Özbek, Mehmet Nuri
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Ozbek, M. Nuri
Ozbek, Mehmet Nuri
Ozbek, Mehmet N.
Ozbek, Mehmet Nuri
Ozbek, Mehmet N.
Job Title
Prof. Dr.
Email Address
mehmetnuriozbek@artuklu.edu.tr
Main Affiliation
Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Status
Current Staff
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ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
3
GOOD HEALTH AND WELL-BEING
6
Research Products
5
GENDER EQUALITY
1
Research Products
Documents
101
Citations
2085
h-index
19
Documents
132
Citations
2121
Scholarly Output
19
Articles
16
Views / Downloads
111/1811
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
51
Scopus Citation Count
53
WoS h-index
4
Scopus h-index
4
Patents
0
Projects
0
WoS Citations per Publication
2.68
Scopus Citations per Publication
2.79
Open Access Source
14
Supervised Theses
0
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| Journal | Count |
|---|---|
| Diabetes, Obesity and Metabolism | 1 |
| Diabetes Research and Clinical Practice | 1 |
| Endocrine | 1 |
| European Heart Journal-Case Reports | 1 |
| European Journal of Pediatrics | 1 |
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Now showing 1 - 10 of 19
Article Citation - Scopus: 1Investigation of the effect of comorbid psychopathologies on glycemic control in children and adolescents with type 1 diabetes mellitus(Turkish J Clinical Psychiatry, 2022) Kardaş, Burcu; Kardaş, Ömer; Demiral, Meliha; Özbek, Mehmet NuriObjective: The presence of comorbid psychiatric conditions in chronic diseases makes the management of the disease difficult. Our study, we aimed to examine the relationship between psychiatric comorbid conditions and glycemic control in children and adolescents with Type 1 Diabetes. Method: In our study, depending on the number of patients, good and moderate controls were evaluated as a single group, and HbA1c levels of 8.5 and below were included in this group. Children for Depression Inventory (CDI), Screen for Child Anxiety-Related Emotional Disorders (SCARED), Turgay Child and Adolescent Behavioral Disorders Based on DSM-IV Screening and Evaluation Scale were applied. The case and parents were evaluated with K-SADS-PL.Among 778 diabetic patients who were followed up in the pediatric endocrinology clinic, 73 cases between the ages of 8 and 17 who were followed up regularly, who did not have any comorbidities and who accepted to participate in the study were evaluated psychiatrically. Results: Of the 73 cases included in the study, 29 were accepted as the patients with good glycemic control (HbA1c <= 8.5 mg / dl), and 44 as with poor glycemic control (HbA1c>8.5mg / dl). In cases with poor glycemic control, parents' education level and income level were significantly lower, while the rate of attention deficit and hyperactivity disorder, major depressive disorder, social anxiety disorder and psychopathology was significantly higher. Discussion: The findings of this study revealed that there are many factors affecting glycemic control and there is a strong relationship between glycemic control and psychopathologies.Article MOLECULAR DIAGNOSIS IN PATIENTS WITH MONOGENIC DIABETES MELLITUS, AND DETECTION OF A NOVEL CANDIDATE GENE(Elsevier, 2023) Gökşen, Damla; Evin, Ferda; Işık, Esra; Özen, Samim; Atık, Tahir; Özkınay, Ferda; Akcan, Neşe; Özkan, Behzat; Büyükinan, Muammer; Özbek, Mehmet Nuri; Darcan, Şükran; Onay, HüseyinAim: We aimed to investigate molecular genetic basis of monogenic diabetes (DM) and novel responsible candidate genes with targeted Next Generation Sequencing (NGS) and Whole Exome Sequencing (WES). Methods: A hundred cases presenting with clinical findings and a family history of monogenic DM were included in the study. Molecular analysis was performed using an NGS panel including 14 genes. Following targeted NGS, WES was planned in cases in whom no variant was detected. Results: Thirty different disease-causing variants in seven different genes were detected in thirty-five (35%) cases with targeted NGS approach. Most common