Yavaş, Mehmet Cihan
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Doç. Dr.
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mcihanyavas@gmail.com, mcihanyavas@artuklu.edu.tr
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Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
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12
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133
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4
Documents
16
Citations
122
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6
Articles
5
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1
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0
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6
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8
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1
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2
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1.00
Scopus Citations per Publication
1.33
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3
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1
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| International Journal of Radiation Research | 1 |
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6 results
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Now showing 1 - 6 of 6
Article Toxic Effects of Tartrazine and the Protective Role of Curcumin on Liver Function and DNA Integrity in Male Rats(Wiley, 2025) Varli, Metin; Yavas, Mehmet Cihan; Canturk Tan, Fazile; Tur, Kardelen; Basmaci, GuldidarTartrazine (TAR) and curcumin (CUR) are commonly utilized in the food manufacturing sector. The present investigation was designed to assess the hepatotoxic impact of the food dye tartrazine on hepatic function and its related biomarkers. We systematically allocated 35 male Wistar rats into five homogeneous groups. The specified groups consisted of: control, TAR at a dosage of 10 mg/kg/day, TAR at a dosage of 100 mg/kg/day, TAR at a dosage of 10 mg/kg/day combined with CUR at 20 mg/kg/day, and TAR at a dosage of 100 mg/kg/day combined with CUR at 20 mg/kg/day. All experimental groups received the treatment via oral gavage. Our findings indicated that as the TAR dosage escalated relative to the control group, the levels of superoxide dismutase (SOD), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) exhibited an increase, while the alpha-fetoprotein (AFP) level demonstrated a decline. In the CUR-treated groups, in comparison with the control groups, the levels of SOD, AST, ALT, LDH, total bilirubin, GGT, and AFP increased in the low-dose TAR groups, whereas ALP levels decreased. Our histopathological analysis disclosed the occurrence of degenerative changes in both TAR and CUR treatment groups. The genotoxic assessment, utilizing the DNA comet assay, revealed that an increase in TAR dosage corresponded with heightened DNA damage; however, the incorporation of CUR mitigated this detrimental effect. Our findings suggest that tartrazine may exert deleterious effects on hepatic function, whereas curcumin has displayed partial therapeutic efficacy.Master Thesis Investigation of Genotoxic Effects of Diethyl Phthalate (DEP) Exposure on Thyroid Function in Wistar Albino Female Rats(2025) Kömürcü, Ayşe; Yavaş, Mehmet CihanYaygın olarak kullanılan bir plastikleştirici olan dietil ftalat (DEP), endokrin bozulma ve oksidatif stres ile ilişkilendirilmektedir. Bu çalışmanın amacı, subakut DEP maruziyetinin Wistar dişi sıçanların tiroit dokusu üzerindeki genotoksik etkilerini; tiroit hormon düzeyleri, oksidatif stres parametreleri, DNA hasarı ve histomorfolojik değişiklikler üzerinden değerlendirildi. Yirmi sekiz dişi Wistar albino dişi sıçanı dört gruba (n=7) ayrılmıştır: kontrol, 100 mg/kg/gün, 300 mg/kg/gün ve 600 mg/kg/gün DEP uygulama grupları. DEP, oral gavaj yoluyla 21 gün süreyle verildi. Deney sonunda serum TSH, T3 ve T4 düzeyleri ELISA ile; oksidatif stres belirteçleri (TAS, TOS, OSI) biyokimyasal analizlerle; DNA hasarı ise Comet Assay yöntemi ile değerlendirildi. Histopatolojik incelemeler yapılmış ve vücut ağırlıkları takip edilmiştir. Kontrol grubu ile karşılaştırmalarda; T3, T4 düzeylerinde azalma (P<0.05), TSH düzeyinde ise artış izlenmiştir (p<0.05), TAS ve OSI düzeyinde azalma (p<0.05), TOS düzeyinde ise artış izlendi (p<0.05). Comet Assay sonuçları, DNA bütünlüğünde bozulma ve hücresel hasarın DEP dozunun artması orantılı yükseldiği (kuyrukta % DNA (tail DNA)) görüldü (p<0.05). Bununla beraber tiroit dokusunda belirgin bir histopatolojik değişime rastlandı. Elde edilen bulgular, DEP'nin tiroit fonksiyonu üzerinde doza bağlı genotoksik etkilere sahip olabileceğini, endokrin ve hücresel düzeyde ciddi bozukluklara yol açabileceğini gösterdi. Bu sonuçlar, DEP'ye karşı çevresel ve bireysel maruziyetin sınırlandırılması gerekliliğini ortaya koydu.Article Citation - Scopus: 1Determination of the Protective Effect of Curcumin Against Tartrazine-Induced DNA Damage and HSP 70 in the Rat Brain(Springer, 2025) Yavas, Mehmet Cihan; Tan, Fazile Canturk; Tur, Kardelen; Keskin, Cumali; Basmaci, GuldidarTartrazine is a widely used food dye, and children often consume large amounts of food products containing this additive due to their appealing appearance. Curcumin, on the other hand, is known for its antioxidant properties. The aim of this study was to investigate the protective effects of curcumin on brain tissue and biochemical parameters in rats exposed to short-term tartrazine administration. Male Wistar albino rats were randomly divided into five equal groups. Group 1 served as the control; Group 2 received tartrazine (10 mg/kg); Group 3 received tartrazine (100 mg/kg); Group 4 received tartrazine (10 mg/kg) along with curcumin (20 mg/kg); and Group 5 received tartrazine (100 mg/kg) along with curcumin (20 mg/kg). All substances were administered via oral gavage. The study lasted for 21 days. Serum samples were analyzed for heat shock protein 70 (HSP70) levels using the ELISA method. Brain tissues were subjected to histopathological examination and DNA damage assessment using the comet assay. Although HSP70 levels increased in the tartrazine groups, the differences were not statistically significant (p = 0.065). Partial damage was observed in the histopathological analysis. Comet assay results indicated a dose-dependent increase in DNA tail percentage with tartrazine, which was reduced following curcumin administration. These findings suggest that curcumin may alleviate tartrazine-induced damage in brain tissue and may have a regulatory effect on serum HSP70 levels in rats.Article Effect of Tartrazine and Curcumin Intake on Serum Carcinoembryonic Antigen (CEA) and Stomach Histopathology in Rats(2025) Yavaş, Mehmet Cihan; Toktaş, İzzettin; Hakseven, Musluh; Varlı, Metin; Basmaci, GuldidarObjective: Food colorants are known to induce physiological and biochemical changes in tissues, raising concerns about their potential health effects. The purpose of this study was to assess tartrazine's effects and curcumin supplementation on stomach tissue and serum carcinoembryonic antigen (CEA) levels in rats. Methods: Thirty-five male rats were randomly divided into five groups (n=7 per group) and treated via oral gavage for three weeks: Group 1 consisted of a control group, Group 2 of low-dose tartrazine, Group 3 of high-dose tartrazine, Group 4 of low-dose tartrazine + curcumin, and Group 5 of high-dose tartrazine + curcumin. Serum CEA levels were measured and stomach tissues were subjected to histopathological examination. Results: Following tartrazine treatment, serum CEA levels were higher than in the control group; however, this difference was not of statistical significance (p > 0.05). CEA levels were somewhat lowered by co-administration of curcumin. When compared to the control, histopathological investigation showed that all tartrazine-treated groups had degenerated stomach tissues. Hyperkeratosis was notably increased in all experimental groups relative to the control group, with the most pronounced effect observed in Group 5 (p < 0.001). While hyperplasia in Group 2 did not differ significantly from the control (p > 0.05), Groups 3, 4, and 5 exhibited a statistically notable rise (p < 0.05). Conclusion: These results show that tartrazine may induce dose-dependent histopathological alterations in stomach tissue, and curcumin may exert a modest protective effect.Article The effect of radiofrequency electromagnetic radiation on rat liver tissue and serum paraoxonase (PON1)(Annals of Medical Research, 2023) Yavaş, Mehmet Cihan; Kilitçi, AsumanAim: The development of technology increases the rate of everyone having a smartphone. Therefore, the possible biological effects of these devices are of concern. In this study, we aimed to investigate the effect of 2100 MHz radiofrequency electromagnetic radiation on rat liver tissue and serum paraoxonase 1 level. Materials and Methods: Within the scope of the study, a 2100 MHz radiofrequency electromagnetic radiation model was created. In our study, we used Sprague Dawley male rats. Two groups were made as sham-control and exposure group (5 h a day for 2 weeks). Liver tissue and serum paraoxonase were studied. Results: The paraoxonase 1 value of the exposure group was higher than the sham control group, and did not have statistically important difference in the comparison of exposure and sham control groups (p>0.05). Did not have important difference in histopathological parameters of rat liver tissue (p>0.05). Conclusion: Although it seems that radiofrequency radiation does not cause liver dam age, more detailed studies with short- and long-term exposure are neededArticle Citation - WoS: 6Citation - Scopus: 7Rat Brain and Testicular Tissue Effects of Radiofrequency Radiation Exposure: Histopathological, Dna Damage of Brain and Qrt-Pcr Analysis(Ijrr-iranian Journal Radiation Res, 2024) Yavas, M. C.; Kilitci, A.; Celik, E.; Yegin, K.; Sirav, B.; Varol, S.Background: : The Background: We evaluate the effects of radiofrequency electromagnetic field (RF-EMF) on rat brain and testicular tissue using histopathology, comet assay, and real-time quantitative PCR techniques. Materials and Methods: Two equal groups of fourteen rats one for sham-control and the other for exposure (n = seven) were created. For a duration of 14 days, the exposure group (2100 MHz, testicular tissue SAR values of 163 mW/kg for 10 g, brain tissue SAR values of 292 mW/ kg on average) was subjected to five hours of exposure per day. Evaluations were conducted on tissue gene expression levels, histopathology, and DNA damage to brain tissue. Results: The histological examination of brain tissue from the exposed group revealed vascular alterations and significant edema (p < 0.05). It was determined that RF radiation-induced much more cellular damage in the exposed group (18.26% tail DNA) than in the control group (4.06% tail DNA). Signs of deterioration in spermatogenic cells in the testicular tissue of the exposed group also changed significantly (p < 0.05). The Bax and bcl-2 genes showed a significant difference (p < 0.05) in the mRNA level data, whereas the p53 genes showed no significant change (p > 0.05). Conclusion: These findings suggest that it may cause some histopathological and cellular damage in brain and testis tissue.
