WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

Browse

Now showing 1 - 20 of 149

2023-2024 Excavations at Boğaziye Höyüğü: a Recently Discovered Mound Settlement in the Upper Khabur Region
(Istanbul Univ, 2025) Gene, Bulent; Sahin, Muaviye; Isik, Senem; Abakay, Ayda; Kaya, Semsihan; Konyar, Erkan; Tan, Armagan
Boğaziye Höyük lies at the northwestern end of the vast and fertile Upper Khabur Region, which stretches along the southern foothills of the Kašiari Mountains. Material culture remains unearthed at the mound by two seasons of excavations (2023-2024) shows significant similarities to assemblages known from other Upper Khabur sites. Our excavations in Trenches BE18-BE17 and BF18 on the northern slope of the mound focused on revealing the stratigraphic sequence in this area. Architectural remains of Building Levels I and II and finds from these contexts in Trench BE18 are dateable to the mid-3rd millennium BC. In Trench BE17, Building Level I also revealed finds that can be dated to the 3rd (especially mid-3rd) millennium BC, and in Trench BF18, ceramic sherds dateable to the 3rd millennium BC were found in Building Level III. This article presents new findings from Boğaziye Höyük and discusses their significance in comparison with the results of surveys and excavations in the Upper Khabur Region, which have continued increasingly since the mid-1930s. We evaluate the significance of Boğaziye Höyük as a regional center within the Upper Khabur basin, and we elucidate its habitation sequence and building levels in the light of our recent excavations. Based on a comparative evaluation of its material culture remains within a regional perspective, we contextualize Boğaziye Höyük in relationship to the cultural horizons of the early and mid-3rd millennium BC in the Upper Khabur Valley.
Abnormal Uterine Bleeding in Adolescent Girls Retrospective Study
(Brieflands, 2025) Ozalkak, Servan; Yildirim, Ruken; Karakaya, Amine Aktar; Tas, Funda Feryal; Oncel, Kahraman; Okur, Nurettin; Ozbek, Mehmet Nuri
Background: Abnormal uterine bleeding (AUB) is the most common reason for gynecology-related hospital admissions in adolescence. Objectives: The present single-center study aimed to evaluate the diagnosis distribution in adolescents with AUB and to compare the clinical features and treatments of patients with hemoglobin levels below and above 10 g/dL. Methods: The present single-center study retrospectively collected demographic and epidemiological data from adolescents aged 10 - 18 years presenting to our institution with a diagnosis of AUB. Patient data were extracted from electronic medical records and analyzed using SPSS software. Descriptive statistics, including frequency, percentage, mean, standard deviation (SD), median, and interquartile range (IQR), were calculated. Patients were classified according to hemoglobin levels (< 10 g/dL as group 1 and >= 10 g/dL as group 2). Results: Among 167 adolescent patients, 35.9% had hemoglobin levels below 10 g/dL. Hospitalization rates were significantly higher in group 1 (86.4%) compared to group 2 (2.8%) (P < 0.001). The most common causes of AUB were anovulation (84.4%) and polycystic ovary syndrome (PCOS) (11.4%). The primary treatments included combined oral contraceptives (COCs) with iron supplementation (45.5%) and iron alone (28.7%). Erythrocyte transfusion (ERT) was performed in 18% of cases, predominantly in group 1. This study is limited by the lack of a standardized quality of life assessment tool for AUB. The single-center design and retrospective data collection may limit the generalizability of the findings and introduce selection bias, respectively. Conclusions: Anovulation and PCOS are the main causes of AUB in adolescents. Patients with hemoglobin levels below 10 g/dL and active bleeding should be evaluated carefully, as ERT may be necessary. A wide differential diagnosis should always be considered when managing adolescent AUB.