pathogenic variant was found in GCK gene in 25 (25%) cases. Four different variants were detected in 4 (4%) patients in ABCC8 gene. In 45 of 65 cases; WES analyses were done. A heterozygous c.2635C>T(p.Gln879Ter) variant was detected in IFIH1 gene in a patient with incidental hyperglycemia. In the segregation analysis affected mother was shown to be heterozygous for the same variant. Conclusion: Molecular etiology was determined in 35% cases with the NGS targeted panel. Seventeen novel variants in monogenic DM genes have been identified. A candidate gene determined by WES analysis in a case that could not be diagnosed with NGS panel in this study.Article Citation - WoS: 6Citation - Scopus: 7Evaluation of patients diagnosed with phenylketonuria and biotinidase deficiency by the newborn screening program: a ten-year retrospective study(The Turkish Journal of Pediatrics, 2022) Toktaş, İzzettin; Sarıbaş, Seyfettin; Canpolat, Semih; Erdem, Özgür; Özbek, Mehmet NuriBackground. Phenylketonuria (PKU) and biotinidase deficiency (BD) are autosomal recessive diseases. If they are not identified and treated early, severe intellectual disability and developmental delay occur. This study was conducted to calculate the ten-year incidence of PKU and BD in the Diyarbakır province of Turkey. Methods. This cross-sectional study included patients born between 2011-2020 and diagnosed with PKU and BD. Patients with a clear diagnosis had their records evaluated retrospectively. Results. Between 2011 and 2020, blood was taken from 417,525 newborns’ heels in Diyarbakir province. As a result of further diagnostic testing, 53 PKU (Incidence: 1:7878) and 177 BD (Incidence: 1:2359) were detected. Of the patients with BD, 56% had profound BD and 44% had partial BD. The records of a total of 269 patients (PKU: 25; BD: 123; Hyperphenylalaninemia: 121) were examined. Parents of 65% (n=15) of the patients diagnosed with PKU and 46.6% (n=55) of the patients diagnosed with BD were consanguineous. Conclusions. The incidence of both PKU and BD was found to be high in our region. The high number of consanguineous marriages was regarded as the most important explanation for the high frequency of these illnesses.Article Citation - WoS: 1Citation - Scopus: 1Evaluation of Children and Adolescents With Thalassemia Major in Terms of Osteoporosis: a Single-Centre Experience(Mdpi, 2025) Orhan, Ozhan; Demir, Hasan; Talay, Mehmet Nur; Ozgun, Nezir; Ozbek, Mehmet NuriBackground/Objectives: This study aimed to determine the frequency of osteoporosis in children and adolescents with thalassemia major (TM) and to identify risk factors for the early development of osteoporosis. Methods: This retrospective study included 27 patients under 18 years of age receiving regular blood transfusions and chelation therapy for TM at our hospital. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry, and a lumbar spine Z-score <-2 was considered osteoporotic. Patients with osteoporosis were classified as Group 1 and those without osteoporosis as Group 2. Results: Osteoporosis was detected in 22.2% of the study population. The mean age was 13.83 +/- 2.85 years in Group 1 and 7.95 +/- 5.05 years in Group 2 (p = 0.012). Body weight and height were significantly lower in Group 1 (p = 0.012 and p = 0.004). Ferritin levels were 5306 +/- 1506 ng/mL in Group 1 and 2020 +/- 1205 ng/mL in Group 2, and the difference was significant (p = 0.001). Group 1 had significantly lower Ca and P levels (p < 0.001, p = 0.038). BMD was negatively correlated with ferritin (r = -0.791, p < 0.001) and positively correlated with calcium (r = 0.499, p = 0.008). Conclusions: Osteoporosis is a common condition in TM patients. Patients with risk factors should be followed more closely. These patients should be identified before BMD decreases. To prevent osteoporosis, regular BMD scans should be performed, calcium and vitamin D supplementation should be provided, and physical activity should be encouraged.Article Citation - WoS: 2Citation - Scopus: 1The Clinical and Laboratory Features of Patients With