second study utilized a case study design, engaging 29 professionals (15 females, 14 males; M = 33.38 years) through similar interview methods. Findings highlight a stark discrepancy between the educational and psychosocial needs of students and the limited capacity of support professionals to respond effectively, primarily due to systemic constraints exacerbated by pre-existing inequalities and the need to reconceptualise their professional roles to include family engagement. The pandemic exposed a critical paradox: while student distress and learning disruption surged to historic levels, the digital divide, institutional inertia, and lack of policy coordination rendered many core competencies of support professionals inoperable. Crucially, the study reveals that effective educational continuity in crisis contexts requires transforming families from passive recipients to active partners in student support, challenging the conventional school-cantered support model. The long-term implications of this mismatch between demand and support capacity, alongside inadequate home-school partnerships, pose significant risks to educational equity and are likely to reverberate across educational settings for years to come.
Citation - Scopus: 3
The Effect of Cognitive Behavioural Therapy–Based Psychoeducation on Medication Adherence and Aggression in Individuals Diagnosed With Schizophrenia: an Experimental Study
(John Wiley and Sons Inc, 2025) Can, S.Y.; Budak, F.K.
Introduction: It is known that treatment compliance is low and aggression is higher in individuals diagnosed with schizophrenia compared to the normal population. Cognitive behavioural therapy (CBT) is known to reduce relapse and hospitalisation and increase well-being in individuals diagnosed with schizophrenia. However, there are almost no studies on increasing treatment compliance and decreasing aggression. Aims: This study was conducted to determine how CBT–based psychoeducation affects medication adherence and aggression in individuals diagnosed with schizophrenia. Methods: The study was conducted as a quasi-experimental model with the pre-test–post-test control group with 73 schizophrenic patients (33 experimental, 40 control) between June 2022 and July 2023. Data were collected using the Descriptive Characteristics Form, Morisky Medication Adherence Scale (MMAS) and Buss–Perry Aggression Questionnaire (BPSQ). The schizophrenic patients in the experimental group were given eight sessions of CBT-based psychoeducation, while the schizophrenic patients in the control group were not given any training. The data were analysed using mean, standard deviation, chi-squared test, dependent samples t-test and independent samples t-test. Results: It was determined that the aggression level of the experimental group before the training was 80.51 ± 19.38, and after the CBT-based psychoeducation, it was 73.12 ± 15.28. It was determined that the aggression level of the control group before the training was 84.22 ± 12.13, and after the post-test, it was 85.60 ± 11.72. It was determined that the medication adherence level of the experimental group before the training was 2.75 ± 1.25, and after the CBT-based psychoeducation, it was 3.57 ± 0.67. It was determined that the medication adherence level of the control group before the training was 2.05 ± 1.33, and after the post-test, it was 2.17 ± 1.36. The psychoeducation based on CBT caused a statistically significant difference (p = 0.001) in medication adherence and aggression levels in the experimental group. Discussion: It was determined that CBT applied to individuals diagnosed with schizophrenia was effective on increasing their medication adherence and reducing their aggression. It is recommended for psychiatric nurses to include CBT-based psychoeducation in their nursing practices in order to increase medication adherence and reduce aggression in individuals with schizophrenia. Implications for Practice: The findings emphasise that CBT-based psychoeducation increases treatment adherence and significantly decreases the level of aggression in individuals diagnosed with schizophrenia. Psychiatric nurses should include CBT-based psychoeducation in their treatments. © 2024 The Author(s). Journal of Psychiatric and Mental Health Nursing published by John Wiley & Sons Ltd.
Effect of Progressive Relaxation Exercise on Psychological Symptoms and Mental Well-Being in Individuals With Schizophrenia
(Slack Inc, 2026) Isil, Ozlem; Tanriverdi, Omer
PURPOSE: The current study aimed to investigate the effects of a nurse-led progressive relaxation exercise (PRE) program on the severity of psychiatric symptoms and mental well-being in individuals with schizophrenia. METHOD: The study was conducted in three community mental health centers (CMHCs) in two provinces in the southeast and east Anatolia regions, using a quasiexperimental pre-/posttest control group design.The sample comprised individuals diagnosed with schizophrenia who regularly received health care services at a CMHC (N = 90; n = 45 in the intervention group, n = 45 in the control group) and met research criteria. RESULTS: PRE, delivered by psychiatric-mental health nurses (PMHNs), was found to effectively reduce psychiatric symptoms and increase mental well-being in individuals with schizophrenia. Mean pretest total score on the Brief Psychiatric Rating Scale was 47.87 (SD = 18.61), whereas mean posttest total score was 39.22 (SD = 16.28). Mean pretest total score of the Warwick-Edinburgh Mental Well-Being Scale was 39.96 (SD = 10.67), whereas mean posttest total score was 50.42 (SD = 8.06); these differences were statistically significant (p < .05). CONCLUSION: According to results of the current study, PRE is recommended as an evidence-based, complementary treatment that can easily be integrated into the routine care of individuals with schizophrenia by PMHNs and other mental health professionals.
