TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/1836

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Now showing 1 - 11 of 11

Citation - WoS: 9
Citation - Scopus: 12
Allelic variations of glutenin subunits and their association with quality traits in bread wheat genotypes
(2017) Aktaş, Hüsnü; Baloch, Faheem Shehzad
The present study was conducted to evaluate the genotype × environment interaction of the yield and quality traits for five bread wheat varieties commonly grown in the Southeastern Anatolia Region of Turkey and 20 advanced lines developed within the framework of the International Winter Wheat Improvement Project. We also determined the allelic pattern of the Glu-1 and Glu-3 loci of these genotypes and examined whether these loci had an effect on the quality traits. There was a significant variation among the genotypes and environments in terms of grain yield, protein content, sedimentation volume (SV), and the extensograph dough energy value (EDEV). The results of the study indicated that genotypic effect was more influential on SV and EDEV than environmental effect; thus, both traits could be used in breeding programs to develop elite cultivars with better quality. Twelve different high-molecularweight (HMW) glutenin alleles were identified at the Glu-A1, Glu-B1, and Glu-D1 loci, resulting in 14 allelic combinations, and 17 different alleles were observed in 19 combinations for low-molecular-weight (LMW) subunits. Furthermore, among all the genotypes, 13 + 16 and 13 + 19 alleles at Glu-B1 and 5 + 12 at Glu-D1 were observed to have the lowest frequency. Our study indicated that the combinations of HMW glutenin alleles with 2* at Glu-A1, 17 + 18 and 13 + 16 at Glu-B1, and 5 + 10 at Glu-D1, as well as the combinations of LMW alleles with subunits c and d at Glu-A3; subunits d, b, c, and g at Glu-B3; and subunits a and b at Glu-D3 had positive effects on the quality traits.
Citation - WoS: 2
Citation - Scopus: 1
Evaluation of the Results of the Patients Who Underwent Plasmapheresis in the Pediatric Intensive Care Unit
(Tubitak Scientific & Technological Research Council Turkey, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Kangin, Murat; Turanli, Ese Eda; Ozbek, Mehmet Nuri
Background/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Ya & scedil;argil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients' diagnosis, weight, type of procedure and type of device, where the procedure was performed, duration of the procedure, amount of blood and plasma processed, complications, number of procedures, and death during the procedure or independent of the procedure were evaluated. Results: The median age was 93.0 (14.0-167.0) months. Hemolytic uremic syndrome (HUS) was the most common TPE indication with nine patients. The most common complication related to TPE was fever (11 patients), while no complication was observed in 18 patients. When laboratory results were evaluated according to American Society for Apheresis (ASFA) categories, a significant improvement was observed in the values of platelet, AST, ALT, LDH, urea, and creatinine in ASFA1 after TPE. No significant improvement was observed in ASFA2 (p > 0.05). In ASFA3, a significant improvement was observed in INR, AST, ALT, LDH, total bilirubin, creatinine, pH, and lactate values after TPE (p < 0.05). Five patients died from ASFA1, one from ASFA2, and three patients from ASFA3. Conclusion: Since significant adjustments are observed in clinical and laboratory values in sepsis-MOF, which is in the ASFA3 category, we believe that it should be evaluated in the ASFA2 or ASFA1 category in the early treatment of these diseases. In addition, we think that MIS -C cases, which have not been in any category according to ASFA, should be included in the ASFA2 or ASFA3 category, considering our TPE results.
Kürtlerin Avrupa Birliği'ne Yönelimi: Düşük Bilgi Düzeyi, Yüksek İdealist Beklentiler
(2016) Samur, Hakan; Demirtepe,Turgut
Kürt sorunu sadece uzun zamandır Türkiye'nin en önemli sorunlarından biri olmakla kalmamış aynı zamanda AB üyelik süreci bakımından da her zaman en önemli gündem maddelerinin başında yer almıştır. Bu açıdan, Kürtlerin AB ile ilgili meselelerde durdukları yer ve sahip oldukları görüşler kritik değere sahiptir. Elinizdeki çalışmada, üniversite mezunu Kürtler arasında gerçekleştirilen bir alan çalışmasından hareketle; literatürde kullanılan iki ana oryantasyon moduna, farkındalık (ilgi ve bilgi) düzeyine ve sübjektif değerlendirmelere dayalı olarak Kürtlerin AB'ye oryantasyonları (yönelimleri) analiz edilmeye çalışılmıştır.