Triple a Syndrome: a Single-Center Experience in Turkey(Springer, 2023) Yildirim, Ruken; Unal, Edip; Tekmenuray Unal, Aysel; Tas, Funda Feryal; Ozalkak, Servan; Cayir, Atilla; Ozbek, Mehmet NuriAim Triple-A Syndrome (TAS) is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia, and alacrimia. This disorder is caused by mutations in the AAAS gene. The aim of this study is to discuss the clinical, laboratory and molecular genetic analysis results of 12 patients with TAS. Method We evaluated 12 patients from 8 families. Clinical and laboratory data were retrospectively collected from the medical records of the patients in the database for the period 2015-2020. All exons and exon-intron junctions of the AAAS gene were evaluated by next-generation sequencing method. Detected variants were classified according to American Collage of Medical Genetics criteria. Results Alacrimia was found in all patients (100%); achalasia was found in 10 patients (83.3%) and adrenal insufficiency was found in 10 patients (83.3%). In addition, hyperreflexia(6/12), learning disability(5/12), hypernasal speech(5/12), muscle weakness(8/12), delayed walking(7/12), delayed speech(6/12), excessive sweating(7/12), optic atrophy(1/12), epilepsy(1/12), palmoplantar hyperkeratosis(5/12), multiple dental caries(9/12), atrophy of the thenar/hypothenar muscles(4/12) and short stature(4/12) were detected. The DHEA-S levels were measured in 10 patients and were found to be low in 8 of them. In all patients, the sodium and potassium levels were found to be normal. AAAS gene sequencing revealed four previously reported c.1066_1067del (p.Leu356fs*8), c.1432 C > T (p.Arg478*), c.688 C > T (p.Arg230*), and c.1368_1372del (p.Gln456fs*38) variants and two novel homozygous c.1250-1 G > A and c.398_399 + 2del variants in the AAAS gene. Conclusion We detected two novel variants in the AAAS gene. While the classic triad is present in 66.7% of the cases, neurological dysfunction, skin and dental pathologies also occur quite frequently. The earliest and most common finding of TAS is alacrimia. Therefore, adrenal insufficiency should be investigated in all patients with alacrimia and if necessary, genetic analysis should be performed for TAS. In addition, TAS should be followed up with a multidisciplinary approach since it involves many systems.Article Citation - WoS: 1Citation - Scopus: 2Evaluation and management of neonatal onset hyperinsulinemic hypoglycemia: a single neonatal center experience(Taylor & Francis, 2023) Bezirganoğlu, Handan; Okur, Nilifer; Feryal Taş, Funda; Çelik, Kıymet; Özbek, Mehmet NuriObjectives: To evaluate the clinical characteristics and treatment options of neonates requiring prolonged hospitalization due to persistent hyperinsulinemic hypoglycemia (HH). Methods: This retrospective cohort study included infants >34 weeks of gestation at birth who were born in our hospital between 2018 and 2021, diagnosed with HH, and required diazoxide within the first 28 days of life. The baseline clinical characteristics, age at the time of diagnosis and treatment options in diazoxide resistance cases were recorded. Genetic mutation analysis, if performed, was also included. Results: A total of 32 infants diagnosed with neonatal HH were followed up. Among the cohort, 25 infants were classified as having transient form of HH and seven infants were classified as having congenital hyperinsulinemic hypoglycemia (CHI). Thirty-one percent of the infants had no risk factors. The median birth weight was significantly higher in the CHI group, whereas no differences were found in other baseline characteristics. Patients diagnosed with CHI required higher glucose infusion rate, higher doses, and longer duration of diazoxide treatment than those in the transient HH group. Eight patients were resistant to diazoxide, and six of them required treatment with octreotide and finally sirolimus. Sirolimus prevented the need of pancreatectomy in five of six patients without causing major side effects. Homozygous mutations in the ABCC8 gene were found in four patients with