WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Citation - WoS: 48
Citation - Scopus: 51
Adolescent Transport and Unintentional Injuries: a Systematic Analysis Using the Global Burden of Disease Study 2019
(Elsevier Sci Ltd, 2022) Peden, Amy E.; Cullen, Patricia; Francis, Kate Louise; Moeller, Holger; Peden, Margaret M.; Ye, Pengpeng; Ivers, Rebecca Q.
Background Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10-24 years during the past three decades. Methods Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10-14, 15-19, and 20-24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings In 2019, 369 061 deaths (of which 214337 [58%] were transport related) and 31.1 million DALYs (of which 16.2 million [52%] were transport related) among adolescents aged 10-24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34.4% (from 17.5 to 11.5 per 100 000) for transport injuries, and by 47.7% (from 15.9 to 8.3 per 100000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80.5% to 42 774 for transport injuries and by 39.4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010-19, the rate per 100 000 of transport injury DALYs was reduced by 16.7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48.5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0.2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010-19. Interpretation As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low-middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.
Adsorption Behaviors of Malachite Green by Using Crosslinked Chitosan/Polyacrylic Acid/Bentonite Composites with Different Ratios
(Elsevier, 2020) Yildirim, Ayfer; Bulut, Yasemin
In this study, by using different quantities of methylenebisacrylamide (MBA) and acrylic acid (AA), chitosan/polyacrylic acid/bentonite composites (CCS/PAA/BNTs) were synthesized and used for the adsorption of malachite green (MG). The fourier transmission infrared spectra, thermogravimetric analysis-differential thermal analysis and scanning electron microscopy techniques were used to determine synthesized composites. The effects of initial concentration, contact time, temperature and pH were investigated. Kinetic studies indicated that, due to the pseudo-second order model, correlation coefficients (R-2 >0.98) were the best fit thus, by using k(ps), the activation energies (E-a) were calculated (19.06, 15.64, 19.49, 8.29, 24.53 kJmol(-1)). The equilibrium data of MG agreed with the Langmuir model. The highest adsorption capacity calculated was found as 384.62-454.55 mgg(-1) for MG adsorption at 298-318 K. Thermodynamic studies demonstrated that MG adsorption was endothermic, caused spontaneous reaction and increased the entropy between 298-318 K. The adsorption reactions of MG were revealed as physisorption (Delta H<80 kJmol(-1)). The optimum pH was found as 6. The CCS/PAA/BNT2 composite indicated the highest adsorption capacity and best thermal stability compared to the other composites. (C) 2019 Elsevier B.V. All rights reserved.
Citation - WoS: 189
Citation - Scopus: 323
Analysis and Mitigation of Power Quality Issues in Distributed Generation Systems Using Custom Power Devices
(IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2018) Hossain, Eklas; Tur, Mehmet Rida; Padmanaban, Sanjeevikumar; Ay, Selim; Khan, Imtiaj; 17.02. Department of Electricity and Energy / Elektrik ve Enerji Bölümü; 17. Vocational Higher School / Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This paper discusses the power quality issues for distributed generation systems based on renewable energy sources, such as solar and wind energy. A thorough discussion about the power quality issues is conducted here. This paper starts with the power quality issues, followed by discussions of basic standards. A comprehensive study of power quality in power systems, including the systems with dc and renewable sources is done in this paper. Power quality monitoring techniques and possible solutions of the power quality issues for the power systems are elaborately studied. Then, we analyze the methods of mitigation of these problems using custom power devices, such as D-STATCOM, UPQC, UPS, TVSS, DVR, etc., for micro grid systems. For renewable energy systems, STATCOM can be a potential choice due to its several advantages, whereas spinning reserve can enhance the power quality in traditional systems. At Last, we study the power quality in dc systems. Simpler arrangement and higher reliability are two main advantages of the dc systems though it faces other power quality issues, such as instability and poor detection of faults.
Analysis of Adaptation Processes and Anxiety Levels of University Students Staying with Earthquake Survivor Families in State Dormitories
(BMC, 2025) Dag, Ibrahim; Olgac, Kadriye
Background This study aimed to examine the adaptation processes and anxiety levels of university students living with earthquake survivor families placed in state dormitories after recent major earthquakes.
