WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

Browse

Now showing 1 - 2 of 2

Citation - WoS: 2
Citation - Scopus: 3
Effects of Concomitant Use of N-Acetylcysteine and Cyclosporine a on Acetaminophen-Induced Acute Kidney Injury in Mice
(Agricultural Research Communication Centre, 2024) Kocamueftueoglu, Gonca Ozan; Tektemur, Nalan Kaya; Guzel, Elif Erdem; Tektemur, Ahmet; Ozan, Ibrahim Enver; Kocamüftüoǧlu, Gonca Ozan
Background: Acetaminophen (APAP), a commonly used analgesic, causes acute kidney injury (AKI) in overdose although it is rare. Mitochondrial dysfunction plays a major role in the pathophysiology of renal damage, although the exact molecular mechanism is unknown. This study aimed to evaluate the potential therapeutic effect of cyclosporin A (CsA), a mitochondrial membrane permeability Methods: Male BALB/c mice were divided into Control, APAP, APAP+NAC, APAP+CsA and APAP+NAC+CsA groups (n=6). A single dose of APAP (400 mg/kg) was administered intraperitoneally. All other treatments (1200 mg/kg NAC, 50 mg/kg CsA) were performed intraperitoneally 3 h after APAP administration. All animals were decapitated and blood samples and kidney tissue samples were collected for evaluation. Serum creatinine (Cr) and blood urea nitrogen (BUN) levels were measured. The kidney tissue 8-hydroxydeoxyguanosine (8-OHdG), cytochrome c (Cytc) and 3-nitrotyrosine (3-NT) levels and cytochrome c (Cytc) expressions were determined. Result: Increased Cr and BUN levels, histopathological examinations and expressions of 8-OHdG, 3-NT and Cytc were detected in the APAP group. Combined NAC+CsA treatment sufficiently reversed oxidative stress, serum Cr and BUN levels and histopathological alterations induced by APAP. Moreover, cytc levels and renal tubular injury were remarkably reduced by combined drug treatment compared to the APAP+NAC group. These data suggest that the therapeutic effect of combined NAC+CsA treatment in mice with APAP-induced nephrotoxicity can be related to the combination of the antioxidant effect of NAC and the mitochondrial MPTP inhibitor effect of CsA.
Effects of Different Organic Fertilizer Compositions (Leonardite and Vermicompost) on Chickpea (Cicer Arietinum L.) Yield and Macro-Micro Nutrient Content
(Agricultural Research Communication Centre, 2026) Eren, Abdullah
Background: Organic fertilizers (leonardite and vermicompost) applied to soil have a positive impact on plant nutrient uptake and productivity. Understanding the effects of different organic fertilizer application rates on the legume chickpea (Cicer arietinum L.) is crucial aspect of crop production that should not be overlooked. Methods: The research was carried out in a farmer's field in the Artuklu district of Mardin during two growing seasons (2022-2023 and 2023-2024). Vermicompost was used at VC1: 150, VC2: 200, VC3: 250 and VC4: 300 kg da-1, while Leonardite was used at L1: 50, 2: 100, L3: 200 and L4: 400 kg da-1. Examined how various techniques used for chickpea affected its nutrient content and yield. Statistical analyses were performed to assess the significance of year, application and year*application interaction. Result: The analyses indicated that year and application significantly affected most parameters, while the year*application interaction was generally not significant. Nutrient contents in chickpea plants varied as follows: total nitrogen (N) 2.98-3.61%, phosphorus (P) 3010-3833 mg kg-1, potassium (K) 6625-7086 mg kg-1, copper (Cu) 6.13-10.07 mg kg-1, manganese (Mn) 21.8-24.1 mg kg-1, iron (Fe) 51.7-70.1 mg kg-1 and zinc (Zn) 30.9-38.6 mg kg-1. Grain yield ranged from 148.3 to 183.7 kg da-1, with annual means of 156.0 and 170.0 kg da-1, respectively. The lowest yield was observed in the control, whereas the highest yield was achieved with 400 kg da-1 leonardite application.

Browse

Browsing WoS İndeksli Yayınlar Koleksiyonu by Publisher "Agricultural Research Communication Centre"