PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3597

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Citation - WoS: 6
Citation - Scopus: 11
Activated Carbon-Coated Iron Oxide Magnetic Nanocomposite (ionps@ctac) Loaded With Morin Hydrate for Drug-Delivery Applications
(Frontiers Media Sa, 2024) Dogan, Yusuf; Ozic, Cem; Ertas, Erdal; Baran, Ayse; Rosic, Gvozden; Selakovic, Dragica; Eftekhari, Aziz; 06.02. Department of Plant Protection / Bitki Koruma Bölümü; 06. Faculty of Agricultural Sciences and Technologies in Kızıltepe / Kızıltepe Tarım Bilimleri ve Teknolojileri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Cancer is a major disease that affects millions of people around the world every year. It affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug-release systems have been developed to reduce the side effects caused by anticancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure. It has been extensively researched for its antioxidant, anti-inflammatory, antitumoral, and antibacterial properties, especially found in Chinese herbs and fruits, and its multiple positive effects on different diseases. In this study, a nanocomposite with magnetic properties was synthesized by coating biocompatible activated carbon obtained using the fruits of the Celtis tournefortii plant on the surface of iron oxide magnetic nanoparticles. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, dynamic light scattering, zeta potential, and vibrating sample magnetometry. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (colorectal), T98-G (glioblastoma) cancer cell lines, and human umbilical vein endothelial cell (HUVEC) healthy cell line. The morin loading and release behavior of the activated carbon-coated iron oxide magnetic nanocomposite were studied, and the results showed that up to 60% of the adsorbed morin was released within 4 h. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of the morin drug.
Citation - WoS: 48
Citation - Scopus: 51
Adolescent Transport and Unintentional Injuries: a Systematic Analysis Using the Global Burden of Disease Study 2019
(Elsevier Sci Ltd, 2022) Peden, Amy E.; Cullen, Patricia; Francis, Kate Louise; Moeller, Holger; Peden, Margaret M.; Ye, Pengpeng; Ivers, Rebecca Q.
Background Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10-24 years during the past three decades. Methods Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10-14, 15-19, and 20-24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings In 2019, 369 061 deaths (of which 214337 [58%] were transport related) and 31.1 million DALYs (of which 16.2 million [52%] were transport related) among adolescents aged 10-24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34.4% (from 17.5 to 11.5 per 100 000) for transport injuries, and by 47.7% (from 15.9 to 8.3 per 100000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80.5% to 42 774 for transport injuries and by 39.4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010-19, the rate per 100 000 of transport injury DALYs was reduced by 16.7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48.5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0.2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010-19. Interpretation As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low-middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.
Citation - WoS: 1
Citation - Scopus: 1
Antioxidant Properties of allium Turcicum Özhatay & Cowley Plant Extract, Its Effects on the Proliferation and Migration of Cancer Cells
(Frontiers Media Sa, 2024) Ipek, Polat; Baran, Ayse; Cebe, Deniz Baris; Ahmadian, Elham; Eftekhari, Aziz; Baran, Mehmet Firat; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Cancer is a type of non-communicable disease that is responsible for numerous deaths worldwide. Cancer incidence and mortality rates are on the rise due to a combination of factors, such as a growing population, aging, and poor dietary habits. The Allium turcicum & Ouml;zhatay & Cowley plant is an endemic plant in the area where it grows and is consumed by the public due to its various benefits. This endemic plant, which generally grows in high-altitude regions, is sold in bunches because it is costly, mixed with rock salt, crushed into powder, and consumed as a spice. The cytotoxic and growth-inhibitory effects of A. turcicum & Ouml;zhatay & Cowley herb extract on human glioblastoma U373 cells, human colorectal carcinoma cell HCT-116, and healthy HUVEC cell lines were determined by the MTT method. After 24 and 48 h of application, logIC50 values in HUVEC, HCT-116, and U373 cells were defined as 3.737, 3.765; 3.513, 3.696, 4.476, and 4.104 mu g/mL, respectively. We conducted a cell migration experiment to study the A. turcicum & Ouml;zhatay & Cowley Extract (AT & Ouml;CE) impact on cancer cells' metastatic behavior. Our findings indicate that AT & Ouml;CE has an inhibitory effect on the migration potential of the cells used in the study. We conducted experiments using DPPH, ABTS, CUPRAC, and total phenolic content to assess the antioxidant properties of AT & Ouml;CE. The findings from the antioxidant activity experiments revealed an activity level of 0.20 +/- 0.046 at IC50. Additionally, the total phenolic content was measured to be 0.26 +/- 0.044 mg GAE/g.