Materials and Methods A descriptive, cross-sectional quantitative study was conducted in a state dormitory between May and August 2023. A total of 108 students participated using the snowball sampling method. Data were collected through a Descriptive Characteristics Form and the Beck Anxiety Scale. Statistical analyses included descriptive statistics and linear regression using SPSS 25.0.
Results Among the participants, 49% reported increased frequency of contact with their families after the earthquake. Sharing the same dormitory space with earthquake-affected families led to limited personal space for 56%, emotional impact for 51%, and benefits such as emotional support for 56%. Additionally, 45% noted changes in their attitudes, 46% in their social lives, and 56% in their social responsibility awareness. Regression analysis showed that sharing the same environment with families explained 33.7% of the variance in Beck anxiety scores. A significant positive relationship was found between cohabitation with families and anxiety levels (B=0.337, p<0.001), where each unit increase in cohabitation was associated with a 5.379-point increase in anxiety scores.
Conclusions The findings indicate that post-earthquake family cohabitation significantly affects students' psychological and social well-being. Living in close proximity to affected family members increases anxiety levels. Providing psychological support services for students is crucial to reduce anxiety and facilitate post-disaster recovery and adaptation.
Citation - WoS: 30
Citation - Scopus: 29
Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia
(Science, 2022) Acar, Ayşe; Lazaridis, Iosif; Alpaslan-Roodenberg, Songül; Açıkkol, Ayşen; Agelarakis, Anagnostis; Davtyan, Ruben; 02.01. Department of Anthropology / Antropoloji Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
We present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.
Citation - WoS: 4
Citation - Scopus: 4
Antibiotic Resistance and Mortality in Icu Patients: a Retrospective Analysis of First Culture Growth Results
(Mdpi, 2025) Kilinc, Metin; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Objectives: This study aimed to analyze the antibiotic resistance patterns of microorganisms isolated from intensive care unit (ICU) patients and evaluate their impact on mortality and length of ICU stay. Given the increasing prevalence of multidrug-resistant (MDR) pathogens in critically ill patients, understanding their resistance profiles is crucial for optimizing empirical antibiotic therapy and improving patient outcomes. Methods: This retrospective study included 237 ICU patients admitted between 1 July 2022, and 1 January 2024. The initial culture growth results from blood and urine samples were analyzed. Microorganism identification was performed using VITEK 2 Compact and conventional bacteriological methods, while antibiotic susceptibility testing followed CLSI 2022 and EUCAST 2022 guidelines. Results: A total of 237 ICU patients were included in this study. The most frequently isolated microorganisms were Escherichia coli (E. coli) (44.3%), Klebsiella pneumoniae (K. pneumoniae) (35.0%), and Pseudomonas aeruginosa (P. aeruginosa) (25.3%), with Acinetobacter baumannii (A. baumannii) (31.2%) being the most resistant pathogen. Among Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) (12.2%) and vancomycin-resistant enterococci (VRE) (21.5%) were the most frequently identified multidrug-resistant (MDR) pathogens. Regarding antimicrobial resistance, carbapenem resistance was highest in A. baumannii (55%), followed by P. aeruginosa (40%) and K. pneumoniae (30%). Additionally, ESBL-producing E. coli (43.2%) and K. pneumoniae (38.5%), as well as carbapenemase-producing K. pneumoniae (18.6%) and E. coli (9.2%), were identified as key resistance mechanisms impacting clinical outcomes. Patients with MDR infections had significantly longer ICU stays (p < 0.05) and higher mortality rates. The Kaplan-Meier survival analysis revealed that A. baumannii infections were associated with the highest mortality risk (HR: 4.6, p < 0.001), followed by MRSA (HR: 3.5, p = 0.005) and P. aeruginosa (HR: 2.8, p = 0.01). Among laboratory biomarkers, elevated procalcitonin (>= 2 ng/mL, OR: 2.8, p = 0.008) and CRP (>= 100 mg/L, OR: 2.2, p = 0.01) were significantly associated with ICU mortality. Additionally, patients who remained in the ICU for more than seven days had a 1.4-fold increased risk of mortality (p = 0.02), further emphasizing the impact of prolonged hospitalization on adverse outcomes. Conclusions: MDR pathogens, particularly A. baumannii, MRSA, P. aeruginosa, and K. pneumoniae, are associated with longer ICU stays and higher mortality rates. Carbapenem, cephalosporin, fluoroquinolone, and aminoglycoside resistance significantly impact clinical outcomes, emphasizing the urgent need for antimicrobial stewardship programs. ESBL, p-AmpC, and carbapenemase-producing Enterobacterales further worsen patient outcomes, highlighting the need for early infection control strategies and optimized empirical antibiotic selection. Biomarkers such as procalcitonin and CRP, alongside clinical severity scores, serve as valuable prognostic tools for ICU mortality.