CHI. Conclusions: The risk of persistent neonatal hyperinsulinism should be considered in hypoglycemic neonates particularly located in regions with high rates of consanguinity. Our study demonstrated sirolimus as an effective treatment option in avoiding pancreatectomy in severe cases.Article Citation - WoS: 2Citation - Scopus: 2Evaluation of patients diagnosed with congenital hypothyroidism by newborn screening between 2011-2019 in Diyarbakir, Turkey(LWW, 2023) Toktaş, İzzettin; Erdem, Özgür; Sarıbaş, Seyfettin; Özbek, Mehmet NuriThis study aimed to determine the incidence of congenital hypothyroidism in Turkey’s Diyarbakir Province and assess the development and growth conditions of people with congenital hypothyroidism. Patients born between 2011-2019 and diagnosed with congenital hypothyroidism within the scope of the newborn screening program were included. The medical records of these patients were retrospectively reviewed. The length and weight for age, weight for length, and body mass index standard deviation scores were calculated. We investigated the treatment status of the patients, whether their relatives had a similar disorder, and the presence of consanguinity between parents. Blood samples were collected from 380,592 newborns. As a result of further tests, 498 newborns were diagnosed with congenital hypothyroidism (incidence: 1/764). Demographic and anthropometric data of 241 patients were analyzed. The patients comprised 46.9% (n = 113) females and 53.1% (n = 128) males. It was determined that 44.4% of the individuals had transient congenital hypothyroidism and 53.6% had permanent congenital hypothyroidism. The parents of 29.8% of the individuals diagnosed with transient congenital hypothyroidism and 44.2% of the individuals diagnosed with permanent congenital hypothyroidism were consanguineous (P = .02). According to the latest anthropometric assessment, 6.8% of individuals diagnosed with congenital hypothyroidism had a weight z-score below −2 SD and 16.9% had a length z-score below −2 SD. The incidence of congenital hypothyroidism was higher in our region. The ratio of consanguinity between parents was higher in patients diagnosed with permanent congenital hypothyroidism than in those diagnosed with transient congenital hypothyroidism. According to the most recent follow-up, weight and age were found to be similar in patients with transient and permanent congenital hypothyroidism.Article Abnormal Uterine Bleeding in Adolescent Girls Retrospective Study(Brieflands, 2025) Ozalkak, Servan; Yildirim, Ruken; Karakaya, Amine Aktar; Tas, Funda Feryal; Oncel, Kahraman; Okur, Nurettin; Ozbek, Mehmet NuriBackground: Abnormal uterine bleeding (AUB) is the most common reason for gynecology-related hospital admissions in adolescence. Objectives: The present single-center study aimed to evaluate the diagnosis distribution in adolescents with AUB and to compare the clinical features and treatments of patients with hemoglobin levels below and above 10 g/dL. Methods: The present single-center study retrospectively collected demographic and epidemiological data from adolescents aged 10 - 18 years presenting to our institution with a diagnosis of AUB. Patient data were extracted from electronic medical records and analyzed using SPSS software. Descriptive statistics, including frequency, percentage, mean, standard deviation (SD), median, and interquartile range (IQR), were calculated. Patients were classified according to hemoglobin levels (< 10 g/dL as group 1 and >= 10 g/dL as group 2). Results: Among 167 adolescent patients, 35.9% had hemoglobin levels below 10 g/dL. Hospitalization rates were significantly higher in group 1 (86.4%) compared to group 2 (2.8%) (P < 0.001). The most common causes of AUB were anovulation (84.4%) and polycystic ovary syndrome (PCOS) (11.4%). The primary treatments included combined oral contraceptives (COCs) with iron supplementation (45.5%) and iron alone (28.7%). Erythrocyte transfusion (ERT) was performed in 18% of cases, predominantly in group 1. This study is limited by the lack