Abu Ubayd’s Understanding Of Naskh;
(Hitit Univ, 2022) Yasar, Mehmet Aziz; Nas, Taha
In the period when Islamic sciences were formed, a large number ofscholars with absolute ijtihad capacity were trained. One of the scholars mentioned is Abu `Ubayd al- Qasim ibn Sallam al-Khurasani al-Harawi who was educated by many famous scholars of the period, had a great influence on both the scientific and political circles. For this reason, he could not be shared by different sect biographers. As a matter of fact, some Shafi'i tabaqat writers counted Ebu Ubeyd as a follower of Imam Shafii. On the other hand, some Hanbali scholars have mentioned Ebu Ubeyd among the class of Hanbali scholars. However, it was concluded that it would be more correct to see Ebu Ubeyd as an independent mujtahid rather than a follower of any madhhab. For, in his own works, the fact that he refers more to Imam Malik rather than Imam Shafii and Ahmad ibn Hanbal and sometimes refers to the views of Abu Hanifa and Imamey indicates this. Ebu Ubeyd, who came to the forefront with his faqih and muhaddis aspects, had a deep knowledge of the subject of naskh, which has a close relationship with these two sciences, and in this regard, he wrote a rare work called en-Nasih ve'l-mensu. fi'l-kur.ani'l-aziz ve ma fihi mine'l-fera'iz ve's-sunen. While revealing Ebu Ubeyd's understanding of naskh, his work en-Nasi. ve'l-mensu. was used as the main source. In addition to this, his other works related to the subject, especially his work called Kitabu'l- emval, were among the first hand sources that were consulted. It has been tried to determine his approach to naskh based on the statements he made on the subject and the examples he gave in this regard. In this context, Ebu Ubeyd's approach to the nature and framework of naskh and his views on the evidences that can abrogate each other are examined in this study. Ebu Ubeyd discussed the abrogation in a broader sense as "the modification of a shar'i ruling by a later evidence", not the established meaning in the methodology as "removal of a shar'i ruling with a later shar'i proof". In this context, naskh is also used for the allocation of public, the denial of the absolute, the statement of conciseness, the correction of a wrong understanding and the exception made from a general rule. This is known as the understanding of naskh among the companions, tabi`in and early convert scholars. However, although Ebu Ubeyd is at the same age as Imam Shafii and has copied and benefited from his works, it is noteworthy that he preferred the predecessor's approach to the subject rather than the naskh understanding he adopted. It is important to investigate this. He adopted the approach of the public regarding the Shari'a evidences of Ebu Ubeyd that could naskh each other. According to him, the verses of the Qur'an can naskh each other. He gave many examples of this. Another point that draws attention here is to ascribe the concept of naskh used for the verse of the Qur'an by Ebu Ubeyd, from the Lawh-i Mahfuz, in the form of a verse whose recitation is lasting and its meaning is naskhed, and a verse that is removed from people's hearts by canceling both its recitation and used in different meanings. Ebu Ubeyd stated that sunnah can be naskhed with sunnah, without making any distinction between ahad and mutawatir about sunnah and its naskh. However, despite giving many examples of the naskh of the ahad sunnah with its own like, no example has been encountered of the naskh of the ahad sunnah with its own like or with ahad and the ahad sunnah with the mutawatir sunnah. As it can be understood from my statements on the subject, Ebu Ubeyd saw that it is permissible to naskh both mutawatir and ahad sunnah with the Qur'an. However, while there is an example for the naskh of the ahad sunnah with the Qur'an in his related works, there is no example for the other. Although there is no clear statement on the issue that the Qur'an can be naskhed with the sunnah, it is understood from some examples that he gives permission for this.