Anticancer, Antioxidant and Antimicrobial Activity of Elaeagnus Angustifolia L. Leaf Extract
(Dove Medical Press Ltd, 2025) Do Gan, Serap; Mese, Ahmet; Baran, Mehmet Firat; Baran, Ayse; Aktepe, Necmettin; Ahmadian, Elham; Aktas, Husnu
Objective: This study was conducted to determine and compare the antioxidant, cytotoxic, and antimicrobial effects of spindle leaves of Elaeagnus angustifolia L. (E. angustifolia) (oleaster) leaves. Methods: Total phenolic content was measured using the Folin-Ciocalteu method, phenolic compound analysis by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and antimicrobial effect by the minimum inhibition concentration (MIC) method. The free radical scavenging activity was determined by the (2,2-Diphenyl-1-picrylhydrazyl) DPPH method, the free radical scavenging activity was determined by the ABTS method, and cytotoxicity assays were performed by the MTT method in human retinal epithelium cells (RPE-1), human osteosarcoma cells (U2OS), and prostate cancer cells (DU-145) cell lines. Results: High amounts of gallic acid, protocatechuic acid, and o-coumaric acid were identified as phenolic compounds. E. angustifolia was found to have a good antioxidant capacity and high free radical scavenging capacity. In this study, for the first time, E. angustifolia leaf extract was used to investigate cytotoxic effects on human retinal epithelium (RPE-1), human osteosarcoma cells (U2OS), and prostate cancer (DU-145) cells and antimicrobial effects on Listeria monocytogenes American Type Culture Collection (ATTC) 7644, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 11774, and Candida albicans ATCC 10231 microorganisms. The highest cytotoxic effect was observed in the DU-145 cell line, and the highest antimicrobial effect was observed in Listeria monocytogenes ATTC 7644 and Candida albicans ATCC 10231. The leaf extract of the plant contains some important phenolic compounds and has high free radical scavenging capacity, a good anticancer effect, and effective antimicrobial activity on yeast species such as C. albicans. Conclusion: Our study will contribute greatly to the search for anticancer and antimicrobial agents, especially from a pharmacological perspective, by examining biological activity using three different methods.
Antifungal Potential of Endophytic Bacteria from Lavender (Lavandula angustifolia) Against Fusarium culmorum and Neoscytalidium dimidiatum Under Greenhouse Conditions
(Springer, 2025) Guney, Inci Guler; Keske, Mehmet Ata
This study investigated the antifungal potential of endophytic bacteria (EB) isolated from lavender (Lavandula angustifolia) against two phytopathogenic fungi Fusarium culmorum and Neoscytalidium dimidiatum under greenhouse conditions. Seventy EB isolates were obtained and subjected to phenotypic characterization and enzymatic activity profiling. Through 16S rRNA gene sequencing, five isolates were identified as Bacillus sp. (Lvt24, Lvt25, Lvt32, Lvt58 and Lvt62). Greenhouse experiments showed lavender plants treated with a mixture of Bacillus sp. isolates (Lvt24 + Lvt62) via root dipping and soil application grew better than other treatments and the control. Similarly, Bacillus sp. (Lvt25) application alone improved plant health and growth. Plants inoculated with N. dimidiatum had 81.07% disease incidence and 77.7% severity, while those inoculated with F. culmorum had 88.43% disease incidence and 81.6% severity, indicating a high level of infection. Inoculating with the pathogens and Lvt25 isolate reduced disease incidence and severity by 56.2 and 57.9% respectively, compared to control plants infected with N. dimidiatum, and by 57.7 and 57.8%, respectively, compared to control plants infected with F. culmorum. These findings indicate that Bacillus sp. Lvt25 isolate has a beneficial effect in reducing disease against these pathogens and has the potential to be a biological control agent.