of a standardized quality of life assessment tool for AUB. The single-center design and retrospective data collection may limit the generalizability of the findings and introduce selection bias, respectively. Conclusions: Anovulation and PCOS are the main causes of AUB in adolescents. Patients with hemoglobin levels below 10 g/dL and active bleeding should be evaluated carefully, as ERT may be necessary. A wide differential diagnosis should always be considered when managing adolescent AUB.Article Citation - WoS: 2Citation - Scopus: 1Evaluation of the Results of the Patients Who Underwent Plasmapheresis in the Pediatric Intensive Care Unit(Tubitak Scientific & Technological Research Council Turkey, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Kangin, Murat; Turanli, Ese Eda; Ozbek, Mehmet NuriBackground/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Ya & scedil;argil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients' diagnosis, weight, type of procedure and type of device, where the procedure was performed, duration of the procedure, amount of blood and plasma processed, complications, number of procedures, and death during the procedure or independent of the procedure were evaluated. Results: The median age was 93.0 (14.0-167.0) months. Hemolytic uremic syndrome (HUS) was the most common TPE indication with nine patients. The most common complication related to TPE was fever (11 patients), while no complication was observed in 18 patients. When laboratory results were evaluated according to American Society for Apheresis (ASFA) categories, a significant improvement was observed in the values of platelet, AST, ALT, LDH, urea, and creatinine in ASFA1 after TPE. No significant improvement was observed in ASFA2 (p > 0.05). In ASFA3, a significant improvement was observed in INR, AST, ALT, LDH, total bilirubin, creatinine, pH, and lactate values after TPE (p < 0.05). Five patients died from ASFA1, one from ASFA2, and three patients from ASFA3. Conclusion: Since significant adjustments are observed in clinical and laboratory values in sepsis-MOF, which is in the ASFA3 category, we believe that it should be evaluated in the ASFA2 or ASFA1 category in the early treatment of these diseases. In addition, we think that MIS -C cases, which have not been in any category according to ASFA, should be included in the ASFA2 or ASFA3 category, considering our TPE results.Article Çocukluk Çağında Yeni Tanı Almış 140 Diyabet Olgusunun Tanı Tipleri ve Klinik Özellikleri: Tek Merkez Deneyimi(2025) Yıldırım, Ruken; Ozbek, Mehmet Nuri; Trabzon, Gül; Orhan, Özhan; Karakaya, Amine AktarAmaç: Çocukluk çağındaki diyabetes mellitusun (DM) çoğunluğunu tip 1 diyabet (T1DM) oluşturur. Ancak son yıllarda tip 2 diyabetes mellitus (T2DM) sıklığında ve monogenik diyabet (MD) tanısı koymada artış gözlenmektedir. Bu çalışmada 0-18 yaş arasında tanı konulan diyabetli hastalarda klinik ve laboratuvar bulgularının, DM tiplerinin değerlendirilmesi amaçlandı. Gereç ve yöntem: Çalışmada kliniğimizde DM tanısı alan 140 hasta retrospektif olarak değerlendirildi. Bulgular: Üç yıllık süreçte 140 hastaya (76 erkek, %54,3) diyabet tanısı konuldu. Hastaların ortalama tanı yaşı 10±4,19 yıldı. Hastaların %93,6'sına T1DM, %2,8'ine T2DM, %3,6'sına MD tanısı konuldu. Tip 1 diyabetes mellitus vakalarının 5-9 (%36,6) ve 10-14 (%37,4) yaş gruplarında zirve yaptığı görüldü. Diyabetik ketoasidoz (DKA) prevalansı %61,8 idi. Yine bu olguların %64,9'u sonbahar/kış aylarında tanı aldı. Tip2 diyabetli hastaların %75'i kadındı ve ortalama tanı yaşı 15,05±1,11 idi. Monogenik diyabetli olgularının ikisi neonatal DM, ikisi GCK-MODY ve biri CEL-MODY idi. Sonuç: Çocukluk çağı diyabet vakalarının çoğunluğu T1DM olmasına rağmen, özellikle obez ergenlerde T2DM sıklığı artma eğilimindedir. Otoantikor pozitif T1DM’li hastalarda da obezitenin olabileceği akılda tutulmalıdır. Tip1 diyabet olgularının daha çok kış mevsiminde, 10-14 yaş grubunda başvurduğu ve DKA sıklığının yüksek olduğu saptandı. Monogenik diyabet şüphesi olan olgulara genetik inceleme yapılmalıdır.