Actors: Kurdish National, Religious and Economic Blocs
(I B Tauris & Co Ltd, 2017) Cicek, Cuma; 04.03. Department of Political Science and International Relations / Siyaset Bilimi ve Uluslararası İlişkiler Bölümü; 04. Faculty of Economics and Administrative Sciences / İktisadi ve İdari Bilimler Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
[No Abstract Available]
Adapting To Conflict: Iran's Proxy Warfare Strategy in
(Kafkas University Iibf, 2025) Kazdal, Melıh; 04.03. Department of Political Science and International Relations / Siyaset Bilimi ve Uluslararası İlişkiler Bölümü; 04. Faculty of Economics and Administrative Sciences / İktisadi ve İdari Bilimler Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Bu çalışma İran’ın, Suriye ve Yemen’de vekalet savaşını nasıl kullandığını incelemektedir. Çalışmada vekalet savaşı kavramsal çerçevesi kullanılmış ve sahadaki uygulaması Andrew Mumford’un ortaya koyduğu dörtlü çerçeve olan, insan gücü temini, askeri malzeme temini, finansal yardım ve askeri olmayan yardım üzerinden incelenmiştir. Çalışmada, hem vakalar içindeki hem de vakalar arasındaki durumların incelenmesine olanak tanıyan çoklu vaka analizi yöntemi kullanılmıştır. Bu yaklaşımı kullanarak vakaların benzerliklerini, farklılıklarını ve altında yatan nedenleri ortaya koymak amaçlanmıştır. Suriye ve Yemen’in vaka analizi için seçilmesi, İran’ın bölgedeki vekalet savaşı stratejisinin değerlendirilmesine olanak tanıyan farklı çevresel ve sosyo-politik faktörlere dayanmaktadır. Çalışmanın zaman aralığı Arap Baharı sürecinin başlangıcından sonraki on yılı kapsamakta ve Kasım Süleymani'nin öldürülmesi ile sona ermektedir. Bu çalışma, İran’ın, esnek bir vekalet savaşı stratejisi kullandığını, değişen savaş dinamikleri ve çatışma noktalarına göre yaklaşımını değiştirdiğini göstermektedir.
Ahmed Anzavur: Soldier, Governor, and Rebel. a Reevaluation of a Late Ottoman Military Man
(Oriental Inst Czech Acad Sci, 2023) Yelbasi, Caner
Following the Russian conquest of the North Caucasus, many Muslims from the region were exiled to the Ottoman Empire from the 1860s onwards. They were settled in different parts of the empire from the Balkans to Anatolia to the Syria and Iraq vilayets. By following this policy, the Ottoman state ensured that many Circassians would become part of the Ottoman army, ruling elites, harems and agricultural workforce. Anzavur Ahmed's family was one of them. Although he did not graduate from military school, he participated in the army during the war in Libya (1911), the Balkan Wars (1912-1913), and the First World War (1914-1918). He was also appointed as the governor of Izmit (1920). Anzavur Ahmet is portrayed as a rebel by Turkish official historiography, but in reality, he was much more than that. He was an Ottoman Governor, and supported by Ottoman administrators such as Damad Ferid and Ali Kemal, who were against the Kuvayi Milliye because they believed that the empire would eventually emerge from the chaotic atmosphere of the post-First World War period and make an agreement with the British. This article argues that although Ahmed Anzavur has been labeled a rebel and a traitor according to the official historiography, it is difficult to use these labels given the circumstances of his time.
Altın Nanopartiküllerin Yeşil Sentezi, Karakterizasyonu ve Biyouyumlu Yapılarının Biyomedikal Uygulamalarda (antibakteriyel, Antifungal ve Antikanser) Değerlendirilmesi
(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2023) Baran, Ayse; Keskin, Cumali
Gold nanoparticles (AuNPs) stand out due to their low toxicity and high compatibility, and the large and modifiable surface areas they provide. In this study, the leaves of Celtis tournefortii Lam. (CT) were used for the green synthesis of gold nanoparticles (AuNPs) first time. The size, shape, surface charge, and functionality of the synthesized AuNPs are described in detail. The suggested mechanisms of action on the tested target cells are highlighted. The biological activities (antibacterial, antifungal, and anticancer) of "green" AuNPs and their further biomedical application possibilities are also discussed. Synthesized AuNPs displayed a spherical appearance, surface plasmon resonance band at 553.67 nm wavelength, and surface charge of -16.53 mV. Particle morphology, size, and surface charge were observed to be affected by the leaf extract used in the reduction reaction. FTIR and TGA-DTA data revealed that functional groups from the CT extract participate in the synthesis and stabilization of AuNPs. AuNPs showed antibacterial and antifungal effects on all the strains and yeast tested by microdilution method (MIC). AuNPs showed dose-dependent cytotoxic activity on cancerous cell lines (SKOV-3, CaCo2, and U118). The obtained results highlight a potentially low-cost green synthesis method using CT leaf extract to synthesize AuNPs showing important biological properties.