Yavaş gelişen etlik piliçlerin karkas özelliklerine ve et kalitesine serbest yetiştirme sisteminin etkisi
(2012) Ahmet Şekeroğlu; Merve Diktaş
Bu çalışma, altlıklı yer sistemi, yarı açık gezinmeli serbest sistem ve gezinmeli serbest sistemin; yavaş gelişen etlik piliçlerin karkas özellikleri ve et kalitesine etkilerinin araştırılması amacıyla yapılmıştır. Denemede 270 adet yavaş gelişen Hubbard Isa Red-JA civcivi kullanılmıştır. Denemenin 61. gününde her yetiştirme sisteminden 12 adet, toplam olarak 36 adet yavaş gelişen etlik piliç, karkas ve et kalitesini saptamak amacıyla seçilmiştir. Araştırma sonuçlarına göre; yetiştirme sisteminin karkas randımanı, but oranı ve kanat oranına etkisi önemli bulunurken (P<0.05), göğüs oranı, sırt ve boyun oranına etkisi önemli bulunmamıştır (P>0.05). Göğüs eti pH, renk, protein, yağ, kül, kuru madde ve su tutma kapasitesi bakımından yetiştirme sistemleri arasındaki farklılık önemli çıkmamıştır (P>0.05). Göğüs eti çoklu doymamış yağ asitleri bakımından yetiştirme sistemleri arasındaki farklılık önemli bulunmuştur (P<0.01). Yağ asitlerinden miristoleik asit bakımından yetiştirme sistemleri arasındaki farklılık önemli (P<0.05), ele alınan diğer yağ asitleri arasındaki farklılık önemsiz bulunmuştur (P>0.05). Göğüs eti besin madde içeriği, çoklu doymamış yağ asidi ve tekli doymamış yağ asitlerinden miristoleik asit bakımından yarı açık gezinmeli serbest sistem diğer sistemlere göre bir üstünlük sağlamıştır.
Allelic variations of glutenin subunits and their association with quality traits in bread wheat genotypes
(Turkish Journal of Agriculture and Forestry, 2017) Aktaş , Hüsnü; Baloch, Faheem Shehzad
The present study was conducted to evaluate the genotype × environment interaction of the yield and quality traits for five bread wheat varieties commonly grown in the Southeastern Anatolia Region of Turkey and 20 advanced lines developed within the framework of the International Winter Wheat Improvement Project. We also determined the allelic pattern of the Glu-1 and Glu-3 loci of these genotypes and examined whether these loci had an effect on the quality traits. There was a significant variation among the genotypes and environments in terms of grain yield, protein content, sedimentation volume (SV), and the extensograph dough energy value (EDEV). The results of the study indicated that genotypic effect was more influential on SV and EDEV than environmental effect; thus, both traits could be used in breeding programs to develop elite cultivars with better quality. Twelve different high-molecularweight (HMW) glutenin alleles were identified at the Glu-A1, Glu-B1, and Glu-D1 loci, resulting in 14 allelic combinations, and 17 different alleles were observed in 19 combinations for low-molecular-weight (LMW) subunits. Furthermore, among all the genotypes, 13 + 16 and 13 + 19 alleles at Glu-B1 and 5 + 12 at Glu-D1 were observed to have the lowest frequency. Our study indicated that the combinations of HMW glutenin alleles with 2* at Glu-A1, 17 + 18 and 13 + 16 at Glu-B1, and 5 + 10 at Glu-D1, as well as the combinations of LMW alleles with subunits c and d at Glu-A3; subunits d, b, c, and g at Glu-B3; and subunits a and b at Glu-D3 had positive effects on the quality traits.
Citation - WoS: 2
Citation - Scopus: 2
Ascorbic Acid Exhibits More of a Protective Effect Than Estradiol Against Nephrotoxicity Induced by Malathion in Rats: a Histopathological and Molecular Docking Study
(TUBITAK Scientific & Technological Research Council Turkey, 2025) Alhilal, Mohammad; Salem, Mahmoud E. L. S. A. Y. E. D. M. O. H. A. M. E. D.; Ali Albakoush, Ahmed; Alhilal, Suzan; Farag, Basant; Gomha, Sobhi M.
