WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Citation - WoS: 8
Citation - Scopus: 8
Hydrogel burn dressing effectiveness in burn pain
(Elsevier Sci Ltd, 2024) Celik, Enes; Akelma, Hakan
Severe burns are painful and dramatic injuries. Studies show that pain is underestimated and often not adequately treated. This study aims to evaluate the analgesic efficacy of hydrogel burn dressing and silver sulfadiazine, which are two agents commonly used in first-aid dressings for burn patients. This study, designed as a prospective, observational, and cross-sectional study. Study included 64 pediatric patients admitted to our burn center between 01.03.2020 and 01.09.2020 who were examined by our burn service after their first treatment in the emergency dressing room. Two groups of patients were included in the study. Pain level was assessed in the dressing room before and 10 min after the procedure using the Visual Analog Scale and FLACC (Face, Legs, Activity, Cry, Consolability) pain assessment scales.During the study period, Burnaid (R) was applied to 62.5% of patients (40 patients) and silver sulfadiazine to 37.5% (24 patients). In terms of pain scores, pre-dressing FLACC values were higher in Group B (p = 0.039); post-dressing VAS and FLACC values were significantly lower in group B (p 0.001; p 0.001). In terms of additional analgesia, we found more patients in Group S received analgesics (p 0.001).We believe that its effect on burn wound pain is superior to that of silver sulfadiazine.(c) 2023 Elsevier Ltd and ISBI. All rights reserved.
Citation - WoS: 5
Citation - Scopus: 11
Determinants of Mediation Success in Post-Conflict Bosnia: A Focused Comparison
(Routledge Journals, Taylor & Francis Ltd, 2015) Zenelaj, Reina; Beriker, Nimet; Hatipoglu, Emre
The main goal of this study is to look at factors determining mediation success in post-conflict environments. More specifically, the authors focus on the level of involvement of the mediator in a post-conflict setting and argue that relational mediation strategies should fare better in such environments. A most similar systems comparison of the European Union/USA and Turkish mediation efforts in Bosnia-Herzegovina, both of which started in October 2009, renders support for the authors' argument. Their analysis of these two cases suggests that Turkey's relational mediation strategy delivered concrete outcomes in post-Dayton Bosnia compared to the structural intervention style adopted by the European Union/USA. The authors conclude that a relational mediation strategy facilitates the achievement of constructive solutions by helping third parties to make broader assessments of the conflict situation, and by offering flexible options in issue selection and process design.
Citation - WoS: 5
Citation - Scopus: 6
A novel blight and root rot of chickpea: A new host for Neoscytalidium dimidiatum
(ScienceDirect, 2023) Güney, İnci Güler; Bozoğlu, Tuba; Özer, Göksel; Derviş, Sibel
In the southeastern province of Mardin in Turkey, a severe and novel fungal infection affected all chickpea plant parts, resulting in blight symptoms on stem, petiole, branch, and leaf, defoliation, seed and root rot, and death. Neoscytalidium dimidiatum was identified as the agent responsible for this new blight and root rot using sequence analysis of the ITS, tef1, and tub2 loci as well as morphological data. The pathogen was found in all surveyed districts and fields, with varying incidences of blight and root rot, blight being nearly twice (40%) as common as root rot (21%), and root-rotted and blighted plants co-occurring in the majority of instances. All 92 N. dimidiatum isolates from various tissues induced necrotic lesions on the inoculated plants, indicating they were pathogenic for chickpea. Conidia exhibited germination across a temperature range, with increasing temperatures positively influencing germination rates, and mycelial growth was significantly influenced by temperature, with the optimal growth temperature observed to be 35 °C. The response of 25 Turkish chickpea cultivars and three other genotypes when subjected to inoculation with Ciar 12 and Ciar 78 isolates, representative of phylogenetic clusters, was evaluated based on the severity of blight and root rot. The majority of cultivars and genotypes displayed high susceptibility and suffered mortality when exposed to either soil or spray inoculation with each isolate. Among the assessed cultivars and genotypes, Çağatay had the lowest severity of root rot. This study is the first to report a natural infection of chickpea plants by N. dimidiatum. Under global warming, this may be detrimental to chickpea cultivation and habitat in southeastern Turkey, which is the origin of chickpeas.