Citation - WoS: 1
Citation - Scopus: 1
Antioxidant Properties of allium Turcicum Özhatay & Cowley Plant Extract, Its Effects on the Proliferation and Migration of Cancer Cells
(Frontiers Media Sa, 2024) Ipek, Polat; Baran, Ayse; Cebe, Deniz Baris; Ahmadian, Elham; Eftekhari, Aziz; Baran, Mehmet Firat; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Cancer is a type of non-communicable disease that is responsible for numerous deaths worldwide. Cancer incidence and mortality rates are on the rise due to a combination of factors, such as a growing population, aging, and poor dietary habits. The Allium turcicum & Ouml;zhatay & Cowley plant is an endemic plant in the area where it grows and is consumed by the public due to its various benefits. This endemic plant, which generally grows in high-altitude regions, is sold in bunches because it is costly, mixed with rock salt, crushed into powder, and consumed as a spice. The cytotoxic and growth-inhibitory effects of A. turcicum & Ouml;zhatay & Cowley herb extract on human glioblastoma U373 cells, human colorectal carcinoma cell HCT-116, and healthy HUVEC cell lines were determined by the MTT method. After 24 and 48 h of application, logIC50 values in HUVEC, HCT-116, and U373 cells were defined as 3.737, 3.765; 3.513, 3.696, 4.476, and 4.104 mu g/mL, respectively. We conducted a cell migration experiment to study the A. turcicum & Ouml;zhatay & Cowley Extract (AT & Ouml;CE) impact on cancer cells' metastatic behavior. Our findings indicate that AT & Ouml;CE has an inhibitory effect on the migration potential of the cells used in the study. We conducted experiments using DPPH, ABTS, CUPRAC, and total phenolic content to assess the antioxidant properties of AT & Ouml;CE. The findings from the antioxidant activity experiments revealed an activity level of 0.20 +/- 0.046 at IC50. Additionally, the total phenolic content was measured to be 0.26 +/- 0.044 mg GAE/g.
An Assessment of Intermittent and Continuous Enteral Feeding in Critically Ill Children
(Mdpi, 2025) Misirlioglu, Merve; Yildizdas, Dincer; Ekinci, Faruk; Akcay, Nihal; Bingol, Ilyas; Sahin, Ebru; Coban, Yasemin
Background: The inability to ensure adequate nutrition for patients, and failure to provide adequate calorie and protein intake, result in malnutrition, leading to increased morbidity and mortality. The present study assesses the two approaches to enteral nutrition-intermittent and continuous enteral feeding-in critically ill pediatric patients in T & uuml;rkiye to determine the superiority of one method over the other. Methods: Included in this multicenter prospective study were patients receiving enteral nutrition via a tube who were followed up over a 3-month period. Anthropometric data, calorie and protein intake, and signs of feeding intolerance were evaluated in a comparison of the different feeding methods. Results: A total of 510 patients were examined. In the continuous enteral feeding (CEF) group, 20.2% of patients developed metabolic abnormalities, and 49.5% experienced enteral nutrition intolerance, both of which were higher than in the intermittent enteral feeding (IEF) group, and the differences were statistically significant. No significant differences were observed between the two feeding methods in terms of reaching the target calorie intake on days 2 and 7 (p > 0.05). On day 7, there were significant differences between the two feeding methods in terms of calorie and protein intake (p = 0.023 and 0.014, respectively). Conclusions: In the present study, assessing the IEF and CEF approaches to enteral nutrition, critically ill pediatric patients receiving intermittent feeding exhibited lower rates of enteral nutrition intolerance and metabolic abnormalities. Furthermore, the calorie and protein intake on day 7 were noted to be higher in the IEF group than in the CEF group. Further randomized controlled trials are needed to confirm the findings of the present study.