An Assessment of Intermittent and Continuous Enteral Feeding in Critically Ill Children
(Mdpi, 2025) Misirlioglu, Merve; Yildizdas, Dincer; Ekinci, Faruk; Akcay, Nihal; Bingol, Ilyas; Sahin, Ebru; Coban, Yasemin
Background: The inability to ensure adequate nutrition for patients, and failure to provide adequate calorie and protein intake, result in malnutrition, leading to increased morbidity and mortality. The present study assesses the two approaches to enteral nutrition-intermittent and continuous enteral feeding-in critically ill pediatric patients in T & uuml;rkiye to determine the superiority of one method over the other. Methods: Included in this multicenter prospective study were patients receiving enteral nutrition via a tube who were followed up over a 3-month period. Anthropometric data, calorie and protein intake, and signs of feeding intolerance were evaluated in a comparison of the different feeding methods. Results: A total of 510 patients were examined. In the continuous enteral feeding (CEF) group, 20.2% of patients developed metabolic abnormalities, and 49.5% experienced enteral nutrition intolerance, both of which were higher than in the intermittent enteral feeding (IEF) group, and the differences were statistically significant. No significant differences were observed between the two feeding methods in terms of reaching the target calorie intake on days 2 and 7 (p > 0.05). On day 7, there were significant differences between the two feeding methods in terms of calorie and protein intake (p = 0.023 and 0.014, respectively). Conclusions: In the present study, assessing the IEF and CEF approaches to enteral nutrition, critically ill pediatric patients receiving intermittent feeding exhibited lower rates of enteral nutrition intolerance and metabolic abnormalities. Furthermore, the calorie and protein intake on day 7 were noted to be higher in the IEF group than in the CEF group. Further randomized controlled trials are needed to confirm the findings of the present study.
Citation - WoS: 1
Citation - Scopus: 1
Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy
(Mdpi, 2025) Orhan, Ozhan; Gokdemir, Gul Sahika; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.
Citation - WoS: 5
Citation - Scopus: 5
Assessment of Walnut (juglans Regia L.) Cultivation Land Suitability Using a Multiple-Criteria Decision-Making Method in Southeastern Turkey
(Nature Portfolio, 2025) Mercan, Cagri; 17.06. Department of Architecture and Urban Planning / Mimarlık ve Şehir Planma Bölümü; 17. Vocational Higher School / Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Site selection for agricultural products is critical for agricultural planning, productivity, and farmers. Site selection is also critical for agricultural sustainability, as it helps ensure the efficient use of natural resources and avoids environmental degradation. This research proposes an evaluation model for walnut cultivation in the Savur (Mardin, Turkey) district in the Southeastern Anatolia region. Based on literature data, expert opinion, and local walnut producers' perspectives, a spatial decision support system was developed using Geographic Information System (GIS)-based Multi-Criteria Decision Analysis (MCDA). This model provides farmers and stakeholders with a comprehensive evaluation of the different walnut-producing sites in the Savur district. It allows them to make informed decisions about the most suitable areas for walnut production. The land suitability assessment for walnut orchards included four primary evaluation aspects, ten main criteria, and forty-seven sub-criteria. Evaluation criteria were weighted using the Analytic Hierarchy Process (AHP). A land suitability map was created using the weighted overlay method in overlap with the evaluation criteria. The results showed 442.56 ha of very highly suitable land, 9789.43 ha of highly suitable land, and 1140.76 ha of moderately suitable land in the Savur district. In order to determine the accuracy of the study model, ROC (Receiver Operating Characteristic) analysis was conducted. As a result of the validation analysis, the constructed model had an Area Under the Curve (AUC) of 0.911, which indicates an excellent fit between the model and reality; therefore, the model is acceptable. This study demonstrates that integrating AHP and GIS can aid agricultural land use planning and decision-making.