Background/aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses. Materials and methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion and the effects of estradiol and ascorbic on nephrotoxicity were evaluated. After 4 weeks of treatment, the animals were sacrificed and the kidneys were examined following hematoxylin and eosin (H&E) staining. Histopathology results were supported by molecular docking studies of estradiol and ascorbic acid against a target protein (PDB ID: 2YMX), the peptide inhibitor Fab408 inhibiting acetylcholinesterase (AChE). The inhibition of AChE is the primary mechanism of the toxic effects of malathion. Results: Histopathological examination revealed a notable elevation (p < 0.001) in degeneration and necrosis within the tubular epithelium and interstitial nephritis in the malathion group compared to the sham group. Daily administration of estradiol and ascorbic acid resulted in a notable reduction (p = 0.0022) in the severity of these histopathological changes in the malathion + estradiol and malathion + ascorbic acid groups compared to the malathion group. Of these, the most significant decreases were observed in the malathion + ascorbic acid group. Docking studies of these compounds against the selected protein (PDB ID: 2YMX) revealed promising binding scores. Ascorbic acid exhibited the highest docking score (-6.44 kcal/mol), indicating a favorable binding interaction with this protein. Conclusion: Estradiol and ascorbic acid exert protective effects against malathion-induced nephrotoxicity, whereas ascorbic acid showed superior efficacy compared to estradiol. This result was further supported by molecular docking studies.
Citation - WoS: 5
Citation - Scopus: 6
Characterization and Bioremediation Potential of Heavy-Metal Resistant Bacteria Isolated From Agricultural Soil
(Tubitak Scientific & Technological Research Council Turkey, 2024) Dahnoun, Kheira; Djadouni, Fatima; Essghaier, Badiaa; Naccache, Chahnez; Zitouna, Nadia; Zehdi-Azouzi, Salwa; Bourguiba, Hedia
Heavy metal pollution is a major environmental issue that has a negative impact on soil quality and food security. As result, heavy metal removal or remediation from hazardous sites has become mandatory. Bioremediation based on microorganisms is promising method to remediate heavy metal-contaminated areas due to its ecofriendly, cost-effective, and highly efficient characteristics. This study aimed to isolate, identify, and characterize rhizospheric bacteria able to resist, reduce, and detoxify heavy metals [chromium (Cr), nickel (Ni), and aluminum (Al)] from agricultural soil. Two isolates were chosen due to their high level of heavy metal resistance and could serve as potential in situ remediation agents at the site of isolation. On the basis of morphological, cultural, biochemical, and molecular characterization, these two isolates were identified as Pseudomonas aeruginosa (S1) and Bacillus cereus (S2). The results revealed a minimum inhibitory concentrations (MICs) of the three heavy metals studied, ranging from 1000 to 1400 mu g/mL for the two bacterial isolates. Atomic absorption spectroscopy analysis was used to evaluate the degrading potential. B. cereus was able to reduce Cr and Al more than P. aeruginosa (42% and 67.78% vs. 38.44% and 58.85, respectively). On the other hand, P. aeruginosa showed a higher capacity to degrade Ni than B. cereus (62.33% and 50.76%, respectively). The findings of the analysis revealed information regarding the use of these heavy metal-resistant bacterial isolates as potential bioremediation agents in contaminated environments. Microbial bioremediation offers sustainable alternatives to the traditional physical or chemical remediation technologies of agricultural land.
Citation - WoS: 8
Citation - Scopus: 14
Employing deep learning architectures for image-based automatic cataract diagnosis
(TÜBİTAK, 2021) Acar, Emrullah; Türk, Ömer; Ertuğrul, Ömer Faruk; Aldemir, Erdoğan
Various eye diseases affect the quality of human life severely and ultimately may result in complete vision loss. Ocular diseases manifest themselves through mostly visual indicators in the early or mature stages of the disease by showing abnormalities in optics disc, fovea, or other descriptive anatomical structures of the eye. Cataract is among the most harmful diseases that affects millions of people and the leading cause of public vision impairment. It shows major visual symptoms that can be employed for early detection before the hypermature stage. Automatic diagnosis systems intend to assist ophthalmological experts by mitigating the burden of manual clinical decisions and on health care utilization. In this study, a diagnosis system based on color fundus images are addressed for cataract disease. Deep learning-based models were performed for the automatic identification of cataract diseases. Two pretrained robust architectures, namely VGGNet and DenseNet, were employed to detect abnormalities in descriptive parts of the human eye. The proposed system is implemented on a wide and unique dataset that includes diverse color retinal fundus images that are acquired comparatively in low-cost and common modality, which is considered a major contribution of the study. The dataset show symptoms of cataracts in different phases and represents the characteristics of the cataract. By the proposed system, dysfunction associated with cataracts could be identified in the early stage. The achievement of the proposed system is compared to various traditional and up-to-date classification systems. The proposed system achieves 97.94% diagnosis rate for cataract disease grading.