Citation - WoS: 5
Citation - Scopus: 7
Attitudes promoting coping with death anxiety among parents of children with disabilities
(Taylor and Francis Online, 2021) Kaçan, Havva; Sakız, Halis; Bayram Deger, Vasfiye; 02.04. Department of Educational Sciences / Eğitim Bilimleri Bölümü; 09.01. Department of Nursing / Hemşirelik Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
We investigated death anxiety among parents of children with disabilities and its associations with coping attitudes and psycho-demographic factors. Surveys were administered to 382 parents of children who possess a severe disability and data were analyzed via descriptive and inferential statistics. Findings revealed that parents experienced high levels of death anxiety; the level of death anxiety changed according to some psycho-demographic factors, such as external support, type of disability, and death-related beliefs; and death anxiety was significantly explained by demographic variables, death-related thoughts, and experiences, and adaptive and maladaptive coping attitudes.
Automatic Detection of Brain Tumors With the Aid of Ensemble Deep Learning Architectures and Class Activation Map Indicators by Employing Magnetic Resonance Images
(Elsevier, 2024) Turk, Omer; Ozhan, Davut; Acar, Emrullah; Akinci, Tahir Cetin; Yilmaz, Musa
Today, as in every life-threatening disease, early diagnosis of brain tumors plays a life-saving role. The brain tumor is formed by the transformation of brain cells from their normal structures into abnormal cell structures. These formed abnormal cells begin to form in masses in the brain regions. Nowadays, many different techniques are employed to detect these tumor masses, and the most common of these techniques is Magnetic Resonance Imaging (MRI). In this study, it is aimed to automatically detect brain tumors with the help of ensemble deep learning architectures (ResNet50, VGG19, InceptionV3 and MobileNet) and Class Activation Maps (CAMs) indicators by employing MRI images. The proposed system was implemented in three stages. In the first stage, it was determined whether there was a tumor in the MR images Tumor) were detected from MR images (Multi-class Approach). In the last stage, CAMs of each tumor group were created as an alternative tool to facilitate the work of specialists in tumor detection. The results showed that the overall accuracy of the binary approach was calculated as 100% on the ResNet50, InceptionV3 and MobileNet architectures, and 99.71% on the VGG19 architecture. Moreover, the accuracy values of 96.45% with ResNet50, 93.40% with VGG19, 85.03% with InceptionV3 and 89.34% with MobileNet architectures were obtained in the multi-class approach.
Citation - WoS: 78
Citation - Scopus: 110
Bibliometric mapping of mobile learning
(Telematics and Informatics, 2021) Göksu, İdris; 02.04. Department of Educational Sciences / Eğitim Bilimleri Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This study aims to reveal the tendency towards research in the field of mobile learning with the analysis of co-authorship, bibliographic coupling, co-occurrence, and citation by taking into consideration of author, publication, keyword, journal, country, university and citation variables. As of September 2019, the meta-data of a total of 5167 studies in the Web of Science database constituted the scope of this study. VOSviewer and sciMAT were used for the bibliometric analysis while Harzing's Publish and Perish software was used for the h-index. As a result of the bibliometric analysis, it was concluded that the most effective countries in mobile learning are Taiwan, USA, China, and England. According to the keyword co-occurrence analysis, mobile devices, higher education, mobile technologies, tablet, and smartphone keywords stand out in the field of mobile learning. Within the period of 2015–2019, trending topics were broadly educational technologies and, more specifically, tablets, mobile phones, MOOCs and learning strategies. It was found that G. J. Hwang is the most influential researcher and National Taiwan University of Science and Technology is the most influential university. It can be concluded that the most effective researches are augmented reality, higher education, and smartphone oriented mobile learning researches. According to the analyses conducted in the context of journals, Computers & Education, British Journal of Educational Technology and Educational Technology & Society were the most contributing journals