Effects of Carvacrol on Oxidative Stress and Fibrosis in Streptozotocin-Induced Diabetic Nephropathy: Histological, Gene Expression, and Biochemical Insights
(MDPI, 2025) Canbaz, Halime Tuba; Sozen, Mehmet Enes; Cinar Ayan, Ilknur; Savas, Hasan Basri; Canbaz, Furkan Adem; Cuce, Gokhan; Kalkan, Serpil
Diabetes mellitus (DM) leads to renal damage through oxidative stress. Carvacrol (CAR), a monoterpenoid phenol, possesses anti-inflammatory and antioxidant properties. We investigated the potential effects of CAR on histological, gene expression, and biochemical parameters in a rat model of DM. Four groups were created: group 1, control; group 2 (n = 9), DM; group 3 (n = 9), DM + dimethyl sulfoxide (DMSO); and group 4 (n = 9), DM + CAR. DM was created by injecting streptozotocin (STZ). CAR (20 mg/kg) was prepared through dissolution in 0.1% DMSO. CAR and 0.1% DMSO were administered daily for 4 weeks to groups 4 and 3, respectively. At the end of this study, urea, creatinine, paraoxonase-1 (PON-1), and arylesterase (ARES) were measured in serum samples. Histopathological changes and expression of Nuclear factor erythroid 2-related factor 2 (Nrf-2) in renal tissues were assessed. Immunohistochemical(ihc) staining and RT-qPCR analysis were performed to evaluate apoptosis, focusing on Bax and Bcl-2gene expression. Masson's trichrome(MT) staining and RT-qPCR analysis of COL1A1 and COL3A1 mRNA levels were used to assess fibrosis. Increased urea and creatinine levels in DM were significantly decreased after CAR administration. CAR application also improved reduced levels of PON 1 and ARES, which are associated with diabetes. Both immunohistochemistry and RT-qPCR analyses revealed that CAR therapy mitigated the diabetes-induced elevation in Bax and reduction in Bcl-2 expression. CAR treatment improved histopathological findings and renal Nrf-2 immunofluorescence(if) intensity. Furthermore, gene expression analysis demonstrated that COL1A1 and COL3A1 were upregulated in DM, while CAR administration downregulated them. In conclusion, CAR has a protective role in decreasing renal impairment linked to DM by regulating Bax and Bcl-2 levels and rectifying histological damage.
Retrospective Evaluation of Patients Admitted to the Intensive Care Unit Due to Obstetric Reasons in Terms of Maternal Near-Miss, a Five-Year Case-Control Study
(BMC, 2025) Erdem, Ozgur; Oglak, Suleyman Cemil; Toktas, Izzettin; Baydemir, Seher; Yosunkaya, Ahmet; Erdem, Ali
Background Maternal Near-Miss (MNM) has become globally recognized as an indicator of pregnancy, birth and the first 42 days of postpartum care services. The World Health Organization has taken a new approach to detail and better analyze maternal deaths. The clinic-based criteria to evaluate maternal care and the quality of related care services have been developed. Methods This is a retrospective case-control study that was conducted in a tertiary hospital. In the study, the medical files of all patients admitted to the intensive care unit during the five-year period between 2018 and 2022 were examined. All patients who met the MNM criteria of WHO during pregnancy, birth and puerperium were included in the case group of the study. Meanwhile, the participants in the control group were selected from mothers who gave birth in the same hospital between August 15 and October 31, 2023 and did not develop any complications during puerperium, using the systematic sampling method. Data collection was performed using an interviewer-administered structured questionnaire and data abstraction. Results In this five-year period, 198 mothers were diagnosed with MNM. In our study, the prevalence of MNM was found as 218/100.000. The most common laboratory changes that met the MNM criteria were elevated lactate levels (38.89%), acidosis (24.24%) and acute thrombocytopenia. Patients were most frequently admitted to the intensive care unit due to hemorrhage (23.74%), placental abruption (18.18%), pre-eclampsia (15.66%) and cesarean Sect. (10.10%), respectively. The frequency of co-morbidities (Diabetes mellitus, Hypertension, Asthma, Hypothyroidism, etc.) in patients diagnosed with MNM (n = 48; 26.67%) was found to be 5.5 times that of the control group (n = 25; 6.20%) (p < 0.001). Conclusions It can be said that co-morbidities directly affect the course of motherhood. the education level and family income were found higher in the MNM group compared to the control group. In this regard, the results of our study differ from the studies in the literature in terms of the effects of the education level of mothers and the economic status of families. The effects of socioeconomic and cultural factors on MNM may vary.
Skin Lesion Classification Using Focal Modulation Networks
(John Wiley and Sons Inc, 2025) Zan, H.