Antecedents of Gastronomy Destination Brand Equity: an Examination of Gastronomy Experience, Motivation, and Destination Satisfaction
(Akdeniz Univ, Tourism Fac, 2023) Kodas, Davut; Ozel, cagil Hale
This paper aims to test the relationships among gastronomic experience, motivation, destination satisfaction, and gastronomy destination brand equity. Data (n:600) was gathered from domestic visitors visiting Gaziantep in March, April to May 2018. Scale development to measure gastronomy experiences and scale adaptation process of destination brand equity were carried out. The relationships among the variables were examined with structural equation modeling. According to the findings, except H5 and H8, all hypotheses are significant in the research model. At the end of the study, significant theoretical and managerial implications were provided for the tourism providers and destination marketers, and managers.
Antioxidant, Ache Inhibitory, and Anticancer Effects of Verbascum Thapsus Extract
(CMB Assoc, 2023) Zhang, Na; Baran, Ayse; Valioglu, Ferzane; Teng, Lei; Atalar, Mehmet Nuri; Keskin, Cumali; Beilerli, Aferin
Verbascum thapsus (Mullein) is a medicinal plant used in folk medicine to treat various ailments. For this study, the biological functions of Verbascum thapsus (VT) methanol extract were determined in vitro. The plant's methanol extract was created through the maceration process. The phytochemical composition of plant extracts was investigated using liquid chromatography-electrospray ionization tandem mass spectrometry. The antioxidant capacity of the extract was determined using the 2,2-diphenyl-1-picrylhydrazil (DPPH radical) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS radical). Cell lines Caco-2 (human colorectal adenocarcinoma cells), LNCaP (Lymph Node Carcinoma of Prostate), and HEK293 (Human embryonic kidney 293 cells) were used to model colon, prostate, and non-cancerous cells. The cytotoxic activity of the plant extract on the proliferation of these cells was determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) assay protocol. VT extract showed moderate DPPH and ABTS radical scavenging activities at 30 mg/ml concentration. With this, VT extract was determined to inhibit acetylcholinesterase (AChE) enzyme and had strong cytotoxic activity on cancerous cell lines. In addition, our findings clearly showed that the plant extract had greater cytotoxic activity on the viability of cancerous cells compared to non-cancerous (Human embryonic kidney cells; HEK293) cells. The current findings showed that V. thapsus might be a promising anti-cancer medication candidate for the treatment of human colorectal adenocarcinoma and colon cancer, as well as a good source antioxidans. Copyright: (c) 2023 by the C.M.B. Association. All rights reserved.
Arap Edebiyatı Tarihi Yazımının Kuramsal ve Metodolojik Temelleri
(Hitit Univ, 2024) Simsek, Sultan; Araz, Ismail
The writing of literary history as a scientific discipline was initiated by Western researchers in the late 18th century, as a result of a modern research endeavor, distinct from the long-standing tradition of literary works. In the modern era, firstly the literature of the history of nations was written. Arabic literary history also benefited from this process, and it is considered one of the earliest examples of literary historiography. In the second half of the 19th century, the works of writers such as Hammer Purgstall (d. 1856) and Alfred von Kremer (d. 1889) on the history of Arabic literature emerged as pioneering studies. The writing process accelerated with Carl Brockelmann's (d. 1956) comprehensive work, leading to the production of numerous Arabic literary history books in both the West and the East, continuing to the present day. While this process contributed to enriching the literature of literary history, it also sparked various theoretical and methodological debates. Since the 19th century, different approaches have been proposed in the writing of Arabic literary history, and there is no theoretical unity in this regard. This situation, which complicates the understanding and interpretation of literary history works, poses an obstacle to developing literary history writing based on scientific criteria. To benefit greatly from reading literary history books, it is crucial to know the authors' perspectives, approaches to the subject, and methods. Aware of this importance, our article focuses on the theoretical and methodological framework used in studies of Arabic literary history. The article examines the writing theories and methods that are often not clearly and explicitly expressed by the authors in the writing of Arabic literary history. However, philosophical differences between the East and the West in literary historiography, the relationship between literature and history, criteria for determining periods, and the ideal method for writing literary history, which is beyond the scope of the article, are not discussed. The main aim of the article is to provide information about the methods and theories applied in Arabic literary history writing, to raise the awareness of researchers about the background of works in this field, offer a more informed