Beslenme ve Diyetetik Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/223

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1-(2-Hydroxyethyl)-2-imidazolidinone as corrosion inhibitor of mild steel in 0.5 M HCl solution: thermodynamic, electrochemical and theoretical studies
(Journal of Adhesion Science and Technology, 2019) Keleşoğlu, Ayşen; Yıldız, Reşit; Dehri, İlyas; Yıldız, Reşit
The inhibition effect of 1-(2-Hydroxyethyl)-2-imidazolidinone (2-HEI) on mild steel (MS) corrosion in 0.5M HCl solution was investigated at different inhibitor concentration and temperature by electrochemical experiments, such as linear polarization resistance (LPR), electrochemical impedance spectroscopy (EIS), potentiodynamic polarization and quantum chemical calculations. The inhibitor adsorption process on mild steel in 0.5M HCl system was studied at different temperatures (20 C–50 C). Furthermore, the surface morphology of MS was also investigated with SEM in the absence and the presence of inhibitor. The adsorption of 1-(2-Hydroxyethyl)-2-imidazolidinone on MS surface is an exothermic process and this process obeys the Langmuir adsorption isotherm. The Quantum chemical findings are good agreed with the empirical data.
Effect of seasonal variation on lipid and fatty acid profile in muscle tissue of male and female Silurus triostegus
(SPRINGER INDIA, 2016) Kacar, Semra; Bashan, Mehmet; Oymak, Seyit Ahmet
Fatty acid (FA) compositions of total lipid, phospholipid (PL) and triacylglycerol (TAG) fractions have been determined in muscle tissues of Silurus triostegus. The distributions of saturated fatty acid (SFA), monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) proportions were found to be different among total lipid, PL and TAG fractions from lipids in muscle tissues of the male and female S. triostegus in all seasons. Triacylglycerol contained a lower proportion of PUFA and a higher proportion of MUFA and SFA than PL while PL contained higher proportion of PUFA than proportion of MUFA and SFA compared to TAG. Triacylglycerol and PL fatty acid compositions in muscle tissues of the male and female fish species were found different. The most abundant fatty acids in the investigated seasons were palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1 n-9), palmitoleic acid (C16:1 n-7) and docosahexaenoic acid (C22:6 n-3). It was shown that the total lipid content and FA compositions in muscle tissues of the male and female S. triostegus were influenced by reproduction period and season.
The effects of oxytocin on penile tissues in experimental priapism model in rats
(SPRINGER, 2019) Kolukçu, Engin; Kılıç, Şahin; Parlaktaş, Bekir Süha; Erdemir, Fikret; Ünsal, Velid; Atılgan, Doğan; Uluocak, Nihat
PurposeThis study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.MethodsForty Wistar Albino strain male rats were divided into four groups. The control group (n=10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30min following priapism. Rats in Group 4 rats were given oxytocin 30min before the induction of reperfusion following priapism. All rats were penectomized, and adequate amounts of blood sample were drawn. Inflammation, vasocongestion, desquamation, and edema in penile tissue were scored between 0 and 3 points (0: normal, 1: mild, 2: moderate, 3: severe) to evaluate the severity of tissue damage. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA), and nitric oxide (NO) in blood samples were determined spectrophotometrically.ResultsIn histopathological examination, statistically significant positive changes were detected in vasocongestion, inflammation, desquamation, and edema scores in Group 4 than in Group 2 and Group 3 (p<0.001). Biochemical test results revealed that NO levels were significantly lower in Group 4 than in Group 3 (p<0.001). Serum GSH-Px activities in Group 4 significantly increased when compared with the other groups 2 and 3 (p=0.002, p=0.001, respectively). There was no statistical difference among the groups regarding SOD activities and MDA levels (p>0.05).ConclusionsOxytocin protected against priapism-induced ischemia-reperfusion injury developed in cavernosal tissue as observed based on histopathological and biochemical evidence. Although this is an experimental study, oxytocin can be thought as an alternative drug in the treatment of priapism.