The automatic classification of dermoscopic images is essential for the early diagnosis and treatment of skin cancer. However, this task remains challenging due to high visual similarity among lesion types, variations in lesion appearance across progression stages, and the presence of artifacts in the images. While deep learning-based approaches have outperformed traditional machine learning methods, many existing models are computationally intensive and offer limited interpretability. These limitations hinder their integration into clinical workflows where efficiency and transparency are critical. In this study, I propose a framework based on focal modulation networks (FMNs) for skin lesion classification. FMNs are designed to efficiently capture both local and global features, addressing the limitations of transformer-based models in processing high-resolution medical images. I evaluate four FMN variants, namely, Tiny, Small, Base, and Large, on three public datasets: ISIC 2017, ISIC 2018, and ISIC 2019. The highest classification accuracy was obtained on ISIC 2019 with 97.8%, followed by 96.4% on ISIC 2018, and 88.1% on ISIC 2017. These results match or exceed those reported in several previous studies. Additionally, FMNs offer model interpretability through modulator visualization. Overall, the proposed method provides an accurate, efficient, and transparent solution for automated skin lesion classification. © 2025 The New York Academy of Sciences.
Citation - WoS: 58
Citation - Scopus: 60
Preconcentration of metal ions using microbacteria
(SPRINGER WIEN, 2013) Ozdemir, Sadin; Okumus, Veysi; Dundar, Abdurrahman; Kilinc, Ersin
This review (160 refs). covers the current state of the art of microbacteria-based sorbents for preconcentration of metal ions at trace levels. We highlight advantages and major challenges of the techniques and discuss future perspectives of both batch and column-based methods. Particular attention is paid to the preconcentration of metal ions using resin-immobilized microbacteria for solid phase extractions. We also discuss detection methods including UV-vis spectrophotometry, FAAS, ICP-OES and ICP-MS. Analytical figures of merit are compared, and examples are given for the application to a variety of samples including food, beverages, alloys, water, soil, and geological samples.
Chemometric Differentiation of Organic Honeys From Southeastern Türkiye Based on Free Amino Acid and Phenolic Profiles
(MDPI, 2025) Gurbuz, Semra; Kivrak, Seyda
Verifying the geographical origin of honey is crucial for its market value and for preventing fraudulent practices. This study aimed to characterize the chemical profiles of organic honeys from three distinct regions in Southeastern T & uuml;rkiye-& Scedil;& imath;rnak Fara & scedil;in, Siirt Merkez, and Siirt Pervari-to establish a robust method for geographical authentication. A total of 51 multifloral honey samples were analyzed. The concentrations of 20 free amino acids (FAAs) and 16 phenolic compounds were quantified using (UPLC-ESI-MS/MS). The resulting data were subjected to both an unsupervised (PCA, CA) and supervised (PLS-DA, RF, SVM) chemometric analysis to identify biochemical markers for each region. The results revealed a distinct chemical fingerprint for each region. Based on the FAA profiles, the PLS-DA method provided the best overall classification, achieving an excellent discrimination with a total accuracy of 94.1% in the & Scedil;& imath;rnak Fara & scedil;in honeys. For the phenolic compound profiles, the RF method achieved the highest correct classification rate for & Scedil;& imath;rnak Fara & scedil;in honeys at 88.2%. This study demonstrates that an integrated approach, combining FAA and phenolic profiles with supervised chemometric methods, provides a successful and reliable model for determining the geographical origin of these multifloral honeys.
Citation - WoS: 10
Citation - Scopus: 11
Qualitative properties of certain non-linear differential systems of second order
(TAYLOR & FRANCIS LTD, 2017) Tunc, Cemil; Dinc, Yavuz
In this paper, we study the boundedness and square integrability of solutions in certain non-linear systems of differential equations of second order. We establish two new theorems, which include suitable sufficient conditions guaranteeing the boundedness and square integrability of solutions to the considered systems. The presented proofs simplify previous works since the Gronwall inequality is avoided which is the usual case. The technique of proof involves the integral test, and two examples are included to illustrate the results. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Taibah University.