Citation - WoS: 1
Citation - Scopus: 1
A Characterization of Some Class Nonlinear Eigenvalue Problem in VELS
(Hindawi Ltd, 2019) Akin, Lutfi
A normal mode analysis of a vibrating mechanical or electrical system gives rise to an eigenvalue problem. Faber made a fairly complete study of the existence and asymptotic behavior of eigenvalues and eigenfunctions, Green's function, and expansion properties. We will investigate a new characterization of some class nonlinear eigenvalue problem.
The Involvement of the Serotonergic System in Ketamine and Fluoxetine Combination-Induced Cognitive Impairments in Mice
(Ataturk Univ, 2024) Uyar, Emre; Erdinc, Meral; Kelle, Lker; Erdinc, Levent; Seker, Ugur; Nergiz, Yusuf
Background: Gluta mater gic N-methyl-D-aspartate (NMDA) receptors play vital roles in memory formation. Changes in the activity of these receptors influence memory processes. Ketamine is a noncompetitive NMDA receptor antagonist drug with promising mood-altering and pain-reducing effects ff ects in low doses. These effects ff ects are believed to be related to altered serotonergic transmission. Methods: The present study investigated the involvement of the serotonergic system in low-dose ketamine administrations' effects ff ects on memory acquisition, consolidation, and retrieval processes. Sixty-four male BALB/c mice were used in this experiment and separated into 8t groups. Mice were treated subchronically with a selective serotonin reuptake inhibitor, fluoxetine, and a serotonin depletion agent, p-chlorophenylalanine (pCPA). A serotonin antagonist, methiothepin, and ketamine were acutely administered 60 minutes before or after the behavioral tests. A passive avoidance (PA) test measured emotional memory acquisition, consolidation, and retrieval processes. Hippocampi malondialdehyde (MDA) levels were analyzed, and histopathological examinations were performed. Results: Ketamine alone did not significantly affect ff ect memory encoding processes in the PA test, while the ketamine-fluoxetine combination disrupted memory consolidation. Fluoxetine negatively affected ff ected the memory acquisition process, which was normalized during the consolidation and retrieval trials. Drug applications did not significantly alter hippocampal MDA levels. In all ketamine-applied groups, histopathologic alterations were evident. Conclusion: Low-dose ketamine administration induces neurodegeneration, and it also impairs memory functions when combined with fluoxetine, indicating increased serotonergic transmission may be involved in the memory-impairing and neurotoxic effects ff ects of ketamine.
Citation - WoS: 7
Citation - Scopus: 10
Metabolic Syndrome in School Children in Mardin, South-Eastern of Turkey
(AVES Ibrahim Kara, 2014) Battaloğlu İnanç, Betül
Amaç: Okul çocukları popülasyonunda, metabolik sendrom (MES) prevelansının tespit edilmesi amaçlandı.Gereç ve Yöntem: Türkiye'nin güneydoğusundaki, Mardin şehir merkezinde, üç ilköğretim okulundaki, 7-15 yaşları arası, üç bin dört yüz altmış çocuk, Nisan-Mayıs 2011'de çalışmaya dahil edildi. Yaş, cins, boy, ağırlık, bel çevresi, kalça çevresi, bel/kalça oranı, sistolik ve diyas tolik kan basınçları ölçüldü ve kan testleri kaydedildi. MES tanısı için Uluslararası Diyabet Federasyonu (IDF) kriterleri kullanıldı.Bulgular: Çocukların %9,42'si fazla kilolu ve %8'i obezdi. Obezite kızlarda %9,1, erkekler de %6,9'du. Obezite prevelansı, kızlar arasında erkeklerden daha yüksek ve anlamlıydı (p<0.001). Vücut kitle indeksi (VKI) ve bel ve kalça çevresi, bel/kalça oranı, sistolik ve diyasto lik kan basıncı, trigliserid arasında pozitif korelasyon bulundu (p=0.0001). Total kolesterol, trigliserid, VKI, sistolik ve diyastolik kan basıncı obez MES'lu grupta, obez olmayanlardan anlamlı farklı idi (p<0.05). Kızların bel/kalça oranı referans değerleri, erkeklerinkinden anlamlı olarak daha yüksekti (p>0.05). MES prevelansı %6,3'tü. MES, kızlarda ve obezlerde daha yüksekti. Obez çocuklarda MES oranı %30,3'tü.Sonuç: Çocukluk döneminde obezite, hipertansiyon ve MES sıklığı her geçen gün artmakta dır. Santral obezite ve yüksek vücut kitle indeksine sahip olan çocuklar, MES için daha dikkat li değerlendirilmelidir. Ve toplumun yaşam kalitesi, yaşam tarzı değişiklikleri ile risklerin azaltılması yoluna gidilerek, gerekli tedavi ve takiplerle sağlanmalıdır.

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