reading perspective, and draw attention to the many aspects of the subject that still await further study. Today, despite the numerous studies on Arabic literary history that focus on specific periods, literary figures, and genres, research on theoretical approaches and methodology is almost nonexistent, leaving a significant gap in the field. Our article can be considered a modest step toward filling this gap. To substantiate the conclusions reached in the article, descriptive methods of qualitative research were employed throughout the study, and the obtained data were evaluated by using analytical methods. In this context, the emergence of Arabic literary history and its transmission to the Eastern world were highlighted to provide a better understanding of the scope of the subject. The article discusses how writing of literature history was applied among Arabic literary historians as a theoretical and methodological problem during this transmission process from the West to the East, based on primary sources. At this point, the methodological foundations and areas of influence in Arabic literary history writing were discussed. Additionally, the most widely adopted literary history method and its implications among the methodological problems were examined. As a result of the evaluations, it was determined that the methods followed in the writing of Arabic literary history were highly diverse and that some methods were synthesized. The article concludes that there is a need for indepth new research to evaluate holistically the accumulated knowledge in this area, given the diverse methods employed by literary historians, the complex and multifaceted nature of the field, and the lack of consensus on a single method.
The Architecture and Village-Spatial Organization of the Middle PPNB Period at Boncuklu Tarla: Some Observations on the Domestic and Public Areas
(Istanbul Univ, 2025) Kodak, Ergul; Ciftci, Yunus; Kodak, Charlotte Labedan; Cin, Rustem
Boncuklu Tarla is a settlement located within the borders of the village of Il & imath;su in the Darge & ccedil;it district of Mardin. The settlement provides important information on the architecture ofthe PPNA and PPNB periods, in particularthe architectural traditions ofthe Middle PPNB, the focus ofthis article. In addition, these remain to allow the evaluation of village-space organization. The architectural remains found at Boncuklu Tarla also provide the opportunity to compare the Middle PPNB period architecture unearthed atvarious settlements such as & Ccedil;ay & ouml;n & uuml;, Nevali & Ccedil;ori, Gritille, Tell Halula, Akar & ccedil;ay Tepe, Gre F & imath;lla and Cafer H & ouml;y & uuml;k in a regional context. This study aims to present and discuss new information on how village spatial organization changed within the PPNB period, following on from previous discussions on the PPNA period data. Especially within the Middle PPNB period, it is thought that the village spatial organization model of being centered around public buildings was abandoned at Boncuklu Tarla. It is believed that with this change the public buildings were separated from the dwellings but still influenced their spatial organization.
Armillaria Species Causing Kiwifruit Vine Decline and Root Rot in Northeastern Turkiye: a Growing Concern for Kiwifruit Health (Vol 172, E13409, 2024)
(Wiley, 2025) Turkkan, Muharrem; Bozoglu, Tugba; Dervis, Sibel; Erper, Ismail; Ozer, Goksel; 16.01. Department of Organic Agriculture / Organik Tarım Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Assessment of Genetic Diversity and Fusarium Root Rot Response in Turkish Bread Wheat
(Springer, 2025) Sesiz, Ugur; Elis, Seval; Kizilgeci, Ferhat; Yildirim, Mehmet; Palacioglu, Gulsum
Understanding the genetic diversity and population structure of bread wheat germplasm is essential for effective breeding and conservation strategies. This study evaluated 96 bread wheat genotypes from Turkiye-including advanced lines, commercial cultivars, and landraces-using Start Codon Targeted (SCoT) and inter-Primer Binding Site (iPBS) retrotransposon markers. Six SCoT and four iPBS primers generated 81.32% and 75.59% polymorphic bands, respectively, producing clear and reproducible profiles. The average polymorphism information content was 0.19 for both marker systems, with resolving power values of 3.13 (SCoT) and 2.35 (iPBS). Unweighted pair group method with arithmetic mean (UPGMA) cluster analysis grouped the genotypes into two major clusters with 41% overall similarity. Principal coordinate analysis (PCoA) clearly illustrated the genetic differentiation among the genotypes. Analysis of molecular variance (AMOVA) revealed that 69% of genetic variation was distributed within populations. Pathogenicity assays revealed differential disease responses among 21 genotypes to Fusarium culmorum isolate, with the cultivar Empire exhibiting moderate resistance. SCoT and iPBS markers effectively revealed genetic variation and supported the exploitation of promising genotypes for resistance breeding. The identification of genetically distinct and moderately resistant genotypes underscores the potential of Turkish wheat germplasm to support future breeding efforts.