A Novel Factor for Primary Arteriovenous Fistula Failure Hyperinsulinism
(Oxford Univ Press, 2015) Akin, Davut; Ozmen, Sehmus; Kaya, Ramazan
Citation - WoS: 20
Citation - Scopus: 26
Preconcentrations of Ni(II) and Co(II) by using immobilized thermophilic Geobacillus stearothermophilus eSO-20 before ICP-OES determinations
(ELSEVIER SCI LTD, 2018) Yalcin, M. Serkan; Ozdemir, Sadin; Kilinc, Ersin
This study deals with the preconcentrations of Ni(II) and Co(II) ions in real samples using the solid phase extraction method (SPE) before their determinations by inductively coupled plasma optical emission spectrometry (ICP-OES). Thermophilic bacterium Geobacillus stearothermophilus SO-20 (Accession number: KJ095002), loaded with Amberlite XAD-4, was utilized as a novel biosorbent. Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscope (SEM) were employed for the investigation of the bacterial surface before and after Ni(II) and Co(II) biosorption. The experimental parameters were examined to find the best conditions. The retained Ni(II) and Co(II) ions on the biosorbent were eluted by using 5.0 ml of 1.0 mol l(-1) HCI as the best eluent. The sorption capacities were found to be 16.8 mg g(-1) for Ni(II) and 21.6 mg g(-1) for Co(II). It was also successfully used for the quantification of Ni(II) and Co(II) in a river water sample, some vegetables and soil.
Citation - WoS: 1
Citation - Scopus: 1
Comparison of Single-Incision Laparoscopic Percutaneous and Cystoscope Forceps Assisted Morgagni Hernia Repair Techniques
(W. B. Saunders Co-Elsevier Inc, 2024) Okur, Mehmet Hanifi; Aydogdu, Bahattin; Azizoglu, Mustafa; Arslan, Serkan; Bayram, Salih; Basuguy, Erol
Objective: Our goal was to compare single-incision laparoscopic percutaneous and cystoscope forcepsassisted Morgagni hernia repair techniques. Materials and methods: A total of 40 patients were allocated to two groups, each with 20 patients. Group 1: Single incision (port) laparoscopic surgical percutaneous Morgagni hernia repair (with a 5 mm Storz laparoscopic scope entered through the umbilicus). Group 2: Single incision (port) laparoscopic surgical percutaneous Morgagni hernia repair (with an 11 Fr [3.6 mm] cystoscope entered through the umbilicus + using forceps + sac plication, and sac cauterization). In Group 1; the sac was not removed. In group 2; we advanced the forceps through the cystoscope, caught the sac, pushed the needle through the sac, plicated the sac, and then cauterized the sac with Bugbee electrode. Results: Of the 40 patients, 70 % (n 1 / 4 28) were male. The symptoms at admission included repeated chest infections (40 %), dyspnea (30 %), vomiting (22 %), and abdominal pain (22 %). No difference was found between groups in terms of age, gender symptomatology, or associated anomalies. The operation time was shorter in group 2 compared to group 1 (p < 0.05; 25 min vs 40 min). Although there was one recurrence in Group 1, no recurrence was reported in Group 2. The recurrence incidence did not differ between groups (p > 0.05). Conclusions: Cystoscope-assisted repair of Morgagni hernia was found to be superior in terms of safety and shorter operation time. Level of evidence: Type III. Type of the study: Retrospective study. (c) 2023 Elsevier Inc. All rights reserved.
Prevalence of Hirsutism in Turkey: Data of the Dermatoendocrinology Study Group
(Wiley, 2024) Cebeci Kahraman, Filiz; Temiz, Selami Aykut; Erdogan, Sevil Savas; Ozturk, Perihan; Guven, Munevver; Celik, Hilal Ayvaz; Kus, Celal
The Influence of Dietary Inflammatory Index and Food Security Status on Estimated Glomerular Filtration Rate
(W B Saunders Co-elsevier inc, 2025) Ceylan, Jiyan; Laborade, Juan Andrade; Andrade, Jeanette
Evaluation of Antibiotic Resistance, Staphylococci Carriage and Biochemical Parameters of Intensive Care Unit Patients
(Nature Portfolio, 2025) Aslan, Ercan; Cetik Yildiz, Songul
Carriers and diseases caused by Staphylococci, one of the important hospital pathogens, are an important problem in the emergence of antibiotic resistance and finding effective treatments. Our study aimed to investigate the relationship between changes in hematological and biochemical parameters and the development of antibiotic-resistant Staphylococcus infections in patients hospitalized in the intensive care unit (ICU). The study included the 1st and 5th day data of 100 patients who had been hospitalized in the adult ICU for at least 5 days. Demographic data, blood and biochemical parameters and culture samples of the patients were evaluated. The higher NLR, CRP, LAC, and WBC values and lower HGB values observed on the 5th day compared to the 1st day suggest that patients in the ICU were likely exposed to hospital-acquired Staphylococcus infections, which adversely affected their prognosis. Indeed, the 31 Staphylococcus strains identified were isolated from blood (18), sputum (6), wound (4), urine (0), stool (0) and, catheter (3) cultures. It was determined that the most isolated strains, S. aureus, were resistant to levofloxacin, erythomycin, tetracycline, nitroforantoin, trimethoprim/sulfamethoxazole, oxacillin MIC, clindamycin, fusidic acid and oxsf. Based on our results, the observed increase in hematological and biochemical values on day 5 relative to day 1 reinforces the probability of hospital-acquired infection. Since this situation will put the life of the patient and the individuals related to the patient at risk, monitoring these values, early diagnosis and initiation of treatment are vital.