Citation - WoS: 2
Citation - Scopus: 2
Association of Inflammatory and Metabolic Markers With Mortality in Patients With Postoperative Femur Fractures in the Intensive Care Unit
(Mdpi, 2025) Kilinc, Metin; Celik, Enes; Demir, Ibrahim; Aydemir, Semih; Akelma, Hakan; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background and Objectives: Postoperative femur fracture in elderly patients is associated with high morbidity and mortality, especially in the intensive care unit (ICU). Various factors, including demographic and laboratory parameters, may influence mortality in this population. The aim of this study was to evaluate the association of inflammatory and metabolic markers with mortality in ICU patients with postoperative femur fractures and to identify key predictors to enhance risk stratification and improve patient outcomes. Materials and Methods: In this retrospective single-center study, we analyzed 121 patients aged over 65 years with postoperative femur fractures who were admitted to the ICU between January 2023 and January 2024. Demographic and clinical data, including comorbidities, Charlson Comorbidity Index (CCI), and Acute Physiology and Chronic Health Evaluation (APACHE II) score, were collected. Laboratory parameters such as white blood cell count (WBC), albumin, C-reactive protein (CRP), D-dimer, Pan-Immune-Inflammation Value (PIV), CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and others were analyzed. Linear regression, logistic regression, and Receiver Operating Characteristic (ROC) analyses were performed to determine the predictive value of these markers for ICU mortality. Results: The mean age of the patients was 76.3 +/- 9.6 years, and 52.1% were female. The most common comorbidities were hypertension (67.8%) and diabetes (49.6%). ICU mortality occurred in 24 patients (20%). Significant predictors of mortality included higher CRP (>62.8 mg/L), NLR (>10.0), PIV (>450), and APACHE II scores (>23) (p < 0.001 for all). Lower albumin levels (<2.5 g/dL) were strongly associated with increased mortality (p < 0.001). ROC analysis demonstrated that the APACHE II score had the highest predictive accuracy for mortality (AUC = 0.83), followed by albumin (AUC = 0.79) and PIV (AUC = 0.76). Extended ICU stay (>10 days) was also significantly correlated with increased mortality (p < 0.001). Conclusions: This study successfully demonstrates the utility of combining traditional clinical markers, such as APACHE II score, with novel inflammatory markers, such as PIV, CAR, and NLR, in predicting mortality in ICU patients following femur fracture surgery. The integration of emerging biomarkers with well-established scoring systems offers enhanced predictive accuracy and provides valuable insights into patient management.
Citation - WoS: 5
Citation - Scopus: 7
Attitudes promoting coping with death anxiety among parents of children with disabilities
(Taylor and Francis Online, 2021) Kaçan, Havva; Sakız, Halis; Bayram Deger, Vasfiye; 02.04. Department of Educational Sciences / Eğitim Bilimleri Bölümü; 09.01. Department of Nursing / Hemşirelik Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
We investigated death anxiety among parents of children with disabilities and its associations with coping attitudes and psycho-demographic factors. Surveys were administered to 382 parents of children who possess a severe disability and data were analyzed via descriptive and inferential statistics. Findings revealed that parents experienced high levels of death anxiety; the level of death anxiety changed according to some psycho-demographic factors, such as external support, type of disability, and death-related beliefs; and death anxiety was significantly explained by demographic variables, death-related thoughts, and experiences, and adaptive and maladaptive coping attitudes.