Bioactive Profile, Anticarcinogenic, Antimicrobial, Antidiabetic Effects, and in Silico Pharmacokinetic Properties of Astragalus Elatus
(Academic Press inc Elsevier Science, 2025) Ercan, Leyla; Akan, Hasan; Caliskan, Cemile Gunbegi
Because of the numerous useful components they contain, plants are significant resources that are being explored for their varied purposes in industry, food, and medicine. Recently, particularly endemic species have gained attention with the identification of their different ingredients and characteristics and the exploration of their precious features. This research assessed the endemic species Astragalus elatus's bioactive components utilizing UHPLC-Orbitrap (R)-HRMS, its antibacterial qualities utilizing the disc diffusion method, its cytotoxic impact on cervical cancer utilizing the MTT method, and its apoptosis effect by annexin V methods. Additionally, Astragalus elatus's antidiabetic activity was revealed by in silico and in vitro examinations of its inhibitory effect on the enzymes alpha-Amylase and alpha-Glucosidase. Consequently, it was discovered that A. elatus can be utilized in the treatment of cervical cancer and has effective cytotoxic and apoptotic effects on HeLa cells. Additionally, it was detected that A. elatus possesses antibacterial and anti-diabetic properties. Compared to gram-negative bacteria, A. elatus had a greater inhibitory effect on gram-positive bacteria. The pharmacokinetically significant characteristics and their tendency for chemical reactions of this plant's primary phenolic compounds were identified by utilizing DFT, molecular docking, and ADME/T.
Bodily Boundaries Transgressed: Corporal Alteration Through Ornamentation in the Pre-Pottery Neolithic at Boncuklu Tarla, Turkiye
(Cambridge Univ Press, 2024) Kodas, Ergul; Baysal, Emma L.; Ozkan, Kazim
Lack of contextual evidence for the use of small personal ornaments means that much of our understanding of ornamentation traditions within archaeological cultures is reconstructed from ethnographic comparisons. New in situ finds from the areas around the ears and mouth in burials at Boncuklu Tarla, a Neolithic settlement in Turkiye, add a novel dimension to the interpretation of stone 'tokens' or 'plugs'. This article presents a new typology for these artefacts and argues for their use as ear ornaments or labrets in a practice involving significant and lasting corporal alteration.
Body Image, Self-Esteem, and Attitudes Toward Sexuality in Older Adults With Chronic Illnesses
(Springer/Plenum Publishers, 2025) Utli, Adil; Ersu, Nilay Filoglu; Ozbay, Hediye
This study aimed to examine the effect of the association between body image and self-esteem levels on attitudes toward sexuality in older adults with chronic illnesses. The research was descriptive, cross-sectional, and correlational. The study sample comprised 1,004 people over the age of 65 who visited family health centers in a province in the east of T & uuml;rkiye. The Older Person's Description Form, the Body-Cathexis Scale, the Rosenberg Self-Esteem Scale Short Form, and the Sexual Attitude Scale for Elderly People were used for data collection. For the data analysis, Pearson's r correlation test, simultaneous multiple linear regression, and binary logistic regression were employed. The mean age of the participants was 69.97 +/- 5.74 years, and 66.9% were between 65 and 74 years of age. Furthermore, 53.8% of the participants were male and 56.2% had two chronic illnesses. It was found that the participants' age, body image, and self-esteem explained 84% of the total variance in their permissive attitudes toward sexuality. Furthermore, as the age of the older adults with chronic illnesses increased, there were negative effects on their permissive attitudes toward sexuality. However, as their body image and self-esteem levels improved, there was a positive effect on their permissive attitudes toward sexuality. These findings will be of benefit in encouraging and developing sexual health in older adults with chronic illnesses.