Citation - WoS: 19
Citation - Scopus: 22
Canker and leaf scorch on olive (Olea europaea L.) caused by Neoscytalidium dimidiatum in Turkey
(ScienceDirect, 2022) Güney, İnci Güler; Özer, Göksel; Türkölmez, Şahimerdan; Derviş, Sibel
In a recent survey of olive groves in the Southeast Anatolia Region of Turkey, a new and serious decline of olive trees, beginning with foliar scorching and then dieback of twigs, branches, and even whole trees, was observed for the first time. In more advanced stages of the disease, necrosis and cankers were observed on the bark of the trunk, branches, and twigs. Isolations from symptomatic tissues from multiple cultivars in diverse locations yielded Neoscytalidium dimidiatum, which were identified using ITS, tef1, and tub2 loci of genomic DNA, in combination with morphological data. In vitro studies showed that conidial germination, hyphal growth, and pycnidia formation of the pathogen were positively correlated with elevated temperatures. Wild type olive “Delice”, “Edincik Su”, and “Memecik” seemed like the most resistant cultivars on which disease severity values were the lowest among 14 screened olive cultivars in two experimental orchards under natural conditions. Pathogenicity tests showed that “Gemlik” was the most susceptible cultivar showing the largest cankers and extensive scorch lesions. Isolates caused canker but not leaf scorch on O. europaea cultivars “Arbequina” “Halhalı”, “Manzanilla”, “Nizip Yağlık”, and “Saurani”. Neoscytalidium isolates are likely to have a negative impact on the health of diverse olive groves, which are primarily confined to Mediterranean-type climatic regions. These findings suggest an increased risk of infection in environments with increasing temperatures, as is common in the Southeast Anatolia Region of Turkey. The information gathered in this study will be used to examine the disease's epidemiology and establish disease control initiatives. This is also the first report of N. dimidiatum infecting O. europaea in the world.
Citation - WoS: 212
Citation - Scopus: 266
The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review
(TUOMS PRESS, 2020) Unsal, Velid; Dalkıran, Tahir; Çiçek, Mustafa; Kölükçü, Engin
Cadmium (Cd) is a significant ecotoxic heavy metal that adversely affects all biological processes of humans, animals and plants. Exposure to acute and chronic Cd damages many organs in humans and animals (e.g. lung, liver, brain, kidney, and testes). In humans, the Cd concentration at birth is zero, but because the biological half-life is long (about 30 years in humans), the concentration increases with age. The industrial developments of the last century have significantly increased the use of this metal. Especially in developing countries, this consumption is higher. Oxidative stress is the imbalance between antioxidants and oxidants. Cd increases reactive oxygen species (ROS) production and causes oxidative stress. Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles. This damage has been associated with various diseases. These include cancer, hypertension, ischemia/perfusion, cardiovascular diseases, chronic obstructive pulmonary disease, diabetes, insulin resistance, acute respiratory distress syndrome, idiopathic pulmonary fibrosis, asthma, skin diseases, chronic kidney disease, eye diseases, neurodegenerative diseases (amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, and Huntington disease). Natural antioxidants are popular drugs that are used by the majority of people and have few side effects. Natural antioxidants play an important role in reducing free radicals caused by Cd toxicity. Our goal in this review is to establish the relationship between Cd and oxidative stress and to discuss the role of natural antioxidants in reducing Cd toxicity.