Evaluation and characterization of Pleurotus eryngii extract-loaded chitosan nanoparticles as antimicrobial agents against some human pathogens
(Taylor & Francis Online, 2020) Acay, Hilal; Yıldırım, Ayfer; Erdem Güzel, Elif; Kaya, Nalan; Baran, Mehmet Fırat
With the increase of antibiotic resistance, which is present at a worrying rate, research on the use of newly developed nanoparticles as an antimicrobial agent with green biotechnology has intensified. The study aimed to investigate the antimicrobial effects of chitosan nanoparticles (CSNP) synthesized using Pleurotus eryngii extract (PE). Characterization of P. eryngii-loaded chitosan nanoparticles (PE-CSNPs) was performed with Fourier transform infrared spectrophotometer, X-ray diffraction, Field-emission scanning electron microscopy, Brunauer-Emmett-Teller, Differential scanning calorimetry, and zeta potential techniques. The FE-SEM images showed that the surface morphology of nanoparticles is similar to CS, but has more porosity network and smaller dimensions structure. The average particle size of spherical PE-CSNPs was obtained as 330.1 nm. The specific surface area and average pore diameter of the synthesized nanoparticles were found as 3.99 m2g-1 and 2.25 nm, respectively. X-ray diffraction determines the presence of an amorphous peak at 2θ = 21.2° results from CS and PE. PE-CSNPs synthesized using P. eryngii extract showed strong antimicrobial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Candida albicans as 0.0156, 0.0625, 0.0625 and 0.0312 mg ml-1, respectively. Thus, it was determined that chitosan nanoparticles formed by the green synthesis of P. eryngii extract showed strong anti-microbial properties.
Experimental and theoretical study on hydrogen production by using Ag nanoparticle‐decorated graphite/Ni cathode
(2021) Yıldız, Reşit; Doğru, Mert, Başak; KARAZEHİR, TOLGA; GÜRDAL DURĞUN, YELİZ; Toprak Döşlü, Serap; Yıldız, Reşit
In this study, graphite (G) electrode was coated with nickel and decorated with silver nanoparticles (G/Ni/Ag) with the help of galvanostatic method, and electrodes were used as a cathode in alkaline water electrolysis system. The characterization was achieved using X-ray diffraction and field emission scanning electron microscopy. Hydrogen evolution performance of electrodes was investigated via cyclic voltammetry, chronoamperometry, cathodic polarization curves, and electrochemical impedance measurements. Electrochemical results showed that hydrogen production efficiency significantly increased and charge transfer resistance decreased via G/Ni/Ag. The electrochemical water splitting performance of G/Ni/Ag, was established in a joint experimental and computational effort. Water and proton adsorption on Ag-decorated Ni surface were investigated using density functional theory. Electronic structure calculations identified the role of Ag adatom and Ni surface on water and proton adsorptions. From the computational studies, O in water was more reliable to adsorb at the bridge position of the Ag and Ni atoms, leading improved orbital overlap between H and Ni atoms and maximized chemical and physical interactions between the H2O molecules. Therefore, the Ag-decorated Ni(111) surface provides preferable adsorption site for the O atom in water and direct interactions between water Hs and available surface Ni atoms promote water dissociation.