Bioactive Profile, Anticarcinogenic, Antimicrobial, Antidiabetic Effects, and in Silico Pharmacokinetic Properties of Astragalus Elatus
(Academic Press inc Elsevier Science, 2025) Ercan, Leyla; Akan, Hasan; Caliskan, Cemile Gunbegi
Because of the numerous useful components they contain, plants are significant resources that are being explored for their varied purposes in industry, food, and medicine. Recently, particularly endemic species have gained attention with the identification of their different ingredients and characteristics and the exploration of their precious features. This research assessed the endemic species Astragalus elatus's bioactive components utilizing UHPLC-Orbitrap (R)-HRMS, its antibacterial qualities utilizing the disc diffusion method, its cytotoxic impact on cervical cancer utilizing the MTT method, and its apoptosis effect by annexin V methods. Additionally, Astragalus elatus's antidiabetic activity was revealed by in silico and in vitro examinations of its inhibitory effect on the enzymes alpha-Amylase and alpha-Glucosidase. Consequently, it was discovered that A. elatus can be utilized in the treatment of cervical cancer and has effective cytotoxic and apoptotic effects on HeLa cells. Additionally, it was detected that A. elatus possesses antibacterial and anti-diabetic properties. Compared to gram-negative bacteria, A. elatus had a greater inhibitory effect on gram-positive bacteria. The pharmacokinetically significant characteristics and their tendency for chemical reactions of this plant's primary phenolic compounds were identified by utilizing DFT, molecular docking, and ADME/T.
Citation - WoS: 22
Citation - Scopus: 24
Boletus edulis loaded with gamma-Fe2O3 nanoparticles as a magnetic sorbent for preconcentration of Co(II) and Sn(II) prior to their determination by ICP-OES
(SPRINGER WIEN, 2018) Özdemir, Sadin; Yalçın, M. Serkan; Kılınç, Ersin; Soylak, Mustafa; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The authors show that the fungus Boletus edulis loaded with gamma-Fe2O3 nanoparticles is a viable sorbent for magnetic solid phase extraction of trace levels of Co(II) and Sn(II). The surface structure of immobilized magnetized B. edulis was characterized by FT-IR, SEM and EDX. Experimental parameters were optimized. Following elution with 1 M HCl, the ions were quantified by ICP-OES. The limits of detection are 21 pg.mL(-1) for Co(II), and 19 pg.mL(-1) for Sn(II). The preconcentration factors are 100 for both ions. The sorption capacities of the sorbent are 35.8 mg.g(-1) for Co(II) and 29.6 mg.g(-1) for Sn(II). The method was applied to the analysis of certificated reference materials and gave >= 95% recoveries with low RSDs. It was also successfully applied to the quantification of Co(II) and Sn(II) in spiked environmental and food samples.
Causes of Diagnostic and Treatment Delays in Locally Advanced Breast Cancer: a Nationwide Multicenter Survey and Electronic Health Records Analysis in Turkiye
(Oxford Univ Press, 2025) Karadeniz Cakmak, Guldeniz; Tali, Ufuk; Balbaloglu, Hakan; Tasdoven, Ilhan; Ozkurt, Enver; Karanlik, Hasan; Ozmen, Vahit
Delays in breast cancer (BC) diagnosis and treatment negatively impact survival outcomes. Understanding patient- and provider-related factors behind these delays is crucial. This study aimed to identify nationwide reasons for delayed diagnosis and treatment of locally advanced BC in Turkiye. A prospective, multicenter hospital-based survey was conducted across 35 institutions between 2023 and 2024. Patient- and provider-related delays were assessed via a structured 61-item face-to-face survey, supplemented by clinical data from electronic health records. Delays exceeding 3 months were clinically categorized as significant. A total of 1322 women participated from seven regions across Turkiye. Factors contributing to diagnostic delays on a national level included economic reasons (5.5%), lack of family support (3.3%), lack of knowledge (12.4%), lack of time due to household work (3.8%), difficulty in finding an appointment (6.7%), pregnancy-related reasons (1.1%), fear of losing the breast (8.9%), fear of death (9.8%), and transportation difficulties (5.1%). Provider-related delays were infrequent. About 89.3% of the patients had the initial doctor appointment and 89.6% had the first specialist consultation within one month. Treatment planning was predominantly based on a multidisciplinary team decision in 88.3% of patients. Regarding treatment initiation, 93.2% started required treatment within 1 month of decision. Patient-related factors are the major causes of diagnostic delay in Turkiye. On the other hand, from the provider's perspective, the presence of multidisciplinary teams, including dedicated breast surgeons, represents a key factor in ensuring the timely implementation of diagnostic procedures and treatment strategies.