Bedouin Bureaucrats: Mobility and Property in the Ottoman Empire.
(Burhan Caglar, 2024) Ciftci, Erdal; 17.06. Department of Architecture and Urban Planning / Mimarlık ve Şehir Planma Bölümü; 17. Vocational Higher School / Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This monograph examines the imperial nation-building process in the latter half of the nineteenth century, centering on tent-dwelling Bedouin tribes of inner Syria, predominantly in the Transjordan region. Investigating interactions among Bedouin chiefs, commercial-capitalists, urban elites, and Ottoman officials from the eighteenth to the early twentieth century, it illustrates the central role of Bedouin bureaucrats in fostering mutually beneficial relationships within or outside the state sphere.
Between Reason and Revelation: Twin Wisdoms Reconciled. an Annotated English Translation of Nasir-I Khusraw's Kitab-I Jami' Al-Hikmatayn
(Walter de Gruyter Gmbh, 2016) Keskin, Mesut; 12.02. Kurdish Language and Culture Programme / Kürt Dili ve Kültürü Programı; 12. Institute of Living Languages / Türkiye’de Yaşayan Diller Enstitüsü; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Bioarchaeology and Funerary Practices at the Syriac Orthodox Cemetery of Mor Yaqub Churchyard, Nusaybin, Turkey
(Routledge Journals, Taylor & Francis Ltd, 2019) Acar, Ayse
The Syriacs have been, until recently, an important part of the socio-cultural life in the Mardin region. This study evaluates the burial customs of the Syriac Orthodox from the human skeletal remains found during excavations at the Mor Yaqub churchyard cemetery in Nusaybin, in south-east Turkey. The excavations were carried out in 2013, directed by the Mardin Archaeological Museum as part of its Culture and Faith Park Project. As part of the project the burial traditions of the Syriac community from the past to the present were investigated. Macroscopic bioarchaeological excavation techniques were followed and 33 graves were unearthed. There appear to be 66 individuals: 43 adults, 23 infants and juveniles. Of the adults: 11 are female; 14 are male; the remaining 18 are unsexed. Multiple burial customs have been observed from the graves examined. This study illustrates that the burial customs of the Syriac Orthodox have passed from generation to generation, surviving even until today.
Biological Evaluation and Molecular Docking Studies of Novel Aza-Acyclic Nucleosides as Putative Antimicrobial, Anticancer, and Antioxidant Agents
(BioMed Central Ltd, 2025) Alhilal, M.; Alhilal, S.; Gomha, S.M.; Farag, B.; Sabancilar, I.; Ouf, S.A.