Effects of Aromatherapy and Music on Stress and Self-Esteem in Nursing Students
(Slack Inc, 2026) Aktura, Seher Cevik; Erol, Ahmet; Ozbay, Hediye; Oner, Ugur
Background: Nursing students frequently experience elevated anxiety during injection practices, which can negatively affect their performance and well-being. Exploring supportive, nonpharmacological interventions is crucial in clinical education. Method: This single-blind, pretest/ posttest, randomized controlled study included 102 firstyear nursing students (aromatherapy = 34, aromatherapy + music = 34, control = 34) at a state university. Data were collected using validated tools between February 28, 2025, and May 10, 2025. Statistical analyses included t tests, analysis of variance, and Bonferroni post-hoc tests. Results: Both intervention groups demonstrated a significant reduction in systolic blood pressure and anxiety levels compared to the control group (p < .001). Conclusion: Aromatherapy and music-assisted aromatherapy are effective in reducing anxiety and systolic blood pressure during injection practice. Integrating such complementary methods into nursing education may support students' psychological well-being and enhance clinical learning experiences.
Effects of Different Organic Fertilizer Compositions (Leonardite and Vermicompost) on Chickpea (Cicer Arietinum L.) Yield and Macro-Micro Nutrient Content
(Agricultural Research Communication Centre, 2026) Eren, Abdullah
Background: Organic fertilizers (leonardite and vermicompost) applied to soil have a positive impact on plant nutrient uptake and productivity. Understanding the effects of different organic fertilizer application rates on the legume chickpea (Cicer arietinum L.) is crucial aspect of crop production that should not be overlooked. Methods: The research was carried out in a farmer's field in the Artuklu district of Mardin during two growing seasons (2022-2023 and 2023-2024). Vermicompost was used at VC1: 150, VC2: 200, VC3: 250 and VC4: 300 kg da-1, while Leonardite was used at L1: 50, 2: 100, L3: 200 and L4: 400 kg da-1. Examined how various techniques used for chickpea affected its nutrient content and yield. Statistical analyses were performed to assess the significance of year, application and year*application interaction. Result: The analyses indicated that year and application significantly affected most parameters, while the year*application interaction was generally not significant. Nutrient contents in chickpea plants varied as follows: total nitrogen (N) 2.98-3.61%, phosphorus (P) 3010-3833 mg kg-1, potassium (K) 6625-7086 mg kg-1, copper (Cu) 6.13-10.07 mg kg-1, manganese (Mn) 21.8-24.1 mg kg-1, iron (Fe) 51.7-70.1 mg kg-1 and zinc (Zn) 30.9-38.6 mg kg-1. Grain yield ranged from 148.3 to 183.7 kg da-1, with annual means of 156.0 and 170.0 kg da-1, respectively. The lowest yield was observed in the control, whereas the highest yield was achieved with 400 kg da-1 leonardite application.
Engineering Polyethylenimine-Metal Functionalized Cryogels for Superior Catalase Binding, Activity, and Long-Term Durability
(Nature Portfolio, 2026) Alkan, Mehmet Huseyin; Erol, Kadir; Alacabey, Ihsan
Cryogels with interconnected macroporous architectures offer significant advantages as enzyme immobilization supports due to their high permeability, mechanical robustness, and tunable surface chemistry. In this study, a novel Poly(HEMA-co-GMA) cryogel was synthesized and subsequently modified through polyethyleneimine (PEI) grafting and transition-metal chelation to create high-affinity matrices for catalase immobilization. Among the metal ions tested with Cu(II), Ni(II), and Co(II), the Cu(II)-functionalized cryogel exhibited superior physicochemical properties, including the highest water retention capacity (438.4%), well-preserved porosity, and strong coordination interactions with amine-rich PEI domains. FT-IR, SEM, TGA, BET, elemental analysis, and ICP-OES results confirmed successful stepwise modification and metal loading. Catalase immobilization studies revealed that the Poly(HEMA-co-GMA)-PEI-Cu(II) cryogel achieved the highest enzyme loading (391.9 mg & centerdot;g(-)& sup1;), with an optimal immobilization time of 8 h and optimum pH near neutrality. Kinetic analysis demonstrated a substantial decrease in K-m (from 57.3 to 14.4 mM), indicating enhanced substrate affinity, while k(cat)/K-m increased 2.8-fold relative to the free enzyme. The immobilized catalase exhibited improved thermal tolerance, strong operational stability (34.2% activity after 15 cycles), high desorption efficiency (96% in the first cycle), and markedly superior storage stability (62.1% activity after 70 days at 4 degrees C) compared to its free counterpart. These results validate the Cu(II)-chelated Poly(HEMA-co-GMA)-PEI cryogel as a highly efficient and reusable biocatalytic platform with significant potential for industrial and environmental enzyme-based applications.
Evaluation of Clinical Features of Patients Diagnosed with Spinal Muscular Atrophy Type 1 Receiving Nusinersen Treatment before and after Newborn Screening Program: A Multicenter Experience in Turkiye
(Pergamon-Elsevier Science Ltd, 2025) Caglar, E.; Herguner, O.; Komur, M.; Ceylan, A.; Yildiz, E.; Sarigecilli, E.; Turkdogan, D.

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