Citation - WoS: 57
Citation - Scopus: 64
Changes in volatile compounds, sugars and organic acids of different spices of peppers (Capsicum annuum L.) during storage
(FOOD CHEMISTRY, 2020) Korkmaz, Aziz; Atasoy, Ahmet Ferit; Hayaloglu, Ali Adnan; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Changes in sugars, organic acids and volatile compounds (VC) of red pepper flakes (RPF), traditional (TRI), and industrial (INI) isot peppers were evaluated during one year storage at the room condition. The changes in the flavor components were significantly affected by the production methods and storage time. Glucose content decreased gradually along storage and reduced by about 21.23, 47.22 and 56.65% for TRI, INI and RPF, respectively. However, fructose decreased significantly only in RPF (11.29%). Citric and succinic acids exhibited slight changes, but malic acid showed an increasing trend, especially in RPF (4-fold). Most of the VC in all samples decreased or disappeared after storage. The major quantitative losses in these compounds were found in TRI during the first 3 months as 81.76%. The storage was found to be caused deterioration flavor properties in red pepper spices and revealed the importance of appropriate storage conditions.
Characterising Acute and Chronic Care Needs: Insights From the Global Burden of Disease Study 2019
(Nature Research, 2025) Zuniga, Y.M.H.; Zumla, A.; Zuhlke, L.J.; Zoladl, M.; Ziaeian, B.; Zhong, C.; Gallus, S.
Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © The Author(s) 2025.
Comparative Aggressiveness and Fungicide Sensitivity of Phytopythium vexans and P. litorale Associated with Kiwifruit Vine Decline in Turkiye
(John Wiley & Sons Ltd, 2025) Polat, Zuhtu; Gultekin, Mehmet Akif; Ozer, Goksel; Turkkan, Muharrem; Dervis, Sibel
Background: Kiwifruit vine decline syndrome (KVDS) is an economically critical disease threatening production in Turkiye. The oomycetes Phytopythium vexans and P. litorale are increasingly implicated, but their comparative roles and effective management remain poorly understood, creating an urgent need for sustainable control strategies. This study aimed to (i) compare the virulence of these two species and (ii) evaluate the in vitro versus in vivo efficacy of key fungicides to identify reliable control strategies. Results: Pathogenicity assays revealed that P. litorale was significantly more aggressive, causing severe disease (Disease Severity Index, DSI > 70%), whereas P. vexans induced only moderate symptoms (DSI < 42%). A critical disconnect was observed between laboratory and greenhouse fungicide performance. For instance, oxathiapiprolin, which was highly potent in vitro (EC50 = 0.001169-0.006158 mu g mL(-1)), provided only moderate disease control in vivo. Conversely, pyraclostrobin-based fungicides delivered superior protection against the highly aggressive P. litorale, reducing the DSI to a range of 20.83-21.88% and significantly enhancing root biomass. Conclusion: This study establishes P. litorale as a highly aggressive pathogen in KVDS etiology and demonstrates that in vitro data alone are misleading for predicting fungicide field performance. Pyraclostrobin-based fungicides are identified as the most effective candidates for managing KVDS caused by P. litorale. These findings underscore the necessity of integrating in vivo validation in screening protocols and adopting species-specific management approaches, providing a critical roadmap for developing sustainable solutions against this devastating disease. (c) 2025 Society of Chemical Industry.
Control Strategy Evaluation for Reactive Power Management in Grid-Connected Photovoltaic Systems Under Varying Solar Conditions
(Nature Portfolio, 2025) Adak, Suleyman
Solar energy is environmentally friendly and one of the most significant renewable energy sources. This energy is a leading renewable energy source, contributing significantly to sustainable development goals. In grid-connected photovoltaic (PV) systems, reactive power management is essential for maintaining voltage stability and ensuring reliable operation. However, the influence of fluctuating solar irradiation (G) on reactive power (Q) behavior is often underrepresented in conventional inverter control strategies. This research addresses this gap by modeling the dependence of reactive power on solar irradiance using a data-driven curve-fitting approach. The methodology involves the acquisition of real-world operational data, preprocessing, selection of an appropriate analytical model, and validation of its performance. The findings indicate that reactive power increases under low irradiance conditions, primarily due to inverter behavior and grid voltage support requirements. The resulting analytical expression offers a practical framework for integrating irradiance-dependent reactive power control into inverter firmware or grid management software. The model performed with high accuracy with an R2 of 0.9955. This contribution enhances the ability of PV systems to respond dynamically to environmental changes, improving grid compatibility, operational efficiency, and voltage regulation in modern distributed energy networks.