Citation - WoS: 22
Citation - Scopus: 24
Boletus edulis loaded with gamma-Fe2O3 nanoparticles as a magnetic sorbent for preconcentration of Co(II) and Sn(II) prior to their determination by ICP-OES
(SPRINGER WIEN, 2018) Özdemir, Sadin; Yalçın, M. Serkan; Kılınç, Ersin; Soylak, Mustafa; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The authors show that the fungus Boletus edulis loaded with gamma-Fe2O3 nanoparticles is a viable sorbent for magnetic solid phase extraction of trace levels of Co(II) and Sn(II). The surface structure of immobilized magnetized B. edulis was characterized by FT-IR, SEM and EDX. Experimental parameters were optimized. Following elution with 1 M HCl, the ions were quantified by ICP-OES. The limits of detection are 21 pg.mL(-1) for Co(II), and 19 pg.mL(-1) for Sn(II). The preconcentration factors are 100 for both ions. The sorption capacities of the sorbent are 35.8 mg.g(-1) for Co(II) and 29.6 mg.g(-1) for Sn(II). The method was applied to the analysis of certificated reference materials and gave >= 95% recoveries with low RSDs. It was also successfully applied to the quantification of Co(II) and Sn(II) in spiked environmental and food samples.
Bronchiectasis in Türkiye: Data From a Multicenter Registry (Turkish Adult Bronchiectasis Database)
(Galenos Publ House, 2024) Edis, Ebru Cakir; Cilli, Aykut; Kizilirmak, Deniz; Coskun, Ayson Sakar; Guler, Nurcan; Cicek, Sedat; Sayiner, Abdullah
Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry -based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in T & uuml;rkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in T & uuml;rkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non -cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 +/- 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation -related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in T & uuml;rkiye. The study results will provide important data that can guide the development of health policies in T & uuml;rkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.
Calcium-Mediated Mitigation Strategies and Novel Approaches To Alleviate Arsenic Induced Plant Stress
(Elsevier Ireland Ltd, 2025) Alam, Pravej; Iqbal, Sumera; Waheed, Zainab; Eren, Abdullah; Shamsi, Anas; Shahwan, Moyad; Faizan, Mohammad
One worldwide environmental concern is the presence of potentially hazardous elements (PTEs) in air, soil, and water resources. Arsenic is one of the PTEs that is thought to be the most poisonous and carcinogenic. Plants exposed to arsenic may experience several morphological, physiological, and biochemical changes-even at extremely low concentrations. Arsenic toxicity to plants varies with its speciation in plants (e.g., arsenite, As(III); arsenate, As(V)), with the kind of plant species, and with other soil parameters affecting arsenic accumulation in plants, according to new study on arsenic in the soil-plant system. Arsenic stress modifies metabolic cascades in plants at different developmental stages by affecting the pattern of gene expressions mediated by small non-coding RNAs (micro-RNAs), which are essential for plant adaptation to oxidative stress and play a key role in the moderation of numerous cellular processes. In this review, we investigated the impact of calcium (Ca2 +) on the toxicity of arsenic in plant and soil environments. Plant grown with arsenic exhibited enhanced arsenic uptake, increased oxidative stress and growth inhibition. Arsenic toxicity modulates carbohydrate, lipid, and protein metabolism along with DNA structure. Role of Ca2+, Ca channels and Ca sensors to signaling pathways also described briefly. A worldwide issue for humanity is the poisoning of soil ecosystems by arsenic. Its toxicity, tolerance, and phytoremediation of polluted soils utilizing calcium were the main points of the recent review, which also highlighted the significant mechanisms of arsenic in soil-plant systems.
Camels and the Last Nomadic Pastoralists of Anatolia (Türkiye)
(Springer/Plenum Publishers, 2025) Siddiq, Abu B.; Sanli, Suleyman; Erturk, Devirm
We explore the complex relationships between camels and humans, focusing on the agency of both within the last remaining nomadic and semi-nomadic pastoral communities in Anatolia. Among the nomadic Y & ouml;r & uuml;ks of the Taurus Mountains and the semi-nomadic Ko & ccedil;ers around Mount Karacada & gbreve;, camels are valued not only for their practical roles in transport and transhumance but also as revered companions, symbolizing social prestige and family heritage. We highlight how camels and humans co-create multispecies pastoral landscapes based on mutual recognition, emotional bonds, and shared environmental adaptation. Our approach particularly emphasizes the ethical, emotional, and relational aspects of camel-human coexistence that might otherwise be overlooked in purely functional or utilitarian perspectives.

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