Prognostic significance of the chemerin level in coronavirus disease 2019 patients

dc.contributor.author Arac, Songul
dc.contributor.author Yokus, Beran
dc.contributor.author Gokdemir, Guel Sahika
dc.contributor.author Gokdemir, Mehmet Tahir
dc.date.accessioned 2024-04-15T10:45:32Z
dc.date.accessioned 2025-09-17T14:28:04Z
dc.date.available 2024-04-15T10:45:32Z
dc.date.available 2025-09-17T14:28:04Z
dc.date.issued 2024
dc.description Gokdemir, Gul Sahika/0000-0002-8691-1504 en_US
dc.description.abstract Increased serum chemerin levels have been reported in several inflammatory diseases. Few studies have investigated the relationship between chemerin and clinical features of COVID-19. Thus, chemerin may modulate the development and progression of COVID-19. We compared the serum chemerin concentration between patients with and without SARS-CoV-2 infection and its association with the severity and prognosis of COVID-19 pneumonia. This is a prospective, single-center, cross-sectional study. We enrolled COVID-19 patients who presented to our tertiary hospital and healthy controls. The COVID-19 patients were conducted and the dates of symptom onset were recorded. After admission to the hospital and stabilization, blood samples were obtained for routine hemogram, biochemistry, and chemerin. The chemerin level was 37.93 +/- 17.3 ng/mL in patients followed in the ICU, 29.41 +/- 12.79 ng/mL in inpatients, 30.48 +/- 10.86 ng/mL in outpatients, and 25.12 +/- 9.82 ng/mL in healthy controls. The difference between patients treated in the ICU and healthy controls was significant (P < .001). The high-sensitivity C-reactive protein (hs-CRP), ferritin, procalcitonin (PCT), and D-dimer levels were significantly higher in the intensive care unit (ICU) group (P < .001). Moreover, the chemerin level of patients who died was significantly higher than that of those who survived (P < .001). The chemerin level was increased in COVID-19 patients and also increased with increasing disease severity. The chemerin level was higher in the COVID-19 patients than healthy controls and was significantly higher in patients who died compared to those who did not. en_US
dc.identifier.citation Gokdemir, Gül Şahika PhDa,*; Gokdemir, Mehmet Tahir MDb; Araç, Songül MDc; Yokuş, Beran PhDd. Prognostic significance of the chemerin level in coronavirus disease 2019 patients. Medicine 103(14):p e37743, April 05, 2024. | DOI: 10.1097/MD.0000000000037743 en_US
dc.identifier.doi 10.1097/MD.0000000000037743
dc.identifier.issn 0025-7974
dc.identifier.issn 1536-5964
dc.identifier.scopus 2-s2.0-85190080849
dc.identifier.uri https://doi.org/10.1097/MD.0000000000037743
dc.identifier.uri https://hdl.handle.net/20.500.12514/9366
dc.language.iso en en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Chemerin en_US
dc.subject Coronavirus Disease 2019 en_US
dc.subject Intensive Care Unit en_US
dc.subject Outpatient en_US
dc.title Prognostic significance of the chemerin level in coronavirus disease 2019 patients
dc.title Prognostic Significance of the Chemerin Level in Coronavirus Disease 2019 Patients en_US
dc.type Article en_US
dspace.entity.type Publication

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