Hemşirelik Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/222

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Citation - WoS: 7
Citation - Scopus: 7
Analysis of bioactive compounds using LC-ESI-MS/MS, cytotoxic, antimicrobial effects, and enzyme activities from Cyclotrichium origanifolium
(Wiley Online Library, 2022) Aktepe, Necmettin; Baran, Ayşe; Atalar, Mehmet Nuri; Baran, Mehmet Fırat; Keskin, Cumali; Taşkin, Abdullah; Yavuz, Ömer; Demirtaş, İbrahim; Oğuz, Ercan; Jahan, Israt
Cyclotrichium origanifolium is a medicinal plant belonging to the Lamiaceae family. In this study, phenolic content analysis, antimicrobial effects, and cytotoxic effects of extracts of C. origanifolium were investigated. In the extracts, phenolic compound analysis by the liquid chromatography–electrospray ionization– tandem mass spectrometry method, antimicrobial effect by the minimum inhibition concentration method, and cytotoxic effect on human dermal fibroblasts (HDF), glioblastoma cell (U87), ovarian adenocarcinoma cell (Skov-3), and human colorectal adenocarcinoma cell (CaCo-2) cancer cell lines were investigated. Cytotoxicity analyses were performed by the MTT method. In addition, the GST and AChE enzyme activities of the extracts were also measured. Around 18 compounds were detected in both the methanol and ethanol extract. It was found that the best antimicrobial effect on Gram-negative Pseudomonas aeruginosa was on methanol extract, while the ethanol extract was on Candida albicans fungus (respectively, 2.50mg/ml, 5.0 μg/ml). A 500μg/ml of methanol extract has been shown to have cytotoxic activity high effect on HDF cells. GST and AChE activity were found to decrease in a concentration-dependent manner.
Citation - WoS: 2
Citation - Scopus: 2
Determination of Chemical Composition and Antioxidant, Cytotoxic, Antimicrobial, and Enzyme Inhibition Activities of Rumex Acetosella L. Plant Extract
(Springer int Publ AG, 2024) Kandemir, Sevgi Irtegun; Aktepe, Necmettin; Baran, Ayse; Baran, Mehmet Firat; Atalar, Mehmet Nuri; Keskin, Cumali; Khalilov, Rovshan
Purpose The phenolic composition, antioxidant, antimicrobial activity, enzyme inhibition activity, and cytotoxic activity potentials of the plant Rumex acetosella L. (R. acetosella) were examined in this study. Materials and Methods: The chemical composition of R. acetosella methanol extract was identified by the LC-MS/MS method. The antioxidant activity was tested using beta-carotene/linoleic acid, DPPH free radical scavenging, ABTS cation radical scavenging, CUPRAC reducing power, and metal chelating activity methods. The cytotoxic activity was determined by the MTT assay using human ovarian adenocarcinoma (Skov-3), glioblastoma (U87), human dermal fibroblasts (HDF), and human colorectal adenocarcinoma (CaCo-2) cell lines. The antimicrobial activity of methanolic extracts was tested on gram-negative (Escherichia coli and Pseudomonas aeuriginosa) and gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) using the in vitro minimum inhibition concentration method (MIC). Enzyme inhibition activity of R. acetosella methanol extract was measured spectrophotometrically against acetylcholinesterase (AChE) and glutathione S-transferase (GST) enzymes. Results: The findings showed that the major components of the methanol extract content were luteolin-7-O-glucoside (1.599 m/L), polydatin (91,024 m/L), and shikimic acid (0.773 m/L). It was determined that the extract and standard antioxidant (a-tocopherol) results in DPPH center dot, and ABTS center dot + tests performed to determine the antioxidant activity were close to each other, and this value was more effective than the standard antioxidant (alpha-tocopherol) in the CUPRAC test. These results suggested that the plant's antioxidant potential was higher when compared with reference antioxidant compounds. It was determined that the methanol extract of R. acetosella had a weaker effect on the growth of the tested microorganisms than the antibiotics used as standard. The activity of the GST and AChE enzymes was found to be severely inhibited by the methanol extract of R. acetosella. Conclusion: Based on these findings, R. acetosella L. is a medicinal and commercially beneficial plant that warrants further investigation.
Citation - WoS: 3
Citation - Scopus: 5
Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency
(Turkish journal of obstetrics and gynecology, 2020) Demir, Bülent; Sarıdaş Demir, Süreyya; Özkan Karacaer, Kübra; Paşa, Semir; Sılan, Fatma
Objective: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory markers of hemogram parameters in POI. Materials and Methods: The study compared 47 healthy women and 47 women diagnosed as having POI retrospectively by scanning electronic and written recording systems. Complete blood counts, day-3 hormone profiles levels of all subjects were analyzed. The neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), platelet ratio (RPR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) mean platelet lymphocyte ratio (MPLR) were calculated from the complete blood count parameters. Results: White blood cell and MPV values, platelet, and lymphocyte counts were significantly higher in the POI patients (p<0.001, p=0.042, p=0.038, p=0.049, respectively), RPR was significantly lower than the control group (p=0.011), but there were no significant differences in hemoglobin, RDW, NLR, PLR, and MPLR (p=0.454, p=0.057, p=0.635, p=0.780, p=0.126, respectively). The neutrophil count of the study group was higher than in the control group (p=0.057). Bivariate correlation analyses showed no correlations between blood parameters and hormone levels. The area under the receiver operating characteristic curve for RPR in POI was 0.652, with a threshold value 0.053, sensitivity=63% and specificity=63. Conclusion: Inflammatory markers of hemogram detected higher in patients with POI then control subjects.