Mental and Physical Outcomes of Yoga Participation in Women with Spinal Disorders: A Qualitative Study
(Frontiers Media S.A., 2025) Akyol, Gamze; Ermis, Sermin Agrali; Karakullukcu, Omur Fatih; Guler, Ozkan; Karakulak, Izzet; Arslanoglu, Cansel; Kucuk, Hamza
Yoga, a holistic practice supporting both physical and mental integrity, has gained increasing attention in recent years as a public health-promoting activity. Particularly among women with spinal disorders (e.g., hernia, lordosis, scoliosis, kyphosis), yoga is recognized not only for improving physical functionality but also for contributing significantly to psychosocial parameters such as stress management, self-awareness, and life satisfaction. In this context, the present study aimed to explore the mental and physical outcomes of regular yoga practice in women diagnosed with spinal disorders, using qualitative methods. This study was conducted using a phenomenological design, as the participants had experienced the situation under investigation. It included semi-structured, in-depth interviews with 15 adult participants diagnosed with spinal disorders and with at least 3 months of yoga experience. In line with the nature of qualitative research, the number of participants was deemed sufficient, and it was accepted that data saturation was reached through the interviews conducted with 15 participants. The findings revealed multidimensional benefits, including mental and physical relaxation, improved stress management, postural enhancement, better quality of life, and increased self-compassion. Participants also highlighted the positive influence of yoga on body-mind balance, awareness of personal limits, and a deeper understanding of their condition. These results suggest that yoga functions both as a physical intervention and a psychological support mechanism for women with spinal disorders, promoting active engagement in their treatment process and enhancing public health outcomes. In conclusion, yoga practice was found to provide significant and sustainable contributions to spinal health and overall psychosocial well-being.
The Moderating Effects of Gender and Emotional Eating on the Relationship Between Social Media Addiction and Hedonic Hunger in University Students
(Nature Portfolio, 2025) Ceylan, Jiyan Aslan
The widespread use of social media has become an important factor influencing eating behaviors, particularly among university students who are heavily exposed to digital content. The aim of this study was to examine the relationship between social media addiction and hedonic hunger and to explore the moderating roles of gender and emotional eating. This cross-sectional study was conducted online during the 2023-2024 academic years and included 930 university students from T & uuml;rkiye. Data were collected using the Social Media Addiction Scale-Adult Form (SMAS-AF) and the Power of Food Scale (PFS). Emotional eating was assessed by asking participants about their overall mood and whether their emotional state influenced their eating behavior, including changes in food intake (increased, decreased, or no change). Statistical analyses were conducted using SPSS and the PROCESS Macro, with significance set at p < 0.05. Findings revealed a significant positive relationship between SMAS-AF and PFS scores (B = 0.61, p < 0.01). Emotional eating significantly moderated this relationship (B = - 0.24, p < 0.01), while gender did not. Students who perceived their nutritional knowledge as inadequate, reported unbalanced eating habits, or viewed themselves as overweight or obese consistently exhibited higher scores on both the scales (p < 0.05). These results underscore the need for interventions that address emotional regulation, nutrition literacy, and media awareness to mitigate the impact of social media on eating behaviors in young adults.
Citation - WoS: 1
Citation - Scopus: 1
Evaluation of Children and Adolescents With Thalassemia Major in Terms of Osteoporosis: a Single-Centre Experience
(Mdpi, 2025) Orhan, Ozhan; Demir, Hasan; Talay, Mehmet Nur; Ozgun, Nezir; Ozbek, Mehmet Nuri
Background/Objectives: This study aimed to determine the frequency of osteoporosis in children and adolescents with thalassemia major (TM) and to identify risk factors for the early development of osteoporosis. Methods: This retrospective study included 27 patients under 18 years of age receiving regular blood transfusions and chelation therapy for TM at our hospital. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry, and a lumbar spine Z-score <-2 was considered osteoporotic. Patients with osteoporosis were classified as Group 1 and those without osteoporosis as Group 2. Results: Osteoporosis was detected in 22.2% of the study population. The mean age was 13.83 +/- 2.85 years in Group 1 and 7.95 +/- 5.05 years in Group 2 (p = 0.012). Body weight and height were significantly lower in Group 1 (p = 0.012 and p = 0.004). Ferritin levels were 5306 +/- 1506 ng/mL in Group 1 and 2020 +/- 1205 ng/mL in Group 2, and the difference was significant (p = 0.001). Group 1 had significantly lower Ca and P levels (p < 0.001, p = 0.038). BMD was negatively correlated with ferritin (r = -0.791, p < 0.001) and positively correlated with calcium (r = 0.499, p = 0.008). Conclusions: Osteoporosis is a common condition in TM patients. Patients with risk factors should be followed more closely. These patients should be identified before BMD decreases. To prevent osteoporosis, regular BMD scans should be performed, calcium and vitamin D supplementation should be provided, and physical activity should be encouraged.

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