Milrinone ameliorates ischaemia-reperfusion injury in experimental testicular torsion/detorsion rat model
(Andrologia, 2021) Unsal, Velid; Kölükçü, Engin; Atılgan, Doğan; Uluocak, Nihat; Deresoy, Faik Alev; Katar, Muzaffer
This experimental study aims to evaluate the efficacy of milrinone against ischaemia-reperfusion injury due to testicular torsion/detorsion. Group 1 was defined as the control group. Testicular torsion/detorsion model was performed in Group 2. Group 3 had similar procedures to the rats in Group 2. In addition, 0.5 mg/kg of milrinone was administered intraperitoneally immediately after testicular torsion in Group 3. Histopathological examinations indicated a dramatic improvement in terms of inflammation, haemorrhage, oedema, congestion, Cosentino and Johnson scores in Group 3 compared to Group 2 (p =.037, p =.045, p =.018, p =.040, p =.033 and p =.03 respectively). Blood biochemical analyses, superoxide dismutase (SOD), glutathione peroxidase (GSH-px) activity and total antioxidant status (TAS) levels increased significantly in Group 3 compared to Group 2 (p =.001, p =.024 and p <.001). Malondialdehyde (MDA), protein carbonyl (PC), interleukin 1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and total oxidant status (TOS) levels decreased in Group 3 compared to Group 2 (p =.001, p =.018, p <.001, p =.036 and p =.002 respectively). Tissue biochemical analyses determined an increase in SOD and GSH-px activity in Group 3 compared to Group 2, while PC and MDA levels were reduced (p =.001, p <.001, p =.038 and p <.001 respectively). Milrinone attenuates ischaemia-reperfusion injury that causes highly harmful effects due to testicular torsion/detorsion.
Morchella esculenta-based chitosan bionanocomposites: Evaluation as an antifungal agent
(Wiley Online Library, 2022) Acay, Hilal; Yildirim, Ayfer; Güney, İnci Güler; Derviş, Sibel
Considering the damage caused by fungicides to human health and problems such as microbial resistance, biological control against plant pathogens has started to gain importance worldwide. This research demonstrates a new, simple, cost-effective, and environmentally friendly method for synthesizing chitosan bionanocomposite (CBNC) from Morchella esculenta (L) Pers-extract (MEE). The antifungal property of the synthesized Morchella esculenta (L) Pers-chitosan bionanocomposite (MCBNC) against some plant pathogens was also evaluated. FTIR, XRD, FE-SEM, DSC, TGA, and BET were used to characterize the synthesized MCBNC. Mushroom-based chitosan nanoparticles were evaluated for antifungal activity against some fungal pathogens, including Neoscytalidium novaehollandiae, N. dimidiatum, Alternaria alternata, Verticillium dahliae, Bipolaris sorokiniana, and Colletotrichum sp. The findings obtained clearly showed that chitosan nanoparticles have antifungal activity. The results suggest that the chitosan nanoparticle can be used in the field to protect various crops from phytopathogens. Novelty impact statement Chitosan bionanocomposite (MCBNC) synthesis was performed for the first time using the wild mushroom Morchella esculenta, which has strong bioactive properties. It was observed that the bionanomaterial, which was characterized by FTIR, XRD, FE-SEM, DSC, TGA, and BET analyses, has high antifungal activity against plant pathogens such as Alternaria alternata and Bipolaris sorokiniana. MCBNCs synthesized by the green synthesis method can be an important area of use in the fight against plant pathogens, which corresponds to 1/3 of the world's agricultural production potential.
Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism
(Andrologia, 2021) Unsal, Velid; Kölükçü, Engin; S. Parlaktaş, Bekir; Kölükçü, Vildan; Fırat, Fatih; Deresoy, Faik A.; Katar, Muzaffer; Kuyucu, Yunus Emre
The study aimed to investigate the effects of dexmedetomidine against ischaemia-reperfusion injury occurring after priapism in a model of induced-priapism in rats. A total of 18 male rats were randomised into three groups. Group 1 was the control group. A priapism model was performed rats in Group 2 and then ischaemia-reperfusion injury was evaluated. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 100 μg/kg dexmedetomidine administered intraperitoneally immediately after reperfusion. Blood and tissue samples were analysed. Biochemical analysis of blood samples revealed a decrease in the levels of the pro-inflammatory cytokines including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:.04, p:.009 and p:.009, respectively). Similarly, the highest malondialdehyde (MDA) level was in Group 2 (p:.002). The levels of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were significantly higher in Group 3 than that of Group 2 (p:.037 and p:.045, respectively). Direct microscopic examinations revealed positive changes in desquamation, oedema, inflammation and vasocongestion scores in Group 3 compared to Group 2 (p:.007, p:.008, p:.007 and p:.006, respectively). Dexmedetomidine has a protective effect against ischaemia-reperfusion injury in penile tissue.
Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats
(Andrologia, 2021) Unsal, Velid; Kölükçü, Engin; Gevrek, Fikret; Fırat, Fatih
This study aimed to investigate the protective effect of sinapic acid (SA) on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. Twenty-four rats were randomised into four groups: sham group, ischemia/reperfusion (IR) group subjected to testicular torsion for 2 hr and then detorsion for 4 hr, and two groups treated with SA1 and SA2 (10 mg/kg and 20 mg/kg, by single intraperitoneal injection, 30 min before reperfusion). Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured by an autoanalyzer, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), protein carbonyl (PC), and nitric oxide (NO) oxidative stress parameters by spectrophotometric methods, and tumour necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6) parameters by the Elisa method. In addition, immunohistochemical and histopathological examinations were performed on testicular tissues. There was no significant difference between the groups in terms of serum testosterone, FSH and LH levels (p >.05). SA significantly reduced increased testicular damage, oxidative stress, inflammation, cell death and also restored decreased antioxidant enzyme activities (p <.05). Pre-treatment of rats with SA reduced testicular dysfunction and morphological changes IRI. SA's antioxidant, anti-inflammatory, and antiapoptotic properties were found to be protective against testicular IR
Utilization of Morchella esculenta-mediated green synthesis golden nanoparticles in biomedicine applications
(Taylor & Francis Online, 2021) Acay, Hilal
This study aimed to synthesize gold nanoparticles (AuNPs) by hot water extract in room conditions using edible Morchella esculenta (ME) and investigate the bioactive properties of the synthesized Morchella esculenta-based gold nanoparticles (ME-AuNPs). The characterization of the biologically synthesized ME-AuNPs was made using the ultraviolet-visible spectrophotometry, X-ray crystallography, scanning electron microscopy, Fourier transforms infrared spectroscopy, and energy dispersive X-ray spectrum methods. The ME-AuNPs, with a particle size of 16.51 nm, were found to have strong bioactive properties. The antioxidant activity of the ME-AuNPs attempted by metal chelating activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity and the β-carotene linoleate model system. The activities at 10 mg/mL were 82, 85, and 77% for the chelation of ferrous ions, DPPH scavenging, and β-carotene linoleate tests, respectively. The ME-AuNPs also showed strong antimicrobial activity against various pathogen microorganisms and strong cytotoxic activity in the A549 and HepG2 cell lines. This study demonstrated the possibility of using a cheap and nontoxic fungal extract as a reducing and stabilizing agent for the synthesis of size-controlled, large-scale, and biocompatible AuNPs that could be used in future diagnostic and therapeutic applications.
Volatile Compounds, Bioactive Properties and Chlorophylls Contents in Dried Spearmint (Mentha Spicata L.) as Affected by Different Drying Methods
(Journal of Agricultural Sciences, 2023) Korkmaz, Aziz; Arslan, Erhan; Koşan, Meltem
This study presents a comparison of the quality characteristics of spearmint (Mentha spicata L.) dried by a photovoltaic thermal dryer (PVT), the shade dried spearmint (SDS), and an oven dried spearmint (ODS). The obtained samples were evaluated with respect to volatile compounds (VC), total phenolic content (TPC) and flavonoid content (TFC), antioxidant capacity (AC) and chlorophylls (Chl) contents. PDS had the highest amount of TPC, TFC and AC, while SDS and ODS did not differ significantly from each other in terms of these features. SDS exhibited the highest Chl a and Chl b contents, whereas ODS showed the lowest. The composition of VC in the dried spearmints was significantly affected by the drying methods used. The total amount of terpenoids, especially carvone, responsible for spearmint’s characteristic aroma in SDS was higher than those of the others, while the concentrations of most VC were lowest in ODS. According to the results, the PVT can be recommended for drying spearmint.

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