Exploring attendance at emergency departments for children with non-urgent conditions in Turkey: a qualitative study of parents and healthcare staff perspectives
(Wolters Kluwer, 2022) Bütün, Ahmet; Lynn, Fiona; McGaughey, Jennifer; McLaughlin, Katrina; Linden, Mark
Background: Overcrowding in Emergency Departments (EDs) is a significant global concern with negative consequences for patients, healthcare staff, and healthcare systems. The use of EDs by parents of children with non-urgent conditions is associated with overcrowding, higher healthcare costs, lower quality of care, and longer waiting times. Research in this area has largely been conducted in high-income countries, with a dearth of work originating in middle and low-income regions. The aim of this study was to explore the reasons for parents attending EDs with their child for non-urgent conditions in Turkey. Method: Semi-structured interviews were conducted with 13 parents, 15 ED staff, and 10 General Practitioners (GPs) in 2 regions of Turkey between March and May 2017. Data were analyzed using the principles of grounded theory. Results: The findings were classified into 5 core categories: (1) parents’ feelings, knowledge, and perceived inability to provide self-care; (2) perceived limitations of healthcare services, system, and staff; (3) parents’ preferences for hospital and ED services; (4) adverse impact on ED services; and (5) perceived needs for care. Conclusion: This is the first study conducted in a middle-income country regarding parental reasons for using the ED for nonurgent conditions. Greater efforts must be made to reduce unnecessary visits to the ED to better meet service user needs and to increase the satisfaction of both parents and healthcare staff. The findings of this study may inform healthcare providers, policymakers, healthcare staff, and researchers to design interventions in order to mitigate overcrowding in the ED.
Citation - WoS: 10
Citation - Scopus: 8
Exploring Attendance at Emergency Departments for Children With Non-Urgent Conditions in Turkey: a Qualitative Study of Parents and Healthcare Staff Perspectives
(Lippincott Williams & Wilkins, 2022) Butun, Ahmet; Lynn, Fiona; McGaughey, Jennifer; McLaughlin, Katrina; Linden, Mark
Background:Overcrowding in Emergency Departments (EDs) is a significant global concern with negative consequences for patients, healthcare staff, and healthcare systems. The use of EDs by parents of children with non-urgent conditions is associated with overcrowding, higher healthcare costs, lower quality of care, and longer waiting times. Research in this area has largely been conducted in high-income countries, with a dearth of work originating in middle and low-income regions. The aim of this study was to explore the reasons for parents attending EDs with their child for non-urgent conditions in Turkey.Method:Semi-structured interviews were conducted with 13 parents, 15 ED staff, and 10 General Practitioners (GPs) in 2 regions of Turkey between March and May 2017. Data were analyzed using the principles of grounded theory.Results:The findings were classified into 5 core categories: (1) parents' feelings, knowledge, and perceived inability to provide self-care; (2) perceived limitations of healthcare services, system, and staff; (3) parents' preferences for hospital and ED services; (4) adverse impact on ED services; and (5) perceived needs for care.Conclusion:This is the first study conducted in a middle-income country regarding parental reasons for using the ED for nonurgent conditions. Greater efforts must be made to reduce unnecessary visits to the ED to better meet service user needs and to increase the satisfaction of both parents and healthcare staff. The findings of this study may inform healthcare providers, policymakers, healthcare staff, and researchers to design interventions in order to mitigate overcrowding in the ED.
Citation - WoS: 5
Citation - Scopus: 7
Relationship Between School Performance and Breakfast Quality in Refugee Children: Case Study of Mardin Region
(IRANIAN JOURNAL OF PEDIATRICS, 2021) Bayram Deger, Vasfiye; Arslan, Nurgul; Dag, Ibrahim; CifCi, Sema
Background: Many studies have found that the academic success of school-age children is proved to be in close relation with regular and healthy nutrition. Objectives: This study aims to investigate the relationship between breakfast quality and academic success of refugee primaryschool children. Methods: After scanning 24 schools in the city center, 384 students who were refugee Syrians from primary schools in Mardin city center were included. In addition to the demographic characteristics of the individuals, breakfast habits of these students were investigated. Results: In this study, 91.6% of the children stated that they have breakfast habits. The reasons for skipping breakfast among students of all levels can be listed as being late for school (67.8%) and not liking to have breakfast (18.8%). The breakfast quality index (BQI) score was low in both boys and girls and all age groups. According to this marked value, all age groups had poor nutrition in terms of breakfast. Although girls showed a significant difference in all age groups (P = 0.046), this difference was not significant among boys (P = 0.671). The number of students with a breakfast quality score higher than 8 was very low. It was observed that boys had the highest academic success with the lowest breakfast quality score. The breakfast quality score of girls with the best academic success ranged between 4 - 7 points. Conclusions: It was observed that academic success was linked to having breakfast habit, and students had breakfast habit performed relatively better in school compared to those who did not.
Citation - WoS: 6
Citation - Scopus: 8
Seven-membered Rings with Three Heteroatoms: Chemistry of 1,2,5-and 1,4,5-Thiadiazepines
(BENTHAM SCIENCE PUBL LTD, 2018) Doğru Mert, Başak; Elattar, Khaled M.
This review describes the chemistry of 1,2,5- and 1,4,5- thiadiazepines. The investigated heterocycles are monocyclic and fused 1,2,5- and 1,4,5- thiadiazepines. The different sections cover: structural elucidation "spectroscopy", reactivity of substituents attached to ring carbon and nitrogen atoms, synthesis of monocyclic and fused heterocycles incorporated 1,2,5- and 1,4,5- thiadiazepine moiety. Nitrogen and sulfur atoms of thiadiazepine ring system have the ability to donate the electrons pairs in order to form coordination bonds forming different complexes. The aim of this review is to discuss the chemistry of title compounds up till now. The reaction mechanisms are described and discussed, as well as, the biological applications of the target compounds.

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