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Induction of apoptosis in human hormone-refractory prostate cancer cell lines by using resveratrol in combination with AT-101

dc.authorid 0000-0003-2192-9049
dc.authorid 0000-0003-4944-0819
dc.contributor.author Aktepe, Necmettin
dc.contributor.author Yukselten, Yunus
dc.contributor.other Department of Nursing / Hemşirelik Bölümü
dc.date.accessioned 2021-10-21T06:19:23Z
dc.date.available 2021-10-21T06:19:23Z
dc.date.issued 2021
dc.department MAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü en_US
dc.description.abstract The aim of this study was to determine the appropriate doses of AT-101 and resveratrol combination in the in vitro hormone-refractory prostate cancer (PC) cell lines, in order to evaluate the cytotoxic and genotoxic effects of this combination on the proliferation of cancer cells, namely PC-3, DU-145 and LNCAP. Cytotoxicity in PC cell lines was analysed by using the XTT Cell Proliferation Assay. DNA damage was performed with the cell death assay. Apoptotic protein levels were performed by Roche Human Apoptosis Array. IC50 values were determined by XTT analysis. The strongest combined doses (100 µM resveratrol + 5µM AT-101) were found to have the strongest synergistic apoptotic and cytotoxic effects on DU-145 cells at 72 hr. While the combined use of resveratrol and AT-101 increased the expression of markers in apoptotic cell pathways on cells, a decrease in the expression of anti-apoptotic markers was detected (p ˂ 0.05). Combined applications of these compounds showed an important synergism in the hormone-refractory PC cell lines, and it was determined that after the post-translational modification, they were significantly effective on the apoptotic pathway. These results have revealed that the combination of resveratrol and AT-101 holds great expectation as a new chemotherapeutic application in the treatment of human prostate cancer. en_US
dc.description.citation Aktepe, N., & Yukselten, Y. (2021). Induction of apoptosis in human hormone‐refractory prostate cancer cell lines by using resveratrol in combination with AT‐101. In Andrologia. Wiley. https://doi.org/10.1111/and.14267 en_US
dc.identifier.doi 10.1111/and.14267
dc.identifier.pmid 34633104
dc.identifier.scopus 2-s2.0-85116724500
dc.identifier.uri https://doi.org/10.1111/and.14267
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000705332400001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=F2yD84a3mpZOfw1zNMF
dc.identifier.uri https://www.scopus.com/record/display.uri?eid=2-s2.0-85116724500&origin=resultslist&sort=plf-f&src=s&sid=490e2dd39833da2bc1ffbfd6cc1f1cd6&sot=b&sdt=b&sl=22&s=DOI%2810.1111%2fand.14267%29&relpos=0&citeCnt=0&searchTerm=
dc.identifier.uri https://hdl.handle.net/20.500.12514/2895
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/34633104/
dc.identifier.wos WOS:000705332400001
dc.identifier.wosquality Q3
dc.indekslendigikaynak Web of Science en_US
dc.indekslendigikaynak Scopus en_US
dc.indekslendigikaynak PubMed en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.ispartof ANDROLOGIA en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 2
dc.subject apoptosis; AT-101; prostate cancer; protein array; resveratrol en_US
dc.title Induction of apoptosis in human hormone-refractory prostate cancer cell lines by using resveratrol in combination with AT-101 en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
relation.isAuthorOfPublication 9b8ee110-5811-4b71-8b78-4d852abadcba
relation.isAuthorOfPublication.latestForDiscovery 9b8ee110-5811-4b71-8b78-4d852abadcba
relation.isOrgUnitOfPublication 1afe7739-9ea9-4c3b-af5c-fb0baee4f95c
relation.isOrgUnitOfPublication.latestForDiscovery 1afe7739-9ea9-4c3b-af5c-fb0baee4f95c

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