This study aimed to synthesize new aza-acyclic nucleosides (aza-acyclovir) and evaluate the efficacy of these synthetic compounds as potential antimicrobial, anticancer, and antioxidant agents. We prepared two novel aza-acyclic nucleosides via two reactions. The first reaction involved trichloroisocyanuric acid and dibenzosulphonyl diethylamine, and the second reaction involved trichloroisocyanuric acid and diethanolamine. We then used one-dimensional nuclear magnetic resonance (NMR) spectroscopy, two-dimensional NMR spectroscopy, infrared spectroscopy, and mass spectrometry to determine the structures of the resulting compounds. In this regard, we first tested the antimicrobial activity of these compounds against various bacteria, including Bacillus cereus, B. subtilis, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa, and against fungal pathogens, including Aspergillus fumigatus, Candida tropicalis, and Alternaria solani. Next, the precise mode for the interaction between synthesized aza-acyclic nucleosides and the target protein 8HQ5 was elucidate using molecular docking analysis. Subsequently, we tested the synthesized compounds for putative anticancer activity at different concentrations (i.e., 12.5, 25, 50, 100, and 200 µg/mL) against A549 cell (Human epithelial lung carcinoma) and human umbilical vein endothelial cell (HUVEC) lines. In addition, compounds antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl-based and cupric reducing antioxidant capacity-based methods at different concentrations (i.e., 31.25, 62.5, 125, 250, and 500 µg/mL). Results revealed that both aza-acyclic nucleosides inhibited both bacterial and fungal strains, although toxicity toward bacterial strains was generally greater than toward fungal strains. We also observed that the molecular docking results were consistent with the results of in vitro antimicrobial assessments. Further, both aza-cyclic nucleosides exhibited cytotoxic effects against both the A549 cell and HUVEC lines. Despite exhibiting lower radical scavenging activity than ascorbic acid (an antioxidant compound used as a standard), Compound 1 from the novel synthetic aza-acyclic nucleosides showed a higher reduction capacity, which was dose-dependent. Overall, we report newly synthesized compounds that show promising antimicrobial, anticancer, and antioxidant effects. © 2025 Elsevier B.V., All rights reserved.
Black Turks, White Turks and Mountain Turks Preface
(I B Tauris & Co Ltd, 2014) Brennan, Shane; 02.14. Department of History / Tarih Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Career Construction Experiences of Syrian Refugee Women in Turkish Higher Education: Opportunities and Obstacles
(York Univ, Center Refugee Studies, 2025) Cirkin, Zeynep; Sakiz, Halis; Cuhadar, Pinar
This study explores the career construction and higher education opportunities and challenges faced by Syrian refugee women in Turkiye through semi-structured interviews with 40 women enrolled at a public university. Findings reveal significant challenges in career construction and higher education stemming from the intersectionality of gender and refugee status, including job market discrimination, increased housework and caregiving responsibilities, and moral concerns about independent women. The study also identifies opportunities for empowerment through women's rights, autonomy, equality, and self-sufficiency. It contributes to refugee studies, higher education, and integration by acknowledging the transformative potential of education and employment for Syrian refugee women.
Characterization of Durum Wheat (triticum durum L.) Landraces Regarding To Some Agronomic Traits
(Univ Namik Kemal, 2023) Durmaz, Abdurrahman; Aktas, Husnu
This research was conducted in 2019-20 wheat growing season under rainfall condition of Mardin - Artuklu province. 80 durum wheat landraces originated from Southeast Anatolia and 10 registered durum wheat cultivars were evaluated according to Augmented Trail Design. 20 landraces and 10 cultivars were used for each bloc. We determined large variations in durum wheat landraces for observed traits. Results indicated that mean of observed traits of landraces and varieties were ranged between 229 kg/da - 371 kg/da for grain yield; 1313 kg/kg - 1218 kg/kg for biomass, 18.02 % - 14.94 % for grain protein content. Mean thousand kernel weight of landraces and standard varieties changed between 42.9 g and 40.15 g; heading days ranged from 117.8 to 111 days respectively. According to observed data, landraces had longer heading days and grain stage and also higher grain protein content and biomass compare to standard varieties. Results of this study showed that landraces has high potential to increase biomass and grain protein content and they can be used as a genitor in wheat breeding programs to improving desirable durum wheat genotypes. Observation according to GGE biplot methodology (which-wonwhere) indicated that ST8 (Check) and G80 (landrace) have high values for grain yield, number of seed pers spike, seed weight per spike while G8 (landrace) showed high values for thousand grain weight, length of peduncle, plant height, grain protein content, biomass and heading days. Obtained results from this study indicated that landraces should be preserved for sustainable agriculture activities specially for marginal areas, also they have high diversity and useful traits for national and international wheat breeding programs.

Browse

Browsing WoS İndeksli Yayınlar Koleksiyonu by WoS Q "N/A"