Citation - WoS: 21
Citation - Scopus: 24
Determination of Antimicrobial and Toxic Metal Removal Activities of Plant-Based Synthesized (capsicum Annuum L. Leaves), Ecofriendly, Gold Nanomaterials
(Wiley-v C H verlag Gmbh, 2020) Baran, Mehmet Firat; Acay, Hilal; Keskin, Cumali; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Nanoparticles are valuable materials with widespread use. The fact that these materials are obtained by biological resources with an environmentally friendly method contributes to the development of studies in this field. Gold nanoparticles (AuNPs) from waste vegetable sources (green leaves of Capsicum annum L.) are economically and easily synthesized. The obtained particles are characterized by UV-vis spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. The antimicrobial activity of the particles on the pathogenic microorganisms Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis bacteria, and Candida albicans yeast are found to have a significant suppressive effect. The removal activities of eight toxic metals (Pd, Cd, Fe, Ni, Co, Mn, Zn, Pb) in Diyarbakir drinking water and artificially prepared water within different pHs are investigated. Gold nanoparticles synthesized from Capsicum annuum L. leaves are found to be effective in toxic metal removal in water samples.
Citation - WoS: 6
Citation - Scopus: 8
Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials
(Cell Press, 2024) Ipek, Polat; Atalar, Mehmet Nuri; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, Rovshan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.
Does Helicobacter Pylori Have a Role in the Pathogenesis of Otitis Media with Effusion, or Is It a Fallacy
(Springer Science and Business Media Deutschland GmbH, 2025) Gunduz, A. Yasemin; Kalcioǧlu, Mahmut Tayyar; Celik, Serdal; Arı, Oğuz; Durmaz, R.
Purpose: Helicobacter pylori, causing chronic systemic infection, may colonize in middle ear milieu and conduce to effusion collection. Many investigations on relationship between pathogenesis of otitis media with effusion (OME) and Helicobacter pylori yielded conflicting results. We investigated Helicobacter pylori presence in effusion and adenoid samples of children having OME and in middle ear and adenoid samples of children with healthy middle ears to elucidate its role on OME pathogenesis. Methods: This prospective case-control study included 300 patients aged 1–12 years. One-hundred effusion samples collected from 100 children undergoing ventilation tube insertion and adenoidectomy due to chronic OME and adenoid hypertrophy formed study group, and 100 adenoid samples collected from adenoids of these children formed Group-1. One-hundred healthy-looking middle ear irrigation solutions collected from 100 children undergoing cochlear implantation formed Group-2. One-hundred adenoid samples collected from 100 children having no effusion and only undergoing adenoidectomy formed Group-3. After DNA isolation of samples, Helicobacter pylori 16 S rRNA and 23 S rRNA gene for clarithromycin-resistance were investigated by real time-polymerase chain reaction (Rt-PCR). Results: The median age of 300 children was 5, and 179 were boys and 121 were girls. Helicobacter pylori was detected by Rt-PCR in none (%0) of the 400 samples (200 middle ear, 200 adenoid). Conclusion: In this largest sample-size study utilizing updated molecular methods to date, negative results indicate that Helicobacter pylori does not play role as an active pathogen in polymicrobiality of OME, and adenoids do not serve as a reservoir for Helicobacter pylori in this process. © 2025 Elsevier B.V., All rights reserved.
Citation - WoS: 5
Citation - Scopus: 7
The effect of acupressure on postoperative pain of lumbar disc hernia: A quasi-experimental study
(ELSEVIER SCI LTD, 2018) Tanrıverdi, Seher; Sarıtaş, Serdar; 09.06. Department of Social Services/ Sosyal Hizmet Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Lumbar disc herniation (LDH) is a disease characterized by lumbar and leg pain that occurs as a result of compression of the lumbar spinal root by the degenerated disc. The results of the study showed that 80% of humans experienced lumbar pain in any period of their lives [[1], [2], [3]]. Comprising an important part of lumbar pain; lumbar disc herniation (LDH) has an prevalence of approximately 15–56% per year [4,5]. One of the treatment methods preferred for patients diagnosed with lumbar disc herniation is surgery. Patients, who undergo surgery, experience intense pain in the early postoperative period [6]. It is known that medications are commonly used in pain control. Analgesic treatment used for pain control is the most preferred treatment method for pain relief as it has a rapid action and is administered easily [7,8]. Damages in both individual and national economy due to preferring carelessly and frequently analgesics affect negatively some physiological functionings and have negative effects such as development of addiction with the increase of dosages every time especially in cases where narcotics are preferred [9]. Thus, it is indicated that the administration of non-pharmaceutical methods by nurses to relieve the postoperative pain in patients in addition to medications increases the action of medications [8]. It is anticipated that there are numerous non-pharmaceutical methods which are efficient in pain management, such as distraction, relaxation, therapeutic touch, transcutaneous nerve stimulation (TENS), informing, hypnotherapy, acupuncture, massage, aromatherapy, music and meditation, yoga, attention-grabbing, imagination, cognitive-behavioral techniques. But, it is known that nurses do not use these methods adequately to relieve pain [10]. It may be asserted that non-pharmaceutical treatments are among independent nursing roles of professional nurses who have theoretical knowledge and problem solving ability. Nurses are required to take a role in non-pharmaceutical interventions in order to meet the health needs of individuals, families and society [11]. One of the non-pharmaceutical treatment methods used in pain relief is acupressure. Applied with touch pressuring on the acupuncture points using hands, fingers, thumbs or small beads according to the traditional Chinese medicine; acupressure is a non-pharmaceutical pain relief example that balances energy in the body [[12], [13], [14]]. Advantages of acupressure include low cost, learning convenience and non-invasive characteristics [14]. Besides, randomized clinical studies conducted to compare physiotherapy and acupressure in decreasing lumbar pain (LBP) have reveal that acupressure might be effective [[15], [16], [17]]. The use of acupressure in nursing practices by taking all its positive effects into consideration will contribute to the establishment of qualified nursing care standards.
Effect of Mediterranean Diet Adherence During the Third Trimester of Pregnancy on Maternal and Newborn Health Outcomes
(Elsevier Science inc, 2025) Ceylan, Jiyan Aslan
Objectives: The aim of this study was to explore the impact of Mediterranean diet (MD) adherence during the third trimester of pregnancy on both maternal and newborn health, focusing on birth weight, cranial perimeter, and maternal biochemical markers. Methods: This cross-sectional study was conducted with 300 volunteer pregnant women. Maternal sociodemographic, nutritional, and biochemical data were collected before delivery (weeks 27-41 of pregnancy), while newborn anthropometric measurements were obtained within 2 d of birth. MD adherence was assessed using the KIDMED index, classifying participants into low, moderate, or optimal adherence groups. Results: 54.0% of pregnant women had very low, 27.7% moderate, and 18.3% optimal adherence to MD. Maternal urea, free T4, hemoglobin, and vitamin B12 levels were higher in the moderate adherence group, while folate and vitamin D levels were lower in the very low adherence group (P < 0.05). Logistic regression analysis indicated that maternal adherence to MD was not significantly associated with birth weight (P = 0.10, AOR = 1.082) and cranial perimeter (P = 0.63, AOR = 1.016). Pregnancy weight gain was significantly associated with a lower risk of low birth weight (P < 0.01, AOR = 2.312), and folate levels showed a borderline significant association (P = 0.05, AOR = 0.921). Factors influencing cranial perimeter included prepregnancy body mass index (P = 0.05), weight gain (P < 0.01, AOR = 2.007), folate (P = 0.04, AOR = 0.947), and vitamin B12 levels (P < 0.01, AOR = 0.996). Conclusions: MD adherence did not directly impact neonatal anthropometric outcomes, but its effect on maternal biochemical markers, lifestyle and nutritional habits suggests potential benefits for maternal health. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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